Olfactory neuroblastoma - Revision history

Michael at 15:31, 17 October 2024

2024-10-17T15:31:46Z

← Older revision		Revision as of 15:31, 17 October 2024
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	[[Category:Head and neck pathology]]		[[Category:Head and neck pathology]]
	[[~~Categorgy~~:Neuropathology]]		[[Category:Neuropathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael at 15:29, 17 October 2024

2024-10-17T15:29:54Z

← Older revision		Revision as of 15:29, 17 October 2024
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	==IHC==		==IHC==
			*[[Neuroendocrine markers]]:<ref name=pmid36452592>{{cite journal \|vauthors=Rao KR, Upadhya IB \|title=A Review on Esthesioneuroblastoma \|journal=Indian J Otolaryngol Head Neck Surg \|volume=74 \|issue=Suppl 2 \|pages=1584–1590 \|date=October 2022 \|pmid=36452592 \|pmc=9702120 \|doi=10.1007/s12070-021-02726-2 \|url=}}</ref>
			**CD56 +ve.
			**Synaptophysin +ve.
			**Chromogranin A +ve.
			**NSE +ve.
			***Lower expression of neuroendocrine markers in IDH2 mutant tumors.{{fact}}
	*S-100:		*S-100:
	**Small round cells -ve.		**Small round cells -ve.
	**Sustentacular cells +ve.		**Sustentacular cells +ve.
	***Neuronal ONB subtype is enriched for the presence of S100 sustentacular cells.		***Neuronal ONB subtype is enriched for the presence of S100 sustentacular cells.
	*[[Neuroendocrine markers]] +ve (CD56, synaptophysin).
	**lower expression of neuroendocrine markers in IDH2 mutant tumors.

	Others:		Others:
	*CD45 -ve (r/o [[lymphoma]]).		*CD45 -ve (r/o [[lymphoma]]).
	*AE1/AE3 ~~usu.~~ -ve (r/~~o carcinoma~~).		*AE1/AE3 usually -ve (~1/3 are +ve<ref name=pmid36452592/>).
	*CAM5.2 usu. -ve -- up to 35% +ve.<ref name=Ref_WMSP41>{{Ref WMSP\|41}}</ref>		*CAM5.2 usu. -ve -- up to 35% +ve.<ref name=Ref_WMSP41>{{Ref WMSP\|41}}</ref>
	**Higher expression of cytokeratins in IDH2 mutant tumors.		**Higher expression of cytokeratins in IDH2 mutant tumors.

Michael at 15:22, 17 October 2024

2024-10-17T15:22:35Z

← Older revision		Revision as of 15:22, 17 October 2024
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	+/-Flexner-Wintersteiner [[rosette]] (rosette with empty centre), +/-Fibrillary, eosinophilic material (neuropil-like)		+/-Flexner-Wintersteiner [[rosette]] (rosette with empty centre), +/-Fibrillary, eosinophilic material (neuropil-like)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = other small round blue cell tumours, e.g. [[small cell carcinoma of the lung]], large cell lymphoma (e.g. [[DLBCL]]), basaloid squamous cell carcinoma		\| LMDDx = other small round blue cell tumours (e.g. [[small cell carcinoma of the lung]]), large cell lymphoma (e.g. [[DLBCL]]), basaloid squamous cell carcinoma
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael at 15:22, 17 October 2024

2024-10-17T15:22:06Z

← Older revision		Revision as of 15:22, 17 October 2024
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	+/-Flexner-Wintersteiner [[rosette]] (rosette with empty centre), +/-Fibrillary, eosinophilic material (neuropil-like)		+/-Flexner-Wintersteiner [[rosette]] (rosette with empty centre), +/-Fibrillary, eosinophilic material (neuropil-like)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = other small round blue cell tumours, e.g. [[small cell carcinoma of the lung]], basaloid squamous cell carcinoma		\| LMDDx = other small round blue cell tumours, e.g. [[small cell carcinoma of the lung]], large cell lymphoma (e.g. [[DLBCL]]), basaloid squamous cell carcinoma
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael at 15:21, 17 October 2024

2024-10-17T15:21:18Z

← Older revision		Revision as of 15:21, 17 October 2024
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Esthesioneuroblastoma HE.jpg
			\| Width =
			\| Caption = Olfactory neuroblastoma
			\| Synonyms =
			\| Micro = [[Small round cell tumour\|small round (blue) cell tumour]] (stippled chromatin, high NC ratio),
			+/-Flexner-Wintersteiner [[rosette]] (rosette with empty centre), +/-Fibrillary, eosinophilic material (neuropil-like)
			\| Subtypes =
			\| LMDDx = other small round blue cell tumours, e.g. [[small cell carcinoma of the lung]], basaloid squamous cell carcinoma
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site =
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Olfactory neuroblastoma''', also known as '''esthesioneuroblastoma''', is a rare aggressive tumour of the [[head and neck pathology\|head and neck]].		'''Olfactory neuroblastoma''', also known as '''esthesioneuroblastoma''', is a rare aggressive tumour of the [[head and neck pathology\|head and neck]].

