Non-small cell lung cancer - Revision history

Michael: Redirected page to Non-small cell lung carcinoma

2014-04-09T01:41:14Z

Redirected page to Non-small cell lung carcinoma

← Older revision		Revision as of 01:41, 9 April 2014
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	~~'''Non-small cell [[lung]] cancer''', abbreviated '''NSCLC''', is a malignant neoplasm of the lung that is ''not'' [[small cell carcinoma of the lung]].~~		#redirect [[Non-small cell lung carcinoma]]

	It can be understood as a synonym for '''large cell carcinoma''' and '''non-small cell lung carcinoma'''. It is umbrella term that includes [[squamous cell carcinoma of lung]], [[adenocarcinoma of the lung]] and [[adenosquamous carcinoma of the lung]].<ref>{{Cite journal \| last1 = Song \| first1 = Z. \| last2 = Lin \| first2 = B. \| last3 = Shao \| first3 = L. \| last4 = Zhang \| first4 = Y. \| title = Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinoma. \| journal = J Chin Med Assoc \| volume = 76 \| issue = 9 \| pages = 481-5 \| month = Sep \| year = 2013 \| doi = 10.1016/j.jcma.2013.05.007 \| PMID = 23769878 }}</ref>

	~~==General==~~
	*''Non-small cell lung carcinoma~~'' can be considered a [[waffle diagnosis]] and as such its use should be limited.~~
	**It is preferable to be more specific if this is possible, i.e. call ''adenocarcinoma'' or ''squamous cell carcinoma''.
	*Historically, it was sufficient to differentiate between [[small cell carcinoma of the lung\|small cell]] and non-small cell carcinomas, as the treatment for all non-small cell lung carcinomas was the same.

	~~==Microscopic==~~
	~~Features:~~
	*Large cells with abundant cytoplasm.
	*+/-[[Nucleoli]].
	*No stippled chromatin.
	**This suggests the ''large cell variant of small cell carcinoma''.

	~~DDx:~~
	*[[Squamous cell carcinoma of the lung]].
	*[[Adenocarcinoma of the lung]].
	*[[Small cell carcinoma of the lung]].
	*Large cell variant of [[small cell carcinoma of the lung]].

	~~==IHC==~~
	Sloan-Kettering algorithm - Rekhtman ''et al.'':<ref name=pmid21623384>{{Cite journal \| last1 = Rekhtman \| first1 = N. \| last2 = Ang \| first2 = DC. \| last3 = Sima \| first3 = CS. \| last4 = Travis \| first4 = WD. \| last5 = Moreira \| first5 = AL. \| title = Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens. \| journal = Mod Pathol \| volume = 24 \| issue = 10 \| pages = 1348-59 \| month = Oct \| year = 2011 \| doi = 10.1038/modpathol.2011.92 \| PMID = 21623384 }}</ref>
	~~{\| class="wikitable sortable"~~
	~~! TTF-1\p63~~
	~~! p63 -ve (0% of cells)~~
	~~! p63 +ve <50% of cells~~
	~~! p63 +ve >=50% of cells~~
	\|-
	~~\| TTF-1 +ve >=50% of cells~~
	~~\| [[adenocarcinoma of the lung\|Adenocarcinoma]]~~
	~~\| Adenocarcinoma~~
	~~\| Adenocarcinoma~~
	\|-
	~~\| TTF-1 +ve <50% of cells~~
	~~\| Adenocarcinoma~~
	~~\| Adenocarcinoma~~
	~~\| [[Lung SCC\|Squamous carcinoma]]~~
	\|-
	~~\| TTF-1 -ve (0% of cells)~~
	~~\| Adenocarcinoma~~
	~~\| CK5/6 to determine~~
	~~\| Squamous carcinoma~~
	\|}

	~~==See also==~~
	*[[Lung tumours]].

