Pleomorphic xanthoastrocytoma - Revision history

Jensflorian: /* Images */ APXA

2019-10-11T12:38:24Z

Images: APXA

← Older revision		Revision as of 12:38, 11 October 2019
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	File:PXA Gomori Reticulin Stain.jpg \| A delicate meshwork of retiulin fibers in PXA. Gomori, intermed magnification.(WC/jensflorian)		File:PXA Gomori Reticulin Stain.jpg \| A delicate meshwork of retiulin fibers in PXA. Gomori, intermed magnification.(WC/jensflorian)
	File:PXA GFAP IHC.jpg \| GFAP IHC is often heterogenous in PXA. Intermed magnification.(WC/jensflorian)		File:PXA GFAP IHC.jpg \| GFAP IHC is often heterogenous in PXA. Intermed magnification.(WC/jensflorian)
			File:Anaplastic_pxa_histology.jpg\| HE of anaplastic PXA.
	</gallery>		</gallery>
	www:		www:

Jensflorian: WHO 2016 update

2016-05-18T13:35:39Z

WHO 2016 update

← Older revision		Revision as of 13:35, 18 May 2016
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	*Associated with seizures.		*Associated with seizures.
	*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal \| last1 = Fouladi \| first1 = M. \| last2 = Jenkins \| first2 = J. \| last3 = Burger \| first3 = P. \| last4 = Langston \| first4 = J. \| last5 = Merchant \| first5 = T. \| last6 = Heideman \| first6 = R. \| last7 = Thompson \| first7 = S. \| last8 = Sanford \| first8 = A. \| last9 = Kun \| first9 = L. \| title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. \| journal = Neuro Oncol \| volume = 3 \| issue = 3 \| pages = 184-92 \| month = Jul \| year = 2001 \| doi = \| PMID = 11465399 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>		*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal \| last1 = Fouladi \| first1 = M. \| last2 = Jenkins \| first2 = J. \| last3 = Burger \| first3 = P. \| last4 = Langston \| first4 = J. \| last5 = Merchant \| first5 = T. \| last6 = Heideman \| first6 = R. \| last7 = Thompson \| first7 = S. \| last8 = Sanford \| first8 = A. \| last9 = Kun \| first9 = L. \| title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. \| journal = Neuro Oncol \| volume = 3 \| issue = 3 \| pages = 184-92 \| month = Jul \| year = 2001 \| doi = \| PMID = 11465399 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>
	** very rare: anaplastic PXA (grade III).		*Anaplastic PXA (grade III) - rare. <ref>{{Cite journal \| last1 = Louis \| first1 = DN. \| last2 = Perry \| first2 = A. \| last3 = Reifenberger \| first3 = G. \| last4 = von Deimling \| first4 = A. \| last5 = Figarella-Branger \| first5 = D. \| last6 = Cavenee \| first6 = WK. \| last7 = Ohgaki \| first7 = H. \| last8 = Wiestler \| first8 = OD. \| last9 = Kleihues \| first9 = P. \| title = The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. \| journal = Acta Neuropathol \| volume = 131 \| issue = 6 \| pages = 803-20 \| month = Jun \| year = 2016 \| doi = 10.1007/s00401-016-1545-1 \| PMID = 27157931 }}</ref>
	*ICD-O: 9424/3.		*ICD-O: 9424/3.

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	*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>		*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>
	*Inflammatory cells (lymophocytic perivascular cuffs).		*Inflammatory cells (lymophocytic perivascular cuffs).


			==Grading==
			* Grade II: Mitotic activity is low, no necrosis.
			* Grade III anaplastic PXA: more than 5/10 HPF, may have necrosis.

	Notes:		Notes:
	*Mitotic activity is low (except in ~~anaplastic PXA, more than 5/10 HPF)~~.		Anaplastic PXA was introduced in the WHO2016 revision as a distinct entity.
	*No necrosis (except in anaplastic ~~PXA)~~.		In the past, the tumor was called ''PXA with anaplastic features''.

