Oncocytoma of the salivary gland - Revision history

Michael: vauthors -> authors

2021-03-25T17:23:16Z

vauthors -> authors

← Older revision		Revision as of 17:23, 25 March 2021
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	*Associated with radiation exposure.		*Associated with radiation exposure.
	*Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal \| last1 = Zhou \| first1 = CX. \| last2 = Gao \| first2 = Y. \| title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. \| journal = Oral Oncol \| volume = 45 \| issue = 12 \| pages = e232-8 \| month = Dec \| year = 2009 \| doi = 10.1016/j.oraloncology.2009.08.004 \| PMID = 19796983 }}</ref>		*Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal \| last1 = Zhou \| first1 = CX. \| last2 = Gao \| first2 = Y. \| title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. \| journal = Oral Oncol \| volume = 45 \| issue = 12 \| pages = e232-8 \| month = Dec \| year = 2009 \| doi = 10.1016/j.oraloncology.2009.08.004 \| PMID = 19796983 }}</ref>
	*Case report of oncocytoma of parotid as manifestation of [[Birt-Hogg-Dubé syndrome]].<ref name=pmid29971177>{{cite journal \|~~vauthors~~=Yoshida K, Miyagawa M, Kido T, Ide K, Sano Y, Sugawara Y, Takahata H, Monden N, Furuya M, Mochizuki T \|title=Parotid Oncocytoma as a Manifestation of Birt-Hogg-Dubé Syndrome \|journal=Case Rep Radiol \|volume=2018 \|issue= \|pages=6265175 \|date=2018 \|pmid=29971177 \|pmc=6008813 \|doi=10.1155/2018/6265175 \|url=}}</ref>		*Case report of oncocytoma of parotid as manifestation of [[Birt-Hogg-Dubé syndrome]].<ref name=pmid29971177>{{cite journal \|authors=Yoshida K, Miyagawa M, Kido T, Ide K, Sano Y, Sugawara Y, Takahata H, Monden N, Furuya M, Mochizuki T \|title=Parotid Oncocytoma as a Manifestation of Birt-Hogg-Dubé Syndrome \|journal=Case Rep Radiol \|volume=2018 \|issue= \|pages=6265175 \|date=2018 \|pmid=29971177 \|pmc=6008813 \|doi=10.1155/2018/6265175 \|url=}}</ref>

	==Gross==		==Gross==
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	*p63 +ve<ref name=pmid20614263>{{Cite journal \| last1 = McHugh \| first1 = JB. \| last2 = Hoschar \| first2 = AP. \| last3 = Dvorakova \| first3 = M. \| last4 = Parwani \| first4 = AV. \| last5 = Barnes \| first5 = EL. \| last6 = Seethala \| first6 = RR. \| title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. \| journal = Head Neck Pathol \| volume = 1 \| issue = 2 \| pages = 123-31 \| month = Dec \| year = 2007 \| doi = 10.1007/s12105-007-0031-4 \| PMID = 20614263 \| PMC = 2807526}}</ref> focally in nucleus.		*p63 +ve<ref name=pmid20614263>{{Cite journal \| last1 = McHugh \| first1 = JB. \| last2 = Hoschar \| first2 = AP. \| last3 = Dvorakova \| first3 = M. \| last4 = Parwani \| first4 = AV. \| last5 = Barnes \| first5 = EL. \| last6 = Seethala \| first6 = RR. \| title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. \| journal = Head Neck Pathol \| volume = 1 \| issue = 2 \| pages = 123-31 \| month = Dec \| year = 2007 \| doi = 10.1007/s12105-007-0031-4 \| PMID = 20614263 \| PMC = 2807526}}</ref> focally in nucleus.
	*DOG1 -ve.<ref name=pmid26425134>{{Cite journal \| last1 = Canberk \| first1 = S. \| last2 = Onenerk \| first2 = M. \| last3 = Sayman \| first3 = E. \| last4 = Goret \| first4 = CC. \| last5 = Erkan \| first5 = M. \| last6 = Atasoy \| first6 = T. \| last7 = Kilicoglu \| first7 = GZ. \| title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. \| journal = Cytojournal \| volume = 12 \| issue = \| pages = 18 \| month = \| year = 2015 \| doi = 10.4103/1742-6413.162774 \| PMID = 26425134 }}</ref>		*DOG1 -ve.<ref name=pmid26425134>{{Cite journal \| last1 = Canberk \| first1 = S. \| last2 = Onenerk \| first2 = M. \| last3 = Sayman \| first3 = E. \| last4 = Goret \| first4 = CC. \| last5 = Erkan \| first5 = M. \| last6 = Atasoy \| first6 = T. \| last7 = Kilicoglu \| first7 = GZ. \| title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. \| journal = Cytojournal \| volume = 12 \| issue = \| pages = 18 \| month = \| year = 2015 \| doi = 10.4103/1742-6413.162774 \| PMID = 26425134 }}</ref>
	*PAX8 -ve.<ref name=pmid24771139>{{cite journal \|~~vauthors~~=Butler RT, Alderman MA, Thompson LD, McHugh JB \|title=Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms \|journal=Head Neck Pathol \|volume=9 \|issue=1 \|pages=47–50 \|date=March 2015 \|pmid=24771139 \|pmc=4382472 \|doi=10.1007/s12105-014-0546-4 \|url=}}</ref>		*PAX8 -ve.<ref name=pmid24771139>{{cite journal \|authors=Butler RT, Alderman MA, Thompson LD, McHugh JB \|title=Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms \|journal=Head Neck Pathol \|volume=9 \|issue=1 \|pages=47–50 \|date=March 2015 \|pmid=24771139 \|pmc=4382472 \|doi=10.1007/s12105-014-0546-4 \|url=}}</ref>

	==EM==		==EM==

Michael: /* IHC */

2021-02-10T18:19:40Z

IHC

← Older revision		Revision as of 18:19, 10 February 2021
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	*p63 +ve<ref name=pmid20614263>{{Cite journal \| last1 = McHugh \| first1 = JB. \| last2 = Hoschar \| first2 = AP. \| last3 = Dvorakova \| first3 = M. \| last4 = Parwani \| first4 = AV. \| last5 = Barnes \| first5 = EL. \| last6 = Seethala \| first6 = RR. \| title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. \| journal = Head Neck Pathol \| volume = 1 \| issue = 2 \| pages = 123-31 \| month = Dec \| year = 2007 \| doi = 10.1007/s12105-007-0031-4 \| PMID = 20614263 \| PMC = 2807526}}</ref> focally in nucleus.		*p63 +ve<ref name=pmid20614263>{{Cite journal \| last1 = McHugh \| first1 = JB. \| last2 = Hoschar \| first2 = AP. \| last3 = Dvorakova \| first3 = M. \| last4 = Parwani \| first4 = AV. \| last5 = Barnes \| first5 = EL. \| last6 = Seethala \| first6 = RR. \| title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. \| journal = Head Neck Pathol \| volume = 1 \| issue = 2 \| pages = 123-31 \| month = Dec \| year = 2007 \| doi = 10.1007/s12105-007-0031-4 \| PMID = 20614263 \| PMC = 2807526}}</ref> focally in nucleus.
	*DOG1 -ve.<ref name=pmid26425134>{{Cite journal \| last1 = Canberk \| first1 = S. \| last2 = Onenerk \| first2 = M. \| last3 = Sayman \| first3 = E. \| last4 = Goret \| first4 = CC. \| last5 = Erkan \| first5 = M. \| last6 = Atasoy \| first6 = T. \| last7 = Kilicoglu \| first7 = GZ. \| title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. \| journal = Cytojournal \| volume = 12 \| issue = \| pages = 18 \| month = \| year = 2015 \| doi = 10.4103/1742-6413.162774 \| PMID = 26425134 }}</ref>		*DOG1 -ve.<ref name=pmid26425134>{{Cite journal \| last1 = Canberk \| first1 = S. \| last2 = Onenerk \| first2 = M. \| last3 = Sayman \| first3 = E. \| last4 = Goret \| first4 = CC. \| last5 = Erkan \| first5 = M. \| last6 = Atasoy \| first6 = T. \| last7 = Kilicoglu \| first7 = GZ. \| title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. \| journal = Cytojournal \| volume = 12 \| issue = \| pages = 18 \| month = \| year = 2015 \| doi = 10.4103/1742-6413.162774 \| PMID = 26425134 }}</ref>
			*PAX8 -ve.<ref name=pmid24771139>{{cite journal \|vauthors=Butler RT, Alderman MA, Thompson LD, McHugh JB \|title=Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms \|journal=Head Neck Pathol \|volume=9 \|issue=1 \|pages=47–50 \|date=March 2015 \|pmid=24771139 \|pmc=4382472 \|doi=10.1007/s12105-014-0546-4 \|url=}}</ref>

	==EM==		==EM==

Michael: /* Microscopic */

2021-02-10T18:15:55Z

Microscopic

← Older revision		Revision as of 18:15, 10 February 2021
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	DDx:		DDx:
	*[[Warthin tumour]].		*[[Warthin tumour]] - have lymphocytes, classical bilayer.
	*[[Acinic cell carcinoma]].		*[[Acinic cell carcinoma]].
	*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]].		*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]].

Michael: /* Microscopic */ +WT

2021-02-10T18:07:50Z

Microscopic: +WT

← Older revision		Revision as of 18:07, 10 February 2021
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	DDx:		DDx:
			*[[Warthin tumour]].
	*[[Acinic cell carcinoma]].		*[[Acinic cell carcinoma]].
	*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]].		*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]].

Michael: /* General */ +BHD syndrome

2021-02-10T18:04:31Z

General: +BHD syndrome

← Older revision		Revision as of 18:04, 10 February 2021
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	*Associated with radiation exposure.		*Associated with radiation exposure.
	*Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal \| last1 = Zhou \| first1 = CX. \| last2 = Gao \| first2 = Y. \| title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. \| journal = Oral Oncol \| volume = 45 \| issue = 12 \| pages = e232-8 \| month = Dec \| year = 2009 \| doi = 10.1016/j.oraloncology.2009.08.004 \| PMID = 19796983 }}</ref>		*Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal \| last1 = Zhou \| first1 = CX. \| last2 = Gao \| first2 = Y. \| title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. \| journal = Oral Oncol \| volume = 45 \| issue = 12 \| pages = e232-8 \| month = Dec \| year = 2009 \| doi = 10.1016/j.oraloncology.2009.08.004 \| PMID = 19796983 }}</ref>
			*Case report of oncocytoma of parotid as manifestation of [[Birt-Hogg-Dubé syndrome]].<ref name=pmid29971177>{{cite journal \|vauthors=Yoshida K, Miyagawa M, Kido T, Ide K, Sano Y, Sugawara Y, Takahata H, Monden N, Furuya M, Mochizuki T \|title=Parotid Oncocytoma as a Manifestation of Birt-Hogg-Dubé Syndrome \|journal=Case Rep Radiol \|volume=2018 \|issue= \|pages=6265175 \|date=2018 \|pmid=29971177 \|pmc=6008813 \|doi=10.1155/2018/6265175 \|url=}}</ref>

	==Gross==		==Gross==

Michael: /* EM */

2016-04-12T12:11:21Z

← Older revision		Revision as of 12:11, 12 April 2016
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	*Increased numbers of mitochondria.		*Increased numbers of mitochondria.

	:
	~~The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated.~~
	==Sign out==		==Sign out==
	<pre>		<pre>

Michael: /* Sign out= */

2016-04-12T12:09:29Z

Sign out=

← Older revision		Revision as of 12:09, 12 April 2016
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	:		:
	The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated.		The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated.
	=Sign out==		==Sign out==
	<pre>		<pre>
	Nodule, Right Parotid Gland, Core Biopsy:		Nodule, Right Parotid Gland, Core Biopsy:

Michael: /* Sign out */ tweak

2016-04-12T12:09:05Z

Sign out: tweak

← Older revision		Revision as of 12:09, 12 April 2016
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	*Increased numbers of mitochondria.		*Increased numbers of mitochondria.

	==Sign out==		:
			The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated.
			=Sign out==
	<pre>		<pre>
	Nodule, Right Parotid Gland, Core Biopsy:		Nodule, Right Parotid Gland, Core Biopsy:
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	Comment:		Comment:
	The ~~sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated.~~		The tumour stains as follows:

	~~The cells in the biopsy stain~~ as follows:
	POSITIVE: p63 (focal, nuclear).		POSITIVE: p63 (focal, nuclear).
	NEGATIVE: CD10, RCC, S-100, CD68, vimentin.		NEGATIVE: CD10, RCC, S-100, CD68, vimentin.
	</pre>		</pre>

			===Micro===
			The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is absent.

	==See also==		==See also==

Michael at 18:38, 11 April 2016

2016-04-11T18:38:19Z

← Older revision		Revision as of 18:38, 11 April 2016
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	\| Prevalence = very rare		\| Prevalence = very rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads = ~~blend~~ with normal salivary gland on T1 postcontrast and fat-saturated T2 MR images		\| Rads = blends with normal salivary gland on T1 postcontrast and fat-saturated T2 MR images
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = benign		\| Prognosis = benign

Michael at 18:33, 11 April 2016

2016-04-11T18:33:36Z

← Older revision		Revision as of 18:33, 11 April 2016
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	==EM==		==EM==
	*Increased numbers of mitochondria.		*Increased numbers of mitochondria.

			==Sign out==
			<pre>
			Nodule, Right Parotid Gland, Core Biopsy:
			- ONCOCYTOMA.

			Comment:
			The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is not appreciated.

			The cells in the biopsy stain as follows:
			POSITIVE: p63 (focal, nuclear).
			NEGATIVE: CD10, RCC, S-100, CD68, vimentin.
			</pre>

	==See also==		==See also==