Peutz-Jeghers polyp - Revision history

Michael: /* Sign out */

2018-04-25T18:22:12Z

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← Older revision		Revision as of 18:22, 25 April 2018
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	Image:Colon histology with Peutz-Jeghers polyp.jpg \| Peutz-Jeghers (colonic) polyp (WC)		Image:Colon histology with Peutz-Jeghers polyp.jpg \| Peutz-Jeghers (colonic) polyp (WC)
	</gallery>		</gallery>

			==IHC==
			*[[Chromogranin A]] - increased staining in relation to background; increased enterochromaffin cells.<ref name=pmid24364221>{{Cite journal \| last1 = Krstić \| first1 = M. \| last2 = Katić \| first2 = V. \| last3 = Stojnev \| first3 = S. \| last4 = Mihailović \| first4 = D. \| last5 = Mojsilović \| first5 = M. \| last6 = Radovanović \| first6 = Z. \| last7 = Zivković \| first7 = V. \| title = Peutz-Jeghers syndrome: quantitative study on enterochromaffin cells in hamartomatous intestine polyps. \| journal = Srp Arh Celok Lek \| volume = 141 \| issue = 9-10 \| pages = 602-7 \| month = \| year = \| doi = \| PMID = 24364221 }}</ref>

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Brigitte: /* Images */

2018-04-08T21:15:50Z

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← Older revision		Revision as of 21:15, 8 April 2018
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	Image:Colon histology with Peutz-Jeghers polyp.jpg \| Peutz-Jeghers (colonic) polyp (WC)		Image:Colon histology with Peutz-Jeghers polyp.jpg \| Peutz-Jeghers (colonic) polyp (WC)
	</gallery>		</gallery>
	~~www:~~
	*[http://www.nature.com/modpathol/journal/v16/n4/fig_tab/3880773f3.html Peutz-Jeghers polyp (nature.com)].

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Michael: /* Images */

2014-07-15T18:31:47Z

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← Older revision		Revision as of 18:31, 15 July 2014
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	<gallery>		<gallery>
	Image:Peutz-Jeghers_syndrome_polyp.jpg \| Peutz-Jeghers polyp - intestine (WC/Nephron)		Image:Peutz-Jeghers_syndrome_polyp.jpg \| Peutz-Jeghers polyp - intestine (WC/Nephron)
			</gallery>
			<gallery>
	Image:Gastric_Peutz-Jeghers_polyp_-_very_low_mag.jpg \| Peutz-Jeghers polyp - stomach - very low mag. (WC/Nephron)		Image:Gastric_Peutz-Jeghers_polyp_-_very_low_mag.jpg \| Peutz-Jeghers polyp - stomach - very low mag. (WC/Nephron)
	Image: Gastric Peutz-Jeghers polyp - low mag.jpg \| Peutz-Jeghers polyp - stomach - low mag. (WC/Nephron)		Image: Gastric Peutz-Jeghers polyp - low mag.jpg \| Peutz-Jeghers polyp - stomach - low mag. (WC/Nephron)
	Image: Gastric Peutz-Jeghers polyp - intermed mag.jpg \| Peutz-Jeghers polyp - stomach - intermed. mag. (WC/Nephron)		Image: Gastric Peutz-Jeghers polyp - intermed mag.jpg \| Peutz-Jeghers polyp - stomach - intermed. mag. (WC/Nephron)
			</gallery>
			<gallery>
			Image:Colon histology with Peutz-Jeghers polyp.jpg \| Peutz-Jeghers (colonic) polyp (WC)
	</gallery>		</gallery>
	www:		www:

Michael: /* Images */ +images

2013-11-06T16:09:55Z

Images: +images

← Older revision		Revision as of 16:09, 6 November 2013
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	<gallery>		<gallery>
	Image:Peutz-Jeghers_syndrome_polyp.jpg \| Peutz-Jeghers polyp - intestine (WC/Nephron)		Image:Peutz-Jeghers_syndrome_polyp.jpg \| Peutz-Jeghers polyp - intestine (WC/Nephron)
	Image:Gastric_Peutz-Jeghers_polyp_-_very_low_mag.jpg \| Peutz-Jeghers polyp - stomach (WC/Nephron)		Image:Gastric_Peutz-Jeghers_polyp_-_very_low_mag.jpg \| Peutz-Jeghers polyp - stomach - very low mag. (WC/Nephron)
			Image: Gastric Peutz-Jeghers polyp - low mag.jpg \| Peutz-Jeghers polyp - stomach - low mag. (WC/Nephron)
			Image: Gastric Peutz-Jeghers polyp - intermed mag.jpg \| Peutz-Jeghers polyp - stomach - intermed. mag. (WC/Nephron)
	</gallery>		</gallery>
	www:		www:

Michael: tweak

2013-11-06T13:37:33Z

tweak

← Older revision		Revision as of 13:37, 6 November 2013
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	\| pathoutlines =		\| pathoutlines =
	}}		}}
	'''Peutz-Jeghers polyp''' is an uncommon gastrointestinal polyp. It is usually associated with [[Peutz-Jeghers syndrome]].		'''Peutz-Jeghers polyp''', abbreviated '''PJP''', is an uncommon [[hamartoma\|hamartomous]] [[gastrointestinal polyp]]. It is usually associated with [[Peutz-Jeghers syndrome]].

	==General==		==General==

Michael at 13:36, 6 November 2013

2013-11-06T13:36:43Z

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	**The '''key''' is "thick" smooth muscle bundles - if one is lucky one sees branching.<ref>C. Streutker. 26 July 2011.</ref>		**The '''key''' is "thick" smooth muscle bundles - if one is lucky one sees branching.<ref>C. Streutker. 26 July 2011.</ref>
	***"Thick" ~= thickness of muscularis mucosae.		***"Thick" ~= thickness of muscularis mucosae.

			DDx:
			*[[Hyperplastic polyp of the stomach]] - should ''not'' have thickened muscle.
			**May be confused with PJP as branching may not be apparent.

	===Images===		===Images===

Michael: gr

2013-07-29T17:14:27Z

← Older revision		Revision as of 17:14, 29 July 2013
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = benign lesion; suggests ~~increase~~ malignancy risk		\| Prognosis = benign lesion; suggests increased malignancy risk
	\| Other =		\| Other =
	\| ClinDDx = other [[gastrointestinal polyps]]		\| ClinDDx = other [[gastrointestinal polyps]]

Michael at 09:18, 29 July 2013

2013-07-29T09:18:54Z

← Older revision		Revision as of 09:18, 29 July 2013
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	\| Assdx =		\| Assdx =
	\| Syndromes = [[Peutz-Jeghers syndrome]]		\| Syndromes = [[Peutz-Jeghers syndrome]]
	\| Clinicalhx = family history of cancer - esp. [[~~CRC~~]]		\| Clinicalhx = family history of cancer - esp. gastrointestinal and [[breast cancer\|breast]]
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =

Michael: tweak

2013-07-29T09:16:36Z

tweak

← Older revision		Revision as of 09:16, 29 July 2013
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	\| Width =		\| Width =
	\| Caption = Peutz-Jeghers polyp. [[H&E stain]].		\| Caption = Peutz-Jeghers polyp. [[H&E stain]].
	\| Micro = polyp with~~: (1) muscosal epithelium, (2) lamina propria and (3) muscularis mucosae - esp.~~ branching ''or'' thickened		\| Micro = polyp with branching ''or'' thickened muscularis mucosae, benign epithelium, and lamina propria
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx =
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	==General==		==General==
	===Epidemiology===		===Epidemiology===
	Features:<ref name=Ref_PBoD859/><ref name=pmid12692201>{{Cite journal \| last1 = Bronner \| first1 = MP. \| title = Gastrointestinal inherited polyposis syndromes. \| journal = Mod Pathol \| volume = 16 \| issue = 4 \| pages = 359-65 \| month = Apr \| year = 2003 \| doi = 10.1097/01.MP.0000062992.54036.E4 \| PMID = 12692201 \| url = http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html }}</ref>		Features:<ref name=Ref_PBoD859>{{Ref PBoD\|859}}</ref><ref name=pmid12692201>{{Cite journal \| last1 = Bronner \| first1 = MP. \| title = Gastrointestinal inherited polyposis syndromes. \| journal = Mod Pathol \| volume = 16 \| issue = 4 \| pages = 359-65 \| month = Apr \| year = 2003 \| doi = 10.1097/01.MP.0000062992.54036.E4 \| PMID = 12692201 \| url = http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html }}</ref>
	*[[Peutz-Jeghers syndrome]] is autosomal dominant.		*[[Peutz-Jeghers syndrome]] is autosomal dominant.
	*Altered gene: STK11.		*Altered gene: STK11.

Michael: split out

2013-07-29T09:14:52Z

split out

← Older revision		Revision as of 09:14, 29 July 2013
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	#~~redirect~~ [[~~Gastrointestinal_tract_polyps#~~Peutz-~~Jeghers_polyp~~]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Peutz-Jeghers_syndrome_polyp.jpg
			\| Width =
			\| Caption = Peutz-Jeghers polyp. [[H&E stain]].
			\| Micro = polyp with: (1) muscosal epithelium, (2) lamina propria and (3) muscularis mucosae - esp. branching ''or'' thickened
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular = STK11 mutation
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[colon]], [[small bowel]], [[stomach]], others
			\| Assdx =
			\| Syndromes = [[Peutz-Jeghers syndrome]]
			\| Clinicalhx = family history of cancer - esp. [[CRC]]
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign lesion; suggests increase malignancy risk
			\| Other =
			\| ClinDDx = other [[gastrointestinal polyps]]
			}}
			{{ Infobox external links
			\| Name = Peutz-Jeghers polyp
			\| EHVSC = 10180
			\| pathprotocols =
			\| wikipedia =
			\| pathoutlines =
			}}
			'''Peutz-Jeghers polyp''' is an uncommon gastrointestinal polyp. It is usually associated with [[Peutz-Jeghers syndrome]].

			==General==
			===Epidemiology===
			Features:<ref name=Ref_PBoD859/><ref name=pmid12692201>{{Cite journal \| last1 = Bronner \| first1 = MP. \| title = Gastrointestinal inherited polyposis syndromes. \| journal = Mod Pathol \| volume = 16 \| issue = 4 \| pages = 359-65 \| month = Apr \| year = 2003 \| doi = 10.1097/01.MP.0000062992.54036.E4 \| PMID = 12692201 \| url = http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html }}</ref>
			*[[Peutz-Jeghers syndrome]] is autosomal dominant.
			*Altered gene: STK11.

			===Clinical===
			Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/175200 http://www.ncbi.nlm.nih.gov/omim/175200]. Accessed on: 13 July 2010.</ref>
			*Melanocytic macules.
			**Lips, buccal mucosa, and digits.
			**Multiple Peutz-Jeghers polyps.

			Increased risk of various neoplasms - primarily:
			*Breast and gastrointestinal cancer.<ref name=pmid20581245>{{cite journal \|author=Beggs AD, Latchford AR, Vasen HF, ''et al.'' \|title=Peutz-Jeghers syndrome: a systematic review and recommendations for management \|journal=Gut \|volume=59 \|issue=7 \|pages=975–86 \|year=2010 \|month=July \|pmid=20581245 \|doi=10.1136/gut.2009.198499 \|url=}}</ref>
			*Others tumours:<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/175200 http://www.ncbi.nlm.nih.gov/omim/175200]. Accessed on: 22 December 2010.</ref>
			**[[Granulosa cell tumour]].
			**[[Sertoli cell tumour]] - esp. with calcification.

			==Microscopic==
			Features:<ref name=Ref_PBoD859/><ref name=pmid12692201>{{Cite journal \| last1 = Bronner \| first1 = MP. \| title = Gastrointestinal inherited polyposis syndromes. \| journal = Mod Pathol \| volume = 16 \| issue = 4 \| pages = 359-65 \| month = Apr \| year = 2003 \| doi = 10.1097/01.MP.0000062992.54036.E4 \| PMID = 12692201 \| url = http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html }}</ref>
			*Frond-like polyp with all three components of mucosa:
			*# Muscosal epithelium (melanotic mucosa, goblet cells).
			*# Lamina propria.
			*# M. mucosae.

			Notes:
			*''Frond'' = leaflike expansion.<ref>URL: [http://dictionary.reference.com/browse/frond http://dictionary.reference.com/browse/frond]. Accessed on: 26 July 2011.</ref>
			**The '''key''' is "thick" smooth muscle bundles - if one is lucky one sees branching.<ref>C. Streutker. 26 July 2011.</ref>
			***"Thick" ~= thickness of muscularis mucosae.

			===Images===
			<gallery>
			Image:Peutz-Jeghers_syndrome_polyp.jpg \| Peutz-Jeghers polyp - intestine (WC/Nephron)
			Image:Gastric_Peutz-Jeghers_polyp_-_very_low_mag.jpg \| Peutz-Jeghers polyp - stomach (WC/Nephron)
			</gallery>
			www:
			*[http://www.nature.com/modpathol/journal/v16/n4/fig_tab/3880773f3.html Peutz-Jeghers polyp (nature.com)].

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			===Duodenum===
			<pre>
			POLYPS, DUODENUM, EXCISION:
			- PEUTZ-JEGHERS POLYPS (x2) WITH BRUNNER'S GLANDS.
			- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
			</pre>

			===Colon===
			<pre>
			POLYP, COLON (40 CM), EXCISION:
			- PEUTZ-JEGHERS POLYP.
			- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
			</pre>

			==See also==
			*[[Gastrointestinal tract polyps]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]