POEMS syndrome - Revision history

Mark: typically osteosclerotic

2021-03-26T22:34:25Z

typically osteosclerotic

← Older revision		Revision as of 22:34, 26 March 2021
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	==Pathology==		==Pathology==
	*The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal \|author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L \|title=Glomeruloid haemangioma is not always associated with POEMS syndrome \|journal=Clin. Exp. Dermatol. \|volume=34 \|issue=7 \|pages=800–3 \|year=2009 \|month=October \|pmid=19077091 \|doi=10.1111/j.1365-2230.2008.02997.x \|url=}}</ref>		*The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal \|author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L \|title=Glomeruloid haemangioma is not always associated with POEMS syndrome \|journal=Clin. Exp. Dermatol. \|volume=34 \|issue=7 \|pages=800–3 \|year=2009 \|month=October \|pmid=19077091 \|doi=10.1111/j.1365-2230.2008.02997.x \|url=}}</ref>
	*POEMS syndrome ~~does not~~ typically cause osteosclerotic bone deposits (so-called osteosclerotic myeloma), in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].{{fact}}		*POEMS syndrome typically cause osteosclerotic bone deposits (so-called osteosclerotic myeloma), in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].{{fact}}

	==See also==		==See also==

Michael at 17:36, 25 March 2021

2021-03-25T17:36:14Z

← Older revision		Revision as of 17:36, 25 March 2021
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	# Papilloedema.		# Papilloedema.
	# Thrombocytosis/polycythemia.		# Thrombocytosis/polycythemia.

	~~POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].~~

	==Pathology==		==Pathology==
	*The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal \|author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L \|title=Glomeruloid haemangioma is not always associated with POEMS syndrome \|journal=Clin. Exp. Dermatol. \|volume=34 \|issue=7 \|pages=800–3 \|year=2009 \|month=October \|pmid=19077091 \|doi=10.1111/j.1365-2230.2008.02997.x \|url=}}</ref>		*The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal \|author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L \|title=Glomeruloid haemangioma is not always associated with POEMS syndrome \|journal=Clin. Exp. Dermatol. \|volume=34 \|issue=7 \|pages=800–3 \|year=2009 \|month=October \|pmid=19077091 \|doi=10.1111/j.1365-2230.2008.02997.x \|url=}}</ref>
			*POEMS syndrome does not typically cause osteosclerotic bone deposits (so-called osteosclerotic myeloma), in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].{{fact}}

	==See also==		==See also==

Michael: /* Diagnostic criteria */

2021-03-25T17:34:28Z

Diagnostic criteria

← Older revision		Revision as of 17:34, 25 March 2021
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	''Mandatory:''		''Mandatory:''
	# Polyneuropathy (typically demyelinating)		# Polyneuropathy (typically demyelinating).
	# Monoclonal plasma cell proliferation (usually lambda)		# Monoclonal plasma cell proliferation (usually lambda).
	''Major:''		''Major:''
	# [[Castleman disease]]		# [[Castleman disease]]
	# Sclerotic bone lesions		# Sclerotic bone lesions.
	# Vascular endothelial growth factor elevation		# Vascular endothelial growth factor elevation.
	''Minor:''		''Minor:''
	# Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)		# Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy).
	# Extravascular volume overload		# Extravascular volume overload.
	# Endocrinopathy		# Endocrinopathy.
	# ~~Sking~~ changes		# Skin changes.
	# Papilloedema		# Papilloedema.
	# Thrombocytosis/polycythemia		# Thrombocytosis/polycythemia.

	POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].		POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].

Michael at 17:33, 25 March 2021

2021-03-25T17:33:07Z

← Older revision		Revision as of 17:33, 25 March 2021
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	*Skin changes.		*Skin changes.

	Diagnostic criteria ~~requires~~ both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal \|authors=Dispenzieri A \|title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management \|journal=Am. J. Hematol. \|volume=94 \|issue=7 \|pages=812–827 \|date=July 2019 \|pmid=31012139 \|doi=10.1002/ajh.25495 \|url=}}</ref>		==Diagnostic criteria==
			Requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal \|authors=Dispenzieri A \|title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management \|journal=Am. J. Hematol. \|volume=94 \|issue=7 \|pages=812–827 \|date=July 2019 \|pmid=31012139 \|doi=10.1002/ajh.25495 \|url=}}</ref>

	''Mandatory:''		''Mandatory:''
	~~;1.~~ Polyneuropathy (typically demyelinating)		# Polyneuropathy (typically demyelinating)
	~~;2.~~ Monoclonal plasma cell proliferation (usually lambda)		# Monoclonal plasma cell proliferation (usually lambda)
	''Major:''		''Major:''
	~~;3.~~ [[Castleman disease]]		# [[Castleman disease]]
	~~;4.~~ Sclerotic bone lesions		# Sclerotic bone lesions
	~~;5.~~ Vascular endothelial growth factor elevation		# Vascular endothelial growth factor elevation
	''Minor:''		''Minor:''
	~~;6.~~ Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)		# Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)
	~~;7.~~ Extravascular volume overload		# Extravascular volume overload
	~~;8.~~ Endocrinopathy		# Endocrinopathy
	~~;9.~~ Sking changes		# Sking changes
	~~;10.~~ Papilloedema		# Papilloedema
	~~;11.~~ Thrombocytosis/polycythemia		# Thrombocytosis/polycythemia

	POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].		POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].

Michael: vauthor

2021-03-25T17:31:16Z

vauthor

← Older revision		Revision as of 17:31, 25 March 2021
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	*Skin changes.		*Skin changes.

	Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal \|~~vauthors~~=Dispenzieri A \|title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management \|journal=Am. J. Hematol. \|volume=94 \|issue=7 \|pages=812–827 \|date=July 2019 \|pmid=31012139 \|doi=10.1002/ajh.25495 \|url=}}</ref>		Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal \|authors=Dispenzieri A \|title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management \|journal=Am. J. Hematol. \|volume=94 \|issue=7 \|pages=812–827 \|date=July 2019 \|pmid=31012139 \|doi=10.1002/ajh.25495 \|url=}}</ref>
	''Mandatory:''		''Mandatory:''
	;1. Polyneuropathy (typically demyelinating)		;1. Polyneuropathy (typically demyelinating)

Mark: list formatting

2020-07-26T14:14:09Z

list formatting

← Older revision		Revision as of 14:14, 26 July 2020
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	Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal \|vauthors=Dispenzieri A \|title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management \|journal=Am. J. Hematol. \|volume=94 \|issue=7 \|pages=812–827 \|date=July 2019 \|pmid=31012139 \|doi=10.1002/ajh.25495 \|url=}}</ref>		Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal \|vauthors=Dispenzieri A \|title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management \|journal=Am. J. Hematol. \|volume=94 \|issue=7 \|pages=812–827 \|date=July 2019 \|pmid=31012139 \|doi=10.1002/ajh.25495 \|url=}}</ref>
	Mandatory:		''Mandatory:''
	1. Polyneuropathy (typically demyelinating)		;1. Polyneuropathy (typically demyelinating)
	2. Monoclonal plasma cell proliferation (usually lambda)		;2. Monoclonal plasma cell proliferation (usually lambda)
	Major:		''Major:''
	3. [[Castleman disease]]		;3. [[Castleman disease]]
	4. Sclerotic bone lesions		;4. Sclerotic bone lesions
	5. Vascular endothelial growth factor elevation		;5. Vascular endothelial growth factor elevation
	Minor:		''Minor:''
	6. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)		;6. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)
	7. Extravascular volume overload		;7. Extravascular volume overload
	8. Endocrinopathy		;8. Endocrinopathy
	9. Sking changes		;9. Sking changes
	10. Papilloedema		;10. Papilloedema
	11. Thrombocytosis/polycythemia		;11. Thrombocytosis/polycythemia

	POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].		POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].

Mark: diagnostic criteria

2020-07-26T14:13:07Z

diagnostic criteria

← Older revision		Revision as of 14:13, 26 July 2020
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	'''POEMS syndrome''' is a constellation of findings:<ref name=pmid18477219>{{cite journal \|author=Yuri T, Yamazaki F, Takasu K, Shikata N, Tsubura A \|title=Glomeruloid hemangioma \|journal=Pathol. Int. \|volume=58 \|issue=6 \|pages=390–5 \|year=2008 \|month=June \|pmid=18477219 \|doi=10.1111/j.1440-1827.2008.02241.x \|url=}}</ref>		'''POEMS syndrome''' is a constellation of findings, best thought of as a paraneoplastic syndrome due to clonal plasma cells:<ref name=pmid18477219>{{cite journal \|author=Yuri T, Yamazaki F, Takasu K, Shikata N, Tsubura A \|title=Glomeruloid hemangioma \|journal=Pathol. Int. \|volume=58 \|issue=6 \|pages=390–5 \|year=2008 \|month=June \|pmid=18477219 \|doi=10.1111/j.1440-1827.2008.02241.x \|url=}}</ref>
	*Polyneuropathy.		*Polyneuropathy.
	*Organomegaly.		*Organomegaly.
Line 5:		Line 5:
	*M-protein.		*M-protein.
	*Skin changes.		*Skin changes.

			Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal \|vauthors=Dispenzieri A \|title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management \|journal=Am. J. Hematol. \|volume=94 \|issue=7 \|pages=812–827 \|date=July 2019 \|pmid=31012139 \|doi=10.1002/ajh.25495 \|url=}}</ref>
			Mandatory:
			1. Polyneuropathy (typically demyelinating)
			2. Monoclonal plasma cell proliferation (usually lambda)
			Major:
			3. [[Castleman disease]]
			4. Sclerotic bone lesions
			5. Vascular endothelial growth factor elevation
			Minor:
			6. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy)
			7. Extravascular volume overload
			8. Endocrinopathy
			9. Sking changes
			10. Papilloedema
			11. Thrombocytosis/polycythemia

	POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].		POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].

Mark: osteosclerotic lesions

2020-07-26T14:04:01Z

osteosclerotic lesions

← Older revision		Revision as of 14:04, 26 July 2020
Line 5:		Line 5:
	*M-protein.		*M-protein.
	*Skin changes.		*Skin changes.

			POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].

	==Pathology==		==Pathology==

Michael: /* See also */

2020-01-14T14:19:32Z

Michael at 14:19, 14 January 2020

2020-01-14T14:19:06Z

← Older revision		Revision as of 14:19, 14 January 2020
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	==Pathology==		==Pathology==
	*The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal \|author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L \|title=Glomeruloid haemangioma is not always associated with POEMS syndrome \|journal=Clin. Exp. Dermatol. \|volume=34 \|issue=7 \|pages=800–3 \|year=2009 \|month=October \|pmid=19077091 \|doi=10.1111/j.1365-2230.2008.02997.x \|url=}}</ref>		*The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal \|author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L \|title=Glomeruloid haemangioma is not always associated with POEMS syndrome \|journal=Clin. Exp. Dermatol. \|volume=34 \|issue=7 \|pages=800–3 \|year=2009 \|month=October \|pmid=19077091 \|doi=10.1111/j.1365-2230.2008.02997.x \|url=}}</ref>

			==See also==
			*[[POEM]].

	==References==		==References==