Pseudoangiomatous stromal hyperplasia - Revision history

Michael: update figure link

2019-04-02T22:22:37Z

update figure link

← Older revision		Revision as of 22:22, 2 April 2019
Line 74:		Line 74:
	</gallery>		</gallery>
	www:		www:
	<ref name=pmid18084246>{{Cite journal \| last1 = Ferreira \| first1 = M. \| last2 = Albarracin \| first2 = CT. \| last3 = Resetkova \| first3 = E. \| title = Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. \| journal = Mod Pathol \| volume = 21 \| issue = 2 \| pages = 201-7 \| month = Feb \| year = 2008 \| doi = 10.1038/modpathol.3801003 \| PMID = 18084246 }}</ref>		*[https://www.nature.com/articles/3801003/figures/2 PASH (nature.com)].<ref name=pmid18084246>{{Cite journal \| last1 = Ferreira \| first1 = M. \| last2 = Albarracin \| first2 = CT. \| last3 = Resetkova \| first3 = E. \| title = Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. \| journal = Mod Pathol \| volume = 21 \| issue = 2 \| pages = 201-7 \| month = Feb \| year = 2008 \| doi = 10.1038/modpathol.3801003 \| PMID = 18084246 }}</ref>

	==IHC==		==IHC==

Brigitte: /* Images */

2019-03-26T01:19:39Z

Images

← Older revision		Revision as of 01:19, 26 March 2019
Line 74:		Line 74:
	</gallery>		</gallery>
	www:		www:
	*[http://www.nature.com/modpathol/journal/v21/n2/fig_tab/3801003f1.html#figure-title PASH (nature.com)].<ref name=pmid18084246>{{Cite journal \| last1 = Ferreira \| first1 = M. \| last2 = Albarracin \| first2 = CT. \| last3 = Resetkova \| first3 = E. \| title = Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. \| journal = Mod Pathol \| volume = 21 \| issue = 2 \| pages = 201-7 \| month = Feb \| year = 2008 \| doi = 10.1038/modpathol.3801003 \| PMID = 18084246 }}</ref>		<ref name=pmid18084246>{{Cite journal \| last1 = Ferreira \| first1 = M. \| last2 = Albarracin \| first2 = CT. \| last3 = Resetkova \| first3 = E. \| title = Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. \| journal = Mod Pathol \| volume = 21 \| issue = 2 \| pages = 201-7 \| month = Feb \| year = 2008 \| doi = 10.1038/modpathol.3801003 \| PMID = 18084246 }}</ref>

	==IHC==		==IHC==

Carvalho: Fixed CD34 staining pattern (is positive).

2018-04-18T00:09:40Z

Fixed CD34 staining pattern (is positive).

← Older revision		Revision as of 00:09, 18 April 2018
Line 8:		Line 8:
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[fibroadenoma]], low-grade [[angiosarcoma]]		\| LMDDx = [[fibroadenoma]], low-grade [[angiosarcoma]]
	\| Stains = Bcl-2 +ve, vimentin +ve, CD34 -ve, CD31 -ve, factor VIII -ve		\| Stains = Bcl-2 +ve, vimentin +ve, CD34 +ve, SMMHC +ve, CD31 -ve, factor VIII -ve
	\| IHC =		\| IHC =
	\| EM =		\| EM =

Michael: touch

2015-04-28T22:35:16Z

touch

← Older revision		Revision as of 22:35, 28 April 2015
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Pseudoangiomatous_stromal_hyperplasia_-_high_mag.jpg		\| Image = Pseudoangiomatous_stromal_hyperplasia_-_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Pseudoangiomatous stromal hyperplasia. [[H&E stain]].		\| Caption = Pseudoangiomatous stromal hyperplasia. [[H&E stain]].

Michael: touch

2015-04-28T21:27:48Z

touch

← Older revision		Revision as of 21:27, 28 April 2015
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Pseudoangiomatous_stromal_hyperplasia_-_high_mag.jpg		\| Image = Pseudoangiomatous_stromal_hyperplasia_-_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Pseudoangiomatous stromal hyperplasia. [[H&E stain]].		\| Caption = Pseudoangiomatous stromal hyperplasia. [[H&E stain]].

