Papillary thyroid carcinoma - Revision history

Michael: BRAF

2024-05-09T17:44:19Z

BRAF

← Older revision		Revision as of 17:44, 9 May 2024
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	\| IHC = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve		\| IHC = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = BRAF mutation - commonly
	\| IF =		\| IF =
	\| Gross =		\| Gross =
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	===Molecular===		===Molecular===
	*~~Currently not widely used~~ in ~~a diagnostic context~~.		*BRAF mutation.<ref name=pmid35670964>{{cite journal \|authors=Lam AK \|title=Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification \|journal=Methods Mol Biol \|volume=2534 \|issue= \|pages=1–15 \|date=2022 \|pmid=35670964 \|doi=10.1007/978-1-0716-2505-7_1 \|url=}}</ref>

	====Tabular summary====		====Tabular summary====

Brigitte: /* Microscopic */

2018-04-26T12:57:36Z

Microscopic

← Older revision		Revision as of 12:57, 26 April 2018
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	Images:		Images:
	*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=2008080217023776 PTC follicular variant (surgicalpathologyatlas.com)].
	*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=2008080216593186 PTC follicular variant (surgicalpathologyatlas.com)].
	*[http://www.thyroidcancercanada.org/userfiles/images/Follicular_slide.jpg PTC follicular variant (thyroidcancercanada.org)].<ref>URL: [http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en]. Accessed on: 9 January 2013.</ref>

	===Papillary thyroid carcinoma cribriform-morular variant===		===Papillary thyroid carcinoma cribriform-morular variant===

Michael: /* IHC */

2016-05-09T14:33:33Z

IHC

← Older revision		Revision as of 14:33, 9 May 2016
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	===IHC===		===IHC===
	Thyroid versus something else:		Thyroid versus something else:
	*Thyroglobulin +ve.		*Thyroglobulin +ve.<ref name=pmid23637102>{{Cite journal \| last1 = Sathiyamoorthy \| first1 = S. \| last2 = Maleki \| first2 = Z. \| title = Cytomorphologic overlap of differentiated thyroid carcinoma and lung adenocarcinoma and diagnostic value of TTF-1 and TGB on cytologic material. \| journal = Diagn Cytopathol \| volume = 42 \| issue = 1 \| pages = 5-10 \| month = Jan \| year = 2014 \| doi = 10.1002/dc.22997 \| PMID = 23637102 }}</ref>
	*TTF-1 ([[thyroid transcription factor-1]]) +ve.		*TTF-1 ([[thyroid transcription factor-1]]) +ve.
	*CD15 +ve.{{fact}}		*CD15 +ve.{{fact}}

