Pneumocytoma - Revision history

Michael at 23:23, 17 March 2019

2019-03-17T23:23:14Z

← Older revision		Revision as of 23:23, 17 March 2019
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	\| Micro = mixed cell population, variable architecture (papillary, sclerotic, solid, hemorrhagic), +/-granulomas		\| Micro = mixed cell population, variable architecture (papillary, sclerotic, solid, hemorrhagic), +/-granulomas
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[carcinoid tumour]]		\| LMDDx = [[carcinoid tumour]], papillary pattern [[lung adenocarcinoma]], metastatic [[papillary thyroid carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = TTF-1 +ve, Ki-67 +ve membranous pattern, PR +ve, CD56 -ve, CD34 -ve		\| IHC = TTF-1 +ve, Ki-67 +ve membranous pattern, PR +ve, CD56 -ve, CD34 -ve

Michael: /* Microscopic */ tweak

2019-03-17T23:22:38Z

Microscopic: tweak

← Older revision		Revision as of 23:22, 17 March 2019
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	DDx:<ref>URL: [http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf]. Accessed on: 17 June 2010.</ref>		DDx:<ref>URL: [http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf]. Accessed on: 17 June 2010.</ref>
	*Papillary ~~adenoma~~.		*Papillary pattern:
	*[[Neuroendocrine tumour]] (carcinoid).		**Papillary pattern [[lung adenocarcinoma]].
			**Metastatic [[papillary thyroid carcinoma]].
			*Solid pattern:
			**[[Neuroendocrine tumour]] (carcinoid).

	===Images===		===Images===

Michael: /* General */

2019-03-17T23:21:18Z

General

← Older revision		Revision as of 23:21, 17 March 2019
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	*Progesterone-receptor positive stromal cells.<ref name=pmid15731902>{{Cite journal \| last1 = Einsfelder \| first1 = BM. \| last2 = Müller \| first2 = KM. \| title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] \| journal = Pathologe \| volume = 26 \| issue = 5 \| pages = 367-77 \| month = Sep \| year = 2005 \| doi = 10.1007/s00292-005-0751-8 \| PMID = 15731902 }}</ref>		*Progesterone-receptor positive stromal cells.<ref name=pmid15731902>{{Cite journal \| last1 = Einsfelder \| first1 = BM. \| last2 = Müller \| first2 = KM. \| title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] \| journal = Pathologe \| volume = 26 \| issue = 5 \| pages = 367-77 \| month = Sep \| year = 2005 \| doi = 10.1007/s00292-005-0751-8 \| PMID = 15731902 }}</ref>
	*Rare - 0.2% to 1% of lung tumours.<ref name=pmid23838116>{{Cite journal \| last1 = Salemis \| first1 = NS. \| last2 = Seretis \| first2 = C. \| last3 = Nakos \| first3 = G. \| last4 = Kantounakis \| first4 = I. \| last5 = Stoumpos \| first5 = C. \| last6 = Spiliopoulos \| first6 = K. \| title = Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. \| journal = Breast Dis \| volume = 34 \| issue = 2 \| pages = 61-5 \| month = Jan \| year = 2013 \| doi = 10.3233/BD-130352 \| PMID = 23838116 }}</ref>		*Rare - 0.2% to 1% of lung tumours.<ref name=pmid23838116>{{Cite journal \| last1 = Salemis \| first1 = NS. \| last2 = Seretis \| first2 = C. \| last3 = Nakos \| first3 = G. \| last4 = Kantounakis \| first4 = I. \| last5 = Stoumpos \| first5 = C. \| last6 = Spiliopoulos \| first6 = K. \| title = Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. \| journal = Breast Dis \| volume = 34 \| issue = 2 \| pages = 61-5 \| month = Jan \| year = 2013 \| doi = 10.3233/BD-130352 \| PMID = 23838116 }}</ref>
			**One large series had 100 cases.<ref name=pmid10895813>{{Cite journal \| last1 = Devouassoux-Shisheboran \| first1 = M. \| last2 = Hayashi \| first2 = T. \| last3 = Linnoila \| first3 = RI. \| last4 = Koss \| first4 = MN. \| last5 = Travis \| first5 = WD. \| title = A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 7 \| pages = 906-16 \| month = Jul \| year = 2000 \| doi = \| PMID = 10895813 }}</ref>

	Management:		Management:

Michael: /* Gross */

2018-03-18T17:47:25Z

Gross

← Older revision		Revision as of 17:47, 18 March 2018
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	*Peripheral, solitary.		*Peripheral, solitary.
	*Well-circumscribed.		*Well-circumscribed.
			*Classically hemorrhagic.