Michael: /* Images */ +images

2015-04-28T16:18:53Z

Images: +images

← Older revision		Revision as of 16:18, 28 April 2015
Line 63:		Line 63:
	===Images===		===Images===
	<gallery>		<gallery>
	Image:~~Pseudoangiomatous_stromal_hyperplasia_~~-a-~~_low_mag~~.jpg \| PASH - low mag. (WC/Nephron)		Image:Pseudoangiomatous stromal hyperplasia -a- low mag.jpg \| PASH - low mag. (WC/Nephron)
	Image:~~Pseudoangiomatous_stromal_hyperplasia_~~-a-~~_intermed_mag~~.jpg \| PASH - intermed. mag. (WC/Nephron)		Image:Pseudoangiomatous stromal hyperplasia -a- intermed mag.jpg \| PASH - intermed. mag. (WC/Nephron)
	Image:~~Pseudoangiomatous_stromal_hyperplasia_~~-~~_high_mag~~.jpg \| PASH - high mag. (WC/Nephron)		Image:Pseudoangiomatous stromal hyperplasia -a2- intermed mag.jpg \| PASH - intermed. mag. (WC/Nephron)
			Image:Pseudoangiomatous stromal hyperplasia -a- high mag.jpg \| PASH - high mag. (WC/Nephron)
			</gallery>
			<gallery>
			Image:Pseudoangiomatous stromal hyperplasia - intermed mag.jpg \| PASH - intermed. mag. (WC/Nephron)
			Image:Pseudoangiomatous stromal hyperplasia - high mag.jpg \| PASH - high mag. (WC/Nephron)
			Image:Pseudoangiomatous stromal hyperplasia - very high mag.jpg \| PASH - very high mag. (WC/Nephron)
	</gallery>		</gallery>
	www:		www:

Michael: tweak - management

2015-04-28T16:15:18Z

tweak - management

← Older revision		Revision as of 16:15, 28 April 2015
Line 28:		Line 28:
	\| Other =		\| Other =
	\| ClinDDx = [[fibroadenoma]]		\| ClinDDx = [[fibroadenoma]]
	\| Tx = excision		\| Tx = followup or excision
	}}		}}
	'''Pseudoangiomatous stromal hyperplasia''', abbreviated ''PASH'', is benign lesion is [[breast pathology]].		'''Pseudoangiomatous stromal hyperplasia''', abbreviated ''PASH'', is benign lesion is [[breast pathology]].
Line 39:		Line 39:
	*An incidental finding ''or'' occasionally a mass.<ref name=pmid21862488>{{Cite journal \| last1 = Drinka \| first1 = EK. \| last2 = Bargaje \| first2 = A. \| last3 = Erşahin \| first3 = ÇH. \| last4 = Patel \| first4 = P. \| last5 = Salhadar \| first5 = A. \| last6 = Sinacore \| first6 = J. \| last7 = Rajan \| first7 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a clinicopathological study of 79 cases. \| journal = Int J Surg Pathol \| volume = 20 \| issue = 1 \| pages = 54-8 \| month = Feb \| year = 2012 \| doi = 10.1177/1066896911418643 \| PMID = 21862488 }}</ref>		*An incidental finding ''or'' occasionally a mass.<ref name=pmid21862488>{{Cite journal \| last1 = Drinka \| first1 = EK. \| last2 = Bargaje \| first2 = A. \| last3 = Erşahin \| first3 = ÇH. \| last4 = Patel \| first4 = P. \| last5 = Salhadar \| first5 = A. \| last6 = Sinacore \| first6 = J. \| last7 = Rajan \| first7 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a clinicopathological study of 79 cases. \| journal = Int J Surg Pathol \| volume = 20 \| issue = 1 \| pages = 54-8 \| month = Feb \| year = 2012 \| doi = 10.1177/1066896911418643 \| PMID = 21862488 }}</ref>
	*May be suspicious on imaging ([[BI-RADS]] 4 or 5).<ref name=pmid19097540>{{Cite journal \| last1 = Wieman \| first1 = SM. \| last2 = Landercasper \| first2 = J. \| last3 = Johnson \| first3 = JM. \| last4 = Ellis \| first4 = RL. \| last5 = Wester \| first5 = SM. \| last6 = Lambert \| first6 = PJ. \| last7 = Ross \| first7 = LA. \| title = Tumoral pseudoangiomatous stromal hyperplasia of the breast. \| journal = Am Surg \| volume = 74 \| issue = 12 \| pages = 1211-4 \| month = Dec \| year = 2008 \| doi = \| PMID = 19097540 }}</ref>		*May be suspicious on imaging ([[BI-RADS]] 4 or 5).<ref name=pmid19097540>{{Cite journal \| last1 = Wieman \| first1 = SM. \| last2 = Landercasper \| first2 = J. \| last3 = Johnson \| first3 = JM. \| last4 = Ellis \| first4 = RL. \| last5 = Wester \| first5 = SM. \| last6 = Lambert \| first6 = PJ. \| last7 = Ross \| first7 = LA. \| title = Tumoral pseudoangiomatous stromal hyperplasia of the breast. \| journal = Am Surg \| volume = 74 \| issue = 12 \| pages = 1211-4 \| month = Dec \| year = 2008 \| doi = \| PMID = 19097540 }}</ref>
	*May be followed or (surgically) excised.<ref name=pmid20887819>{{Cite journal \| last1 = Jaunoo \| first1 = SS. \| last2 = Thrush \| first2 = S. \| last3 = Dunn \| first3 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH): a brief review. \| journal = Int J Surg \| volume = 9 \| issue = 1 \| pages = 20-2 \| month = \| year = 2011 \| doi = 10.1016/j.ijsu.2010.09.005 \| PMID = 20887819 }}</ref>		*May be followed (expectant management) or (surgically) excised.<ref name=pmid20887819>{{Cite journal \| last1 = Jaunoo \| first1 = SS. \| last2 = Thrush \| first2 = S. \| last3 = Dunn \| first3 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH): a brief review. \| journal = Int J Surg \| volume = 9 \| issue = 1 \| pages = 20-2 \| month = \| year = 2011 \| doi = 10.1016/j.ijsu.2010.09.005 \| PMID = 20887819 }}</ref>

