Paget's disease of the breast - Revision history

Michael at 15:49, 23 February 2023

2023-02-23T15:49:27Z

← Older revision		Revision as of 15:49, 23 February 2023
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	Comment:		Comment:
	The Paget-like cells stain as follows:		The Paget-like cells stain as follows:
	POSITIVE: CK7 (moderate, diffuse), HER2 (complete membranous, moderate).		POSITIVE: CK7 (moderate, diffuse), HER2 (complete membranous, moderate/strong).
	NEGATIVE: S-100, HMB-45, CK5, CEA-mono.		NEGATIVE: S-100, HMB-45, CK5, CEA-mono.

Michael: +SO

2023-02-23T15:45:19Z

+SO

← Older revision		Revision as of 15:45, 23 February 2023
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	\|}		\|}

			==Sign out==
			<pre>
			Right Nipple, Biopsy:
			- Paget's disease.

			Comment:
			The Paget-like cells stain as follows:
			POSITIVE: CK7 (moderate, diffuse), HER2 (complete membranous, moderate).
			NEGATIVE: S-100, HMB-45, CK5, CEA-mono.

			The morphologic and immunohistochemical findings are in keeping with Paget's disease of the breast.

			The breast imaging findings are noted.
			</pre>

	==See also==		==See also==

Michael at 20:45, 5 May 2016

2016-05-05T20:45:24Z

← Older revision		Revision as of 20:45, 5 May 2016
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	\| LMDDx = benign Toker cell hyperplasia, [[malignant melanoma]], [[Bowen's disease]], [[apocrine carcinoma of the skin]]		\| LMDDx = benign Toker cell hyperplasia, [[malignant melanoma]], [[Bowen's disease]], [[apocrine carcinoma of the skin]]
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve, CEA +ve, S-100 -ve, CK5/6 -ve, HER2 +ve		\| IHC = CK7 +ve, CEA +ve, S-100 -ve, [[CK5/6]] -ve, HER2 +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	Additional:		Additional:
	*HER2/neu - usually +ve.		*HER2/neu - usually +ve.
	*CK5/6 -ve.<ref>RS. May 2010.</ref>		*[[CK5/6]] -ve.<ref>RS. May 2010.</ref>
	**Usu. +ve in squamous cell carcinoma.<ref name=pmid19170169>{{Cite journal \| last1 = Khayyata \| first1 = S. \| last2 = Yun \| first2 = S. \| last3 = Pasha \| first3 = T. \| last4 = Jian \| first4 = B. \| last5 = McGrath \| first5 = C. \| last6 = Yu \| first6 = G. \| last7 = Gupta \| first7 = P. \| last8 = Baloch \| first8 = Z. \| title = Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. \| journal = Diagn Cytopathol \| volume = 37 \| issue = 3 \| pages = 178-83 \| month = Mar \| year = 2009 \| doi = 10.1002/dc.20975 \| PMID = 19170169 }}</ref>		**Usu. +ve in squamous cell carcinoma.<ref name=pmid19170169>{{Cite journal \| last1 = Khayyata \| first1 = S. \| last2 = Yun \| first2 = S. \| last3 = Pasha \| first3 = T. \| last4 = Jian \| first4 = B. \| last5 = McGrath \| first5 = C. \| last6 = Yu \| first6 = G. \| last7 = Gupta \| first7 = P. \| last8 = Baloch \| first8 = Z. \| title = Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. \| journal = Diagn Cytopathol \| volume = 37 \| issue = 3 \| pages = 178-83 \| month = Mar \| year = 2009 \| doi = 10.1002/dc.20975 \| PMID = 19170169 }}</ref>

Sarah: /* Images */

2015-03-15T10:42:44Z

Images

← Older revision		Revision as of 10:42, 15 March 2015
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	Image:Extramammary_Paget_disease_-_low_mag.jpg \| Paget disease - low mag. (WC/Nephron)		Image:Extramammary_Paget_disease_-_low_mag.jpg \| Paget disease - low mag. (WC/Nephron)
	Image:Extramammary_Paget_disease_-_high_mag.jpg \| Paget disease - high mag. (WC/Nephron)		Image:Extramammary_Paget_disease_-_high_mag.jpg \| Paget disease - high mag. (WC/Nephron)
			Image:Breast PagetDisease HP SNP.jpg\|thumb\|Breast Paget Disease - high power - (SKB)
			Image:Breast PagetsDisease InvasiveDuctalCarcinoma PA.JPG\|thumb\|Breast Paget Disease - underlying invasive carcinoma - medium power - (SKB)
			Image:Breast PagetsDisease HP PA.JPG\|thumb\|Breast Paget Disease - high power - (SKB)
			Image:Breast PagetsDisease PA.JPG\|thumb\|Breast Paget Disease - high power - (SKB)
			Image:Breast PagetDisease LP SNP.jpg\|thumb\|Breast Paget Disease - medium power - (SKB)
	</gallery>		</gallery>
	www:		www:

