Pilomyxoid astrocytoma - Revision history

Jensflorian: + new images + ICD-O

2016-05-18T13:49:19Z

+ new images + ICD-O

← Older revision		Revision as of 13:49, 18 May 2016
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	**Tumors may mature to conventional PA over time.<ref>{{Cite journal \| last1 = Kleinschmidt-DeMasters \| first1 = BK. \| last2 = Donson \| first2 = AM. \| last3 = Vogel \| first3 = H. \| last4 = Foreman \| first4 = NK. \| title = Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. \| journal = Brain Pathol \| volume = 25 \| issue = 4 \| pages = 429-40 \| month = Jul \| year = 2015 \| doi = 10.1111/bpa.12239 \| PMID = 25521223 }}</ref>		**Tumors may mature to conventional PA over time.<ref>{{Cite journal \| last1 = Kleinschmidt-DeMasters \| first1 = BK. \| last2 = Donson \| first2 = AM. \| last3 = Vogel \| first3 = H. \| last4 = Foreman \| first4 = NK. \| title = Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. \| journal = Brain Pathol \| volume = 25 \| issue = 4 \| pages = 429-40 \| month = Jul \| year = 2015 \| doi = 10.1111/bpa.12239 \| PMID = 25521223 }}</ref>
	*Childhood or adolescence.		*Childhood or adolescence.
			*ICD-O: 9425/3

	Grading:		Grading:
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	<gallery>		<gallery>
	Image:Pilomyxoid Astrocytoma HE20x.jpg \| Pilomyxoid astrocytoma. (WC/Marvin 101)		Image:Pilomyxoid Astrocytoma HE20x.jpg \| Pilomyxoid astrocytoma. (WC/Marvin 101)
			File:Pilomyxoid astrocytoma 03.jpg \| Pilomyxoid astrocytoma. (WC)
			File:Pilomyxoid astrocytoma 01.jpg \| Pilomyxoid astrocytoma - Alcian blue (WC)
	</gallery>		</gallery>

Jensflorian: /* General */ Update, dropped tumor grading in WHO 2016

2016-05-18T13:45:16Z

General: Update, dropped tumor grading in WHO 2016

← Older revision		Revision as of 13:45, 18 May 2016
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	*A variant of ''pilocytic astrocytoma''.		*A variant of ''pilocytic astrocytoma''.
	**Some have suggested it is a unique entity.<ref name=pmid16048293>{{cite journal \|author=Komotar RJ, Mocco J, Jones JE, ''et al.'' \|title=Pilomyxoid astrocytoma: diagnosis, prognosis, and management \|journal=Neurosurg Focus \|volume=18 \|issue=6A \|pages=E7 \|year=2005 \|month=June \|pmid=16048293 \|doi= \|url=}}</ref>		**Some have suggested it is a unique entity.<ref name=pmid16048293>{{cite journal \|author=Komotar RJ, Mocco J, Jones JE, ''et al.'' \|title=Pilomyxoid astrocytoma: diagnosis, prognosis, and management \|journal=Neurosurg Focus \|volume=18 \|issue=6A \|pages=E7 \|year=2005 \|month=June \|pmid=16048293 \|doi= \|url=}}</ref>
			**Some say the outcome is less good than conventional pilocytic astrocytoma.<ref>{{Cite journal \| last1 = Louis \| first1 = DN. \| last2 = Perry \| first2 = A. \| last3 = Reifenberger \| first3 = G. \| last4 = von Deimling \| first4 = A. \| last5 = Figarella-Branger \| first5 = D. \| last6 = Cavenee \| first6 = WK. \| last7 = Ohgaki \| first7 = H. \| last8 = Wiestler \| first8 = OD. \| last9 = Kleihues \| first9 = P. \| title = The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. \| journal = Acta Neuropathol \| volume = 131 \| issue = 6 \| pages = 803-20 \| month = Jun \| year = 2016 \| doi = 10.1007/s00401-016-1545-1 \| PMID = 27157931 }}</ref>
			**Tumors may mature to conventional PA over time.<ref>{{Cite journal \| last1 = Kleinschmidt-DeMasters \| first1 = BK. \| last2 = Donson \| first2 = AM. \| last3 = Vogel \| first3 = H. \| last4 = Foreman \| first4 = NK. \| title = Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. \| journal = Brain Pathol \| volume = 25 \| issue = 4 \| pages = 429-40 \| month = Jul \| year = 2015 \| doi = 10.1111/bpa.12239 \| PMID = 25521223 }}</ref>
	*Childhood or adolescence.		*Childhood or adolescence.

