Prostate cancer grading - Revision history

Michael: /* When to use/not to use */

2018-10-10T16:37:20Z

When to use/not to use

← Older revision		Revision as of 16:37, 10 October 2018
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	====When to use/not to use====		====When to use/not to use====
	The ''College of American Pathologist'' synoptic (''Cancer Protocol Template'') says:<ref>Srigley JR ''et al.'', "Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate Gland", College of American Pathologists, Version: 4.0.3.0. (June 2017), Accessed on: 10 October 2018.</ref>		The ''College of American Pathologist'' synoptic (''Cancer Protocol Template'') says:<ref>Srigley JR ''et al.'', "Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate Gland", College of American Pathologists, Version: 4.0.3.0. (June 2017), Accessed on: 10 October 2018.</ref>
	*Grade all prostate specimens with adenocarcinoma except those with prior treatment changes (e.g. radiation therapy or anti-androgen ~~change~~).		*Grade all prostate specimens with adenocarcinoma except those with prior treatment changes (e.g. radiation therapy changes or anti-androgen changes).

	====Tertiary Gleason pattern====		====Tertiary Gleason pattern====

Michael: /* When to use/not to use */

2018-10-10T16:35:46Z

When to use/not to use

← Older revision		Revision as of 16:35, 10 October 2018
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	====When to use/not to use====		====When to use/not to use====
	The ''College of American Pathologist'' synoptic says:<ref>Srigley JR ''et al.'', "Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate Gland", College of American Pathologists, Version: 4.0.3.0. (June 2017), Accessed on: 10 October 2018.</ref>		The ''College of American Pathologist'' synoptic (''Cancer Protocol Template'') says:<ref>Srigley JR ''et al.'', "Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate Gland", College of American Pathologists, Version: 4.0.3.0. (June 2017), Accessed on: 10 October 2018.</ref>
	*Grade all prostate specimens with adenocarcinoma except those with prior treatment changes (e.g. radiation therapy or anti-androgen change).		*Grade all prostate specimens with adenocarcinoma except those with prior treatment changes (e.g. radiation therapy or anti-androgen change).

Michael: /* Overview */

2018-10-10T16:35:15Z

Overview

← Older revision		Revision as of 16:35, 10 October 2018
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	***A biopsy with 98% Gleason pattern 4 and 2% Gleason pattern 3 would be graded as 8/10 (4+4).		***A biopsy with 98% Gleason pattern 4 and 2% Gleason pattern 3 would be graded as 8/10 (4+4).
	*Reported as on prostatectomies as: (primary pattern) + (secondary pattern) = sum, (tertiary pattern)		*Reported as on prostatectomies as: (primary pattern) + (secondary pattern) = sum, (tertiary pattern)

			====When to use/not to use====
			The ''College of American Pathologist'' synoptic says:<ref>Srigley JR ''et al.'', "Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate Gland", College of American Pathologists, Version: 4.0.3.0. (June 2017), Accessed on: 10 October 2018.</ref>
			*Grade all prostate specimens with adenocarcinoma except those with prior treatment changes (e.g. radiation therapy or anti-androgen change).

	====Tertiary Gleason pattern====		====Tertiary Gleason pattern====

Michael: /* See also */

2018-08-24T13:23:09Z

Michael: /* See also */

2018-04-13T20:36:15Z

Michael: /* Order of Gleason score components changed */ +upgrade based on nodule

2018-03-12T16:28:37Z

Order of Gleason score components changed: +upgrade based on nodule

← Older revision		Revision as of 16:28, 12 March 2018
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	The change in the order of the Gleason score components (3+4 on prostatectomy		The change in the order of the Gleason score components (3+4 on prostatectomy
	versus 4+3 on core biopsy) may be explained by sampling.		versus 4+3 on core biopsy) may be explained by sampling.
			</pre>

			====Separate nodule upgrades prostatectomy====
			<pre>
			A tumour nodule in the left mid portion of the gland (1.2 cm) is predominantly 4+3; the Gleason score for the case is assigned on the basis of the tumour nodule as Gleason score 7/10 (4+3).

