Papillary renal cell carcinoma - Revision history

Michael: /* IHC */

2026-05-18T22:53:20Z

IHC

← Older revision		Revision as of 22:53, 18 May 2026
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	Others:		Others:
	*GATA3 +ve - oncocytic variant of PaRCC; negative in other PaRCC subtypes.<ref name=pmid28984673>{{cite journal \|authors=Saleeb RM, Brimo F, Farag M, Rompré-Brodeur A, Rotondo F, Beharry V, Wala S, Plant P, Downes MR, Pace K, Evans A, Bjarnason G, Bartlett JMS, Yousef GM \|title=Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis \|journal=Am J Surg Pathol \|volume=41 \|issue=12 \|pages=1618–1629 \|date=December 2017 \|pmid=28984673 \|doi=10.1097/PAS.0000000000000962 \|url=}}</ref>		*[[GATA3]] +ve - oncocytic variant of PaRCC; negative in other PaRCC subtypes.<ref name=pmid28984673>{{cite journal \|authors=Saleeb RM, Brimo F, Farag M, Rompré-Brodeur A, Rotondo F, Beharry V, Wala S, Plant P, Downes MR, Pace K, Evans A, Bjarnason G, Bartlett JMS, Yousef GM \|title=Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis \|journal=Am J Surg Pathol \|volume=41 \|issue=12 \|pages=1618–1629 \|date=December 2017 \|pmid=28984673 \|doi=10.1097/PAS.0000000000000962 \|url=}}</ref>
	*ABCC2 brush border staining = worse survival.<ref name=pmid37680023>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>		*[[ABCC2]] brush border staining = worse survival.<ref name=pmid37680023>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>

	Metanephric adenoma vs. PaRCC type 1:<ref name=pmid24083046>{{Cite journal \| last1 = Watanabe \| first1 = S. \| last2 = Naganuma \| first2 = H. \| last3 = Shimizu \| first3 = M. \| last4 = Ota \| first4 = S. \| last5 = Murata \| first5 = S. \| last6 = Nihei \| first6 = N. \| last7 = Matsushima \| first7 = J. \| last8 = Mikami \| first8 = S. \| last9 = Kuroda \| first9 = N. \| title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. \| journal = Case Rep Pathol \| volume = 2013 \| issue = \| pages = 675875 \| month = \| year = 2013 \| doi = 10.1155/2013/675875 \| PMID = 24083046 }}</ref>		Metanephric adenoma vs. PaRCC type 1:<ref name=pmid24083046>{{Cite journal \| last1 = Watanabe \| first1 = S. \| last2 = Naganuma \| first2 = H. \| last3 = Shimizu \| first3 = M. \| last4 = Ota \| first4 = S. \| last5 = Murata \| first5 = S. \| last6 = Nihei \| first6 = N. \| last7 = Matsushima \| first7 = J. \| last8 = Mikami \| first8 = S. \| last9 = Kuroda \| first9 = N. \| title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. \| journal = Case Rep Pathol \| volume = 2013 \| issue = \| pages = 675875 \| month = \| year = 2013 \| doi = 10.1155/2013/675875 \| PMID = 24083046 }}</ref>

Michael: /* Micro */

2025-04-22T13:25:13Z

Micro

← Older revision		Revision as of 13:25, 22 April 2025
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	Multiple small lesions, like the largest tumour, less than 1.5 cm are present.		Multiple small lesions, like the largest tumour, less than 1.5 cm are present.

			=====Alternate=====
			The sections show a tumour in the kidney with fibrovascular cores (papillae) that contain macrophages. The papillae predominantly have a single layer of tumour cells. Nucleoli are not prominent with the 10x objective (ISUP nucleolar grade 2).

	===Oncocytic variant===		===Oncocytic variant===

Michael: /* Historical type 1 and type 2 */

2025-03-04T16:58:20Z

Historical type 1 and type 2

← Older revision		Revision as of 16:58, 4 March 2025
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	The WHO GU Blue Book 5th Ed. recommends against subtyping.		The WHO GU Blue Book 5th Ed. recommends against subtyping.

