Placental site nodule - Revision history

Michael: /* References */

2016-05-13T04:27:41Z

References

← Older revision		Revision as of 04:27, 13 May 2016
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	[[Category:Gestational trophoblastic disease]]		[[Category:Gestational trophoblastic disease]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Endometrium]]

Michael at 04:27, 13 May 2016

2016-05-13T04:27:26Z

← Older revision		Revision as of 04:27, 13 May 2016
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Placental site nodule -- very high mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Placental site nodule. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = paucicellular hyaline material scattered cells (variable cell population: small to large cells with clear to eosinophilic cytoplasm), +/-multinucleation, no mitotic activity		\| Micro = paucicellular hyaline material scattered cells (variable cell population: small to large cells with clear to eosinophilic cytoplasm), +/-multinucleation, no mitotic activity
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = invasive [[cervical squamous cell carcinoma]], [[exaggerated placental site]], fibrin +/-inflammatory cells
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image:Placental_site_nodule_-_intermed_mag.jpg \| PSN - intermed. mag. (WC)		Image:Placental_site_nodule_-_intermed_mag.jpg \| PSN - intermed. mag. (WC)
	Image:Placental_site_nodule_-_high_mag.jpg \| PSN - high mag. (WC)		Image:Placental_site_nodule_-_high_mag.jpg \| PSN - high mag. (WC)
			</gallery>
			====Case 2====
			<gallery>
			Image: Placental site nodule -- low mag.jpg \| PSN - low mag.
			Image: Placental site nodule -- intermed mag.jpg \| PSN - intermed. mag.
			Image: Placental site nodule -- high mag.jpg \| PSN - high mag.
			Image: Placental site nodule -- very high mag.jpg \| PSN - very high mag.
	</gallery>		</gallery>
	====www====		====www====

Michael at 04:24, 13 May 2016

2016-05-13T04:24:42Z

← Older revision		Revision as of 04:24, 13 May 2016
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro = paucicellular hyaline material scattered cells (variable cell population: small to large cells with clear to eosinophilic cytoplasm), +/-multinucleation, no mitotic activity
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[endometrium]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = previously pregnant
			\| Signs =
			\| Symptoms = none
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx = none
			}}
	'''Placental site nodule''', abbreviated '''PSN''', is a benign remnant of a [[placenta]]. It is seen on [[endometrium\|endometrial]] biopsies and hysterectomy specimens.		'''Placental site nodule''', abbreviated '''PSN''', is a benign remnant of a [[placenta]]. It is seen on [[endometrium\|endometrial]] biopsies and hysterectomy specimens.

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	Image:Placental_site_nodule_-_high_mag.jpg \| PSN - high mag. (WC)		Image:Placental_site_nodule_-_high_mag.jpg \| PSN - high mag. (WC)
	</gallery>		</gallery>
	www:		====www====
	*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2009_52_2_240_48931_u4.jpg PSN (ijpmonline.org)].<ref name=pmid19332926/>		*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2009_52_2_240_48931_u4.jpg PSN (ijpmonline.org)].<ref name=pmid19332926/>
	*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=12&cat3=1256&stype=d PSN (gfmer.ch)] - includes images from ''Jacob and Mohapatra''.<ref name=pmid19332926/>		*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=12&cat3=1256&stype=d PSN (gfmer.ch)] - includes images from ''Jacob and Mohapatra''.<ref name=pmid19332926/>

Michael: /* References */

2014-05-22T15:46:08Z

References

← Older revision		Revision as of 15:46, 22 May 2014
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	{{Reflist\|1}}		{{Reflist\|1}}

			[[Category:Gestational trophoblastic disease]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: /* Microscopic */

2014-04-16T12:01:52Z

Microscopic

← Older revision		Revision as of 12:01, 16 April 2014
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	*[[Exaggerated placental site]].		*[[Exaggerated placental site]].
	**Different histomorphology than PSN; EPS:<ref name=pmid19332926/> syncytiotrophoblastic tissue, in cords/nests, no hyaline nodules.		**Different histomorphology than PSN; EPS:<ref name=pmid19332926/> syncytiotrophoblastic tissue, in cords/nests, no hyaline nodules.
			*Fibrin +/-inflammatory cells.

	===Images===		===Images===

Michael at 01:08, 21 March 2014

2014-03-21T01:08:35Z

← Older revision		Revision as of 01:08, 21 March 2014
Line 1:		Line 1:
	'''Placental site nodule''', abbreviated '''PSN''', is a benign remnant of a [[placenta]]. It is seen on [[endometrium\|endometrial]] biopsies and hysterectomy specimens.		'''Placental site nodule''', abbreviated '''PSN''', is a benign remnant of a [[placenta]]. It is seen on [[endometrium\|endometrial]] biopsies and hysterectomy specimens.