			Overall, Gleason pattern 3 represents 65% of the cancer in the prostate, and Gleason pattern 4 represents 35% of the cancer in the prostate.
	</pre>		</pre>

Michael: /* Alternates */

2017-05-01T15:15:46Z

Alternates

← Older revision		Revision as of 15:15, 1 May 2017
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	<pre>		<pre>
	~~The World Health Organization (WHO) endorsed prostate cancer grade grouping is: 3 out of 5.~~ Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour.		Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour.
			The World Health Organization (WHO) endorsed prostate cancer grade grouping is: 3 out of 5.
	</pre>		</pre>

Michael: /* Alternate */

2017-05-01T15:13:20Z

Alternate

← Older revision		Revision as of 15:13, 1 May 2017
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	</pre>		</pre>

	=====~~Alternate~~=====		=====Alternates=====
	<pre>		<pre>
	The World Health Organization (WHO) endorsed prostate cancer grade is: 3 out of 5. Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour.		The World Health Organization (WHO) prostate cancer grade is: 3 out of 5. Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour.
			</pre>

			<pre>
			The World Health Organization (WHO) endorsed prostate cancer grade grouping is: 3 out of 5. Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour.
	</pre>		</pre>

Michael: /* Prostate cancer grading system endorsed by the WHO */

2017-05-01T14:47:34Z

Prostate cancer grading system endorsed by the WHO

← Older revision		Revision as of 14:47, 1 May 2017
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	*[[AKA]] ''prognostic Gleason grade groupings''.		*[[AKA]] ''prognostic Gleason grade groupings''.
	*[[AKA]] ''a contemporary prostate cancer grading system'', abbreviated ''CPCGS''.		*[[AKA]] ''a contemporary prostate cancer grading system'', abbreviated ''CPCGS''.
			*[[AKA]] ''Gleason group''.<ref>URL: [http://www.cancer.net/cancer-types/prostate-cancer/stages-and-grades http://www.cancer.net/cancer-types/prostate-cancer/stages-and-grades]. Accessed on: May 1, 2017.</ref>
			This system has been proposed. Currently, it is not widely used. The name of the system is ''not'' completely settled.
	This system has been proposed. Currently, it is not widely used. The name of the system is ''not'' completely settled.		This system has been proposed. Currently, it is not widely used. The name of the system is ''not'' completely settled.

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	====Reporting examples====		====Reporting examples====
			Within a synoptic report:
			<pre>
			Grade group: Grade Group 3, Gleason score 4+3=7.
			</pre>

	As a comment:		As a comment:
	<pre>		<pre>
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	</pre>		</pre>

	~~Within a synoptic report:~~		=====Alternate=====
	<pre>		<pre>
	~~Grade group~~: ~~Grade Group~~ 3, Gleason ~~score~~ 4~~+3=7~~.		The World Health Organization (WHO) endorsed prostate cancer grade is: 3 out of 5. Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour.
	</pre>		</pre>

Michael: /* Prostate cancer grading system endorsed by the WHO */

2017-04-28T14:05:51Z

Prostate cancer grading system endorsed by the WHO

← Older revision		Revision as of 14:05, 28 April 2017
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	\| 11.7		\| 11.7
	\|}		\|}

			===Sign out===
			*The language is still evolving as this is relatively new.
			*As of 2017, many pathologists continue to predominantly use (modified) Gleason grading, and add a comment about (the equivalent grade in) the new grading system.

			====Reporting examples====
			As a comment:
			<pre>
			The World Health Organization (WHO) grade is: 3 out of 5. Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour.
			</pre>

			Within a synoptic report:
			<pre>
			Grade group: Grade Group 3, Gleason score 4+3=7.
			</pre>

	==See also==		==See also==

← Older revision		Revision as of 13:23, 24 August 2018
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	*[[Cancer staging systems]].		*[[Cancer staging systems]].
	*[[Cribriform pattern within invasive prostate carcinoma]].		*[[Cribriform pattern within invasive prostate carcinoma]].
			*[[Apparent diffusion coefficient]].

	==References==		==References==

← Older revision		Revision as of 20:36, 13 April 2018
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	*[[Prostate cancer staging]].		*[[Prostate cancer staging]].
	*[[Cancer staging systems]].		*[[Cancer staging systems]].
			*[[Cribriform pattern within invasive prostate carcinoma]].

	==References==		==References==