	~~==References==~~
	~~{{Reflist\|1}}~~

	~~[[Category:Pulmonary pathology~~]]

Michael: /* IHC */

2014-04-09T01:35:12Z

IHC

← Older revision		Revision as of 01:35, 9 April 2014
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	\|-		\|-
	\| TTF-1 +ve >=50% of cells		\| TTF-1 +ve >=50% of cells
	\| Adenocarcinoma		\| [[adenocarcinoma of the lung\|Adenocarcinoma]]
	\| Adenocarcinoma		\| Adenocarcinoma
	\| Adenocarcinoma		\| Adenocarcinoma
Line 37:		Line 37:
	\| Adenocarcinoma		\| Adenocarcinoma
	\| Adenocarcinoma		\| Adenocarcinoma
	\| Squamous carcinoma		\| [[Lung SCC\|Squamous carcinoma]]
	\|-		\|-
	\| TTF-1 -ve (0% of cells)		\| TTF-1 -ve (0% of cells)
Line 43:		Line 43:
	\| CK5/6 to determine		\| CK5/6 to determine
	\| Squamous carcinoma		\| Squamous carcinoma
	\|}		\|}

	==See also==		==See also==

Michael at 01:33, 9 April 2014

2014-04-09T01:33:40Z

← Older revision		Revision as of 01:33, 9 April 2014
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	~~#redirect~~ [[Non-small cell lung carcinoma]]		'''Non-small cell [[lung]] cancer''', abbreviated '''NSCLC''', is a malignant neoplasm of the lung that is ''not'' [[small cell carcinoma of the lung]].

			It can be understood as a synonym for '''large cell carcinoma''' and '''non-small cell lung carcinoma'''. It is umbrella term that includes [[squamous cell carcinoma of lung]], [[adenocarcinoma of the lung]] and [[adenosquamous carcinoma of the lung]].<ref>{{Cite journal \| last1 = Song \| first1 = Z. \| last2 = Lin \| first2 = B. \| last3 = Shao \| first3 = L. \| last4 = Zhang \| first4 = Y. \| title = Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinoma. \| journal = J Chin Med Assoc \| volume = 76 \| issue = 9 \| pages = 481-5 \| month = Sep \| year = 2013 \| doi = 10.1016/j.jcma.2013.05.007 \| PMID = 23769878 }}</ref>

			==General==
			*''Non-small cell lung carcinoma'' can be considered a [[waffle diagnosis]] and as such its use should be limited.
			**It is preferable to be more specific if this is possible, i.e. call ''adenocarcinoma'' or ''squamous cell carcinoma''.
			*Historically, it was sufficient to differentiate between [[small cell carcinoma of the lung\|small cell]] and non-small cell carcinomas, as the treatment for all non-small cell lung carcinomas was the same.

			==Microscopic==
			Features:
			*Large cells with abundant cytoplasm.
			*+/-[[Nucleoli]].
			*No stippled chromatin.
			**This suggests the ''large cell variant of small cell carcinoma''.

			DDx:
			*[[Squamous cell carcinoma of the lung]].
			*[[Adenocarcinoma of the lung]].
			*[[Small cell carcinoma of the lung]].
			*Large cell variant of [[small cell carcinoma of the lung]].

			==IHC==
			Sloan-Kettering algorithm - Rekhtman ''et al.'':<ref name=pmid21623384>{{Cite journal \| last1 = Rekhtman \| first1 = N. \| last2 = Ang \| first2 = DC. \| last3 = Sima \| first3 = CS. \| last4 = Travis \| first4 = WD. \| last5 = Moreira \| first5 = AL. \| title = Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens. \| journal = Mod Pathol \| volume = 24 \| issue = 10 \| pages = 1348-59 \| month = Oct \| year = 2011 \| doi = 10.1038/modpathol.2011.92 \| PMID = 21623384 }}</ref>
			{\| class="wikitable sortable"
			! TTF-1\p63
			! p63 -ve (0% of cells)
			! p63 +ve <50% of cells
			! p63 +ve >=50% of cells
			\|-
			\| TTF-1 +ve >=50% of cells
			\| Adenocarcinoma
			\| Adenocarcinoma
			\| Adenocarcinoma
			\|-
			\| TTF-1 +ve <50% of cells
			\| Adenocarcinoma
			\| Adenocarcinoma
			\| Squamous carcinoma
			\|-
			\| TTF-1 -ve (0% of cells)
			\| Adenocarcinoma
			\| CK5/6 to determine
			\| Squamous carcinoma
			\|}

			==See also==
			*[[Lung tumours]].

			==References==
			{{Reflist\|1}}

			[[Category:Pulmonary pathology]]

Michael: redirect

2014-04-09T01:29:50Z

redirect

New page

#redirect [[Non-small cell lung carcinoma]]