Jensflorian: /* IHC */ S-100 in neuronal ONB

2019-10-22T06:53:10Z

IHC: S-100 in neuronal ONB

← Older revision		Revision as of 06:53, 22 October 2019
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	==IHC==		==IHC==
	*S-100:		*S-100:
			**Small round cells -ve.
	**Sustentacular cells +ve.		**Sustentacular cells +ve.
	**~~Small round~~ cells ~~-ve~~.		***Neuronal ONB subtype is enriched for the presence of S100 sustentacular cells.
	*[[Neuroendocrine markers]] +ve (CD56, synaptophysin).		*[[Neuroendocrine markers]] +ve (CD56, synaptophysin).
	**lower expression of neuroendocrine markers in IDH2 mutant tumors.		**lower expression of neuroendocrine markers in IDH2 mutant tumors.

Jensflorian: /* Microscopic */ Images added

2019-10-22T06:51:11Z

Microscopic: Images added

← Older revision		Revision as of 06:51, 22 October 2019
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	*[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref>		*[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/figure/Fig6/ Olfactory neuroblastoma (nih.gov)].<ref name=pmid20596981/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/figure/Fig6/ Olfactory neuroblastoma (nih.gov)].<ref name=pmid20596981/>

			<gallery>
			File:Esthesioneuroblastoma HE.jpg \| Olfactory neuroblastoma (H&E).
			File:Olfactory neuroblastoma.jpg \| Olfactory neuroblastoma (AFIP).
			File:Esthesioneuroblastoma.jpg \| Sustenticular cells in ONB (AFIP).
			</gallery>

	==IHC==		==IHC==

Jensflorian: cat

2019-10-22T06:48:45Z

cat

← Older revision		Revision as of 06:48, 22 October 2019
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	[[Category:Head and neck pathology]]		[[Category:Head and neck pathology]]
			[[Categorgy:Neuropathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Jensflorian: /* Molecular */ corr

2019-10-22T06:48:17Z

Molecular: corr

← Older revision		Revision as of 06:48, 22 October 2019
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	==Molecular==		==Molecular==
	* Two major subgroups.<ref>{{Cite journal \| last1 = Capper \| first1 = D. \| last2 = Engel \| first2 = NW. \| last3 = Stichel \| first3 = D. \| last4 = Lechner \| first4 = M. \| last5 = Glöss \| first5 = S. \| last6 = Schmid \| first6 = S. \| last7 = Koelsche \| first7 = C. \| last8 = Schrimpf \| first8 = D. \| last9 = Niesen \| first9 = J. \| title = DNA methylation-based reclassification of olfactory neuroblastoma. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 255-271 \| month = 08 \| year = 2018 \| doi = 10.1007/s00401-018-1854-7 \| PMID = 29730775 }}</ref><ref>{{Cite journal \| last1 = Classe \| first1 = M. \| last2 = Yao \| first2 = H. \| last3 = Mouawad \| first3 = R. \| last4 = Creighton \| first4 = CJ. \| last5 = Burgess \| first5 = A. \| last6 = Allanic \| first6 = F. \| last7 = Wassef \| first7 = M. \| last8 = Leroy \| first8 = X. \| last9 = Verillaud \| first9 = B. \| title = Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. \| journal = Cell Rep \| volume = 25 \| issue = 3 \| pages = 811-821.e5 \| month = 10 \| year = 2018 \| doi = 10.1016/j.celrep.2018.09.047 \| PMID = 30332658 }}</ref>		* Two major subgroups.<ref>{{Cite journal \| last1 = Capper \| first1 = D. \| last2 = Engel \| first2 = NW. \| last3 = Stichel \| first3 = D. \| last4 = Lechner \| first4 = M. \| last5 = Glöss \| first5 = S. \| last6 = Schmid \| first6 = S. \| last7 = Koelsche \| first7 = C. \| last8 = Schrimpf \| first8 = D. \| last9 = Niesen \| first9 = J. \| title = DNA methylation-based reclassification of olfactory neuroblastoma. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 255-271 \| month = 08 \| year = 2018 \| doi = 10.1007/s00401-018-1854-7 \| PMID = 29730775 }}</ref><ref>{{Cite journal \| last1 = Classe \| first1 = M. \| last2 = Yao \| first2 = H. \| last3 = Mouawad \| first3 = R. \| last4 = Creighton \| first4 = CJ. \| last5 = Burgess \| first5 = A. \| last6 = Allanic \| first6 = F. \| last7 = Wassef \| first7 = M. \| last8 = Leroy \| first8 = X. \| last9 = Verillaud \| first9 = B. \| title = Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. \| journal = Cell Rep \| volume = 25 \| issue = 3 \| pages = 811-821.e5 \| month = 10 \| year = 2018 \| doi = 10.1016/j.celrep.2018.09.047 \| PMID = 30332658 }}</ref>
	**Classical ("~~basal~~").		**Classical ("neural").
	**~~Neural~~: G-CIMP+ve with frequent IDH2 R172 mutations.		**Basal: G-CIMP+ve with frequent IDH2 R172 mutations.

	==See also==		==See also==

Jensflorian: /* Molecular */ Two major groups

2019-10-22T06:44:52Z

Molecular: Two major groups

← Older revision		Revision as of 06:44, 22 October 2019
Line 51:		Line 51:
	==Molecular==		==Molecular==
	* Two major subgroups.<ref>{{Cite journal \| last1 = Capper \| first1 = D. \| last2 = Engel \| first2 = NW. \| last3 = Stichel \| first3 = D. \| last4 = Lechner \| first4 = M. \| last5 = Glöss \| first5 = S. \| last6 = Schmid \| first6 = S. \| last7 = Koelsche \| first7 = C. \| last8 = Schrimpf \| first8 = D. \| last9 = Niesen \| first9 = J. \| title = DNA methylation-based reclassification of olfactory neuroblastoma. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 255-271 \| month = 08 \| year = 2018 \| doi = 10.1007/s00401-018-1854-7 \| PMID = 29730775 }}</ref><ref>{{Cite journal \| last1 = Classe \| first1 = M. \| last2 = Yao \| first2 = H. \| last3 = Mouawad \| first3 = R. \| last4 = Creighton \| first4 = CJ. \| last5 = Burgess \| first5 = A. \| last6 = Allanic \| first6 = F. \| last7 = Wassef \| first7 = M. \| last8 = Leroy \| first8 = X. \| last9 = Verillaud \| first9 = B. \| title = Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. \| journal = Cell Rep \| volume = 25 \| issue = 3 \| pages = 811-821.e5 \| month = 10 \| year = 2018 \| doi = 10.1016/j.celrep.2018.09.047 \| PMID = 30332658 }}</ref>		* Two major subgroups.<ref>{{Cite journal \| last1 = Capper \| first1 = D. \| last2 = Engel \| first2 = NW. \| last3 = Stichel \| first3 = D. \| last4 = Lechner \| first4 = M. \| last5 = Glöss \| first5 = S. \| last6 = Schmid \| first6 = S. \| last7 = Koelsche \| first7 = C. \| last8 = Schrimpf \| first8 = D. \| last9 = Niesen \| first9 = J. \| title = DNA methylation-based reclassification of olfactory neuroblastoma. \| journal = Acta Neuropathol \| volume = 136 \| issue = 2 \| pages = 255-271 \| month = 08 \| year = 2018 \| doi = 10.1007/s00401-018-1854-7 \| PMID = 29730775 }}</ref><ref>{{Cite journal \| last1 = Classe \| first1 = M. \| last2 = Yao \| first2 = H. \| last3 = Mouawad \| first3 = R. \| last4 = Creighton \| first4 = CJ. \| last5 = Burgess \| first5 = A. \| last6 = Allanic \| first6 = F. \| last7 = Wassef \| first7 = M. \| last8 = Leroy \| first8 = X. \| last9 = Verillaud \| first9 = B. \| title = Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. \| journal = Cell Rep \| volume = 25 \| issue = 3 \| pages = 811-821.e5 \| month = 10 \| year = 2018 \| doi = 10.1016/j.celrep.2018.09.047 \| PMID = 30332658 }}</ref>
	**Classical.		**Classical ("basal").
	**G-CIMP +ve with frequent IDH2 R172 mutations.		**Neural: G-CIMP+ve with frequent IDH2 R172 mutations.

	==See also==		==See also==