Pulmonary Langerhans cell histiocytosis - Revision history

Michael at 21:45, 15 April 2016

2016-04-15T21:45:56Z

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	'''Pulmonary Langerhans cell histiocytosis''' is an uncommon [[smoking\|smoking-related lung disease]].		'''Pulmonary Langerhans cell histiocytosis''' is an uncommon [[smoking\|smoking-related lung disease]].

	It is also known as '''eosinophilic granuloma of the lung'''.		It is also known as '''eosinophilic granuloma of the lung'''.

			The term ''Langerhans cell histiocytosis'' refers to several different diseases; a separate article deals with the other types of [[Langerhans cell histiocytosis]].

	==General==		==General==

2015-12-23T06:38:40Z

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	\| LMDDx =		\| LMDDx =
	\| Stains =		\| Stains =
	\| IHC = Langerhans cells (CD1a +ve, S-100 +ve, CD207 +ve		\| IHC = Langerhans cells (CD1a +ve, S-100 +ve, CD207 +ve)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

2015-12-23T06:38:13Z

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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = [[smoker]]		\| Clinicalhx = [[smoking\|smoker]], usually male 20-40 years old
	\| Signs = +/-non-productive cough		\| Signs = +/-non-productive cough
	\| Symptoms = +/-[[dyspnea]]		\| Symptoms = +/-[[dyspnea]]

2015-12-23T06:37:49Z

← Older revision		Revision as of 06:37, 23 December 2015
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = [[smoker]]
	\| Signs =		\| Signs = +/-non-productive cough
	\| Symptoms =		\| Symptoms = +/-[[dyspnea]]
	\| Prevalence = uncommon		\| Prevalence = uncommon
	\| Bloodwork =		\| Bloodwork =
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	*Not associated with systemic diseases of Langerhans cells ([[AKA]] [[Langerhans cell histiocytosis\|Hand-Schueller-Christian disease]]).		*Not associated with systemic diseases of Langerhans cells ([[AKA]] [[Langerhans cell histiocytosis\|Hand-Schueller-Christian disease]]).

	Clinical:		Clinical - features:<ref name=pmid25473537>{{Cite journal \| last1 = Martin \| first1 = I. \| last2 = Ballester \| first2 = M. \| last3 = Ruiz \| first3 = Y. \| last4 = Llatjós \| first4 = R. \| last5 = Alarza \| first5 = F. \| last6 = Molina \| first6 = M. \| title = Presentation of pulmonary Langerhans cell histiocytosis before the development of lung cysts. \| journal = Respirol Case Rep \| volume = 1 \| issue = 2 \| pages = 34-5 \| month = Dec \| year = 2013 \| doi = 10.1002/rcr2.11 \| PMID = 25473537 }}</ref>
	*Non-productive cough.		*Non-productive cough.
	*[[Dyspnea]].		*[[Dyspnea]].
			*Typically males - 20-40 years old.
			*Smokers.

	===Subtypes===		===Subtypes===

2015-12-23T06:34:26Z

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	\| Prevalence = uncommon		\| Prevalence = uncommon
	\| Bloodwork =		\| Bloodwork =
	\| Rads = upper lung zones		\| Rads = peribronchial nodules, upper lung zones or mid, multiple irregular cysts
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = good with smoking cessation		\| Prognosis = good with smoking cessation
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	*Not associated with systemic diseases of Langerhans cells ([[AKA]] [[Langerhans cell histiocytosis\|Hand-Schueller-Christian disease]]).		*Not associated with systemic diseases of Langerhans cells ([[AKA]] [[Langerhans cell histiocytosis\|Hand-Schueller-Christian disease]]).

			Clinical:
			*Non-productive cough.
			*[[Dyspnea]].

			===Subtypes===
	Subtypes:<ref name=Ref_PPP234/>		Subtypes:<ref name=Ref_PPP234/>
	*Cellular form.		*Cellular form.
	*Fibrotic form.		*Fibrotic form.

	One form usually predominates.		Note:
			*One form usually predominates.

	==Radiology==		==Radiology==
	*Upper lung zones.		*Upper lung zones.

2015-12-23T06:27:28Z

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	\| Prognosis = good with smoking cessation		\| Prognosis = good with smoking cessation
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = non-pulmonary [[Langerhans cell histiocytosis]]
	\| Tx =		\| Tx =
	}}		}}

2015-12-23T06:27:02Z

Microscopic

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	DDx:		DDx:
	*Non-pulmonary [[Langerhans cell histiocytosis]].		*Non-pulmonary [[Langerhans cell histiocytosis]] - LCH is also found outside of the lung.

	===Images===		===Images===

2015-12-23T06:26:13Z

Microscopic

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	**+/-Eosinophilia (may be rare) - '''significantly narrow DDx'''.		**+/-Eosinophilia (may be rare) - '''significantly narrow DDx'''.
	**Chronic inflammatory cells (lymphocytes). (???)		**Chronic inflammatory cells (lymphocytes). (???)

			DDx:
			*Non-pulmonary [[Langerhans cell histiocytosis]].

	===Images===		===Images===

2015-12-23T06:23:26Z

2015-12-23T06:21:32Z

Microscopic

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	**Chronic inflammatory cells (lymphocytes). (???)		**Chronic inflammatory cells (lymphocytes). (???)

	Images:		===Images===
			<gallery>
			Image: Pulmonary Langerhans cell histiocytosis -- low mag.jpg \| PLCH - low mag. (WC)
			Image: Pulmonary Langerhans cell histiocytosis -- intermed mag.jpg \| PLCH - intermed. mag. (WC)
			Image: Pulmonary Langerhans cell histiocytosis - alt -- intermed mag.jpg \| PLCH - intermed. mag. (WC)
			Image: Pulmonary Langerhans cell histiocytosis -- high mag.jpg \| PLCH - high mag. (WC)
			Image: Pulmonary Langerhans cell histiocytosis -- very high mag.jpg \| PLCH - very high mag. (WC)
			</gallery>
			www:
	*[http://path.upmc.edu/cases/case299.html Pulmonary LCH & adenocarcinoma - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case299.html Pulmonary LCH & adenocarcinoma - several images (upmc.edu)].

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	==See also==		==See also==
	*[[Medical lung diseases]].		*[[Medical lung diseases]].
			*[[Langerhans cell histiocytosis]].
			*[[Smoking]].

	==References==		==References==