Primary mediastinal B-cell lymphoma - Revision history

Mark: DLBCL vs PMBCL

2018-06-16T21:21:31Z

DLBCL vs PMBCL

← Older revision		Revision as of 21:21, 16 June 2018
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	*Rare.		*Rare.
	*Young adults, more common in females (M:F = 1:2)		*Young adults, more common in females (M:F = 1:2)
	*[[Mediastinum]].		*[[Mediastinum]]
			It is distinguished from DLBCL based on the patient demographics, radiological staging (showing mainly mediastinal disease) and immunoprofile (typically CD23+/CD30+). PMBCL has a better prognosis than DLBCL.

	==Microscopic==		==Microscopic==
	Features:		Features:
	*Atypical large lymphoid cells - ~~see~~ ''[[DLBCL]]''.		*Atypical large lymphoid cells - may be morphologically indistinguishable from ''[[DLBCL]]''
	*Classically associated with:		*Classically associated with:
	**Fibrosis		**Fibrosis

Mark: a few points

2018-05-12T17:43:52Z

a few points

← Older revision		Revision as of 17:43, 12 May 2018
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	Features:<ref name=pmid19074109 >{{Cite journal \| last1 = Johnson \| first1 = PW. \| last2 = Davies \| first2 = AJ. \| title = Primary mediastinal B-cell lymphoma. \| journal = Hematology Am Soc Hematol Educ Program \| volume = \| issue = \| pages = 349-58 \| month = \| year = 2008 \| doi = 10.1182/asheducation-2008.1.349 \| PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal \| last1 = Coso \| first1 = D. \| last2 = Rey \| first2 = J. \| last3 = Bouabdallah \| first3 = R. \| title = [Primary mediastinal B-cell lymphoma] \| journal = Rev Pneumol Clin \| volume = 66 \| issue = 1 \| pages = 32-5 \| month = Feb \| year = 2010 \| doi = 10.1016/j.pneumo.2009.12.007 \| PMID = 20207294 }}</ref>		Features:<ref name=pmid19074109 >{{Cite journal \| last1 = Johnson \| first1 = PW. \| last2 = Davies \| first2 = AJ. \| title = Primary mediastinal B-cell lymphoma. \| journal = Hematology Am Soc Hematol Educ Program \| volume = \| issue = \| pages = 349-58 \| month = \| year = 2008 \| doi = 10.1182/asheducation-2008.1.349 \| PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal \| last1 = Coso \| first1 = D. \| last2 = Rey \| first2 = J. \| last3 = Bouabdallah \| first3 = R. \| title = [Primary mediastinal B-cell lymphoma] \| journal = Rev Pneumol Clin \| volume = 66 \| issue = 1 \| pages = 32-5 \| month = Feb \| year = 2010 \| doi = 10.1016/j.pneumo.2009.12.007 \| PMID = 20207294 }}</ref>
	*Rare.		*Rare.
	*Young adults.		*Young adults, more common in females (M:F = 1:2)
	*[[Mediastinum]].		*[[Mediastinum]].

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	DDx:		DDx:
	*Other types of [[DLBCL]].		*Other types of [[DLBCL]] (radiological assessment is important - PMBCL is centred in the mediastinum)
			*B-cell lymphoma with features intermediate between [[DLBCL]] and classical Hodgkins lymphoma
	*Poorly differentiated carcinoma.		*Poorly differentiated carcinoma.

			==IHC==
			*Pan B-cell markers
			*CD10 in minority (~20%)
			*CD23 and CD30 expression more common (~70% and ~85% respectively)
			*EBV negative

	===Images===		===Images===
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	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|2}}


	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Lymphoma]]		[[Category:Lymphoma]]

Michael: split out

2014-03-09T03:51:25Z

split out

← Older revision		Revision as of 03:51, 9 March 2014
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	~~#redirect~~ [[Lymphoma~~#Primary_mediastinal_B~~-~~cell_lymphoma~~]]		'''Primary mediastinal B-cell lymphoma''', abbreviated '''PMBL''', is an uncommon form of large B-cell lymphoma.

			It is also known as '''primary mediastinal large B-cell lymphoma'''.

			==General==
			Features:<ref name=pmid19074109 >{{Cite journal \| last1 = Johnson \| first1 = PW. \| last2 = Davies \| first2 = AJ. \| title = Primary mediastinal B-cell lymphoma. \| journal = Hematology Am Soc Hematol Educ Program \| volume = \| issue = \| pages = 349-58 \| month = \| year = 2008 \| doi = 10.1182/asheducation-2008.1.349 \| PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal \| last1 = Coso \| first1 = D. \| last2 = Rey \| first2 = J. \| last3 = Bouabdallah \| first3 = R. \| title = [Primary mediastinal B-cell lymphoma] \| journal = Rev Pneumol Clin \| volume = 66 \| issue = 1 \| pages = 32-5 \| month = Feb \| year = 2010 \| doi = 10.1016/j.pneumo.2009.12.007 \| PMID = 20207294 }}</ref>
			*Rare.
			*Young adults.
			*[[Mediastinum]].

			==Microscopic==
			Features:
			*Atypical large lymphoid cells - see ''[[DLBCL]]''.
			*Classically associated with:
			**Fibrosis
			**Clear cells.

			Note:
			*Neither fibrosis or clear cells are required for the [[diagnosis]] nor are they pathognomonic.<ref name=pmid11251018 >{{Cite journal \| last1 = van Besien \| first1 = K. \| last2 = Kelta \| first2 = M. \| last3 = Bahaguna \| first3 = P. \| title = Primary mediastinal B-cell lymphoma: a review of pathology and management. \| journal = J Clin Oncol \| volume = 19 \| issue = 6 \| pages = 1855-64 \| month = Mar \| year = 2001 \| doi = \| PMID = 11251018 }}</ref>

			DDx:
			*Other types of [[DLBCL]].
			*Poorly differentiated carcinoma.

			===Images===
			<gallery>
			Image:Primary_mediastinal_large_B-cell_lymphoma_-_very_high_mag.jpg \| PMBL - very high mag. (WC)
			Image:Primary_mediastinal_large_B-cell_lymphoma_-_intermed_mag.jpg \| PMBL - intermed. mag. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case371.html PMBL - several images (upmc.edu)].

			==Sign out==
			<pre>
			MASS, ANTERIOR MEDIASTINAL, CORE BIOPSY:
			- LARGE B-CELL LYMPHOMA IN A FIBROTIC BACKGROUND WITH NECROSIS, SEE COMMENT

			COMMENT:
			Morphology:
			Tumour cells: size ~2x a mature lymphocyte, a moderate quantity of grey/basophilic
			cytoplasm, no clear cells are identified.
			Cells intermixed with tumour: mature lymphocytes, rare eosinophils.
			Architecture: no gland formation, discohesive, no follicles apparent, extensive fibrosis.

			Tumour cells:
			POSITIVE: CD45, CD20, CD10, BCL-6, BCL-2.
			NEGATIVE: pankeratin, PLAP, CD3, CD30.
			Ki-67: 50% of large (lymphoid) cells.
			</pre>

			==See also==
			*[[Lymphoma]].
			*[[Diffuse large B-cell lymphoma]].

			==References==
			{{Reflist\|2}}


	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Lymphoma]]

Michael: +cat.

2011-10-23T00:44:01Z

+cat.

← Older revision		Revision as of 00:44, 23 October 2011
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	#redirect [[Lymphoma#Primary_mediastinal_B-cell_lymphoma]]		#redirect [[Lymphoma#Primary_mediastinal_B-cell_lymphoma]]

			[[Category:Diagnosis]]

Michael: redirect

2011-07-25T02:41:42Z

redirect

New page

#redirect [[Lymphoma#Primary_mediastinal_B-cell_lymphoma]]