	==Microscopic==		==Microscopic==

Michael: /* Sign out */

2017-06-30T20:39:00Z

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← Older revision		Revision as of 20:39, 30 June 2017
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	===Micro===		===Micro===
	The sections show lung with thickened alveolar walls containing bland appearing nuclei without conspicuous nucleoli. Necrosis is absent.		The sections show lung with thickened alveolar walls containing bland appearing cells with round/oval nuclei without conspicuous nucleoli. Necrosis is absent.

	==See also==		==See also==

Michael: /* Sign out */

2017-06-30T19:49:10Z

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← Older revision		Revision as of 19:49, 30 June 2017
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	The lesion stains as follows:		The lesion stains as follows:
	POSITIVE: Ki-67 (membranous pattern), TTF-1, PR.		POSITIVE: Ki-67 (membranous pattern), TTF-1, PR.
	NEGATIVE: CD56, p53.		NEGATIVE: CD56, p53, CD34.
	</pre>		</pre>

Michael: /* Sign out */

2017-06-30T19:48:56Z

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← Older revision		Revision as of 19:48, 30 June 2017
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	NEGATIVE: CD56, p53.		NEGATIVE: CD56, p53.
	</pre>		</pre>

			===Micro===
			The sections show lung with thickened alveolar walls containing bland appearing nuclei without conspicuous nucleoli. Necrosis is absent.

	==See also==		==See also==

Michael: /* IHC */

2017-06-30T13:13:35Z

IHC

← Older revision		Revision as of 13:13, 30 June 2017
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	==IHC==		==IHC==
	Features:<ref name=pmid10716159>{{Cite journal \| last1 = Rodriguez-Soto \| first1 = J. \| last2 = Colby \| first2 = TV. \| last3 = Rouse \| first3 = RV. \| title = A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 3 \| pages = 442-50 \| month = Mar \| year = 2000 \| doi = \| PMID = 10716159 }}</ref>		Features:<ref name=pmid10716159>{{Cite journal \| last1 = Rodriguez-Soto \| first1 = J. \| last2 = Colby \| first2 = TV. \| last3 = Rouse \| first3 = RV. \| title = A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 3 \| pages = 442-50 \| month = Mar \| year = 2000 \| doi = \| PMID = 10716159 }}</ref>
	*EMA +ve.		*[[EMA]] +ve.
	*PR +ve.<ref name=pmid15731902>{{Cite journal \| last1 = Einsfelder \| first1 = BM. \| last2 = Müller \| first2 = KM. \| title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] \| journal = Pathologe \| volume = 26 \| issue = 5 \| pages = 367-77 \| month = Sep \| year = 2005 \| doi = 10.1007/s00292-005-0751-8 \| PMID = 15731902 }}</ref>		*PR +ve.<ref name=pmid15731902>{{Cite journal \| last1 = Einsfelder \| first1 = BM. \| last2 = Müller \| first2 = KM. \| title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] \| journal = Pathologe \| volume = 26 \| issue = 5 \| pages = 367-77 \| month = Sep \| year = 2005 \| doi = 10.1007/s00292-005-0751-8 \| PMID = 15731902 }}</ref>
	*Ki-67 membranous pattern.<ref name=pmid23030396>{{Cite journal \| last1 = Kim \| first1 = BH. \| last2 = Bae \| first2 = YS. \| last3 = Kim \| first3 = SH. \| last4 = Jeong \| first4 = HJ. \| last5 = Hong \| first5 = SW. \| last6 = Yoon \| first6 = SO. \| title = Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. \| journal = APMIS \| volume = 121 \| issue = 2 \| pages = 105-10 \| month = Feb \| year = 2013 \| doi = 10.1111/j.1600-0463.2012.02945.x \| PMID = 23030396 }}</ref>		*[[Ki-67]] membranous pattern.<ref name=pmid23030396>{{Cite journal \| last1 = Kim \| first1 = BH. \| last2 = Bae \| first2 = YS. \| last3 = Kim \| first3 = SH. \| last4 = Jeong \| first4 = HJ. \| last5 = Hong \| first5 = SW. \| last6 = Yoon \| first6 = SO. \| title = Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. \| journal = APMIS \| volume = 121 \| issue = 2 \| pages = 105-10 \| month = Feb \| year = 2013 \| doi = 10.1111/j.1600-0463.2012.02945.x \| PMID = 23030396 }}</ref>

	Negative stains:<ref name=pmid10716159/>		Negative stains:<ref name=pmid10716159/>

Michael: /* Images */

2017-03-10T21:48:05Z

Images

← Older revision		Revision as of 21:48, 10 March 2017
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	Image: Pneumocytoma - TTF1 -- intermed mag.jpg \| Pneumocytoma - TTF-1 - intermed. mag.		Image: Pneumocytoma - TTF1 -- intermed mag.jpg \| Pneumocytoma - TTF-1 - intermed. mag.
	Image: Pneumocytoma - TTF1 -- high mag.jpg \| Pneumocytoma - TTF-1 - high mag.		Image: Pneumocytoma - TTF1 -- high mag.jpg \| Pneumocytoma - TTF-1 - high mag.
	Image: Pneumocytoma - Ki67 -- intermed mag.jpg \| Pneumocytoma - Ki-67 - intermed. mag.		Image: Pneumocytoma - Ki67 -- intermed mag.jpg \| Pneumocytoma - Ki-67 (membranous) - intermed. mag.
	Image: Pneumocytoma - Ki67 -- high mag.jpg \| Pneumocytoma - Ki-67 - high mag.		Image: Pneumocytoma - Ki67 -- high mag.jpg \| Pneumocytoma - Ki-67 (membranous) - high mag.
	</gallery>		</gallery>

	==Sign out==		==Sign out==
	<pre>		<pre>

Michael: +images

2017-03-10T21:46:14Z

+images

← Older revision		Revision as of 21:46, 10 March 2017
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Pneumocytoma - alt -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Pneumocytoma. [[H&E stain]]. (WC/Nephron)
	\| Synonyms = sclerosing hemangioma, benign pneumocytoma		\| Synonyms = sclerosing hemangioma, benign pneumocytoma
	\| Micro = mixed cell population, variable architecture (papillary, sclerotic, solid, hemorrhagic), +/-granulomas		\| Micro = mixed cell population, variable architecture (papillary, sclerotic, solid, hemorrhagic), +/-granulomas
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	*Papillary adenoma.		*Papillary adenoma.
	*[[Neuroendocrine tumour]] (carcinoid).		*[[Neuroendocrine tumour]] (carcinoid).
	~~<!--~~
	===Images===		===Images===
	-->		<gallery>
			Image: Pneumocytoma -- low mag.jpg \| Pneumocytoma - low mag.
			Image: Pneumocytoma -- intermed mag.jpg \| Pneumocytoma - intermed. mag.
			Image: Pneumocytoma -- high mag.jpg \| Pneumocytoma - high mag.
			Image: Pneumocytoma -- very high mag.jpg \| Pneumocytoma - very high mag.

			Image: Pneumocytoma - alt -- low mag.jpg \| Pneumocytoma - low mag.
			Image: Pneumocytoma - alt -- intermed mag.jpg \| Pneumocytoma - intermed. mag.
			</gallery>

	==IHC==		==IHC==
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	*HNF-3 beta +ve.		*HNF-3 beta +ve.

			===Images===
			<gallery>
			Image: Pneumocytoma - TTF1 -- intermed mag.jpg \| Pneumocytoma - TTF-1 - intermed. mag.
			Image: Pneumocytoma - TTF1 -- high mag.jpg \| Pneumocytoma - TTF-1 - high mag.
			Image: Pneumocytoma - Ki67 -- intermed mag.jpg \| Pneumocytoma - Ki-67 - intermed. mag.
			Image: Pneumocytoma - Ki67 -- high mag.jpg \| Pneumocytoma - Ki-67 - high mag.
			</gallery>
	==Sign out==		==Sign out==
	<pre>		<pre>