	==Gross==		==Gross==

Michael: /* General */

2015-04-28T16:12:45Z

General

← Older revision		Revision as of 16:12, 28 April 2015
Line 39:		Line 39:
	*An incidental finding ''or'' occasionally a mass.<ref name=pmid21862488>{{Cite journal \| last1 = Drinka \| first1 = EK. \| last2 = Bargaje \| first2 = A. \| last3 = Erşahin \| first3 = ÇH. \| last4 = Patel \| first4 = P. \| last5 = Salhadar \| first5 = A. \| last6 = Sinacore \| first6 = J. \| last7 = Rajan \| first7 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a clinicopathological study of 79 cases. \| journal = Int J Surg Pathol \| volume = 20 \| issue = 1 \| pages = 54-8 \| month = Feb \| year = 2012 \| doi = 10.1177/1066896911418643 \| PMID = 21862488 }}</ref>		*An incidental finding ''or'' occasionally a mass.<ref name=pmid21862488>{{Cite journal \| last1 = Drinka \| first1 = EK. \| last2 = Bargaje \| first2 = A. \| last3 = Erşahin \| first3 = ÇH. \| last4 = Patel \| first4 = P. \| last5 = Salhadar \| first5 = A. \| last6 = Sinacore \| first6 = J. \| last7 = Rajan \| first7 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a clinicopathological study of 79 cases. \| journal = Int J Surg Pathol \| volume = 20 \| issue = 1 \| pages = 54-8 \| month = Feb \| year = 2012 \| doi = 10.1177/1066896911418643 \| PMID = 21862488 }}</ref>
	*May be suspicious on imaging ([[BI-RADS]] 4 or 5).<ref name=pmid19097540>{{Cite journal \| last1 = Wieman \| first1 = SM. \| last2 = Landercasper \| first2 = J. \| last3 = Johnson \| first3 = JM. \| last4 = Ellis \| first4 = RL. \| last5 = Wester \| first5 = SM. \| last6 = Lambert \| first6 = PJ. \| last7 = Ross \| first7 = LA. \| title = Tumoral pseudoangiomatous stromal hyperplasia of the breast. \| journal = Am Surg \| volume = 74 \| issue = 12 \| pages = 1211-4 \| month = Dec \| year = 2008 \| doi = \| PMID = 19097540 }}</ref>		*May be suspicious on imaging ([[BI-RADS]] 4 or 5).<ref name=pmid19097540>{{Cite journal \| last1 = Wieman \| first1 = SM. \| last2 = Landercasper \| first2 = J. \| last3 = Johnson \| first3 = JM. \| last4 = Ellis \| first4 = RL. \| last5 = Wester \| first5 = SM. \| last6 = Lambert \| first6 = PJ. \| last7 = Ross \| first7 = LA. \| title = Tumoral pseudoangiomatous stromal hyperplasia of the breast. \| journal = Am Surg \| volume = 74 \| issue = 12 \| pages = 1211-4 \| month = Dec \| year = 2008 \| doi = \| PMID = 19097540 }}</ref>
			*May be followed or (surgically) excised.<ref name=pmid20887819>{{Cite journal \| last1 = Jaunoo \| first1 = SS. \| last2 = Thrush \| first2 = S. \| last3 = Dunn \| first3 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH): a brief review. \| journal = Int J Surg \| volume = 9 \| issue = 1 \| pages = 20-2 \| month = \| year = 2011 \| doi = 10.1016/j.ijsu.2010.09.005 \| PMID = 20887819 }}</ref>