Michael at 05:32, 8 February 2015

2015-02-08T05:32:49Z

← Older revision		Revision as of 05:32, 8 February 2015
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	\|CK7 '''+ve'''		\|CK7 '''+ve'''
	\|CAM5.2 ?		\|CAM5.2 ?
	\|EMA +ve ~~(?)~~		\|EMA +ve/-ve<ref name=pmid12680957>{{Cite journal \| last1 = Willman \| first1 = JH. \| last2 = Golitz \| first2 = LE. \| last3 = Fitzpatrick \| first3 = JE. \| title = Clear cells of Toker in accessory nipples. \| journal = J Cutan Pathol \| volume = 30 \| issue = 4 \| pages = 256-60 \| month = Apr \| year = 2003 \| doi = \| PMID = 12680957 }}</ref>
	\|CEA '''-ve'''		\|CEA '''-ve'''<ref name=pmid18758638/>
	\|HER2 -ve<ref name=pmid19601945>{{Cite journal \| last1 = Nofech-Mozes \| first1 = S. \| last2 = Hanna \| first2 = W. \| title = Toker cells revisited. \| journal = Breast J \| volume = 15 \| issue = 4 \| pages = 394-8 \| month = \| year = \| doi = 10.1111/j.1524-4741.2009.00743.x \| PMID = 19601945 }}</ref>		\|HER2 -ve<ref name=pmid19601945>{{Cite journal \| last1 = Nofech-Mozes \| first1 = S. \| last2 = Hanna \| first2 = W. \| title = Toker cells revisited. \| journal = Breast J \| volume = 15 \| issue = 4 \| pages = 394-8 \| month = \| year = \| doi = 10.1111/j.1524-4741.2009.00743.x \| PMID = 19601945 }}</ref>
	\|S100 -ve ~~(?)~~		\|S100 -ve<ref name=pmid18758638>{{Cite journal \| last1 = Fernandez-Flores \| first1 = A. \| title = Toker cell related to the folliculo-sebaceous-apocrine unit: a study of horizontal sections of the nipple. \| journal = Rom J Morphol Embryol \| volume = 49 \| issue = 3 \| pages = 339-43 \| month = \| year = 2008 \| doi = \| PMID = 18758638 }}</ref>
	\|HMB-45 ?		\|HMB-45 ?
	\|-		\|-

Michael: /* Tabular comparison */

2015-02-08T05:23:56Z

Tabular comparison

← Older revision		Revision as of 05:23, 8 February 2015
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	===Tabular comparison===		===Tabular comparison===
	IHC features of Paget disease and its DDx:<ref>URL: [http://www.histopathology-india.net/EPD.htm http://www.histopathology-india.net/EPD.htm]. Accessed on: 4 December 2011.</ref>		IHC features of Paget disease and its DDx:<ref>URL: [http://www.histopathology-india.net/EPD.htm http://www.histopathology-india.net/EPD.htm]. Accessed on: 4 December 2011.</ref><ref name=pmid12189500>{{Cite journal \| last1 = Marucci \| first1 = G. \| last2 = Betts \| first2 = CM. \| last3 = Golouh \| first3 = R. \| last4 = Peterse \| first4 = JL. \| last5 = Foschini \| first5 = MP. \| last6 = Eusebi \| first6 = V. \| title = Toker cells are probably precursors of Paget cell carcinoma: a morphological and ultrastructural description. \| journal = Virchows Arch \| volume = 441 \| issue = 2 \| pages = 117-23 \| month = Aug \| year = 2002 \| doi = 10.1007/s00428-001-0581-x \| PMID = 12189500 }}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	!Entity		!Entity
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	\|CK7 '''+ve'''		\|CK7 '''+ve'''
	\|CAM5.2 ?		\|CAM5.2 ?
	\|EMA ?		\|EMA +ve (?)
	\|CEA '''-ve'''		\|CEA '''-ve'''
	\|HER2 ?		\|HER2 -ve<ref name=pmid19601945>{{Cite journal \| last1 = Nofech-Mozes \| first1 = S. \| last2 = Hanna \| first2 = W. \| title = Toker cells revisited. \| journal = Breast J \| volume = 15 \| issue = 4 \| pages = 394-8 \| month = \| year = \| doi = 10.1111/j.1524-4741.2009.00743.x \| PMID = 19601945 }}</ref>
	\|S100 ?		\|S100 -ve (?)
	\|HMB-45 ?		\|HMB-45 ?
	\|-		\|-

Michael at 02:14, 11 September 2014

2014-09-11T02:14:43Z

← Older revision		Revision as of 02:14, 11 September 2014
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	'''[[Paget's disease]] of the breast''', also '''Paget disease of the breast''' and '''Paget's disease of the nipple''', is a lesion of the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>		'''[[Paget's disease]] of the breast''', also '''Paget disease of the breast''' and '''Paget's disease of the nipple''', is a lesion of the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>

	There is also a ''[[Paget's disease of the bone]]'' - just to make things confusing. This is dealt with in ~~the ''~~[[bone]]~~'' article~~ and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article; these two things just happened to be discovered by the same guy.		There is also a ''[[Paget's disease of the bone]]'' - just to make things confusing. This is dealt with in [[Paget's disease of the bone\|its own article]] and has nothing (from a pathologic perspective) to do with the Paget's disease discussed in this article; these two things just happened to be discovered by the same guy.

	Non-bone Paget's disease is subdivided into:		Non-bone Paget's disease is subdivided into:

Michael at 02:12, 11 September 2014

2014-09-11T02:12:27Z

← Older revision		Revision as of 02:12, 11 September 2014
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	'''[[Paget's disease]] of the breast''', also '''Paget disease of the breast''' and '''Paget's disease of the nipple''', is a lesion of the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>		'''[[Paget's disease]] of the breast''', also '''Paget disease of the breast''' and '''Paget's disease of the nipple''', is a lesion of the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>

	There is also a ''[[Paget disease of the bone]]'' - just to make things confusing. This is dealt with in the ''[[bone]]'' article and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article; these two things just happened to be discovered by the same guy.		There is also a ''[[Paget's disease of the bone]]'' - just to make things confusing. This is dealt with in the ''[[bone]]'' article and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article; these two things just happened to be discovered by the same guy.

	Non-bone Paget disease is subdivided into:		Non-bone Paget's disease is subdivided into:
	#Mammary Paget disease - dealt with in this article.		#Mammary Paget's disease - dealt with in this article.
	#[[Extramammary Paget disease]].		#[[Extramammary Paget's disease]].

	Histologically, i.e. under the [[microscope]], the above are essentially identically; however, the associations (and prognosis) are quite different!		Histologically, i.e. under the [[microscope]], the above are essentially identically; however, the associations (and prognosis) are quite different!

Michael at 02:07, 11 September 2014

2014-09-11T02:07:30Z

← Older revision		Revision as of 02:07, 11 September 2014
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	\| Tx =		\| Tx =
	}}		}}
	'''Paget disease of the breast''', also '''[[Paget's disease]] of the breast''' and '''Paget disease of the nipple''', is a ~~thingy seen in~~ the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>		'''[[Paget's disease]] of the breast''', also '''Paget disease of the breast''' and '''Paget's disease of the nipple''', is a lesion of the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>

	There is also a ''[[Paget disease of the bone]]'' - just to make things confusing. This is dealt with in the ''[[bone]]'' article and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article; these two things just happened to be discovered by the same guy.		There is also a ''[[Paget disease of the bone]]'' - just to make things confusing. This is dealt with in the ''[[bone]]'' article and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article; these two things just happened to be discovered by the same guy.

Michael: change

2014-09-11T02:06:12Z

change

Show changes

← Older revision		Revision as of 10:42, 15 March 2015
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	Image:Extramammary_Paget_disease_-_low_mag.jpg \| Paget disease - low mag. (WC/Nephron)		Image:Extramammary_Paget_disease_-_low_mag.jpg \| Paget disease - low mag. (WC/Nephron)
	Image:Extramammary_Paget_disease_-_high_mag.jpg \| Paget disease - high mag. (WC/Nephron)		Image:Extramammary_Paget_disease_-_high_mag.jpg \| Paget disease - high mag. (WC/Nephron)
			Image:Breast PagetDisease HP SNP.jpg\|thumb\|Breast Paget Disease - high power - (SKB)
			Image:Breast PagetsDisease InvasiveDuctalCarcinoma PA.JPG\|thumb\|Breast Paget Disease - underlying invasive carcinoma - medium power - (SKB)
			Image:Breast PagetsDisease HP PA.JPG\|thumb\|Breast Paget Disease - high power - (SKB)
			Image:Breast PagetsDisease PA.JPG\|thumb\|Breast Paget Disease - high power - (SKB)
			Image:Breast PagetDisease LP SNP.jpg\|thumb\|Breast Paget Disease - medium power - (SKB)
	</gallery>		</gallery>
	www:		www: