Papillary renal neoplasm with reverse polarity - Revision history

Michael: +another case

2025-03-14T20:08:33Z

+another case

← Older revision		Revision as of 20:08, 14 March 2025
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Papillary renal neoplasm with reverse polarity - ~~alt~~ -- high mag.jpg		\| Image = Papillary renal neoplasm with reverse polarity - 2 -- high mag.jpg
	\| Width =		\| Width =
	\| Caption = Papillary renal neoplasm with reverse polarity. [[H&E stain]].		\| Caption = Papillary renal neoplasm with reverse polarity. [[H&E stain]].
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	===Images===		===Images===
			====Case 1====
			<gallery>
			Image: Papillary renal neoplasm with reverse polarity - 2 -- very low mag.jpg \| PRNRP - very low mag.
			Image: Papillary renal neoplasm with reverse polarity - 2 -- low mag.jpg \| PRNRP - low mag.
			Image: Papillary renal neoplasm with reverse polarity - 2 -- intermed mag.jpg \| PRNRP - intermed. mag.
			Image: Papillary renal neoplasm with reverse polarity - 2 -- high mag.jpg \| PRNRP - high mag.
			Image: Papillary renal neoplasm with reverse polarity - 2 -- very high mag.jpg \| PRNRP - very high mag.
			</gallery>

			====Case 2====
	<gallery>		<gallery>
	Image: Papillary renal neoplasm with reverse polarity -- very low mag.jpg \| PRNRP - very low mag.		Image: Papillary renal neoplasm with reverse polarity -- very low mag.jpg \| PRNRP - very low mag.

Michael at 14:09, 16 August 2024

2024-08-16T14:09:10Z

← Older revision		Revision as of 14:09, 16 August 2024
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	==IHC==		==IHC==
	Features:<ref name=pmid31135486/>		Features:<ref name=pmid31135486/>
			*GATA3 +ve (43 of 43 cases<ref name=pmid37797754/>) - '''key stain'''.
			**Negative in other papillary RCCs.<ref name=pmid37797754/>
	*CK7 +ve (88% +ve, 37 of 42 cases<ref name=pmid37797754/>).		*CK7 +ve (88% +ve, 37 of 42 cases<ref name=pmid37797754/>).
	*CD10 +ve/-ve (50% +ve, 21 of 42 cases<ref name=pmid37797754/>).		*CD10 +ve/-ve (50% +ve, 21 of 42 cases<ref name=pmid37797754/>).
	*GATA3 +ve (43 of 43 cases<ref name=pmid37797754/>).
	**Negative in other papillary RCCs.<ref name=pmid37797754/>
	*Vimentin -ve (all cases).		*Vimentin -ve (all cases).
	*CD117 -ve.		*CD117 -ve.
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	*EMA +ve.		*EMA +ve.
	*L1CAM +ve.		*L1CAM +ve.
			*PAX8 +ve.
	*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>).		*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>).
	*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).		*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).

	===~~Stains that help differentiate~~ between papillary RCC and PRNRP ~~adapted~~ from Kim ''et al.''<ref name=pmid37797754/>~~===~~		===Differentiating between papillary RCC and PRNRP===
			Adapted from Kim ''et al.'':<ref name=pmid37797754/>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	!Diagnosis		!Diagnosis

Michael at 14:05, 16 August 2024

2024-08-16T14:05:29Z

← Older revision		Revision as of 14:05, 16 August 2024
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	*Early data suggests an indolent behaviour.<ref name=pmid31135486>{{cite journal \|authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ \|title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study \|journal=Am J Surg Pathol \|volume=43 \|issue=8 \|pages=1099–1111 \|date=August 2019 \|pmid=31135486 \|doi=10.1097/PAS.0000000000001288 \|url=}}</ref>		*Early data suggests an indolent behaviour.<ref name=pmid31135486>{{cite journal \|authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ \|title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study \|journal=Am J Surg Pathol \|volume=43 \|issue=8 \|pages=1099–1111 \|date=August 2019 \|pmid=31135486 \|doi=10.1097/PAS.0000000000001288 \|url=}}</ref>

	==~~Micro~~==		==Microscopic==
	Features:<ref name=pmid31135486/>		Features:<ref name=pmid31135486/>
	*Branching papillae with:		*Branching papillae with:

Michael at 13:57, 16 August 2024

2024-08-16T13:57:46Z

← Older revision		Revision as of 13:57, 16 August 2024
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	\|PRNRP		\|PRNRP
	\| 100% +ve		\| 100% +ve
	\| 10% +ve		\| ~10% +ve
	\| 2% +ve		\| ~2% +ve
	\| 2% +ve		\| ~2% +ve
	\|-		\|-
	\|}		\|}

Michael at 13:56, 16 August 2024

2024-08-16T13:56:04Z

← Older revision		Revision as of 13:56, 16 August 2024
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	*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).		*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).

	===Stains that differentiate between papillary RCC and PRNRP - adapted from Kim ''et al.''<ref name=pmid37797754/>===		===Stains that help differentiate between papillary RCC and PRNRP adapted from Kim ''et al.''<ref name=pmid37797754/>===
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	!Diagnosis		!Diagnosis
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	\|-		\|-
	\|Papillary RCC		\|Papillary RCC
	\| 0%		\| 0% +ve
	\| 85-90%		\| 85-90% +ve
	\| 60-75%		\| 60-75% +ve
	\| 60-70%		\| 60-70% +ve
	\|-		\|-
	\|PRNRP		\|PRNRP
	\| 100%		\| 100% +ve
	\| 10%		\| 10% +ve
	\| 2%		\| 2% +ve
	\| 2%		\| 2% +ve
	\|-		\|-
	\|}		\|}

Michael at 13:52, 16 August 2024

2024-08-16T13:52:48Z

← Older revision		Revision as of 13:52, 16 August 2024
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	*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>).		*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>).
	*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).		*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).

