Pineal gland - Revision history

Michael: vauthors -> authors

2021-03-25T17:20:34Z

vauthors -> authors

← Older revision		Revision as of 17:20, 25 March 2021
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	===Molecular===		===Molecular===
	* Insertions in KBTBD4.<ref name="pmid31768671">{{cite journal \|~~vauthors~~=Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis MA, Schuhmann MU, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr BA, Ellison DW, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister SM, Jones DTW \|title=Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations \|journal=Acta Neuropathol \|volume=139 \|issue=2 \|pages=243–257 \|date=February 2020 \|pmid=31768671 \|doi=10.1007/s00401-019-02101-0 \|url=}}</ref>		* Insertions in KBTBD4.<ref name="pmid31768671">{{cite journal \|authors=Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis MA, Schuhmann MU, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr BA, Ellison DW, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister SM, Jones DTW \|title=Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations \|journal=Acta Neuropathol \|volume=139 \|issue=2 \|pages=243–257 \|date=February 2020 \|pmid=31768671 \|doi=10.1007/s00401-019-02101-0 \|url=}}</ref>


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	===Molecular===		===Molecular===
	* PTEN alterations. <ref name="pmid26113311">{{cite journal \|~~vauthors~~=Heim S, Sill M, Jones DT, Vasiljevic A, Jouvet A, Fèvre-Montange M, Wesseling P, Beschorner R, Mittelbronn M, Kohlhof P, Hovestadt V, Johann P, Kool M, Pajtler KW, Korshunov A, Ruland V, Sperveslage J, Thomas C, Witt H, von Deimling A, Paulus W, Pfister SM, Capper D, Hasselblatt M \|title=Papillary Tumor of the Pineal Region: A Distinct Molecular Entity \|journal=Brain Pathol \|volume=26 \|issue=2 \|pages=199–205 \|date=March 2016 \|pmid=26113311 \|doi=10.1111/bpa.12282 \|url=}}</ref>		* PTEN alterations. <ref name="pmid26113311">{{cite journal \|authors=Heim S, Sill M, Jones DT, Vasiljevic A, Jouvet A, Fèvre-Montange M, Wesseling P, Beschorner R, Mittelbronn M, Kohlhof P, Hovestadt V, Johann P, Kool M, Pajtler KW, Korshunov A, Ruland V, Sperveslage J, Thomas C, Witt H, von Deimling A, Paulus W, Pfister SM, Capper D, Hasselblatt M \|title=Papillary Tumor of the Pineal Region: A Distinct Molecular Entity \|journal=Brain Pathol \|volume=26 \|issue=2 \|pages=199–205 \|date=March 2016 \|pmid=26113311 \|doi=10.1111/bpa.12282 \|url=}}</ref>
	*Chromosome 10 loss.		*Chromosome 10 loss.

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	===Molecular===		===Molecular===
	* DICER1 mutations.<ref name="pmid25022261">{{cite journal \|~~vauthors~~=de Kock L, Sabbaghian N, Druker H, Weber E, Hamel N, Miller S, Choong CS, Gottardo NG, Kees UR, Rednam SP, van Hest LP, Jongmans MC, Jhangiani S, Lupski JR, Zacharin M, Bouron-Dal Soglio D, Huang A, Priest JR, Perry A, Mueller S, Albrecht S, Malkin D, Grundy RG, Foulkes WD \|title=Germ-line and somatic DICER1 mutations in pineoblastoma \|journal=Acta Neuropathol \|volume=128 \|issue=4 \|pages=583–95 \|date=October 2014 \|pmid=25022261 \|pmc=4381868 \|doi=10.1007/s00401-014-1318-7 \|url=}}</ref>		* DICER1 mutations.<ref name="pmid25022261">{{cite journal \|authors=de Kock L, Sabbaghian N, Druker H, Weber E, Hamel N, Miller S, Choong CS, Gottardo NG, Kees UR, Rednam SP, van Hest LP, Jongmans MC, Jhangiani S, Lupski JR, Zacharin M, Bouron-Dal Soglio D, Huang A, Priest JR, Perry A, Mueller S, Albrecht S, Malkin D, Grundy RG, Foulkes WD \|title=Germ-line and somatic DICER1 mutations in pineoblastoma \|journal=Acta Neuropathol \|volume=128 \|issue=4 \|pages=583–95 \|date=October 2014 \|pmid=25022261 \|pmc=4381868 \|doi=10.1007/s00401-014-1318-7 \|url=}}</ref>
	*DROSHA deletions. <ref name="pmid30877433">{{cite journal \|~~vauthors~~=Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA \|title=Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma \|journal=Acta Neuropathol \|volume=137 \|issue=5 \|pages=851–854 \|date=May 2019 \|pmid=30877433 \|pmc=6483828 \|doi=10.1007/s00401-019-01990-5 \|url=}}</ref>		*DROSHA deletions. <ref name="pmid30877433">{{cite journal \|authors=Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA \|title=Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma \|journal=Acta Neuropathol \|volume=137 \|issue=5 \|pages=851–854 \|date=May 2019 \|pmid=30877433 \|pmc=6483828 \|doi=10.1007/s00401-019-01990-5 \|url=}}</ref>

