Osteoid osteoma - Revision history

Michael at 12:04, 20 June 2016

2016-06-20T12:04:46Z

← Older revision		Revision as of 12:04, 20 June 2016
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	}}		}}
	'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]]. It is grouped with the [[chondro-osseous tumours]].		'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]]. It is grouped with the [[chondro-osseous tumours]].

			It should '''not''' be confused with an ''[[osteoma]]''.

	==General==		==General==

Michael: tweak

2016-02-23T20:52:25Z

tweak

← Older revision		Revision as of 20:52, 23 February 2016
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	\| Prevalence =		\| Prevalence =
	\| Bloodwork =		\| Bloodwork =
	\| Rads = <= 1.5 cm (larger ~~lesion~~ [[osteoblastoma]])		\| Rads = <= 2.0 cm (larger lesions ''[[osteoblastoma]]'')
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis =
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	*'''Must''' be less than 2 cm - as per WHO definition.<ref name=pmid25224389>{{Cite journal \| last1 = Yalcinkaya \| first1 = U. \| last2 = Doganavsargil \| first2 = B. \| last3 = Sezak \| first3 = M. \| last4 = Kececi \| first4 = B. \| last5 = Argin \| first5 = M. \| last6 = Basdemir \| first6 = G. \| last7 = Oztop \| first7 = F. \| title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. \| journal = Ann Diagn Pathol \| volume = 18 \| issue = 6 \| pages = 319-25 \| month = Dec \| year = 2014 \| doi = 10.1016/j.anndiagpath.2014.08.006 \| PMID = 25224389 }}</ref> ‡		*'''Must''' be less than 2 cm - as per WHO definition.<ref name=pmid25224389>{{Cite journal \| last1 = Yalcinkaya \| first1 = U. \| last2 = Doganavsargil \| first2 = B. \| last3 = Sezak \| first3 = M. \| last4 = Kececi \| first4 = B. \| last5 = Argin \| first5 = M. \| last6 = Basdemir \| first6 = G. \| last7 = Oztop \| first7 = F. \| title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. \| journal = Ann Diagn Pathol \| volume = 18 \| issue = 6 \| pages = 319-25 \| month = Dec \| year = 2014 \| doi = 10.1016/j.anndiagpath.2014.08.006 \| PMID = 25224389 }}</ref> ‡
	**Larger lesions with the same microscopy are ''[[osteoblastoma]]s''.		**Larger lesions with the same microscopy are ''[[osteoblastoma]]s''.
			*Central nidus with surround sclerotic bone.<ref name=pmid24093694>{{Cite journal \| last1 = Boscainos \| first1 = PJ. \| last2 = Cousins \| first2 = GR. \| last3 = Kulshreshtha \| first3 = R. \| last4 = Oliver \| first4 = TB. \| last5 = Papagelopoulos \| first5 = PJ. \| title = Osteoid osteoma. \| journal = Orthopedics \| volume = 36 \| issue = 10 \| pages = 792-800 \| month = Oct \| year = 2013 \| doi = 10.3928/01477447-20130920-10 \| PMID = 24093694 }}</ref>

	Note:		Note:
	*‡ Previously, the [[diagnostic size cutoffs\|diagnostic size cutoff]] was <=1.5 cm.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4\|286}}</ref>		*‡ Previously, the [[diagnostic size cutoffs\|diagnostic size cutoff]] was <=1.5 cm.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4\|286}}</ref>


	Images:		Images:
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	Note:		Note:
	*Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]'';<ref name=Ref_Sternberg4_286>{{Ref Sternberg4\|286}}</ref> one needs some history to make the diagnosis.		*Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]'';<ref name=Ref_Sternberg4_286>{{Ref Sternberg4\|286}}</ref> one needs some history to make the diagnosis.

			DDx:
			*[[Osteosarcoma]] - lace-like osteoid, no nidus.
			*[[Osteoblastoma]] - larger lesion, clinical features different.

	===Images===		===Images===

Michael: /* Gross */

2016-02-23T20:46:30Z

Gross

← Older revision		Revision as of 20:46, 23 February 2016
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	*Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref>		*Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref>
	*Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref>		*Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref>
	*'''Must''' be ~~<=1.5~~ cm by definition.<ref name=~~Ref_Sternberg4_286~~>{{~~Ref Sternberg4~~\|~~286~~}}</ref>		*'''Must''' be less than 2 cm - as per WHO definition.<ref name=pmid25224389>{{Cite journal \| last1 = Yalcinkaya \| first1 = U. \| last2 = Doganavsargil \| first2 = B. \| last3 = Sezak \| first3 = M. \| last4 = Kececi \| first4 = B. \| last5 = Argin \| first5 = M. \| last6 = Basdemir \| first6 = G. \| last7 = Oztop \| first7 = F. \| title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. \| journal = Ann Diagn Pathol \| volume = 18 \| issue = 6 \| pages = 319-25 \| month = Dec \| year = 2014 \| doi = 10.1016/j.anndiagpath.2014.08.006 \| PMID = 25224389 }}</ref> ‡
	**Larger lesions with the same microscopy are ''[[osteoblastoma]]s''.		**Larger lesions with the same microscopy are ''[[osteoblastoma]]s''.

			Note:
			*‡ Previously, the [[diagnostic size cutoffs\|diagnostic size cutoff]] was <=1.5 cm.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4\|286}}</ref>


	Images:		Images:

Michael: +link to main

2013-08-26T21:40:00Z

+link to main

← Older revision		Revision as of 21:40, 26 August 2013
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	\| ClinDDx = [[osteosarcoma]]		\| ClinDDx = [[osteosarcoma]]
	}}		}}
	'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]].		'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]]. It is grouped with the [[chondro-osseous tumours]].

	==General==		==General==

Michael: chg image

2013-08-25T17:07:51Z

chg image

← Older revision		Revision as of 17:07, 25 August 2013
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Osteoid osteoma - ~~very high~~ mag.jpg		\| Image = Osteoid osteoma - low mag.jpg
	\| Width =		\| Width =
	\| Caption = Osteoid osteoma. [[H&E stain]].		\| Caption = Osteoid osteoma. [[H&E stain]].

Michael: /* Gross */

2013-08-25T17:06:41Z

Gross

← Older revision		Revision as of 17:06, 25 August 2013
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	*Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref>		*Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref>
	*Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref>		*Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref>
			*'''Must''' be <=1.5 cm by definition.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4\|286}}</ref>
			**Larger lesions with the same microscopy are ''[[osteoblastoma]]s''.

	Images:		Images:

Michael at 17:04, 25 August 2013

2013-08-25T17:04:54Z

← Older revision		Revision as of 17:04, 25 August 2013
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	\| Prevalence =		\| Prevalence =
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads = <= 1.5 cm (larger lesion [[osteoblastoma]])
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis =

Michael: tweak

2013-08-25T17:03:12Z

tweak

← Older revision		Revision as of 17:03, 25 August 2013
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	\| Width =		\| Width =
	\| Caption = Osteoid osteoma. [[H&E stain]].		\| Caption = Osteoid osteoma. [[H&E stain]].
	\| Micro = anastomosing bony [[trabeculae]] with variable mineralization, ~~osteoblasts~~ rimming, no nuclear atypia of osteocytes		\| Micro = anastomosing bony [[trabeculae]] with variable mineralization, osteoblast rimming, no nuclear atypia of osteocytes
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[osteoblastoma]], [[osteosarcoma]]		\| LMDDx = [[osteoblastoma]], [[osteosarcoma]]
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	**Variable mineralization.		**Variable mineralization.
	***Mineralization (calcium '''p'''hosphate) = '''p'''urple on [[H&E stain]].		***Mineralization (calcium '''p'''hosphate) = '''p'''urple on [[H&E stain]].
	**~~Osteoblasts~~ rimming.		**Osteoblast rimming.
	***Cells line-up at edge of bone.		***Cells line-up at edge of bone.

Michael: split out, +infobox

2013-08-25T17:02:24Z

split out, +infobox

← Older revision		Revision as of 17:02, 25 August 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Osteoid osteoma - very high mag.jpg
			\| Width =
			\| Caption = Osteoid osteoma. [[H&E stain]].
			\| Micro = anastomosing bony [[trabeculae]] with variable mineralization, osteoblasts rimming, no nuclear atypia of osteocytes
			\| Subtypes =
			\| LMDDx = [[osteoblastoma]], [[osteosarcoma]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[bone]] (femur > tibia > spine > elsewhere)
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = pain relieved by [[NSAIDs]]
			\| Signs =
			\| Symptoms = extremely painful
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = [[osteosarcoma]]
			}}
	'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]].		'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]].

Michael: split-out

2013-08-25T16:58:27Z

split-out

← Older revision		Revision as of 16:58, 25 August 2013
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	~~#redirect~~ [[Chondro-osseous tumours~~#Osteoid osteoma~~]]		'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]].

			==General==
			*Benign bone lesion.

			Clinical:<ref name=Ref_Sternberg4_285>{{Ref Sternberg4\|285}}</ref>
			*Extremely painful.
			**Relieved by [[NSAIDs]].

			==Gross==
			*Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref>
			*Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref>

			Images:
			*[http://njms2.umdnj.edu/tutorweb/casegifs/ostostgross.jpg Osteoid osteoma - gross (umdnj.edu)].<ref>URL: [http://njms2.umdnj.edu/tutorweb/gross.htm http://njms2.umdnj.edu/tutorweb/gross.htm]. Accessed on: 7 May 2012.</ref>
			*[http://radiology.uthscsa.edu/CME/ELTXT/OOT/treatment.html Osteoid osteoma (uthscsa.edu)].

			==Microscopic==
			Features:<ref name=Ref_Sternberg4_285>{{Ref Sternberg4\|285}}</ref>
			*Anastomosing bony [[trabeculae]] with:
			**Variable mineralization.
			***Mineralization (calcium '''p'''hosphate) = '''p'''urple on [[H&E stain]].
			**Osteoblasts rimming.
			***Cells line-up at edge of bone.

			Note:
			*Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]'';<ref name=Ref_Sternberg4_286>{{Ref Sternberg4\|286}}</ref> one needs some history to make the diagnosis.

			===Images===
			<gallery>
			Image:Osteoid_osteoma_-_low_mag.jpg \| Osteoid osteoma - low mag. (WC)
			Image:Osteoid osteoma - intermed mag.jpg \| Osteoid osteoma - intermed. mag. (WC)
			Image:Osteoid_osteoma_-_high_mag.jpg \| Osteoid osteoma - high mag. (WC)
			Image:Osteoid osteoma - very high mag.jpg \| Osteoid osteoma - very high mag. (WC)
			</gallery>
			www:
			*[http://library.med.utah.edu/WebPath/COW/COW211.html Osteoid osteoma - CT scan (med.utah.edu)].
			*[http://www.sciencephoto.com/images/imagePopUpDetails.html?pop=1&id=700030210&pviewid=&country=67&search=gschmeissners&matchtype=FUZZY Osteoid osteoma (sciencephoto.com)].

			==Sign out==
			<pre>
			BONE, RIGHT FEMUR, EXCISION:
			- OSTEOID OSTEOMA.
			</pre>

			===Micro===
			The sections show anastomosing bony trabeculae with variable mineralization and osteoblastic rimming. Multinucleated osteoclasts are scattered through the lesion. Hemosiderin-laden macrophages are present. No osteocyte nuclear atypia is apparent. Mitotic activity is not apparent. The osteoid is not lace-like.

			==See also==
			*[[Chondro-osseous tumours]].
			*[[Bone]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Chondro-osseous tumours]]