Penile intraepithelial neoplasia - Revision history

Michael: /* See also */ +SO

2018-10-04T17:02:39Z

Michael: /* Microscopic */ tweak some more

2015-07-26T21:54:09Z

Microscopic: tweak some more

← Older revision		Revision as of 21:54, 26 July 2015
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	==Microscopic==		==Microscopic==
	Subclassified ~~based on the role of [[HPV]],~~<ref name=pmid22641959>{{Cite journal \| last1 = Velazquez \| first1 = EF. \| last2 = Chaux \| first2 = A. \| last3 = Cubilla \| first3 = AL. \| title = Histologic classification of penile intraepithelial neoplasia. \| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref> ~~similar to in [[vulvar intraepithelial neoplasia]]:~~		Subclassified as:<ref name=pmid22641959>{{Cite journal \| last1 = Velazquez \| first1 = EF. \| last2 = Chaux \| first2 = A. \| last3 = Cubilla \| first3 = AL. \| title = Histologic classification of penile intraepithelial neoplasia. \| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref>
	*Undifferentiated PeIN (uPeIN).		*Undifferentiated PeIN (uPeIN).
	*Differentiated PeIN (dPeIN).		*Differentiated PeIN (dPeIN).

			Note:
			*Subclassification similar to one for [[vulvar intraepithelial neoplasia]], that is based on the role of [[HPV]] in the pathogenesis.

	===Undifferentiated penile intraepithelial neoplasia===		===Undifferentiated penile intraepithelial neoplasia===

Michael: fix some more

2015-07-26T21:51:20Z

fix some more

← Older revision		Revision as of 21:51, 26 July 2015
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	\| Image = Penile intraepithelial neoplasia -- intermed mag.jpg		\| Image = Penile intraepithelial neoplasia -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption = Penile intraepithelial neoplasia (~~classic~~ subtype). [[H&E stain]].		\| Caption = Penile intraepithelial neoplasia (undifferentiated subtype). [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro =
	\| Subtypes = differentiated PeIN, ~~classic~~ PeIN		\| Subtypes = differentiated PeIN, undifferentiated PeIN
	\| LMDDx = [[squamous cell carcinoma of the penis]], [[squamous hyperplasia]]		\| LMDDx = [[squamous cell carcinoma of the penis]], [[squamous hyperplasia]]
	\| Stains =		\| Stains =
	\| IHC = p16 +ve (~~classic PeIN~~) -ve (dPeIN), p53 -ve (~~classic PeIN~~) +ve (dPeIN)		\| IHC = p16 +ve (uPeIN) -ve (dPeIN), p53 -ve (uPeIN) +ve (dPeIN)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	\| Grossing =		\| Grossing =
	\| Site = [[penectomy grossing]]		\| Site = [[penectomy grossing]]
	\| Assdx = [[HPV]] infection (~~classic~~ PeIN), [[lichen sclerosus]] or [[BXO]] (differentiated PeIN)		\| Assdx = [[HPV]] infection (undifferentiated PeIN), [[lichen sclerosus]] or [[BXO]] (differentiated PeIN)
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
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	==IHC==		==IHC==
	*p16 -ve in dPeIN,<ref>{{Cite journal \| last1 = Oertell \| first1 = J. \| last2 = Caballero \| first2 = C. \| last3 = Iglesias \| first3 = M. \| last4 = Chaux \| first4 = A. \| last5 = Amat \| first5 = L. \| last6 = Ayala \| first6 = E. \| last7 = Rodríguez \| first7 = I. \| last8 = Velázquez \| first8 = EF. \| last9 = Barreto \| first9 = JE. \| title = Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. \| journal = Histopathology \| volume = 58 \| issue = 6 \| pages = 925-33 \| month = May \| year = 2011 \| doi = 10.1111/j.1365-2559.2011.03816.x \| PMID = 21585428 }}</ref> +ve in ~~cPeIN~~.		*p16 -ve in dPeIN,<ref>{{Cite journal \| last1 = Oertell \| first1 = J. \| last2 = Caballero \| first2 = C. \| last3 = Iglesias \| first3 = M. \| last4 = Chaux \| first4 = A. \| last5 = Amat \| first5 = L. \| last6 = Ayala \| first6 = E. \| last7 = Rodríguez \| first7 = I. \| last8 = Velázquez \| first8 = EF. \| last9 = Barreto \| first9 = JE. \| title = Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. \| journal = Histopathology \| volume = 58 \| issue = 6 \| pages = 925-33 \| month = May \| year = 2011 \| doi = 10.1111/j.1365-2559.2011.03816.x \| PMID = 21585428 }}</ref> +ve in uPeIN.

	==See also==		==See also==

Michael: /* Microscopic */

2015-07-26T21:49:30Z

Microscopic

← Older revision		Revision as of 21:49, 26 July 2015
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	==Microscopic==		==Microscopic==
	Subclassified based on the role of [[HPV]],<ref name=pmid22641959>{{Cite journal \| last1 = Velazquez \| first1 = EF. \| last2 = Chaux \| first2 = A. \| last3 = Cubilla \| first3 = AL. \| title = Histologic classification of penile intraepithelial neoplasia. \| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]:		Subclassified based on the role of [[HPV]],<ref name=pmid22641959>{{Cite journal \| last1 = Velazquez \| first1 = EF. \| last2 = Chaux \| first2 = A. \| last3 = Cubilla \| first3 = AL. \| title = Histologic classification of penile intraepithelial neoplasia. \| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref> similar to in [[vulvar intraepithelial neoplasia]]:
	*Undifferentiated PeIN (uPeIN).		*Undifferentiated PeIN (uPeIN).
	*Differentiated PeIN (dPeIN).		*Differentiated PeIN (dPeIN).

Michael: /* Microscopic */ fix

2015-07-26T21:48:58Z

Microscopic: fix

← Older revision		Revision as of 21:48, 26 July 2015
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	==Microscopic==		==Microscopic==
	Subclassified based on the role of [[HPV]],<ref name=pmid22641959>{{Cite journal \| last1 = Velazquez \| first1 = EF. \| last2 = Chaux \| first2 = A. \| last3 = Cubilla \| first3 = AL. \| title = Histologic classification of penile intraepithelial neoplasia. \| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]:		Subclassified based on the role of [[HPV]],<ref name=pmid22641959>{{Cite journal \| last1 = Velazquez \| first1 = EF. \| last2 = Chaux \| first2 = A. \| last3 = Cubilla \| first3 = AL. \| title = Histologic classification of penile intraepithelial neoplasia. \| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]:
	*~~Conventional~~ PeIN (~~cPeIN~~).		*Undifferentiated PeIN (uPeIN).
	*Differentiated PeIN (dPeIN).		*Differentiated PeIN (dPeIN).

	===~~Classic~~ penile intraepithelial neoplasia===		===Undifferentiated penile intraepithelial neoplasia===
	Features:		Features:
	*Increased [[NC ratio]].		*Increased [[NC ratio]].
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Penile intraepithelial neoplasia -- low mag.jpg \| ~~cPeIN~~ - low mag. (WC)		Image: Penile intraepithelial neoplasia -- low mag.jpg \| uPeIN - low mag. (WC)
	Image: Penile intraepithelial neoplasia - alt -- low mag.jpg \| ~~cPeIN~~ - low mag. (WC)		Image: Penile intraepithelial neoplasia - alt -- low mag.jpg \| uPeIN - low mag. (WC)
	Image: Penile intraepithelial neoplasia -- intermed mag.jpg \| ~~cPeIN~~ - intermed. mag. (WC)		Image: Penile intraepithelial neoplasia -- intermed mag.jpg \| uPeIN - intermed. mag. (WC)
	Image: Penile intraepithelial neoplasia - alt -- intermed mag.jpg \| ~~cPeIN~~ - intermed. mag. (WC)		Image: Penile intraepithelial neoplasia - alt -- intermed mag.jpg \| uPeIN - intermed. mag. (WC)
	Image: Penile intraepithelial neoplasia -- high mag.jpg \| ~~cPeIN~~ - high mag. (WC)		Image: Penile intraepithelial neoplasia -- high mag.jpg \| uPeIN - high mag. (WC)

	Image: Penile intraepithelial neoplasia - alt -- high mag.jpg \| ~~cPeIN~~ - high mag. (WC)		Image: Penile intraepithelial neoplasia - alt -- high mag.jpg \| uPeIN - high mag. (WC)
	Image: Adjacent parakeratosis and reactive changes -- intermed mag.jpg \| Parakeratosis & reactive changes - intermed. mag. (WC)		Image: Adjacent parakeratosis and reactive changes -- intermed mag.jpg \| Parakeratosis & reactive changes - intermed. mag. (WC)
	</gallery>		</gallery>

Michael at 15:44, 22 July 2015

2015-07-22T15:44:41Z

← Older revision		Revision as of 15:44, 22 July 2015
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	\| Image = Penile intraepithelial neoplasia -- intermed mag.jpg		\| Image = Penile intraepithelial neoplasia -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption = Penile intraepithelial neoplasia. [[H&E stain]].		\| Caption = Penile intraepithelial neoplasia (classic subtype). [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro =

Michael: /* Images */

2015-07-22T15:43:57Z

Images

← Older revision		Revision as of 15:43, 22 July 2015
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Penile intraepithelial neoplasia -- low mag.jpg \| ~~PeIN~~ - low mag.		Image: Penile intraepithelial neoplasia -- low mag.jpg \| cPeIN - low mag. (WC)
	Image: Penile intraepithelial neoplasia - alt -- low mag.jpg \| ~~PeIN~~ - low mag.		Image: Penile intraepithelial neoplasia - alt -- low mag.jpg \| cPeIN - low mag. (WC)
	Image: Penile intraepithelial neoplasia -- intermed mag.jpg \| ~~PeIN~~ - intermed. mag.		Image: Penile intraepithelial neoplasia -- intermed mag.jpg \| cPeIN - intermed. mag. (WC)
	Image: Penile intraepithelial neoplasia - alt -- intermed mag.jpg \| ~~PeIN~~ - intermed. mag.		Image: Penile intraepithelial neoplasia - alt -- intermed mag.jpg \| cPeIN - intermed. mag. (WC)
	Image: Penile intraepithelial neoplasia -- high mag.jpg \| ~~PeIN~~ - high mag.		Image: Penile intraepithelial neoplasia -- high mag.jpg \| cPeIN - high mag. (WC)

	Image: Penile intraepithelial neoplasia - alt -- high mag.jpg \| ~~PeIN~~ - high mag.		Image: Penile intraepithelial neoplasia - alt -- high mag.jpg \| cPeIN - high mag. (WC)
	Image: Adjacent parakeratosis and reactive changes -- intermed mag.jpg \| Parakeratosis & reactive changes - intermed. mag.		Image: Adjacent parakeratosis and reactive changes -- intermed mag.jpg \| Parakeratosis & reactive changes - intermed. mag. (WC)
	</gallery>		</gallery>

Michael: /* Microscopic */ add micro descript.

2015-07-22T15:43:06Z

Microscopic: add micro descript.

← Older revision		Revision as of 15:43, 22 July 2015
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	==Microscopic==		==Microscopic==
	~~See ''~~[[vulvar intraepithelial neoplasia]]''.		Subclassified based on the role of [[HPV]],<ref name=pmid22641959>{{Cite journal \| last1 = Velazquez \| first1 = EF. \| last2 = Chaux \| first2 = A. \| last3 = Cubilla \| first3 = AL. \| title = Histologic classification of penile intraepithelial neoplasia. \| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]:
			*Conventional PeIN (cPeIN).
			*Differentiated PeIN (dPeIN).

			===Classic penile intraepithelial neoplasia===
			Features:
			*Increased [[NC ratio]].
			*Multinucleation.
			*Lack of maturation to surface - not that useful.
			**May have "vertical streaming" - the long axis of the cells are perpendicular to the free surface & basement membrane.
			*Apical mitoses.

	DDx:		DDx:
	*[[Squamous cell carcinoma of the penis]].		*[[Squamous cell carcinoma of the penis]].
	*[[Squamous hyperplasia]] (differentiated PeIN).
	*[[Lichen sclerosus]] (differentiated PeIN).

	===~~Subclassification~~===		===Differentiated penile intraepithelial neoplasia===
	~~Subclassified based on~~ the ~~role of~~ [[~~HPV~~]]~~,<ref>{{Cite journal \| last1 = Velazquez \| first1 = EF~~. ~~\| last2 = Chaux \| first2 = A~~. ~~\| last3 = Cubilla \| first3 = AL~~. ~~\| title = Histologic classification~~ of ~~penile intraepithelial neoplasia~~. ~~\| journal = Semin Diagn Pathol \| volume = 29 \| issue = 2 \| pages = 96-102 \| month = May \| year = 2012 \| doi = \| PMID = 22641959 }}</ref> as~~ in [[~~vulvar intraepithelial neoplasia~~]]:		Features:
	*~~Conventional PeIN (cPeIN)~~.		*Thickening of the stratum spinosum ([[acanthosis]]).
	*~~Differentiated PeIN (dPeIN)~~.		*Elongation of rete ridges with bridging/anastomoses between rete ridges.
			*[[Nuclear atypia]] - esp. of the basal layer.
			*Nuclei in stratum corneum ([[parakeratosis]]).
			*+/-Atypical mitoses.

			DDx:
			*[[Squamous cell carcinoma of the penis]].
			*[[Squamous hyperplasia]].
			*[[Lichen sclerosus]].

	===Images===		===Images===

Michael: +images

2015-07-22T15:37:59Z

+images

← Older revision		Revision as of 15:37, 22 July 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Penile intraepithelial neoplasia -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Penile intraepithelial neoplasia. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro =
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	*Conventional PeIN (cPeIN).		*Conventional PeIN (cPeIN).
	*Differentiated PeIN (dPeIN).		*Differentiated PeIN (dPeIN).

			===Images===
			<gallery>
			Image: Penile intraepithelial neoplasia -- low mag.jpg \| PeIN - low mag.
			Image: Penile intraepithelial neoplasia - alt -- low mag.jpg \| PeIN - low mag.
			Image: Penile intraepithelial neoplasia -- intermed mag.jpg \| PeIN - intermed. mag.
			Image: Penile intraepithelial neoplasia - alt -- intermed mag.jpg \| PeIN - intermed. mag.
			Image: Penile intraepithelial neoplasia -- high mag.jpg \| PeIN - high mag.

			Image: Penile intraepithelial neoplasia - alt -- high mag.jpg \| PeIN - high mag.
			Image: Adjacent parakeratosis and reactive changes -- intermed mag.jpg \| Parakeratosis & reactive changes - intermed. mag.
			</gallery>

	==IHC==		==IHC==

Michael at 04:13, 22 July 2015

2015-07-22T04:13:08Z

← Older revision		Revision as of 04:13, 22 July 2015
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	DDx:		DDx:
	*[[Squamous cell carcinoma of the penis]].		*[[Squamous cell carcinoma of the penis]].
	*[[Squamous hyperplasia]].		*[[Squamous hyperplasia]] (differentiated PeIN).
	*[[Lichen sclerosus]].		*[[Lichen sclerosus]] (differentiated PeIN).

	===Subclassification===		===Subclassification===

← Older revision		Revision as of 17:02, 4 October 2018
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	==IHC==		==IHC==
	*p16 -ve in dPeIN,<ref>{{Cite journal \| last1 = Oertell \| first1 = J. \| last2 = Caballero \| first2 = C. \| last3 = Iglesias \| first3 = M. \| last4 = Chaux \| first4 = A. \| last5 = Amat \| first5 = L. \| last6 = Ayala \| first6 = E. \| last7 = Rodríguez \| first7 = I. \| last8 = Velázquez \| first8 = EF. \| last9 = Barreto \| first9 = JE. \| title = Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. \| journal = Histopathology \| volume = 58 \| issue = 6 \| pages = 925-33 \| month = May \| year = 2011 \| doi = 10.1111/j.1365-2559.2011.03816.x \| PMID = 21585428 }}</ref> +ve in uPeIN.		*p16 -ve in dPeIN,<ref>{{Cite journal \| last1 = Oertell \| first1 = J. \| last2 = Caballero \| first2 = C. \| last3 = Iglesias \| first3 = M. \| last4 = Chaux \| first4 = A. \| last5 = Amat \| first5 = L. \| last6 = Ayala \| first6 = E. \| last7 = Rodríguez \| first7 = I. \| last8 = Velázquez \| first8 = EF. \| last9 = Barreto \| first9 = JE. \| title = Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. \| journal = Histopathology \| volume = 58 \| issue = 6 \| pages = 925-33 \| month = May \| year = 2011 \| doi = 10.1111/j.1365-2559.2011.03816.x \| PMID = 21585428 }}</ref> +ve in uPeIN.

			==Sign out==
			<pre>
			Skin, Penile Lesion, Excision:
			- High-grade penile intraepithelial neoplasia (PeIN), undifferentiated type.
			-- Margin POSITIVE for PeIN.
			</pre>

	==See also==		==See also==

← Older revision		Revision as of 15:43, 22 July 2015
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Penile intraepithelial neoplasia -- low mag.jpg \| ~~PeIN~~ - low mag.		Image: Penile intraepithelial neoplasia -- low mag.jpg \| cPeIN - low mag. (WC)
	Image: Penile intraepithelial neoplasia - alt -- low mag.jpg \| ~~PeIN~~ - low mag.		Image: Penile intraepithelial neoplasia - alt -- low mag.jpg \| cPeIN - low mag. (WC)
	Image: Penile intraepithelial neoplasia -- intermed mag.jpg \| ~~PeIN~~ - intermed. mag.		Image: Penile intraepithelial neoplasia -- intermed mag.jpg \| cPeIN - intermed. mag. (WC)
	Image: Penile intraepithelial neoplasia - alt -- intermed mag.jpg \| ~~PeIN~~ - intermed. mag.		Image: Penile intraepithelial neoplasia - alt -- intermed mag.jpg \| cPeIN - intermed. mag. (WC)
	Image: Penile intraepithelial neoplasia -- high mag.jpg \| ~~PeIN~~ - high mag.		Image: Penile intraepithelial neoplasia -- high mag.jpg \| cPeIN - high mag. (WC)

	Image: Penile intraepithelial neoplasia - alt -- high mag.jpg \| ~~PeIN~~ - high mag.		Image: Penile intraepithelial neoplasia - alt -- high mag.jpg \| cPeIN - high mag. (WC)
	Image: Adjacent parakeratosis and reactive changes -- intermed mag.jpg \| Parakeratosis & reactive changes - intermed. mag.		Image: Adjacent parakeratosis and reactive changes -- intermed mag.jpg \| Parakeratosis & reactive changes - intermed. mag. (WC)
	</gallery>		</gallery>