Pediatric kidney tumours - Revision history

Michael: /* Molecular */

2018-09-11T06:05:00Z

Molecular

← Older revision		Revision as of 06:05, 11 September 2018
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	===Molecular===		===Molecular===
	Cellular mesoblastic nephroma:<ref name=pmid29683818>{{Cite journal \| last1 = Rudzinski \| first1 = ER. \| last2 = Lockwood \| first2 = CM. \| last3 = Stohr \| first3 = BA. \| last4 = Vargas \| first4 = SO. \| last5 = Sheridan \| first5 = R. \| last6 = Black \| first6 = JO. \| last7 = Rajaram \| first7 = V. \| last8 = Laetsch \| first8 = TW. \| last9 = Davis \| first9 = JL. \| title = Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors. \| journal = Am J Surg Pathol \| volume = 42 \| issue = 7 \| pages = 927-935 \| month = Jul \| year = 2018 \| doi = 10.1097/PAS.0000000000001062 \| PMID = 29683818 }}</ref>		Cellular mesoblastic nephroma:<ref name=pmid29683818>{{Cite journal \| last1 = Rudzinski \| first1 = ER. \| last2 = Lockwood \| first2 = CM. \| last3 = Stohr \| first3 = BA. \| last4 = Vargas \| first4 = SO. \| last5 = Sheridan \| first5 = R. \| last6 = Black \| first6 = JO. \| last7 = Rajaram \| first7 = V. \| last8 = Laetsch \| first8 = TW. \| last9 = Davis \| first9 = JL. \| title = Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors. \| journal = Am J Surg Pathol \| volume = 42 \| issue = 7 \| pages = 927-935 \| month = Jul \| year = 2018 \| doi = 10.1097/PAS.0000000000001062 \| PMID = 29683818 }}</ref>
	*t(12:15)(p13;q25) ETV6/NTRK3.		*t(12:15)(p13;q25) ETV6/[[NTRK3]].
	**Same [[translocation]] if found in ''[[infantile fibrosarcoma]]''.		**Same [[translocation]] if found in ''[[infantile fibrosarcoma]]''.

Michael: /* Molecular */

2018-09-11T06:04:47Z

Molecular

← Older revision		Revision as of 06:04, 11 September 2018
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	===Molecular===		===Molecular===
	Cellular mesoblastic nephroma:		Cellular mesoblastic nephroma:<ref name=pmid29683818>{{Cite journal \| last1 = Rudzinski \| first1 = ER. \| last2 = Lockwood \| first2 = CM. \| last3 = Stohr \| first3 = BA. \| last4 = Vargas \| first4 = SO. \| last5 = Sheridan \| first5 = R. \| last6 = Black \| first6 = JO. \| last7 = Rajaram \| first7 = V. \| last8 = Laetsch \| first8 = TW. \| last9 = Davis \| first9 = JL. \| title = Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors. \| journal = Am J Surg Pathol \| volume = 42 \| issue = 7 \| pages = 927-935 \| month = Jul \| year = 2018 \| doi = 10.1097/PAS.0000000000001062 \| PMID = 29683818 }}</ref>
	*t(12:15)(p13;q25) ETV6/NTRK3.		*t(12:15)(p13;q25) ETV6/NTRK3.
	**Same [[translocation]] if found in ''[[infantile fibrosarcoma]]''.		**Same [[translocation]] if found in ''[[infantile fibrosarcoma]]''.

Michael: /* Cellular */

2015-06-01T15:45:43Z

Cellular

← Older revision		Revision as of 15:45, 1 June 2015
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	====Cellular====		====Cellular====
	Features:<ref name=Ref_WMSP284>{{Ref WMSP\|284}}</ref>		Features:<ref name=Ref_WMSP284>{{Ref WMSP\|284}}</ref>
	*Plump cells with vesicular nuclei.		*Plump cells with [[vesicular nuclei]].
	*Well-defined border.		*Well-defined border.
	*Mitotically active.		*Mitotically active.

Michael: /* Renal rhabdoid tumour */ split out

2015-04-04T03:00:29Z

Renal rhabdoid tumour: split out

← Older revision		Revision as of 03:00, 4 April 2015
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	==Renal rhabdoid tumour==		==Renal rhabdoid tumour==
	*[[AKA]] ''rhabdoid tumour of the kidney'', abbreviated ''RTK''.		*[[AKA]] ''rhabdoid tumour of the kidney'', abbreviated ''RTK''.
			{{Main\|Renal rhabdoid tumour}}
	~~===General===~~
	*Similar to ''[[extrarenal malignant rhabdoid tumour]]''.<ref name=Ref_WMSP284>{{~~Ref WMSP~~\|~~284}}</ref>~~
	*Arises from renal medulla.
	*May be associated with a CNS tumour.

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref><ref name=Ref_WMSP284>{{Ref WMSP\|284~~}}~~</ref>~~
	*Variable architecture.
	*Round cells.
	*Abundant cytoplasm with eosinophilic inclusions.
	*Eccentric vesicular nucleus.
	*Prominent [[nucleolus]] -- '''key feature'''.

	~~Images:~~
	*[http://www.flickr.com/photos/ckrishnan/3954115280/in/photostream RTK - low mag. (flickr.com)].
	*[http://www.flickr.com/photos/ckrishnan/3953336593/in/photostream RTK - high mag. (flickr.com)].

	~~===IHC===~~
	*INI1 -ve.

	==Renal cell carcinoma==		==Renal cell carcinoma==

Michael: /* Overview */

2015-02-20T19:47:39Z

Overview

← Older revision		Revision as of 19:47, 20 February 2015
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	Other renal tumours (not covered in this article):		Other renal tumours (not covered in this article):
	*Postneuroblastoma RCC.		*Postneuroblastoma RCC.
	*Neuroblastoma.		*[[Neuroblastoma]].
	*[[PNET]].		*[[PNET]].
	*[[Synovial sarcoma]].		*[[Synovial sarcoma]].
	*[[Lymphoma]].		*[[Lymphoma]].

	The ''[[Kidney_tumours#Renal_translocation_carcinomas\|translocation carcinomas]]'' are covered in ~~the ''~~[[~~kidney tumours~~]]~~'' article~~		The [[Kidney_tumours#Renal_translocation_carcinomas\|renal translocation carcinomas]] are covered in:
			*[[Renal tumour with Xp11.2 translocation]].
			*[[Renal tumour with t(6;11) translocation]].

	=Specific tumours=		=Specific tumours=

Michael: /* Clear cell sarcoma of the kidney */

2014-12-29T17:08:51Z

Clear cell sarcoma of the kidney

← Older revision		Revision as of 17:08, 29 December 2014
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	*NSE -ve.		*NSE -ve.
	*S-100 -ve.		*S-100 -ve.

			===Molecular===
			*t(10;17)(q22;p13) - reported in 6 of 50 cases.<ref name=pmid22294382>{{Cite journal \| last1 = O'Meara \| first1 = E. \| last2 = Stack \| first2 = D. \| last3 = Lee \| first3 = CH. \| last4 = Garvin \| first4 = AJ. \| last5 = Morris \| first5 = T. \| last6 = Argani \| first6 = P. \| last7 = Han \| first7 = JS. \| last8 = Karlsson \| first8 = J. \| last9 = Gisselson \| first9 = D. \| title = Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. \| journal = J Pathol \| volume = 227 \| issue = 1 \| pages = 72-80 \| month = May \| year = 2012 \| doi = 10.1002/path.3985 \| PMID = 22294382 }}</ref>

	==Renal rhabdoid tumour==		==Renal rhabdoid tumour==

Michael: /* Wilms tumour */ split out

2014-05-03T03:16:41Z

Wilms tumour: split out

← Older revision		Revision as of 03:16, 3 May 2014
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	==Wilms tumour==		==Wilms tumour==
	*[[AKA]] nephroblastoma, AKA Wilms' tumour.		*[[AKA]] nephroblastoma, AKA Wilms' tumour.
			{{Main\|Wilms tumour}}
	~~===General===~~
	*Common abdominal [[pediatric pathology\|pediatric]] tumour.
	*May be associated with a syndrome:<ref>URL: [http://emedicine.medscape.com/article/989398-overview http://emedicine.medscape.com/article/989398-overview]. Accessed on: 9 March 2011.</ref>
	**WAGR syndrome (Wilms tumour, Aniridia (absence of iris), GU abnormalities, Retardation).<ref>{{OMIM\|194072}}</ref>
	**[[Beckwith-Wiedemann syndrome]].<ref>{{OMIM\|130650}}</ref>
	**[[Denys-Drash syndrome]].<ref>{{OMIM\|194080}}</ref>

	~~===Gross===~~
	*Lobulated tan mass.

	~~Image: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/rnfrm.html Wilms tumour (med.utah.edu)].~~

	~~===Microscopic===~~
	~~Features - classically three components (blastema, immature stroma, tubules):<ref name=Ref_PCPBoD8_254-5>~~{{~~Ref PCPBoD8~~\|~~254-5}}</ref>~~
	~~#Malignant [[Small round blue cell tumours\|small round blue cells]] ("blastema"):~~
	~~#*Size = ~ 2x RBC diameter.~~
	~~#*Nuclear pleomorphism (variation of size, shape and staining).~~
	~~#**Irregular nuclear membrane - '''important'''.~~
	~~#*Scant/difficult to discern cytoplasm - basophilic (light blue).~~
	~~#*Mitoses - common.~~
	~~#Stroma ("immature stroma"):~~
	~~#*Spindle cells:~~
	~~#**Elliptical nuclear membrane.~~
	~~#**Abundant loose cytoplasm.~~
	~~#Tubular structures ("tubules"):~~
	~~#*Usually clustered.~~
	~~#*Vaguely resemble a glomerulus.~~
	~~#*Usu. have a central (clear/white) space surrounded by a rim of intensely eosinophilic cytoplasm.~~
	~~#*Nuclei of tubular structures often elongated and palisaded.~~

	~~Other findings:~~
	*Commonly seen in association with ''nephrogenic rests''.
	**Cluster of cells small (blue) cells; lack nuclear atypia seen in Wilms tumour.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970416-8 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970416-8]. Accessed on: 28 March 2011.</ref>
	*+/-Heterologous elements (skeletal muscle, smooth muscle adipose tissue, cartilage).<ref name=Ref_WMSP282>{{Ref WMSP\|282}}~~</ref>~~
	**Heterologous = doesn't normally belong there.<ref>URL: [http://www.biology-online.org/dictionary/Heterologous http://www.biology-online.org/dictionary/Heterologous]. Accessed on: 1 October 2011.</ref>

	~~DDx:~~
	*[[Metanephric adenoma]].
	*Nephrogenic nests.
	*Other [[small round cell tumours]].
	*[[Synovial sarcoma]], biphasic - especially in adults.

	~~Notes:~~
	*Palisade = fence made of stakes driven into the ground.<ref>URL: [http://www.thefreedictionary.com/palisaded http://www.thefreedictionary.com/palisaded]. Accessed on: 2 February 2011.</ref>
	*Approximately 30-40% Wilms tumour cases have nephrogenic rests.<ref name=pmid8047084>{{cite journal \|author=Coppes MJ, Haber DA, Grundy PE \|title=Genetic events in the development of Wilms' tumor \|journal=N. Engl. J. Med. \|volume=331 \|issue=9 \|pages=586–90 \|year=1994 \|month=September \|pmid=8047084 \|doi=10.1056/NEJM199409013310906 \|url=}}</ref>
	*The three phases are also called ''blastemal, epithelial and stromal''.<ref name=Ref_WMSP282>{{Ref WMSP\|282}}</ref>

	~~====Images====~~
	~~<gallery>~~
	~~Image:Wilms_tumour_-_low_mag.jpg \| Wilms tumour - low mag. (WC/Nephron)~~
	~~Image:Wilms tumour - intermed mag.jpg \| Wilms tumour - intermed. mag. (WC/Nephron)~~
	~~Image:Wilms tumour - high mag.jpg \| Wilms tumour - high mag. (WC/Nephron)~~
	~~Image:Wilms_tumour_-_very_high_mag.jpg \| Wilms tumour - very high mag. (WC/Nephron)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.biologydisease.com/images/kidney/nephrogenic-rests/nephrogenic-rest.jpg.php Nephrogenic rests (biologydisease.com)].
	*[http://www.webpathology.com/image.asp?n=1&Case=73 Wilms tumour (webpathology.com)].

	~~====Anaplasia====~~
	~~Subclassified as:<ref name=Ref_WMSP282>{{Ref WMSP\|282}}</ref>~~
	~~#Focal anaplasia.~~
	~~#Diffuse anaplasia.~~

	~~Criteria (all of the following):<ref name=Ref_WMSP282>{{Ref WMSP\|282}}</ref>~~
	~~#Atypical mitoses.~~
	~~#Nuclear hyperchromasia.~~
	~~#Nuclear size variation (of the tumour cells) > 3x.~~

	~~===IHC===~~
	*WT-1 +ve.

	==Metanephric stromal tumour==		==Metanephric stromal tumour==

Michael: /* Images */

2013-08-25T12:03:36Z

Images

← Older revision		Revision as of 12:03, 25 August 2013
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	<gallery>		<gallery>
	Image:Wilms_tumour_-_low_mag.jpg \| Wilms tumour - low mag. (WC/Nephron)		Image:Wilms_tumour_-_low_mag.jpg \| Wilms tumour - low mag. (WC/Nephron)
			Image:Wilms tumour - intermed mag.jpg \| Wilms tumour - intermed. mag. (WC/Nephron)
			Image:Wilms tumour - high mag.jpg \| Wilms tumour - high mag. (WC/Nephron)
	Image:Wilms_tumour_-_very_high_mag.jpg \| Wilms tumour - very high mag. (WC/Nephron)		Image:Wilms_tumour_-_very_high_mag.jpg \| Wilms tumour - very high mag. (WC/Nephron)
	</gallery>		</gallery>

Michael: /* Images */ fix

2013-06-26T17:26:52Z

Images: fix

← Older revision		Revision as of 17:26, 26 June 2013
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	====Images====		====Images====
	<gallery>		<gallery>
	Image:Wilms_tumour_-_low_mag.jpg Wilms tumour - low mag. (WC/Nephron)		Image:Wilms_tumour_-_low_mag.jpg \| Wilms tumour - low mag. (WC/Nephron)
	Image:Wilms_tumour_-_very_high_mag.jpg Wilms tumour - very high mag. (WC/Nephron)		Image:Wilms_tumour_-_very_high_mag.jpg \| Wilms tumour - very high mag. (WC/Nephron)
	</gallery>		</gallery>
	www:		www:

Michael: /* Wilms tumour */ +images

2013-06-26T17:26:01Z

Wilms tumour: +images

← Older revision		Revision as of 17:26, 26 June 2013
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	*The three phases are also called ''blastemal, epithelial and stromal''.<ref name=Ref_WMSP282>{{Ref WMSP\|282}}</ref>		*The three phases are also called ''blastemal, epithelial and stromal''.<ref name=Ref_WMSP282>{{Ref WMSP\|282}}</ref>

	Images:		====Images====
			<gallery>
			Image:Wilms_tumour_-_low_mag.jpg Wilms tumour - low mag. (WC/Nephron)
			Image:Wilms_tumour_-_very_high_mag.jpg Wilms tumour - very high mag. (WC/Nephron)
			</gallery>
			www:
	*[http://www.biologydisease.com/images/kidney/nephrogenic-rests/nephrogenic-rest.jpg.php Nephrogenic rests (biologydisease.com)].		*[http://www.biologydisease.com/images/kidney/nephrogenic-rests/nephrogenic-rest.jpg.php Nephrogenic rests (biologydisease.com)].
	*[http://www.webpathology.com/image.asp?n=1&Case=73 Wilms tumour (webpathology.com)].		*[http://www.webpathology.com/image.asp?n=1&Case=73 Wilms tumour (webpathology.com)].
	*[http://commons.wikimedia.org/wiki/File:Wilms_tumour_-_low_mag.jpg Wilms tumour - low mag. (WC)].
	*[http://commons.wikimedia.org/wiki/File:Wilms_tumour_-_very_high_mag.jpg Wilms tumour - very high mag. (WC)].

	====Anaplasia====		====Anaplasia====