	~~Where~~ are 'Type 1' and 'Type 2':		How are ''Type 1'' and ''Type 2'' now classified?
	*The defunct ''Type 1'' is ''papillary renal cell carcinoma''. It is classically associated with a MET gene alteration.		*The defunct ''Type 1'' is ''papillary renal cell carcinoma''. It is classically associated with a MET gene alteration.
	*The defunct ''Type 2'' is a mix of different RCCs, e.g. ALK-RCC, translocation RCC, FH-deficient RCC.		*The defunct ''Type 2'' is a mix of different RCCs, e.g. ALK-RCC, translocation RCC, FH-deficient RCC.

Michael: /* Histological subtyping - historical type 1 and type 2 */

2025-03-04T16:57:40Z

Histological subtyping - historical type 1 and type 2

← Older revision		Revision as of 16:57, 4 March 2025
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	</gallery>		</gallery>

	===Histological subtyping ~~- historical~~ type 1 and type 2===		===Histological subtyping===
			====Historical type 1 and type 2====
	Historically, PaRCC was subtyped:<ref name=Ref_GUP289>{{Ref GUP\|289}}</ref><ref>{{Cite journal \| last1 = Delahunt \| first1 = B. \| last2 = Eble \| first2 = JN. \| title = Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 537-44 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195569 }}</ref>		Historically, PaRCC was subtyped:<ref name=Ref_GUP289>{{Ref GUP\|289}}</ref><ref>{{Cite journal \| last1 = Delahunt \| first1 = B. \| last2 = Eble \| first2 = JN. \| title = Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 537-44 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195569 }}</ref>
	*''Type 1'' - single layer of cells on basement membrane - '''most important'''.		*''Type 1'' - single layer of cells on basement membrane - '''most important'''.

Michael: /* Histological subtyping - historical */

2025-03-04T16:57:14Z

Histological subtyping - historical

← Older revision		Revision as of 16:57, 4 March 2025
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	</gallery>		</gallery>

	===Histological subtyping - historical===		===Histological subtyping - historical type 1 and type 2===
	Historically, PaRCC was subtyped:<ref name=Ref_GUP289>{{Ref GUP\|289}}</ref><ref>{{Cite journal \| last1 = Delahunt \| first1 = B. \| last2 = Eble \| first2 = JN. \| title = Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 537-44 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195569 }}</ref>		Historically, PaRCC was subtyped:<ref name=Ref_GUP289>{{Ref GUP\|289}}</ref><ref>{{Cite journal \| last1 = Delahunt \| first1 = B. \| last2 = Eble \| first2 = JN. \| title = Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 537-44 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195569 }}</ref>
	*''Type 1'' - single layer of cells on basement membrane - '''most important'''.		*''Type 1'' - single layer of cells on basement membrane - '''most important'''.
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	*The defunct ''Type 2'' is a mix of different RCCs, e.g. ALK-RCC, translocation RCC, FH-deficient RCC.		*The defunct ''Type 2'' is a mix of different RCCs, e.g. ALK-RCC, translocation RCC, FH-deficient RCC.

	~~Another~~ subtype:		===Oncocytic subtype===
	*''Oncocytic'' - oncocytic cytoplasm.		*''Oncocytic'' - oncocytic cytoplasm.
	**Extremely rare ~ a few dozen reported.<ref name=pmid19494850 >{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref><ref name=pmid16730306>{{Cite journal \| last1 = Hes \| first1 = O. \| last2 = Brunelli \| first2 = M. \| last3 = Michal \| first3 = M. \| last4 = Cossu Rocca \| first4 = P. \| last5 = Hora \| first5 = M. \| last6 = Chilosi \| first6 = M. \| last7 = Mina \| first7 = M. \| last8 = Boudova \| first8 = L. \| last9 = Menestrina \| first9 = F. \| title = Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases. \| journal = Ann Diagn Pathol \| volume = 10 \| issue = 3 \| pages = 133-9 \| month = Jun \| year = 2006 \| doi = 10.1016/j.anndiagpath.2005.12.002 \| PMID = 16730306 }}</ref>		**Extremely rare ~ a few dozen reported.<ref name=pmid19494850 >{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref><ref name=pmid16730306>{{Cite journal \| last1 = Hes \| first1 = O. \| last2 = Brunelli \| first2 = M. \| last3 = Michal \| first3 = M. \| last4 = Cossu Rocca \| first4 = P. \| last5 = Hora \| first5 = M. \| last6 = Chilosi \| first6 = M. \| last7 = Mina \| first7 = M. \| last8 = Boudova \| first8 = L. \| last9 = Menestrina \| first9 = F. \| title = Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases. \| journal = Ann Diagn Pathol \| volume = 10 \| issue = 3 \| pages = 133-9 \| month = Jun \| year = 2006 \| doi = 10.1016/j.anndiagpath.2005.12.002 \| PMID = 16730306 }}</ref>

Michael: /* Histological subtyping - historical */

2025-03-04T16:56:34Z

Histological subtyping - historical

← Older revision		Revision as of 16:56, 4 March 2025
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	The WHO GU Blue Book 5th Ed. recommends against subtyping.		The WHO GU Blue Book 5th Ed. recommends against subtyping.
	The defunct ''Type 1'' is papillary renal cell carcinoma. It is classically associated with a MET gene alteration.
	The defunct ''Type 2'' is a mix of ~~other tumour~~, e.g. ALK-RCC, translocation RCC, FH-deficient RCC.		Where are 'Type 1' and 'Type 2':
			*The defunct ''Type 1'' is ''papillary renal cell carcinoma''. It is classically associated with a MET gene alteration.
			*The defunct ''Type 2'' is a mix of different RCCs, e.g. ALK-RCC, translocation RCC, FH-deficient RCC.

	Another subtype:		Another subtype:

Michael: /* Histological subtyping */

2025-03-04T16:55:31Z

Histological subtyping

← Older revision		Revision as of 16:55, 4 March 2025
Line 97:		Line 97:
	</gallery>		</gallery>

	===Histological subtyping===		===Histological subtyping - historical===
	Historically, PaRCC was subtyped:<ref name=Ref_GUP289>{{Ref GUP\|289}}</ref><ref>{{Cite journal \| last1 = Delahunt \| first1 = B. \| last2 = Eble \| first2 = JN. \| title = Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 537-44 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195569 }}</ref>		Historically, PaRCC was subtyped:<ref name=Ref_GUP289>{{Ref GUP\|289}}</ref><ref>{{Cite journal \| last1 = Delahunt \| first1 = B. \| last2 = Eble \| first2 = JN. \| title = Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. \| journal = Mod Pathol \| volume = 10 \| issue = 6 \| pages = 537-44 \| month = Jun \| year = 1997 \| doi = \| PMID = 9195569 }}</ref>
	*''Type 1'' - single layer of cells on basement membrane - '''most important'''.		*''Type 1'' - single layer of cells on basement membrane - '''most important'''.
Line 113:		Line 113:

	The WHO GU Blue Book 5th Ed. recommends against subtyping.		The WHO GU Blue Book 5th Ed. recommends against subtyping.
			The defunct ''Type 1'' is papillary renal cell carcinoma. It is classically associated with a MET gene alteration.
			The defunct ''Type 2'' is a mix of other tumour, e.g. ALK-RCC, translocation RCC, FH-deficient RCC.

	Another subtype:		Another subtype:

Michael at 16:52, 4 March 2025

2025-03-04T16:52:49Z

← Older revision		Revision as of 16:52, 4 March 2025
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	Others:		Others:
	*GATA3 +ve - oncocytic variant of PaRCC; negative in other PaRCC subtypes.<ref name=pmid28984673>{{cite journal \|authors=Saleeb RM, Brimo F, Farag M, Rompré-Brodeur A, Rotondo F, Beharry V, Wala S, Plant P, Downes MR, Pace K, Evans A, Bjarnason G, Bartlett JMS, Yousef GM \|title=Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis \|journal=Am J Surg Pathol \|volume=41 \|issue=12 \|pages=1618–1629 \|date=December 2017 \|pmid=28984673 \|doi=10.1097/PAS.0000000000000962 \|url=}}</ref>		*GATA3 +ve - oncocytic variant of PaRCC; negative in other PaRCC subtypes.<ref name=pmid28984673>{{cite journal \|authors=Saleeb RM, Brimo F, Farag M, Rompré-Brodeur A, Rotondo F, Beharry V, Wala S, Plant P, Downes MR, Pace K, Evans A, Bjarnason G, Bartlett JMS, Yousef GM \|title=Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis \|journal=Am J Surg Pathol \|volume=41 \|issue=12 \|pages=1618–1629 \|date=December 2017 \|pmid=28984673 \|doi=10.1097/PAS.0000000000000962 \|url=}}</ref>
	*ABCC2 ~~- may predict~~ survival.<ref>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>		*ABCC2 brush border staining = worse survival.<ref name=pmid37680023>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>


	Metanephric adenoma vs. PaRCC type 1:<ref name=pmid24083046>{{Cite journal \| last1 = Watanabe \| first1 = S. \| last2 = Naganuma \| first2 = H. \| last3 = Shimizu \| first3 = M. \| last4 = Ota \| first4 = S. \| last5 = Murata \| first5 = S. \| last6 = Nihei \| first6 = N. \| last7 = Matsushima \| first7 = J. \| last8 = Mikami \| first8 = S. \| last9 = Kuroda \| first9 = N. \| title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. \| journal = Case Rep Pathol \| volume = 2013 \| issue = \| pages = 675875 \| month = \| year = 2013 \| doi = 10.1155/2013/675875 \| PMID = 24083046 }}</ref>		Metanephric adenoma vs. PaRCC type 1:<ref name=pmid24083046>{{Cite journal \| last1 = Watanabe \| first1 = S. \| last2 = Naganuma \| first2 = H. \| last3 = Shimizu \| first3 = M. \| last4 = Ota \| first4 = S. \| last5 = Murata \| first5 = S. \| last6 = Nihei \| first6 = N. \| last7 = Matsushima \| first7 = J. \| last8 = Mikami \| first8 = S. \| last9 = Kuroda \| first9 = N. \| title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. \| journal = Case Rep Pathol \| volume = 2013 \| issue = \| pages = 675875 \| month = \| year = 2013 \| doi = 10.1155/2013/675875 \| PMID = 24083046 }}</ref>

Michael at 16:39, 4 March 2025

2025-03-04T16:39:55Z

← Older revision		Revision as of 16:39, 4 March 2025
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	Others:		Others:
	*GATA3 +ve - oncocytic variant of PaRCC; negative in other PaRCC subtypes.<ref name=pmid28984673>{{cite journal \|authors=Saleeb RM, Brimo F, Farag M, Rompré-Brodeur A, Rotondo F, Beharry V, Wala S, Plant P, Downes MR, Pace K, Evans A, Bjarnason G, Bartlett JMS, Yousef GM \|title=Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis \|journal=Am J Surg Pathol \|volume=41 \|issue=12 \|pages=1618–1629 \|date=December 2017 \|pmid=28984673 \|doi=10.1097/PAS.0000000000000962 \|url=}}</ref>		*GATA3 +ve - oncocytic variant of PaRCC; negative in other PaRCC subtypes.<ref name=pmid28984673>{{cite journal \|authors=Saleeb RM, Brimo F, Farag M, Rompré-Brodeur A, Rotondo F, Beharry V, Wala S, Plant P, Downes MR, Pace K, Evans A, Bjarnason G, Bartlett JMS, Yousef GM \|title=Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis \|journal=Am J Surg Pathol \|volume=41 \|issue=12 \|pages=1618–1629 \|date=December 2017 \|pmid=28984673 \|doi=10.1097/PAS.0000000000000962 \|url=}}</ref>
			*ABCC2 - may predict survival.<ref>{{cite journal \|authors=Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen VN, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM \|title=ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases \|journal=Histopathology \|volume=83 \|issue=6 \|pages=949–958 \|date=December 2023 \|pmid=37680023 \|doi=10.1111/his.15042 \|url=}}</ref>

	Type 1 versus Type 2:<ref name=pmid9234615>{{Cite journal \| last1 = Ono \| first1 = Y. \| last2 = Ito \| first2 = T. \| last3 = Tsujino \| first3 = S. \| last4 = Aizawa \| first4 = S. \| last5 = Suzuki \| first5 = M. \| title = [A study of papillary renal cell carcinoma. Clinicopathological, immunohistochemical features and its typing]. \| journal = Nihon Hinyokika Gakkai Zasshi \| volume = 88 \| issue = 6 \| pages = 587-95 \| month = Jun \| year = 1997 \| doi = \| PMID = 9234615 }}</ref>
	*CK7:
	**Type 1 ~ 100%.
	**Type 2 ~ 19%.
	*CK19:
	**Type 1 ~ 100%.
	**Type 2 ~ 53%.