	DDx:		DDx:

Jensflorian: typos + anaplastic PXA

2015-04-27T12:25:47Z

typos + anaplastic PXA

← Older revision		Revision as of 12:25, 27 April 2015
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	*Associated with seizures.		*Associated with seizures.
	*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal \| last1 = Fouladi \| first1 = M. \| last2 = Jenkins \| first2 = J. \| last3 = Burger \| first3 = P. \| last4 = Langston \| first4 = J. \| last5 = Merchant \| first5 = T. \| last6 = Heideman \| first6 = R. \| last7 = Thompson \| first7 = S. \| last8 = Sanford \| first8 = A. \| last9 = Kun \| first9 = L. \| title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. \| journal = Neuro Oncol \| volume = 3 \| issue = 3 \| pages = 184-92 \| month = Jul \| year = 2001 \| doi = \| PMID = 11465399 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>		*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal \| last1 = Fouladi \| first1 = M. \| last2 = Jenkins \| first2 = J. \| last3 = Burger \| first3 = P. \| last4 = Langston \| first4 = J. \| last5 = Merchant \| first5 = T. \| last6 = Heideman \| first6 = R. \| last7 = Thompson \| first7 = S. \| last8 = Sanford \| first8 = A. \| last9 = Kun \| first9 = L. \| title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. \| journal = Neuro Oncol \| volume = 3 \| issue = 3 \| pages = 184-92 \| month = Jul \| year = 2001 \| doi = \| PMID = 11465399 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>
			** very rare: anaplastic PXA (grade III).
	*ICD-O: 9424/3.		*ICD-O: 9424/3.

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	*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>		*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>
	*Inflammatory cells (lymophocytic perivascular cuffs).		*Inflammatory cells (lymophocytic perivascular cuffs).
	*Mitotic activity is low (except in anaplastic PXA, more than 5/10 HPF).
	*Usually no necrosis (except in anaplastic PXA).

	Notes:		Notes:
	*~~No mitoses~~.		*Mitotic activity is low (except in anaplastic PXA, more than 5/10 HPF).
	*No [[necrosis]].		*No necrosis (except in anaplastic PXA).

	DDx:		DDx:
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	File:PXA HE xanthomatous cells.jpg\| Focal xanthomatous cells as in the name PXA. HE, intermed magnification.(WC/jensflorian)		File:PXA HE xanthomatous cells.jpg\| Focal xanthomatous cells as in the name PXA. HE, intermed magnification.(WC/jensflorian)
	File:PXA HE X10.jpg \| Perivascular lymphocytic cuffs are not uncommon. HE, intermed-low magnification.(WC/jensflorian)		File:PXA HE X10.jpg \| Perivascular lymphocytic cuffs are not uncommon. HE, intermed-low magnification.(WC/jensflorian)
	File:PXA HE x20.jpg \| ~~Eosionophilc~~ granular bodies in a PXA. HE, intermed magnification.(WC/jensflorian)		File:PXA HE x20.jpg \| Eosinophilc granular bodies in a PXA. HE, intermed magnification.(WC/jensflorian)
	File:PXA Gomori Reticulin Stain.jpg \| A delicate ~~meshowork~~ of retiulin fibers in PXA. Gomori, intermed magnification.(WC/jensflorian)		File:PXA Gomori Reticulin Stain.jpg \| A delicate meshwork of retiulin fibers in PXA. Gomori, intermed magnification.(WC/jensflorian)
	File:PXA GFAP IHC.jpg \| GFAP IHC is often heterogenous in PXA. Intermed magnification.(WC/jensflorian)		File:PXA GFAP IHC.jpg \| GFAP IHC is often heterogenous in PXA. Intermed magnification.(WC/jensflorian)
	</gallery>		</gallery>

Michael: tweak format, re-locate DDx

2015-04-25T04:09:11Z

tweak format, re-locate DDx

← Older revision		Revision as of 04:09, 25 April 2015
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	*No mitoses.		*No mitoses.
	*No [[necrosis]].		*No [[necrosis]].