	==Gross==		==Gross==

Michael: /* Gross */

2014-02-01T00:48:53Z

Gross

← Older revision		Revision as of 00:48, 1 February 2014
Line 42:		Line 42:
	==Gross==		==Gross==
	Features:<ref name=pmid7872425>{{cite journal \|author=Powell CM, Cranor ML, Rosen PP \|title=Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation \|journal=Am. J. Surg. Pathol. \|volume=19 \|issue=3 \|pages=270–7 \|year=1995 \|month=March \|pmid=7872425 \|doi= \|url=}}</ref>		Features:<ref name=pmid7872425>{{cite journal \|author=Powell CM, Cranor ML, Rosen PP \|title=Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation \|journal=Am. J. Surg. Pathol. \|volume=19 \|issue=3 \|pages=270–7 \|year=1995 \|month=March \|pmid=7872425 \|doi= \|url=}}</ref>
	*May form mass~~: grey~~-white & firm~~, with well~~ circumscribed borders.		*May form mass.
			**Grey-white & firm.
			**Well-circumscribed borders.

	==Microscopic==		==Microscopic==

Michael at 00:45, 1 February 2014

2014-02-01T00:45:18Z

← Older revision		Revision as of 00:45, 1 February 2014
Line 37:		Line 37:
	*Benign lesion.		*Benign lesion.
	*Thought to arise due to myofibroblast abnormality - though not well understood.<ref name=pmid7872425>{{cite journal \|author=Powell CM, Cranor ML, Rosen PP \|title=Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation \|journal=Am. J. Surg. Pathol. \|volume=19 \|issue=3 \|pages=270–7 \|year=1995 \|month=March \|pmid=7872425 \|doi= \|url=}}</ref>		*Thought to arise due to myofibroblast abnormality - though not well understood.<ref name=pmid7872425>{{cite journal \|author=Powell CM, Cranor ML, Rosen PP \|title=Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation \|journal=Am. J. Surg. Pathol. \|volume=19 \|issue=3 \|pages=270–7 \|year=1995 \|month=March \|pmid=7872425 \|doi= \|url=}}</ref>
	*~~Often an~~ incidental finding.		*An incidental finding ''or'' occasionally a mass.<ref name=pmid21862488>{{Cite journal \| last1 = Drinka \| first1 = EK. \| last2 = Bargaje \| first2 = A. \| last3 = Erşahin \| first3 = ÇH. \| last4 = Patel \| first4 = P. \| last5 = Salhadar \| first5 = A. \| last6 = Sinacore \| first6 = J. \| last7 = Rajan \| first7 = P. \| title = Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a clinicopathological study of 79 cases. \| journal = Int J Surg Pathol \| volume = 20 \| issue = 1 \| pages = 54-8 \| month = Feb \| year = 2012 \| doi = 10.1177/1066896911418643 \| PMID = 21862488 }}</ref>
			*May be suspicious on imaging ([[BI-RADS]] 4 or 5).<ref name=pmid19097540>{{Cite journal \| last1 = Wieman \| first1 = SM. \| last2 = Landercasper \| first2 = J. \| last3 = Johnson \| first3 = JM. \| last4 = Ellis \| first4 = RL. \| last5 = Wester \| first5 = SM. \| last6 = Lambert \| first6 = PJ. \| last7 = Ross \| first7 = LA. \| title = Tumoral pseudoangiomatous stromal hyperplasia of the breast. \| journal = Am Surg \| volume = 74 \| issue = 12 \| pages = 1211-4 \| month = Dec \| year = 2008 \| doi = \| PMID = 19097540 }}</ref>

	==Gross==		==Gross==
Line 51:		Line 52:
	Notes:		Notes:
	*May mimic angiosarcoma at low power; PASH may have the same architecture but lack nuclear atypia.		*May mimic angiosarcoma at low power; PASH may have the same architecture but lack nuclear atypia.
			*Occasionally has mitotic activity - ''proliferative PASH''.

	DDx:		DDx: