Radiation colitis - Revision history

Michael at 04:56, 28 December 2014

2014-12-28T04:56:04Z

← Older revision		Revision as of 04:56, 28 December 2014
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	\| Tx =		\| Tx =
	}}		}}
	'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. This article also covers '''radiation proctitis'''.		'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. This article also covers '''radiation proctitis''' (abbreviated '''RP''').

	==General==		==General==

Michael: +infobox, +images

2014-12-23T02:03:22Z

+infobox, +images

← Older revision		Revision as of 02:03, 23 December 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Radiation_proctitis_-_2_alt_--_high_mag.jpg
			\| Width =
			\| Caption = Radiation proctitis. [[H&E stain]].
			\| Synonyms =
			\| Micro = ''acute'': mucosal changes ([[necrosis]] of epithelium, "ghost cells" = cells without nuclei, hemorrhage), submucosa edema with neutrophilic infiltrate, +/-fibrin thrombi; ''chronic'': nuclear atypia - esp. of the stromal cells, fibrosis - esp. of the submucosa
			\| Subtypes =
			\| LMDDx = [[inflammatory bowel disease]], [[Infectious colitis]], [[ischemic colitis]], pseudosarcomatous stromal changes, [[sarcoma]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[colon]] and [[rectum]] (''radiation proctitis'')
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = history of radiation, history of [[cancer]]
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = cancer recurrence, colitis/proctitis (idiopathic, infection, ischemic, radiation)
			\| Tx =
			}}
	'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. This article also covers '''radiation proctitis'''.		'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. This article also covers '''radiation proctitis'''.

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	*Telangiectatic lesions.		*Telangiectatic lesions.

	Image:		===Image===
	*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F4.html#figure-title Telangiectatic lesions (nature.com)].<ref name=pmid18174905>{{Cite journal \| last1 = Nielsen \| first1 = OH. \| last2 = Vainer \| first2 = B. \| last3 = Rask-Madsen \| first3 = J. \| title = Non-IBD and noninfectious colitis. \| journal = Nat Clin Pract Gastroenterol Hepatol \| volume = 5 \| issue = 1 \| pages = 28-39 \| month = Jan \| year = 2008 \| doi = 10.1038/ncpgasthep1005 \| PMID = 18174905 }}</ref>		*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F4.html#figure-title Telangiectatic lesions (nature.com)].<ref name=pmid18174905>{{Cite journal \| last1 = Nielsen \| first1 = OH. \| last2 = Vainer \| first2 = B. \| last3 = Rask-Madsen \| first3 = J. \| title = Non-IBD and noninfectious colitis. \| journal = Nat Clin Pract Gastroenterol Hepatol \| volume = 5 \| issue = 1 \| pages = 28-39 \| month = Jan \| year = 2008 \| doi = 10.1038/ncpgasthep1005 \| PMID = 18174905 }}</ref>
	==Microscopic==		==Microscopic==
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	*Infectious colitis.		*Infectious colitis.

	Images:		===Images===
			<gallery>
			Image: Radiation proctitis -- very low mag.jpg \| RP - very low mag.
			Image: Radiation proctitis -- low mag.jpg \| RP - low mag.
			Image: Radiation proctitis - alt -- low mag.jpg \| RP - low mag.
			Image: Radiation proctitis -- intermed mag.jpg \| RP - intermed. mag.
			Image: Radiation proctitis -- high mag.jpg \| RP - high mag.
			Image: Radiation proctitis -- very high mag.jpg \| RP - very high mag.
			Image: Radiation proctitis - 2 -- intermed mag.jpg \| RP - intermed. mag.
			Image: Radiation proctitis - 2 -- high mag.jpg \| RP - high mag.
			Image: Radiation proctitis - 2 alt -- high mag.jpg \| RP - high mag.

			Image: Proctitis with reactive changes -- intermed mag.jpg \| PRC - intermed. mag.
			Image: Proctitis with reactive changes -- high mag.jpg \| PRC - high mag.
			Image: Proctitis with reactive changes - alt -- high mag.jpg \| PRC - high mag.
			</gallery>
			www:
	*[http://gut.bmj.com/content/41/3/354/F2.large.jpg Radiation colitis - rat model (bmj.com)].<ref name=pmid9378391/>		*[http://gut.bmj.com/content/41/3/354/F2.large.jpg Radiation colitis - rat model (bmj.com)].<ref name=pmid9378391/>
	*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F5.html#figure-title Radiation colitis (nature.com)].<ref name=pmid18174905>{{Cite journal \| last1 = Nielsen \| first1 = OH. \| last2 = Vainer \| first2 = B. \| last3 = Rask-Madsen \| first3 = J. \| title = Non-IBD and noninfectious colitis. \| journal = Nat Clin Pract Gastroenterol Hepatol \| volume = 5 \| issue = 1 \| pages = 28-39 \| month = Jan \| year = 2008 \| doi = 10.1038/ncpgasthep1005 \| PMID = 18174905 }}</ref>		*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F5.html#figure-title Radiation colitis (nature.com)].<ref name=pmid18174905>{{Cite journal \| last1 = Nielsen \| first1 = OH. \| last2 = Vainer \| first2 = B. \| last3 = Rask-Madsen \| first3 = J. \| title = Non-IBD and noninfectious colitis. \| journal = Nat Clin Pract Gastroenterol Hepatol \| volume = 5 \| issue = 1 \| pages = 28-39 \| month = Jan \| year = 2008 \| doi = 10.1038/ncpgasthep1005 \| PMID = 18174905 }}</ref>

Michael: /* Sign out */

2014-05-14T17:50:05Z

Sign out

← Older revision		Revision as of 17:50, 14 May 2014
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	REGENERATIVE CHANGES.		REGENERATIVE CHANGES.
	- LARGE ATYPICAL STROMAL CELLS COMPATIBLE WITH RADIATION CHANGES.		- LARGE ATYPICAL STROMAL CELLS COMPATIBLE WITH RADIATION CHANGES.
	- NO EVIDENCE OF MALIGNANCY.		- NO EVIDENCE OF DYSPLASIA AND NO EVIDENCE OF MALIGNANCY.

	COMMENT:		COMMENT:

Michael: /* Sign out */

2014-05-14T17:48:00Z

Sign out

← Older revision		Revision as of 17:48, 14 May 2014
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	COMMENT:		COMMENT:
	The immunostains done (pankeratin, p53, Ki-67) is in keeping		The immunostains done (pankeratin, p53, Ki-67) are in keeping
	with regeneration and radiation changes.		with regeneration and radiation changes.
	</pre>		</pre>

Michael: /* Microscopic */

2014-05-14T17:47:42Z

Microscopic

← Older revision		Revision as of 17:47, 14 May 2014
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	*[http://gut.bmj.com/content/41/3/354/F2.large.jpg Radiation colitis - rat model (bmj.com)].<ref name=pmid9378391/>		*[http://gut.bmj.com/content/41/3/354/F2.large.jpg Radiation colitis - rat model (bmj.com)].<ref name=pmid9378391/>
	*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F5.html#figure-title Radiation colitis (nature.com)].<ref name=pmid18174905>{{Cite journal \| last1 = Nielsen \| first1 = OH. \| last2 = Vainer \| first2 = B. \| last3 = Rask-Madsen \| first3 = J. \| title = Non-IBD and noninfectious colitis. \| journal = Nat Clin Pract Gastroenterol Hepatol \| volume = 5 \| issue = 1 \| pages = 28-39 \| month = Jan \| year = 2008 \| doi = 10.1038/ncpgasthep1005 \| PMID = 18174905 }}</ref>		*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F5.html#figure-title Radiation colitis (nature.com)].<ref name=pmid18174905>{{Cite journal \| last1 = Nielsen \| first1 = OH. \| last2 = Vainer \| first2 = B. \| last3 = Rask-Madsen \| first3 = J. \| title = Non-IBD and noninfectious colitis. \| journal = Nat Clin Pract Gastroenterol Hepatol \| volume = 5 \| issue = 1 \| pages = 28-39 \| month = Jan \| year = 2008 \| doi = 10.1038/ncpgasthep1005 \| PMID = 18174905 }}</ref>

			==Sign out==
			<pre>
			RECTUM, BIOPSY:
			- RECTAL MUCOSA WITH ACTIVE INFLAMMATION, ULCERATION AND
			REGENERATIVE CHANGES.
			- LARGE ATYPICAL STROMAL CELLS COMPATIBLE WITH RADIATION CHANGES.
			- NO EVIDENCE OF MALIGNANCY.

			COMMENT:
			The immunostains done (pankeratin, p53, Ki-67) is in keeping
			with regeneration and radiation changes.
			</pre>

	==See also==		==See also==

Michael at 12:59, 29 October 2013

2013-10-29T12:59:47Z

← Older revision		Revision as of 12:59, 29 October 2013
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	'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic.		'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic. This article also covers '''radiation proctitis'''.

	==General==		==General==

Michael: tweak

2013-04-15T23:23:22Z

tweak

← Older revision		Revision as of 23:23, 15 April 2013
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	'''Radiation colitis''' is inflammation of the [[colon]] due to radiation.		'''Radiation [[colitis]]''' is inflammation of the [[colon]] due to radiation. It is usually iatrogenic.

	==General==		==General==
	*Diagnosis should be supported by clinical history.		*[[Diagnosis]] should be supported by the clinical history.

	~~Causes of colitides~~:		General DDx for a [[colitis]]:
	*[[~~Inflammatory~~ bowel disease]].		*Idiopathic, e.g. [[inflammatory bowel disease]].
	*Infection.		*[[Infectious colitis\|Infection]].
	*[[Ischemic colitis\|Ischemia]].		*[[Ischemic colitis\|Ischemia]].
	*Radiation.		*Radiation.

Michael: /* General */

2013-03-04T01:42:50Z

General

← Older revision		Revision as of 01:42, 4 March 2013
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	*Diagnosis should be supported by clinical history.		*Diagnosis should be supported by clinical history.

	~~Cause~~ of colitides:		Causes of colitides:
	*~~IBD~~.		*[[Inflammatory bowel disease]].
	*Infection.		*Infection.
	*Ischemia.		*[[Ischemic colitis\|Ischemia]].
	*Radiation.		*Radiation.

Michael: /* See also */

2013-02-24T05:15:14Z

Michael: more

2013-02-22T02:48:29Z

← Older revision		Revision as of 02:48, 22 February 2013
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	==Gross==		==Gross==
	*Superficial bowel wall injury - shallow ulceration.<ref name=pmid9378391/>		*Superficial bowel wall injury - shallow ulceration.<ref name=pmid9378391/>
			*Telangiectatic lesions.

			Image:
			*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F4.html#figure-title Telangiectatic lesions (nature.com)].<ref name=pmid18174905>{{Cite journal \| last1 = Nielsen \| first1 = OH. \| last2 = Vainer \| first2 = B. \| last3 = Rask-Madsen \| first3 = J. \| title = Non-IBD and noninfectious colitis. \| journal = Nat Clin Pract Gastroenterol Hepatol \| volume = 5 \| issue = 1 \| pages = 28-39 \| month = Jan \| year = 2008 \| doi = 10.1038/ncpgasthep1005 \| PMID = 18174905 }}</ref>
	==Microscopic==		==Microscopic==
	Features - acute:<ref name=pmid9378391>{{Cite journal \| last1 = Yano \| first1 = Y. \| last2 = Yao \| first2 = H. \| last3 = Aoyagi \| first3 = K. \| last4 = Kawakubo \| first4 = K. \| last5 = Nakamura \| first5 = S. \| last6 = Doi \| first6 = K. \| last7 = Ibayashi \| first7 = S. \| last8 = Fujishima \| first8 = M. \| title = Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats. \| journal = Gut \| volume = 41 \| issue = 3 \| pages = 354-7 \| month = Sep \| year = 1997 \| doi = \| PMID = 9378391 }}</ref>		Features - acute:<ref name=pmid9378391>{{Cite journal \| last1 = Yano \| first1 = Y. \| last2 = Yao \| first2 = H. \| last3 = Aoyagi \| first3 = K. \| last4 = Kawakubo \| first4 = K. \| last5 = Nakamura \| first5 = S. \| last6 = Doi \| first6 = K. \| last7 = Ibayashi \| first7 = S. \| last8 = Fujishima \| first8 = M. \| title = Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats. \| journal = Gut \| volume = 41 \| issue = 3 \| pages = 354-7 \| month = Sep \| year = 1997 \| doi = \| PMID = 9378391 }}</ref>
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Gastrointestinal pathology]]		[[Category:Gastrointestinal pathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

← Older revision		Revision as of 05:15, 24 February 2013
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	*[[Inflammatory bowel disease]].		*[[Inflammatory bowel disease]].
	*[[Colon]].		*[[Colon]].
			*[[Radiation changes]].

	==References==		==References==