			'''Implantation site''' redirects here.
	==General==		==General==
	*Benign.		*Benign.

Michael: /* See also */

2014-03-20T23:15:20Z

Michael: /* References */

2014-03-20T23:15:09Z

References

← Older revision		Revision as of 23:15, 20 March 2014
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	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|1}}


	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael at 23:14, 20 March 2014

2014-03-20T23:14:50Z

← Older revision		Revision as of 23:14, 20 March 2014
Line 1:		Line 1:
	'''Placental site nodule''' is a benign remnant of a [[placenta]]. It is seen on [[endometrium\|endometrial]] biopsies and hysterectomy specimens.		'''Placental site nodule''', abbreviated '''PSN''', is a benign remnant of a [[placenta]]. It is seen on [[endometrium\|endometrial]] biopsies and hysterectomy specimens.
	==General==		==General==
	*Benign.		*Benign.

Michael at 23:14, 20 March 2014

2014-03-20T23:14:02Z

← Older revision		Revision as of 23:14, 20 March 2014
Line 1:		Line 1:
	~~#redirect~~ [[~~Gestational_trophoblastic_disease#Placental_site_nodule~~]]		'''Placental site nodule''' is a benign remnant of a [[placenta]]. It is seen on [[endometrium\|endometrial]] biopsies and hysterectomy specimens.
			==General==
			*Benign.
			*Intermediate trophoblast remnants from a previous gestation.<ref name=pmid19332926>{{Cite journal \| last1 = Jacob \| first1 = S. \| last2 = Mohapatra \| first2 = D. \| title = Placental site nodule: a tumor-like trophoblastic lesion. \| journal = Indian J Pathol Microbiol \| volume = 52 \| issue = 2 \| pages = 240-1 \| month = \| year = \| doi = \| PMID = 19332926 \| url = http://www.ijpmonline.org/text.asp?2009/52/2/240/48931 }}</ref>
			*Usually an incidental finding.

			Clinical:
			*Usually asymptomatic.
			*Vaginal bleeding. (?)
			*Infertility. (?)

			==Microscopic==
			Features:<ref name=pmid19332926/>
			*Paucicellular with hyaline material scattered cells.
			*Variable cell population:
			**Small-large cells.
			**Clear to eosinophilic cytoplasm.
			**+/-Multinucleation.

			Notes:
			*No mitotic activity.

			DDx:
			*Invasive (cervical) [[squamous cell carcinoma]].
			**Can be sorted-out with IHC (SCC will typically be: p16 +ve, MIB1 +ve).
			*[[Exaggerated placental site]].
			**Different histomorphology than PSN; EPS:<ref name=pmid19332926/> syncytiotrophoblastic tissue, in cords/nests, no hyaline nodules.

			===Images===
			<gallery>
			Image:Placental_site_nodule_-_intermed_mag.jpg \| PSN - intermed. mag. (WC)
			Image:Placental_site_nodule_-_high_mag.jpg \| PSN - high mag. (WC)
			</gallery>
			www:
			*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2009_52_2_240_48931_u4.jpg PSN (ijpmonline.org)].<ref name=pmid19332926/>
			*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=12&cat3=1256&stype=d PSN (gfmer.ch)] - includes images from ''Jacob and Mohapatra''.<ref name=pmid19332926/>

			==IHC==
			Features:<ref name=pmid19332926/>
			*Inhibin alpha +ve.
			*CK18 +ve.
			*MIB1 low.

			Other:
			*p16 -ve.

			==Sign out==
			<pre>
			- CONSISTENT WITH MENSTRUAL ENDOMETRIUM (FRAGMENTED ENDOMETRIUM WITH SIMPLE
			GLANDS WITH APOPTOTIC CELLS, ABUNDANT NEUTROPHILS, CONDENSED ENDOMETRIAL STROMA
			(FOCAL) AND BLOOD).
			- PLACENTAL SITE NODULE AND DECIDUA.
			- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
			</pre>

			<pre>
			ENDOMETRIUM, BIOPSY:
			- PROLIFERATIVE PHASE ENDOMETRIUM.
			- BENIGN PLACENTAL SITE NODULE, SMALL.
			- NEGATIVE FOR HYPERPLASIA.
			</pre>

			==See also==
			*[[Gestational trophoblastic disease]].

			==References==
			{{Reflist\|2}}


	[[Category:Diagnosis]]		[[Category:Diagnosis]]