Michael at 15:23, 24 March 2016

2016-03-24T15:23:55Z

← Older revision		Revision as of 15:23, 24 March 2016
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	\| Micro = nuclear changes: nuclear membrane irregularities (e.g. raisinoid shape), +/-nuclear grooves, +/-[[nuclear pseudoinclusions]], +/-nuclear clearing, nuclear enlargement (usu. mild), nucleoli; architectural changes: overlap of nuclei, papillae (not required), +/-[[psammoma bodies]]		\| Micro = nuclear changes: nuclear membrane irregularities (e.g. raisinoid shape), +/-nuclear grooves, +/-[[nuclear pseudoinclusions]], +/-nuclear clearing, nuclear enlargement (usu. mild), nucleoli; architectural changes: overlap of nuclei, papillae (not required), +/-[[psammoma bodies]]
	\| Subtypes = [[Papillary thyroid carcinoma tall cell variant\|tall cell variant]], [[Papillary thyroid carcinoma columnar cell variant\|columnar cell variant]], [[Papillary thyroid carcinoma follicular variant\|follicular variant]], [[Papillary thyroid carcinoma cribriform-morular variant\|cribriform-morular variant]], [[Papillary thyroid carcinoma diffuse sclerosing variant\|diffuse sclerosing variant]], [[Papillary thyroid carcinoma Warthin-like variant\|Warthin-like variant]], [[Papillary thyroid carcinoma solid variant\|solid variant]], [[Papillary thyroid carcinoma oncocytic variant\|oncocytic variant]], others		\| Subtypes = [[Papillary thyroid carcinoma tall cell variant\|tall cell variant]], [[Papillary thyroid carcinoma columnar cell variant\|columnar cell variant]], [[Papillary thyroid carcinoma follicular variant\|follicular variant]], [[Papillary thyroid carcinoma cribriform-morular variant\|cribriform-morular variant]], [[Papillary thyroid carcinoma diffuse sclerosing variant\|diffuse sclerosing variant]], [[Papillary thyroid carcinoma Warthin-like variant\|Warthin-like variant]], [[Papillary thyroid carcinoma solid variant\|solid variant]], [[Papillary thyroid carcinoma oncocytic variant\|oncocytic variant]], others
	\| LMDDx = [[lymphocytic thyroiditis]] ([[Graves disease]], [[Hashimoto thyroiditis]]), [[solid cell nest of thyroid]], [[follicular thyroid carcinoma]], [[follicular thyroid adenoma]], [[adenomatoid nodule]]		\| LMDDx = [[lymphocytic thyroiditis]] ([[Graves disease]], [[Hashimoto thyroiditis]]), [[solid cell nest of thyroid]], [[follicular thyroid carcinoma]], [[follicular thyroid adenoma]], [[adenomatoid nodule]], [[noninvasive follicular thyroid neoplasm with papillary-like nuclear features]] (NIFTP)
	\| Stains =		\| Stains =
	\| IHC = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve		\| IHC = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve

Michael: /* Papillary thyroid carcinoma follicular variant */

2016-03-13T17:07:06Z

Papillary thyroid carcinoma follicular variant

← Older revision		Revision as of 17:07, 13 March 2016
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	DDx:		DDx:
			*[[Noninvasive follicular thyroid neoplasm with papillary-like nuclear features]] (NIFTP).
	*[[Follicular thyroid carcinoma]] - has a fibrous capsule and invasion though it.		*[[Follicular thyroid carcinoma]] - has a fibrous capsule and invasion though it.
	*[[Follicular thyroid adenoma]] - surrounded by a fibrous capsule.		*[[Follicular thyroid adenoma]] - surrounded by a fibrous capsule.

Michael at 02:09, 18 November 2015

2015-11-18T02:09:39Z

← Older revision		Revision as of 02:09, 18 November 2015
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
			\| Staging = [[thyroid cancer staging]]
	\| Site = [[thyroid gland]]		\| Site = [[thyroid gland]]
	\| Assdx =		\| Assdx =

Michael: /* Microscopic */

2015-10-31T04:08:26Z

Microscopic

← Older revision		Revision as of 04:08, 31 October 2015
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	**Homogenous, lightly eosinophilic glassy nuclei (biotin accumulation).		**Homogenous, lightly eosinophilic glassy nuclei (biotin accumulation).
	*Follicles		*Follicles
	**Cribriform, papillary, trabecular and solid patterns.		**[[Cribriform]], papillary, trabecular and solid patterns.
	**Columnar or cuboidal cells.		**Columnar or cuboidal cells.
	**Little colloid		**Little colloid

