Progressive transformation of germinal centers - Revision history

Michael: /* Microscopic */ +images

2013-09-05T04:22:21Z

Microscopic: +images

← Older revision		Revision as of 04:22, 5 September 2013
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	**Expanded mantle zone.		**Expanded mantle zone.

	Images:		===Images===
	*[http:~~//commons~~.~~wikimedia~~.~~org~~/~~wiki/File~~:~~Progressive_transformation_of_germinal_centres_~~-1-~~_very_low_mag~~.jpg PTGCs - very low mag. (WC)].		<gallery>
	*[http:~~//commons~~.~~wikimedia~~.~~org/wiki/File~~:~~Progressive_transformation_of_germinal_centres_~~-1-~~_low_mag~~.jpg PTGCs - ~~low~~ mag. (WC)].		Image:Progressive transformation of germinal centres -1- low mag.jpg\| PTGCs - low mag. (WC)
			Image:Progressive transformation of germinal centres -1- intermed mag.jpg\| PTGCs - intermed. mag. (WC)
			</gallery>
			<gallery>
			Image:Progressive transformation of germinal centers -2- very low mag.jpg\| PTGCs - very low mag. (WC)
			Image:Progressive transformation of germinal centers -2- low mag.jpg\| PTGCs - low mag. (WC)
			Image:Progressive transformation of germinal centers -2- intermed mag.jpg\| PTGCs - intermed. mag. (WC)
			</gallery>

	==See also==		==See also==

Michael: +infobox

2013-09-05T04:20:07Z

+infobox

← Older revision		Revision as of 04:20, 5 September 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Progressive_transformation_of_germinal_centres_-1-_very_low_mag.jpg
			\| Width =
			\| Caption = PTGC. [[H&E stain]].
			\| Micro = follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone
			\| Subtypes =
			\| LMDDx = [[nodular lymphocyte predominant Hodgkin lymphoma]], other lymphomas
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[lymph node]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = lymphadenopathy
			\| Symptoms = asymptomatic
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = [[lymph node metastasis]], [[lymphoma]]
			}}
	'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]].		'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]].

Michael: /* General */ w

2011-11-20T01:03:02Z

General: w

← Older revision		Revision as of 01:03, 20 November 2011
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	*Benign.		*Benign.
	*Classically in younger patients.		*Classically in younger patients.
	*Associated with nodular lymphocyte predominant [[Hodgkin's lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal \|author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC \|title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature \|journal=Acta Haematol. \|volume=108 \|issue=1 \|pages=33–8 \|year=2002 \|pmid=12145465 \|doi= \|url=}}</ref>		*Associated with [[nodular lymphocyte predominant Hodgkin lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal \|author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC \|title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature \|journal=Acta Haematol. \|volume=108 \|issue=1 \|pages=33–8 \|year=2002 \|pmid=12145465 \|doi= \|url=}}</ref>

	Clinical:		Clinical:

Michael: +cat.

2011-11-15T05:52:08Z

+cat.

← Older revision		Revision as of 05:52, 15 November 2011
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	[[Category:Lymph node pathology]]		[[Category:Lymph node pathology]]
			[[Category:Diagnosis]]

Michael: +additional refs

2011-07-20T10:38:57Z

+additional refs

← Older revision		Revision as of 10:38, 20 July 2011
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|1}}

			==Additional reading==
			*{{cite journal \|author=Hansmann ML, Fellbaum C, Hui PK, Moubayed P \|title=Progressive transformation of germinal centers with and without association to Hodgkin's disease \|journal=Am. J. Clin. Pathol. \|volume=93 \|issue=2 \|pages=219–26 \|year=1990 \|month=February \|pmid=2405631 \|doi= \|url=}}
			*{{cite journal \|author=Kojima M, Nakamura S, Motoori T, ''et al.'' \|title=Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients \|journal=Int. J. Surg. Pathol. \|volume=11 \|issue=2 \|pages=101–7 \|year=2003 \|month=April \|pmid=12754626 \|doi= \|url=}}

	[[Category:Lymph node pathology]]		[[Category:Lymph node pathology]]

Michael: more

2011-07-19T19:07:08Z

← Older revision		Revision as of 19:07, 19 July 2011
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	'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare ~~condition seen in~~ [[lymph ~~nodes~~]].		'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]].

	==General==		==General==
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	==See also==		==See also==
	*[[Lymph node pathology]].		*[[Lymph node pathology]].
			*[[Lymph node]].
			*[[Haematopathology]].

	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|1}}

	[[Category:Lymph node pathology]]		[[Category:Lymph node pathology]]

Michael: create

2011-07-19T19:02:56Z

create

New page

'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare condition seen in [[lymph nodes]].

==General==
*Benign.
*Classically in younger patients.
*Associated with nodular lymphocyte predominant [[Hodgkin's lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal |author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC |title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature |journal=Acta Haematol. |volume=108 |issue=1 |pages=33–8 |year=2002 |pmid=12145465 |doi= |url=}}</ref>

Clinical:
*Asymptomatic lymphadenopathy.

==Microscopic==
Features:
*Follicular hyperplasia (many follicles).
*'''Focally''' large germinal centers with:
**Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- '''key feature'''.<ref name=pmid12145465/>
**Expanded mantle zone.

Images:
*[http://commons.wikimedia.org/wiki/File:Progressive_transformation_of_germinal_centres_-1-_very_low_mag.jpg PTGCs - very low mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Progressive_transformation_of_germinal_centres_-1-_low_mag.jpg PTGCs - low mag. (WC)].

==See also==
*[[Lymph node pathology]].

==References==
{{Reflist|2}}

[[Category:Lymph node pathology]]