			DDx:
			*[[Subependymal giant cell astrocytoma]].
			*[[Ganglioglioma]].
			*[[Glioblastoma]].

	===Images===		===Images===
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	* BRAF V600E mutation in 2/3 of the cases<ref>{{Cite journal \| last1 = Schindler \| first1 = G. \| last2 = Capper \| first2 = D. \| last3 = Meyer \| first3 = J. \| last4 = Janzarik \| first4 = W. \| last5 = Omran \| first5 = H. \| last6 = Herold-Mende \| first6 = C. \| last7 = Schmieder \| first7 = K. \| last8 = Wesseling \| first8 = P. \| last9 = Mawrin \| first9 = C. \| title = Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. \| journal = Acta Neuropathol \| volume = 121 \| issue = 3 \| pages = 397-405 \| month = Mar \| year = 2011 \| doi = 10.1007/s00401-011-0802-6 \| PMID = 21274720 }}</ref>		* BRAF V600E mutation in 2/3 of the cases<ref>{{Cite journal \| last1 = Schindler \| first1 = G. \| last2 = Capper \| first2 = D. \| last3 = Meyer \| first3 = J. \| last4 = Janzarik \| first4 = W. \| last5 = Omran \| first5 = H. \| last6 = Herold-Mende \| first6 = C. \| last7 = Schmieder \| first7 = K. \| last8 = Wesseling \| first8 = P. \| last9 = Mawrin \| first9 = C. \| title = Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. \| journal = Acta Neuropathol \| volume = 121 \| issue = 3 \| pages = 397-405 \| month = Mar \| year = 2011 \| doi = 10.1007/s00401-011-0802-6 \| PMID = 21274720 }}</ref>
	**(mostly in temporal, reticulin-fiber rich tumors)<ref>{{Cite journal \| last1 = Koelsche \| first1 = C. \| last2 = Sahm \| first2 = F. \| last3 = Wöhrer \| first3 = A. \| last4 = Jeibmann \| first4 = A. \| last5 = Schittenhelm \| first5 = J. \| last6 = Kohlhof \| first6 = P. \| last7 = Preusser \| first7 = M. \| last8 = Romeike \| first8 = B. \| last9 = Dohmen-Scheufler \| first9 = H. \| title = BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. \| journal = Brain Pathol \| volume = 24 \| issue = 3 \| pages = 221-9 \| month = Apr \| year = 2014 \| doi = 10.1111/bpa.12111 \| PMID = 24345274 }}</ref>		**(mostly in temporal, reticulin-fiber rich tumors)<ref>{{Cite journal \| last1 = Koelsche \| first1 = C. \| last2 = Sahm \| first2 = F. \| last3 = Wöhrer \| first3 = A. \| last4 = Jeibmann \| first4 = A. \| last5 = Schittenhelm \| first5 = J. \| last6 = Kohlhof \| first6 = P. \| last7 = Preusser \| first7 = M. \| last8 = Romeike \| first8 = B. \| last9 = Dohmen-Scheufler \| first9 = H. \| title = BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. \| journal = Brain Pathol \| volume = 24 \| issue = 3 \| pages = 221-9 \| month = Apr \| year = 2014 \| doi = 10.1111/bpa.12111 \| PMID = 24345274 }}</ref>


	~~DDx:~~
	*[[Subependymal Giant Cell Astrocytoma]]
	*[[Ganglioglioma]]
	*[[Glioblastoma]]


	==See also==		==See also==

Jensflorian: +update +pictures from current case

2015-04-24T08:49:07Z

+update +pictures from current case

← Older revision		Revision as of 08:49, 24 April 2015
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	\| Tx =		\| Tx =
	}}		}}
	'''Pleomorphic xanthoastrocytoma''', abbreviated '''PXA''', is [[neuropathology tumour]] classically associated with seizures.		'''Pleomorphic xanthoastrocytoma''', abbreviated '''PXA''', is [[neuropathology tumour]] classically associated with seizures in children.

	==General==		==General==
	Features:		Features:
			*Rare (less than 1% of all astrocytic tumors).
	*Classically in the temporal lobe in children and young adults.		*Classically in the temporal lobe in children and young adults.
	*Associated with seizures.		*Associated with seizures.
	*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal \| last1 = Fouladi \| first1 = M. \| last2 = Jenkins \| first2 = J. \| last3 = Burger \| first3 = P. \| last4 = Langston \| first4 = J. \| last5 = Merchant \| first5 = T. \| last6 = Heideman \| first6 = R. \| last7 = Thompson \| first7 = S. \| last8 = Sanford \| first8 = A. \| last9 = Kun \| first9 = L. \| title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. \| journal = Neuro Oncol \| volume = 3 \| issue = 3 \| pages = 184-92 \| month = Jul \| year = 2001 \| doi = \| PMID = 11465399 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>		*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal \| last1 = Fouladi \| first1 = M. \| last2 = Jenkins \| first2 = J. \| last3 = Burger \| first3 = P. \| last4 = Langston \| first4 = J. \| last5 = Merchant \| first5 = T. \| last6 = Heideman \| first6 = R. \| last7 = Thompson \| first7 = S. \| last8 = Sanford \| first8 = A. \| last9 = Kun \| first9 = L. \| title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. \| journal = Neuro Oncol \| volume = 3 \| issue = 3 \| pages = 184-92 \| month = Jul \| year = 2001 \| doi = \| PMID = 11465399 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>
			*ICD-O: 9424/3.

	==Gross==		==Gross==
	*Temporal lobe - classic.		*Temporal lobe - classic.
	*Usually assoc. with the leptomeninges,<ref name=pmid11465399/> i.e. superficial.		*Usually assoc. with the leptomeninges,<ref name=pmid11465399/> i.e. superficial (in up 96%).

			<gallery>
			File:405663-PLEOMORPHIC XANTHOASTROCYTOMA.jpg \| Typical appearance is one of a superficially situated tumor, here a mural nodule, associated with an underlying cyst (AFIP)
			File:Pleomorphic-xanthoastrocytoma-002.jpg \| Hemorrhagic pleomorphic xanthoastrocytoma (PXA), MRI (WC/RadsWiki)
			</gallery>

	==Microscopic==		==Microscopic==
	Features:<ref name=Ref_PBoD8_1333>{{Ref PBoD8\|1333}}</ref>		Features:<ref name=Ref_PBoD8_1333>{{Ref PBoD8\|1333}}</ref>
	*~~Marked~~ nuclear atypia.		*Fibrillary background.
			*Large cells with marked nuclear atypia.
			*Multinuclear cells possible.
			*Reticulin meshwork.
			*Lipidized cells.
	*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>		*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>
	*~~Inflammation~~ (~~chronic~~).		*Inflammatory cells (lymophocytic perivascular cuffs).
			*Mitotic activity is low (except in anaplastic PXA, more than 5/10 HPF).
			*Usually no necrosis (except in anaplastic PXA).

	Notes:		Notes:
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:Pleo xantho.jpg \| PXA. (WC/AFIP)		Image:Pleo xantho.jpg \| HE smear of a PXA. (WC/AFIP)
			File:PXA HE frozen high mag.jpg \| HE intraoperative frozen section of PXA. (WC/jensflorian)
			File:PXA HE 40x-2.jpg \| The tumor is aptly named due to ist pleomorphic cells. HE, high magnification. (WC/marvin101)
			File:PXA HE pleomorphic cells.jpg \| The pleomorphic cells must not be confused with a higly anaplastic glioma. HE, intermed magnification.(WC/jensflorian)
			File:PXA HE xanthomatous cells.jpg\| Focal xanthomatous cells as in the name PXA. HE, intermed magnification.(WC/jensflorian)
			File:PXA HE X10.jpg \| Perivascular lymphocytic cuffs are not uncommon. HE, intermed-low magnification.(WC/jensflorian)
			File:PXA HE x20.jpg \| Eosionophilc granular bodies in a PXA. HE, intermed magnification.(WC/jensflorian)
			File:PXA Gomori Reticulin Stain.jpg \| A delicate meshowork of retiulin fibers in PXA. Gomori, intermed magnification.(WC/jensflorian)
			File:PXA GFAP IHC.jpg \| GFAP IHC is often heterogenous in PXA. Intermed magnification.(WC/jensflorian)
	</gallery>		</gallery>
	www:		www:
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	==IHC==		==IHC==
	*GFAP +ve.		*GFAP +ve.
			*S-100 +ve.
	*CD68 +ve.		*CD68 +ve.
			*CD34 frequently.
			*MAP2+ve and Synapto+ve pleomorphic cells
			*MIB-1 usually low.

			==Molecular==
			* BRAF V600E mutation in 2/3 of the cases<ref>{{Cite journal \| last1 = Schindler \| first1 = G. \| last2 = Capper \| first2 = D. \| last3 = Meyer \| first3 = J. \| last4 = Janzarik \| first4 = W. \| last5 = Omran \| first5 = H. \| last6 = Herold-Mende \| first6 = C. \| last7 = Schmieder \| first7 = K. \| last8 = Wesseling \| first8 = P. \| last9 = Mawrin \| first9 = C. \| title = Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. \| journal = Acta Neuropathol \| volume = 121 \| issue = 3 \| pages = 397-405 \| month = Mar \| year = 2011 \| doi = 10.1007/s00401-011-0802-6 \| PMID = 21274720 }}</ref>
			**(mostly in temporal, reticulin-fiber rich tumors)<ref>{{Cite journal \| last1 = Koelsche \| first1 = C. \| last2 = Sahm \| first2 = F. \| last3 = Wöhrer \| first3 = A. \| last4 = Jeibmann \| first4 = A. \| last5 = Schittenhelm \| first5 = J. \| last6 = Kohlhof \| first6 = P. \| last7 = Preusser \| first7 = M. \| last8 = Romeike \| first8 = B. \| last9 = Dohmen-Scheufler \| first9 = H. \| title = BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. \| journal = Brain Pathol \| volume = 24 \| issue = 3 \| pages = 221-9 \| month = Apr \| year = 2014 \| doi = 10.1111/bpa.12111 \| PMID = 24345274 }}</ref>


			DDx:
			*[[Subependymal Giant Cell Astrocytoma]]
			*[[Ganglioglioma]]
			*[[Glioblastoma]]


	==See also==		==See also==

Michael: +infobx

2014-12-10T06:45:10Z

+infobx

← Older revision		Revision as of 06:45, 10 December 2014
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	\| Caption = Pleomorphic xanthoastrocytoma.		\| Caption = Pleomorphic xanthoastrocytoma.
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = marked nuclear atypia, eosinophilic granular bodies - very common, inflammation (chronic), no necrosis
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx =
Line 16:		Line 16:
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site =		\| Site = [[brain]] - typical temporal lobe
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = seizure, children & young adults
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =

Michael: split + image

2014-12-10T06:43:27Z

split + image

← Older revision		Revision as of 06:43, 10 December 2014
Line 1:		Line 1:

			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Pleo xantho.jpg
			\| Width =
			\| Caption = Pleomorphic xanthoastrocytoma.
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site =
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Pleomorphic xanthoastrocytoma''', abbreviated '''PXA''', is [[neuropathology tumour]] classically associated with seizures.		'''Pleomorphic xanthoastrocytoma''', abbreviated '''PXA''', is [[neuropathology tumour]] classically associated with seizures.

Line 22:		Line 54:

	===Images===		===Images===
			<gallery>
			Image:Pleo xantho.jpg \| PXA. (WC/AFIP)
			</gallery>
			www:
	*[http://path.upmc.edu/cases/case499.html Pleomorphic xanthoastrocytoma - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case499.html Pleomorphic xanthoastrocytoma - several images (upmc.edu)].
	*[http://path.upmc.edu/cases/case511.html Pleomorphic xanthoastrocytoma with anaplasia - another case - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case511.html Pleomorphic xanthoastrocytoma with anaplasia - another case - several images (upmc.edu)].

Michael: split out

2014-12-10T06:39:06Z

split out

← Older revision		Revision as of 06:39, 10 December 2014
Line 1:		Line 1:
	~~#redirect~~ [[Neuropathology tumours~~#Pleomorphic xanthoastrocytoma~~]]		'''Pleomorphic xanthoastrocytoma''', abbreviated '''PXA''', is [[neuropathology tumour]] classically associated with seizures.

			==General==
			Features:
			*Classically in the temporal lobe in children and young adults.
			*Associated with seizures.
			*Moderately aggressive (WHO Grade II).<ref name=pmid11465399>{{Cite journal \| last1 = Fouladi \| first1 = M. \| last2 = Jenkins \| first2 = J. \| last3 = Burger \| first3 = P. \| last4 = Langston \| first4 = J. \| last5 = Merchant \| first5 = T. \| last6 = Heideman \| first6 = R. \| last7 = Thompson \| first7 = S. \| last8 = Sanford \| first8 = A. \| last9 = Kun \| first9 = L. \| title = Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. \| journal = Neuro Oncol \| volume = 3 \| issue = 3 \| pages = 184-92 \| month = Jul \| year = 2001 \| doi = \| PMID = 11465399 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920613/pdf/11465399.pdf}}</ref>

			==Gross==
			*Temporal lobe - classic.
			*Usually assoc. with the leptomeninges,<ref name=pmid11465399/> i.e. superficial.

			==Microscopic==
			Features:<ref name=Ref_PBoD8_1333>{{Ref PBoD8\|1333}}</ref>
			*Marked nuclear atypia.
			*Eosinophilic granular bodies - very common.<ref name=pmid11465399/>
			*Inflammation (chronic).

			Notes:
			*No mitoses.
			*No [[necrosis]].

			===Images===
			*[http://path.upmc.edu/cases/case499.html Pleomorphic xanthoastrocytoma - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case511.html Pleomorphic xanthoastrocytoma with anaplasia - another case - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case578.html Pleomorphic xanthoastrocytoma with anaplasia - case 3 - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case579.html Cerebellar pleomorphic xanthoastrocytoma - case 4 - several image (upmc.edu)].

			==Stains==
			*[[Reticulin stain]] - intercellular, prominent.<ref name=pmid21479234>{{Cite journal \| last1 = Dias-Santagata \| first1 = D. \| last2 = Lam \| first2 = Q. \| last3 = Vernovsky \| first3 = K. \| last4 = Vena \| first4 = N. \| last5 = Lennerz \| first5 = JK. \| last6 = Borger \| first6 = DR. \| last7 = Batchelor \| first7 = TT. \| last8 = Ligon \| first8 = KL. \| last9 = Iafrate \| first9 = AJ. \| title = BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. \| journal = PLoS One \| volume = 6 \| issue = 3 \| pages = e17948 \| month = \| year = 2011 \| doi = 10.1371/journal.pone.0017948 \| PMID = 21479234 }}</ref>

			Image:
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066220/figure/pone-0017948-g001/ PXA - several images (nih.gov)].<ref name=pmid21479234/>

			==IHC==
			*GFAP +ve.
			*CD68 +ve.

			==See also==
			*[[Neuropathology tumours]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology tumours]]

Michael: redirect

2011-10-18T03:56:02Z

redirect

New page

#redirect [[Neuropathology tumours#Pleomorphic xanthoastrocytoma]]

[[Category:Diagnosis]]