Michael at 21:31, 20 August 2015

2015-08-20T21:31:49Z

← Older revision		Revision as of 21:31, 20 August 2015
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	\| LMDDx = [[lymphocytic thyroiditis]] ([[Graves disease]], [[Hashimoto thyroiditis]]), [[solid cell nest of thyroid]], [[follicular thyroid carcinoma]], [[follicular thyroid adenoma]], [[adenomatoid nodule]]		\| LMDDx = [[lymphocytic thyroiditis]] ([[Graves disease]], [[Hashimoto thyroiditis]]), [[solid cell nest of thyroid]], [[follicular thyroid carcinoma]], [[follicular thyroid adenoma]], [[adenomatoid nodule]]
	\| Stains =		\| Stains =
	\| IHC = HBME-1 +ve, CK19 +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve		\| IHC = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	PTC versus benign:<ref>{{Cite journal \| last1 = Mataraci \| first1 = EA. \| last2 = Ozgüven \| first2 = BY. \| last3 = Kabukçuoglu \| first3 = F. \| title = Expression of cytokeratin 19, HBME-1 and galectin-3 in neoplastic and nonneoplastic thyroid lesions. \| journal = Pol J Pathol \| volume = 63 \| issue = 1 \| pages = 58-64 \| month = Mar \| year = 2012 \| doi = \| PMID = 22535608 }}</ref>		PTC versus benign:<ref>{{Cite journal \| last1 = Mataraci \| first1 = EA. \| last2 = Ozgüven \| first2 = BY. \| last3 = Kabukçuoglu \| first3 = F. \| title = Expression of cytokeratin 19, HBME-1 and galectin-3 in neoplastic and nonneoplastic thyroid lesions. \| journal = Pol J Pathol \| volume = 63 \| issue = 1 \| pages = 58-64 \| month = Mar \| year = 2012 \| doi = \| PMID = 22535608 }}</ref>
	*HBME-1 +ve (strong, diffuse).		*HBME-1 +ve (strong, diffuse).
	*CK19 +ve (strong, diffuse).		*[[CK19]] +ve (strong, diffuse).
	*Galectin-3 +ve (strong, diffuse).		*Galectin-3 +ve (strong, diffuse).

Michael: touch

2015-03-30T23:37:46Z

touch

← Older revision		Revision as of 23:37, 30 March 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Papillary_thyroid_microcarcinoma_-_high_mag.jpg		\| Image = Papillary_thyroid_microcarcinoma_-_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Papillary thyroid carcinoma. [[H&E stain]].		\| Caption = Papillary thyroid carcinoma. [[H&E stain]].

Sarah: /* Papillary thyroid carcinoma cribriform-morular variant */

2015-03-30T12:38:49Z

Papillary thyroid carcinoma cribriform-morular variant

← Older revision		Revision as of 12:38, 30 March 2015
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	*[http://www.thyroidcancercanada.org/userfiles/images/Follicular_slide.jpg PTC follicular variant (thyroidcancercanada.org)].<ref>URL: [http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en]. Accessed on: 9 January 2013.</ref>		*[http://www.thyroidcancercanada.org/userfiles/images/Follicular_slide.jpg PTC follicular variant (thyroidcancercanada.org)].<ref>URL: [http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en]. Accessed on: 9 January 2013.</ref>

	====Papillary thyroid carcinoma cribriform-morular variant====		===Papillary thyroid carcinoma cribriform-morular variant===
	=====General=====		=====General=====
	*Associated with [[familial adenomatous polyposis]] (FAP).<ref name=pmid18612695>{{cite journal \|author=Groen EJ, Roos A, Muntinghe FL, ''et al.'' \|title=Extra-intestinal manifestations of familial adenomatous polyposis \|journal=Ann. Surg. Oncol. \|volume=15 \|issue=9 \|pages=2439–50 \|year=2008 \|month=September \|pmid=18612695 \|pmc=2518080 \|doi=10.1245/s10434-008-9981-3 \|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518080/?tool=pubmed}}</ref>		*Associated with [[familial adenomatous polyposis]] (FAP).<ref name=pmid18612695>{{cite journal \|author=Groen EJ, Roos A, Muntinghe FL, ''et al.'' \|title=Extra-intestinal manifestations of familial adenomatous polyposis \|journal=Ann. Surg. Oncol. \|volume=15 \|issue=9 \|pages=2439–50 \|year=2008 \|month=September \|pmid=18612695 \|pmc=2518080 \|doi=10.1245/s10434-008-9981-3 \|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518080/?tool=pubmed}}</ref>