	Grading:		Grading:
	*''WHO Grade II'' by definition.<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>		*Currently no WHO grade assigned.<ref>{{Cite journal \| last1 = Louis \| first1 = DN. \| last2 = Perry \| first2 = A. \| last3 = Reifenberger \| first3 = G. \| last4 = von Deimling \| first4 = A. \| last5 = Figarella-Branger \| first5 = D. \| last6 = Cavenee \| first6 = WK. \| last7 = Ohgaki \| first7 = H. \| last8 = Wiestler \| first8 = OD. \| last9 = Kleihues \| first9 = P. \| title = The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. \| journal = Acta Neuropathol \| volume = 131 \| issue = 6 \| pages = 803-20 \| month = Jun \| year = 2016 \| doi = 10.1007/s00401-016-1545-1 \| PMID = 27157931 }}</ref>
			** From 2007-2016 the tumor was ''WHO Grade II'' by definition.<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref> Grading was dropped until further studies clarify the true behaviour.

	==Gross==		==Gross==

Michael: /* Gross */

2014-12-10T06:03:30Z

Gross

← Older revision		Revision as of 06:03, 10 December 2014
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	==Gross==		==Gross==
	Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>		Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
	*Classically - hypothalamic location/suprasellar location; may involve the sella turcica.<ref name=pmid19766001>{{cite journal \|author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A \|title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent \|journal=J Clin Neurosci \|volume=16 \|issue=12 \|pages=1648–9 \|year=2009 \|month=December \|pmid=19766001 \|doi=10.1016/j.jocn.2009.01.035 \|url=}}</ref>		*Classically - hypothalamic location/suprasellar location; may involve the [[sella turcica]].<ref name=pmid19766001>{{cite journal \|author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A \|title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent \|journal=J Clin Neurosci \|volume=16 \|issue=12 \|pages=1648–9 \|year=2009 \|month=December \|pmid=19766001 \|doi=10.1016/j.jocn.2009.01.035 \|url=}}</ref>
	*Solid.		*Solid.
	*Well-circumscribed.		*Well-circumscribed.

Michael: split out

2014-12-10T06:01:36Z

split out

← Older revision		Revision as of 06:01, 10 December 2014
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	'''Pilomyxoid astrocytoma''' is a [[neuropathology tumour]] related to [[pilocytic astrocytoma]].		'''Pilomyxoid astrocytoma''' is a [[neuropathology tumour]] related to [[pilocytic astrocytoma]].

	===General===		==General==
	Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>		Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
	*A variant of ''pilocytic astrocytoma''.		*A variant of ''pilocytic astrocytoma''.
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	*Childhood or adolescence.		*Childhood or adolescence.

	===Gross===		Grading:
			*''WHO Grade II'' by definition.<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>

			==Gross==
	Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>		Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
	*Classically - hypothalamic location/suprasellar location; may involve the sella turcica.<ref name=pmid19766001>{{cite journal \|author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A \|title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent \|journal=J Clin Neurosci \|volume=16 \|issue=12 \|pages=1648–9 \|year=2009 \|month=December \|pmid=19766001 \|doi=10.1016/j.jocn.2009.01.035 \|url=}}</ref>		*Classically - hypothalamic location/suprasellar location; may involve the sella turcica.<ref name=pmid19766001>{{cite journal \|author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A \|title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent \|journal=J Clin Neurosci \|volume=16 \|issue=12 \|pages=1648–9 \|year=2009 \|month=December \|pmid=19766001 \|doi=10.1016/j.jocn.2009.01.035 \|url=}}</ref>
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	*Well-circumscribed.		*Well-circumscribed.

	===Microscopic===		==Microscopic==
	Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>		Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
	*Consists of small round/ovoid bland cells in a [[myxoid stroma]].		*Consists of small round/ovoid bland cells in a [[myxoid stroma]].
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	*May rarely have eosinophilic granular bodies.		*May rarely have eosinophilic granular bodies.

			===Images===
	<gallery>		<gallery>
	Image:Pilomyxoid Astrocytoma HE20x.jpg \| Pilomyxoid astrocytoma. (WC/Marvin 101)		Image:Pilomyxoid Astrocytoma HE20x.jpg \| Pilomyxoid astrocytoma. (WC/Marvin 101)
	</gallery>		</gallery>

	~~===Grading===~~
	*''WHO Grade II'' by definition.<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>


	==See also==		==See also==
	*[[Neuropathology tumours]].		*[[Neuropathology tumours]].
			*[[Pilocytic astrocytoma]].

	==References==		==References==

Michael: split out

2014-12-10T06:00:30Z

split out

← Older revision		Revision as of 06:00, 10 December 2014
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	~~#redirect~~ [[~~Neuropathology_tumours#Pilomyxoid_astrocytoma~~]]		'''Pilomyxoid astrocytoma''' is a [[neuropathology tumour]] related to [[pilocytic astrocytoma]].

			===General===
			Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
			*A variant of ''pilocytic astrocytoma''.
			**Some have suggested it is a unique entity.<ref name=pmid16048293>{{cite journal \|author=Komotar RJ, Mocco J, Jones JE, ''et al.'' \|title=Pilomyxoid astrocytoma: diagnosis, prognosis, and management \|journal=Neurosurg Focus \|volume=18 \|issue=6A \|pages=E7 \|year=2005 \|month=June \|pmid=16048293 \|doi= \|url=}}</ref>
			*Childhood or adolescence.

			===Gross===
			Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
			*Classically - hypothalamic location/suprasellar location; may involve the sella turcica.<ref name=pmid19766001>{{cite journal \|author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A \|title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent \|journal=J Clin Neurosci \|volume=16 \|issue=12 \|pages=1648–9 \|year=2009 \|month=December \|pmid=19766001 \|doi=10.1016/j.jocn.2009.01.035 \|url=}}</ref>
			*Solid.
			*Well-circumscribed.

			===Microscopic===
			Features:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
			*Consists of small round/ovoid bland cells in a [[myxoid stroma]].
			*Hair-like fibres ~ 1 micrometer.
			**Often difficult to appreciate on standard (H&E) histologic sections.
			*Usually angiocentric (surround blood vessel) - '''key feature'''.

			Notes:<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>
			*Rosenthal fibres are absent - '''key negative'''.
			*Monophasic (unlike classical pilocytic astrocytomas) - '''key negative'''.
			*May rarely have eosinophilic granular bodies.

			<gallery>
			Image:Pilomyxoid Astrocytoma HE20x.jpg \| Pilomyxoid astrocytoma. (WC/Marvin 101)
			</gallery>

			===Grading===
			*''WHO Grade II'' by definition.<ref name=Ref_PSNP86>{{Ref PSNP\|86}}</ref>


			==See also==
			*[[Neuropathology tumours]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology tumours]]

Michael: +cat.

2011-10-18T03:56:54Z

+cat.

← Older revision		Revision as of 03:56, 18 October 2011
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	#redirect [[Neuropathology_tumours#Pilomyxoid_astrocytoma]]		#redirect [[Neuropathology_tumours#Pilomyxoid_astrocytoma]]

			[[Category:Diagnosis]]

Michael: redirect for now

2011-03-04T22:44:33Z

redirect for now

New page

#redirect [[Neuropathology_tumours#Pilomyxoid_astrocytoma]]