			===Stains that differentiate between papillary RCC and PRNRP - adapted from Kim ''et al.''<ref name=pmid37797754/>===
			{\| class="wikitable sortable"
			!Diagnosis
			!GATA3
			!AMACR
			!RCC
			!Vimentin
			\|-
			\|Papillary RCC
			\| 0%
			\| 85-90%
			\| 60-75%
			\| 60-70%
			\|-
			\|PRNRP
			\| 100%
			\| 10%
			\| 2%
			\| 2%
			\|-
			\|}

	==Molecular==		==Molecular==

Michael: tweak

2024-08-16T13:34:27Z

tweak

← Older revision		Revision as of 13:34, 16 August 2024
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	==IHC==		==IHC==
	Features:<ref name=pmid31135486/>		Features:<ref name=pmid31135486/>
	*CK7 +ve.		*CK7 +ve (88% +ve, 37 of 42 cases<ref name=pmid37797754/>).
	*CD10 +ve (~~all~~ cases).		*CD10 +ve/-ve (50% +ve, 21 of 42 cases<ref name=pmid37797754/>).
	*GATA3 +ve (~~all~~ cases).		*GATA3 +ve (43 of 43 cases<ref name=pmid37797754/>).
			**Negative in other papillary RCCs.<ref name=pmid37797754/>
	*Vimentin -ve (all cases).		*Vimentin -ve (all cases).
	*CD117 -ve.		*CD117 -ve.
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	*EMA +ve.		*EMA +ve.
	*L1CAM +ve.		*L1CAM +ve.
			*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>).
			*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).

	==Molecular==		==Molecular==

Michael: +images

2024-07-02T03:59:44Z

+images

← Older revision		Revision as of 03:59, 2 July 2024
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Papillary renal neoplasm with reverse polarity - alt -- high mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Papillary renal neoplasm with reverse polarity. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = papillary structures, eosinophilic cytoplasm, reverse polarity of nuclei (nuclei at luminal aspect of cell), low nuclear grade		\| Micro = papillary structures, eosinophilic cytoplasm, reverse polarity of nuclei (nuclei at luminal aspect of cell), low nuclear grade
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	*Eosinophilic [[papillary renal cell carcinoma]] - considered distinct from this entity.		*Eosinophilic [[papillary renal cell carcinoma]] - considered distinct from this entity.
	*[[Renal tumours with eosinophilic cytoplasm]].		*[[Renal tumours with eosinophilic cytoplasm]].

			===Images===
			<gallery>
			Image: Papillary renal neoplasm with reverse polarity -- very low mag.jpg \| PRNRP - very low mag.
			Image: Papillary renal neoplasm with reverse polarity -- low mag.jpg \| PRNRP - low mag.
			Image: Papillary renal neoplasm with reverse polarity - alt -- low mag.jpg \| PRNRP - low mag.
			Image: Papillary renal neoplasm with reverse polarity -- intermed mag.jpg \| PRNRP - intermed. mag.
			Image: Papillary renal neoplasm with reverse polarity -- high mag.jpg \| PRNRP - high mag.
			Image: Papillary renal neoplasm with reverse polarity -- very high mag.jpg \| PRNRP - very high mag.
			</gallery>

	==IHC==		==IHC==

Michael: tweka

2024-06-26T20:06:40Z

tweka

← Older revision		Revision as of 20:06, 26 June 2024
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	NEGATIVE: vimentin (stroma), CD117, CD10.		NEGATIVE: vimentin (stroma), CD117, CD10.

	PRNRP is thought to be distinct from papillary RCC.[1][2] Limited data suggests PRNRP has an indolent behaviour.[3] Follow-up is recommended.		The findings are in keeping with papillary renal neoplasm with reverse polarity (PRNRP). PRNRP is thought to be distinct from papillary RCC.[1][2] Limited data suggests PRNRP has an indolent behaviour.[3] Follow-up is recommended.

	1. Pathol Int. 2024 Apr;74(4):222-226. doi: 10.1111/pin.13417. https://pubmed.ncbi.nlm.nih.gov/38456605/		1. Pathol Int. 2024 Apr;74(4):222-226. doi: 10.1111/pin.13417. https://pubmed.ncbi.nlm.nih.gov/38456605/

Michael at 15:19, 18 June 2024

2024-06-18T15:19:40Z

← Older revision		Revision as of 15:19, 18 June 2024
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	\| Tx =		\| Tx =
	}}		}}
	'''Papillary renal neoplasm with reverse polarity''' is a rare [[renal tumour]] and evolving entity.<ref name=pmid31135486>{{cite journal \|authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ \|title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study \|journal=Am J Surg Pathol \|volume=43 \|issue=8 \|pages=1099–1111 \|date=August 2019 \|pmid=31135486 \|doi=10.1097/PAS.0000000000001288 \|url=}}</ref>		'''Papillary renal neoplasm with reverse polarity''' is a rare [[renal tumour]] and an evolving entity.<ref name=pmid31135486>{{cite journal \|authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ \|title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study \|journal=Am J Surg Pathol \|volume=43 \|issue=8 \|pages=1099–1111 \|date=August 2019 \|pmid=31135486 \|doi=10.1097/PAS.0000000000001288 \|url=}}</ref> It has a distinctive morphology that matches the name.

	==General==		==General==