	DDx:		DDx:

Jensflorian: /* Papillary tumour of pineal region (PTPR) */ +molecular

2020-11-11T13:25:15Z

Papillary tumour of pineal region (PTPR): +molecular

← Older revision		Revision as of 13:25, 11 November 2020
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	* EMA mostly -ve.		* EMA mostly -ve.
	* NF and Kir 7.1-ve.		* NF and Kir 7.1-ve.

			===Molecular===
			* PTEN alterations. <ref name="pmid26113311">{{cite journal \|vauthors=Heim S, Sill M, Jones DT, Vasiljevic A, Jouvet A, Fèvre-Montange M, Wesseling P, Beschorner R, Mittelbronn M, Kohlhof P, Hovestadt V, Johann P, Kool M, Pajtler KW, Korshunov A, Ruland V, Sperveslage J, Thomas C, Witt H, von Deimling A, Paulus W, Pfister SM, Capper D, Hasselblatt M \|title=Papillary Tumor of the Pineal Region: A Distinct Molecular Entity \|journal=Brain Pathol \|volume=26 \|issue=2 \|pages=199–205 \|date=March 2016 \|pmid=26113311 \|doi=10.1111/bpa.12282 \|url=}}</ref>
			*Chromosome 10 loss.

	DDx:		DDx:

Jensflorian: /* Pineal parenchymal tumor of intermediate differentiation */ +molecular

2020-11-11T13:22:54Z

Pineal parenchymal tumor of intermediate differentiation: +molecular

← Older revision		Revision as of 13:22, 11 November 2020
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	===Molecular===		===Molecular===
	* Insertions in KBTBD4.<ref name="pmid31768671">{{cite journal \|vauthors=Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis MA, Schuhmann MU, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr BA, Ellison DW, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister SM, Jones DTW \|title=Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations \|journal=Acta Neuropathol \|volume=139 \|issue=2 \|pages=243–257 \|date=February 2020 \|pmid=31768671 \|doi=10.1007/s00401-019-02101-0 \|url=}}</ref>		* Insertions in KBTBD4.<ref name="pmid31768671">{{cite journal \|vauthors=Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis MA, Schuhmann MU, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr BA, Ellison DW, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister SM, Jones DTW \|title=Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations \|journal=Acta Neuropathol \|volume=139 \|issue=2 \|pages=243–257 \|date=February 2020 \|pmid=31768671 \|doi=10.1007/s00401-019-02101-0 \|url=}}</ref>
	* PTEN alterations.

	Images:		Images:

Jensflorian: /* Pineal parenchymal tumor of intermediate differentiation */ +Molecular

2020-11-11T13:20:12Z

Pineal parenchymal tumor of intermediate differentiation: +Molecular

← Older revision		Revision as of 13:20, 11 November 2020
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	*Usually no pinecytomatous rosettes.		*Usually no pinecytomatous rosettes.
	*High pleomorphism possible.		*High pleomorphism possible.

			===Molecular===
			* Insertions in KBTBD4.<ref name="pmid31768671">{{cite journal \|vauthors=Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis MA, Schuhmann MU, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr BA, Ellison DW, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister SM, Jones DTW \|title=Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations \|journal=Acta Neuropathol \|volume=139 \|issue=2 \|pages=243–257 \|date=February 2020 \|pmid=31768671 \|doi=10.1007/s00401-019-02101-0 \|url=}}</ref>
			* PTEN alterations.

	Images:		Images:

Jensflorian: Pineoblastoma /* Molecular */

2020-11-11T13:03:04Z

Pineoblastoma Molecular

← Older revision		Revision as of 13:03, 11 November 2020
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	===Molecular===		===Molecular===
	* DICER1 mutations.<ref name="pmid25022261">{{cite journal \|vauthors=de Kock L, Sabbaghian N, Druker H, Weber E, Hamel N, Miller S, Choong CS, Gottardo NG, Kees UR, Rednam SP, van Hest LP, Jongmans MC, Jhangiani S, Lupski JR, Zacharin M, Bouron-Dal Soglio D, Huang A, Priest JR, Perry A, Mueller S, Albrecht S, Malkin D, Grundy RG, Foulkes WD \|title=Germ-line and somatic DICER1 mutations in pineoblastoma \|journal=Acta Neuropathol \|volume=128 \|issue=4 \|pages=583–95 \|date=October 2014 \|pmid=25022261 \|pmc=4381868 \|doi=10.1007/s00401-014-1318-7 \|url=}}</ref>		* DICER1 mutations.<ref name="pmid25022261">{{cite journal \|vauthors=de Kock L, Sabbaghian N, Druker H, Weber E, Hamel N, Miller S, Choong CS, Gottardo NG, Kees UR, Rednam SP, van Hest LP, Jongmans MC, Jhangiani S, Lupski JR, Zacharin M, Bouron-Dal Soglio D, Huang A, Priest JR, Perry A, Mueller S, Albrecht S, Malkin D, Grundy RG, Foulkes WD \|title=Germ-line and somatic DICER1 mutations in pineoblastoma \|journal=Acta Neuropathol \|volume=128 \|issue=4 \|pages=583–95 \|date=October 2014 \|pmid=25022261 \|pmc=4381868 \|doi=10.1007/s00401-014-1318-7 \|url=}}</ref>
	*DROSHA deletions. <ref name="pmid30877433">{{cite journal \|vauthors=Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA \|title=Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma \|journal=Acta Neuropathol \|volume=137 \|issue=5 \|pages=851–854 \|date=May 2019 \|pmid=~~30877~~		*DROSHA deletions. <ref name="pmid30877433">{{cite journal \|vauthors=Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA \|title=Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma \|journal=Acta Neuropathol \|volume=137 \|issue=5 \|pages=851–854 \|date=May 2019 \|pmid=30877433 \|pmc=6483828 \|doi=10.1007/s00401-019-01990-5 \|url=}}</ref>

	DDx:		DDx:

Jensflorian: /* Pineoblastoma */ +Molecular

2020-11-11T13:01:19Z

Pineoblastoma: +Molecular

← Older revision		Revision as of 13:01, 11 November 2020
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	*Synaptophysin+ve		*Synaptophysin+ve
	*MIB-1: high.		*MIB-1: high.

			===Molecular===
			* DICER1 mutations.<ref name="pmid25022261">{{cite journal \|vauthors=de Kock L, Sabbaghian N, Druker H, Weber E, Hamel N, Miller S, Choong CS, Gottardo NG, Kees UR, Rednam SP, van Hest LP, Jongmans MC, Jhangiani S, Lupski JR, Zacharin M, Bouron-Dal Soglio D, Huang A, Priest JR, Perry A, Mueller S, Albrecht S, Malkin D, Grundy RG, Foulkes WD \|title=Germ-line and somatic DICER1 mutations in pineoblastoma \|journal=Acta Neuropathol \|volume=128 \|issue=4 \|pages=583–95 \|date=October 2014 \|pmid=25022261 \|pmc=4381868 \|doi=10.1007/s00401-014-1318-7 \|url=}}</ref>
			*DROSHA deletions. <ref name="pmid30877433">{{cite journal \|vauthors=Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA \|title=Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma \|journal=Acta Neuropathol \|volume=137 \|issue=5 \|pages=851–854 \|date=May 2019 \|pmid=30877

	DDx:		DDx:

Michael: /* General */

2018-08-21T20:34:27Z

General

← Older revision		Revision as of 20:34, 21 August 2018
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	*Children & young adults.		*Children & young adults.
	*Corresponds to WHO IV (ICD-O: 9362/3).		*Corresponds to WHO IV (ICD-O: 9362/3).
	*May be a manifestation of the [[DICER1 syndrome]].		*May be a manifestation of the [[DICER1 syndrome]].<ref name=pmid28960912>{{Cite journal \| last1 = van Engelen \| first1 = K. \| last2 = Villani \| first2 = A. \| last3 = Wasserman \| first3 = JD. \| last4 = Aronoff \| first4 = L. \| last5 = Greer \| first5 = MC. \| last6 = Tijerin Bueno \| first6 = M. \| last7 = Gallinger \| first7 = B. \| last8 = Kim \| first8 = RH. \| last9 = Grant \| first9 = R. \| title = DICER1 syndrome: Approach to testing and management at a large pediatric tertiary care center. \| journal = Pediatr Blood Cancer \| volume = 65 \| issue = 1 \| pages = \| month = Jan \| year = 2018 \| doi = 10.1002/pbc.26720 \| PMID = 28960912 }}</ref>

	===Microscopic===		===Microscopic===

Michael: /* General */ DICER1

2018-08-21T20:32:04Z

General: DICER1

← Older revision		Revision as of 20:32, 21 August 2018
Line 146:		Line 146:
	*Males > females.		*Males > females.
	*Children & young adults.		*Children & young adults.
	*Corresponds to WHO IV (ICD-O: 9362/3)		*Corresponds to WHO IV (ICD-O: 9362/3).
			*May be a manifestation of the [[DICER1 syndrome]].

	===Microscopic===		===Microscopic===

Jensflorian: /* (PTPR) */

2015-10-14T14:48:12Z

(PTPR)

← Older revision		Revision as of 14:48, 14 October 2015
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	</gallery>		</gallery>

	==Papillary ~~Tumor~~ of ~~Pinealis~~ region (PTPR)==		==Papillary tumour of pineal region (PTPR)==
	===General===		===General===
	*Very rare neuoepithelial tumor of adults.		*Very rare neuoepithelial tumor of adults.

Jensflorian: fix broken gallery tag

2015-05-08T07:17:54Z

fix broken gallery tag

← Older revision		Revision as of 07:17, 8 May 2015
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	**[[Meningioma]]s.		**[[Meningioma]]s.

	===Pineal gland cyst===		==Pineal gland cyst==
	*Quite common. <ref name=pmid17885233> {{Cite journal \| last1 = Pu \| first1 = Y. \| last2 = Mahankali \| first2 = S. \| last3 = Hou \| first3 = J. \| last4 = Li \| first4 = J. \| last5 = Lancaster \| first5 = JL. \| last6 = Gao \| first6 = JH. \| last7 = Appelbaum \| first7 = DE. \| last8 = Fox \| first8 = PT. \| title = High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. \| journal = AJNR Am J Neuroradiol \| volume = 28 \| issue = 9 \| pages = 1706-9 \| month = Oct \| year = 2007 \| doi = 10.3174/ajnr.A0656 \| PMID = 17885233 }}</ref>		*Quite common. <ref name=pmid17885233> {{Cite journal \| last1 = Pu \| first1 = Y. \| last2 = Mahankali \| first2 = S. \| last3 = Hou \| first3 = J. \| last4 = Li \| first4 = J. \| last5 = Lancaster \| first5 = JL. \| last6 = Gao \| first6 = JH. \| last7 = Appelbaum \| first7 = DE. \| last8 = Fox \| first8 = PT. \| title = High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. \| journal = AJNR Am J Neuroradiol \| volume = 28 \| issue = 9 \| pages = 1706-9 \| month = Oct \| year = 2007 \| doi = 10.3174/ajnr.A0656 \| PMID = 17885233 }}</ref>
	*large cysts can cause CSF obstruction. <ref>{{Cite journal \| last1 = Mena \| first1 = H. \| last2 = Armonda \| first2 = RA. \| last3 = Ribas \| first3 = JL. \| last4 = Ondra \| first4 = SL. \| last5 = Rushing \| first5 = EJ. \| title = Nonneoplastic pineal cysts: a clinicopathologic study of twenty-one cases. \| journal = Ann Diagn Pathol \| volume = 1 \| issue = 1 \| pages = 11-8 \| month = Oct \| year = 1997 \| doi = \| PMID = 9869821 }}</ref>		*large cysts can cause CSF obstruction. <ref>{{Cite journal \| last1 = Mena \| first1 = H. \| last2 = Armonda \| first2 = RA. \| last3 = Ribas \| first3 = JL. \| last4 = Ondra \| first4 = SL. \| last5 = Rushing \| first5 = EJ. \| title = Nonneoplastic pineal cysts: a clinicopathologic study of twenty-one cases. \| journal = Ann Diagn Pathol \| volume = 1 \| issue = 1 \| pages = 11-8 \| month = Oct \| year = 1997 \| doi = \| PMID = 9869821 }}</ref>

	</gallery>		<gallery>
	File:Pinealiszyste.jpg \| Pineal gland cyst found at autopsy. (WC/Marvin101)		File:Pinealiszyste.jpg \| Pineal gland cyst found at autopsy. (WC/Marvin101)
	File:Pineal_gland_cyst_low_mag_HE.jpg \| Pineal gland cyst. HE, low mag. (WC/jensflorian)		File:Pineal_gland_cyst_low_mag_HE.jpg \| Pineal gland cyst. HE, low mag. (WC/jensflorian)
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	</gallery>		</gallery>

	~~==Primary pineal tumours==~~
	~~Range from benign to malignant.~~

	==Pineocytoma==		==Pineocytoma==