	Metanephric adenoma vs. PaRCC type 1:<ref name=pmid24083046>{{Cite journal \| last1 = Watanabe \| first1 = S. \| last2 = Naganuma \| first2 = H. \| last3 = Shimizu \| first3 = M. \| last4 = Ota \| first4 = S. \| last5 = Murata \| first5 = S. \| last6 = Nihei \| first6 = N. \| last7 = Matsushima \| first7 = J. \| last8 = Mikami \| first8 = S. \| last9 = Kuroda \| first9 = N. \| title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. \| journal = Case Rep Pathol \| volume = 2013 \| issue = \| pages = 675875 \| month = \| year = 2013 \| doi = 10.1155/2013/675875 \| PMID = 24083046 }}</ref>		Metanephric adenoma vs. PaRCC type 1:<ref name=pmid24083046>{{Cite journal \| last1 = Watanabe \| first1 = S. \| last2 = Naganuma \| first2 = H. \| last3 = Shimizu \| first3 = M. \| last4 = Ota \| first4 = S. \| last5 = Murata \| first5 = S. \| last6 = Nihei \| first6 = N. \| last7 = Matsushima \| first7 = J. \| last8 = Mikami \| first8 = S. \| last9 = Kuroda \| first9 = N. \| title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. \| journal = Case Rep Pathol \| volume = 2013 \| issue = \| pages = 675875 \| month = \| year = 2013 \| doi = 10.1155/2013/675875 \| PMID = 24083046 }}</ref>

Michael: clean-up

2025-03-03T17:52:57Z

clean-up

← Older revision		Revision as of 17:52, 3 March 2025
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	\| Micro = cuboidal or low columnar cells (simple or pseudostratified) on papillae, interstitial foam cells in the vascular cores		\| Micro = cuboidal or low columnar cells (simple or pseudostratified) on papillae, interstitial foam cells in the vascular cores
	\| Subtypes = no ''World Health Organization'' recognized subtypes; defunct subtypes: "type 1" and "type 2", oncocytic variant		\| Subtypes = no ''World Health Organization'' recognized subtypes; defunct subtypes: "type 1" and "type 2", oncocytic variant
	\| LMDDx = [[clear cell renal cell carcinoma]], [[clear cell papillary renal cell carcinoma]], [[metanephric adenoma]] ~~(esp. solid PaRCC type 1)~~, [[collecting duct carcinoma]] ~~(esp. PaRCC type 2)~~, [[renal papillary adenoma]], [[acquired cystic disease-associated renal cell carcinoma]], [[urothelial carcinoma]], [[renal mucinous tubular and spindle cell carcinoma]], [[ALK translocation renal cell carcinoma]], [[Xp11 translocation renal cell carcinoma]]		\| LMDDx = [[clear cell renal cell carcinoma]], [[clear cell papillary renal cell carcinoma]], [[metanephric adenoma]], [[collecting duct carcinoma]], [[renal papillary adenoma]], [[acquired cystic disease-associated renal cell carcinoma]], [[urothelial carcinoma]], [[renal mucinous tubular and spindle cell carcinoma]], [[ALK translocation renal cell carcinoma]], [[Xp11 translocation renal cell carcinoma]], [[FH-deficient renal cell carcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
	\| EM =		\| EM =
	\| Molecular = MET mutation (hereditary papillary renal cell carcinoma~~), FH mutation (hereditary leiomyomatosis and renal cell cancer~~)		\| Molecular = MET mutation (hereditary papillary renal cell carcinoma)
	\| IF =		\| IF =
	\| Gross = may be multifocal, must be >1.5 cm (if low ISUP grade), often necrotic-appearing (brown, soft, friable)		\| Gross = may be multifocal, must be >1.5 cm (if low ISUP grade), often necrotic-appearing (brown, soft, friable)
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	\| Site = [[kidney]] - see [[kidney tumours]]		\| Site = [[kidney]] - see [[kidney tumours]]
	\| Assdx = [[acquired renal cystic disease]] ([[end-stage renal disease]])		\| Assdx = [[acquired renal cystic disease]] ([[end-stage renal disease]])
	\| Syndromes = hereditary papillary renal cell carcinoma~~, [[hereditary leiomyomatosis and renal cell cancer]]~~		\| Syndromes = hereditary papillary renal cell carcinoma
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =