Non-invasive breast carcinoma - Revision history

Michael: /* Lobular carcinoma in situ */

2017-01-23T05:36:03Z

Lobular carcinoma in situ

← Older revision		Revision as of 05:36, 23 January 2017
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	===IHC===		===IHC===
	*E-cadherin -ve ''or'' incomplete membrane staining.		*[[E-cadherin]] -ve ''or'' incomplete membrane staining.
	*p120 catenin +ve cytoplasmic.<ref name="Sarrió-2004">{{Cite journal \| last1 = Sarrió \| first1 = D. \| last2 = Pérez-Mies \| first2 = B. \| last3 = Hardisson \| first3 = D. \| last4 = Moreno-Bueno \| first4 = G. \| last5 = Suárez \| first5 = A. \| last6 = Cano \| first6 = A. \| last7 = Martín-Pérez \| first7 = J. \| last8 = Gamallo \| first8 = C. \| last9 = Palacios \| first9 = J. \| title = Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. \| journal = Oncogene \| volume = 23 \| issue = 19 \| pages = 3272-83 \| month = Apr \| year = 2004 \| doi = 10.1038/sj.onc.1207439 \| PMID = 15077190 }}</ref>		*p120 catenin +ve cytoplasmic.<ref name="Sarrió-2004">{{Cite journal \| last1 = Sarrió \| first1 = D. \| last2 = Pérez-Mies \| first2 = B. \| last3 = Hardisson \| first3 = D. \| last4 = Moreno-Bueno \| first4 = G. \| last5 = Suárez \| first5 = A. \| last6 = Cano \| first6 = A. \| last7 = Martín-Pérez \| first7 = J. \| last8 = Gamallo \| first8 = C. \| last9 = Palacios \| first9 = J. \| title = Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. \| journal = Oncogene \| volume = 23 \| issue = 19 \| pages = 3272-83 \| month = Apr \| year = 2004 \| doi = 10.1038/sj.onc.1207439 \| PMID = 15077190 }}</ref>
	**Membranous staining in DCIS.		**Membranous staining in DCIS.

Michael: /* Atypical lobular hyperplasia */ split out

2016-11-28T05:39:36Z

Atypical lobular hyperplasia: split out

← Older revision		Revision as of 05:39, 28 November 2016
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	==Atypical lobular hyperplasia==		==Atypical lobular hyperplasia==
	*Abbreviated ''ALH''.		*Abbreviated ''ALH''.
			{{Main\|Atypical lobular hyperplasia}}
	~~===General===~~
	*May occur with ''ductal involvement by cells of atypical lobular hyperplasia'' (abbreviated ''DIALH'').<ref name=pmid3343034>{{~~Cite journal~~ \| ~~last1 = Page \| first1 = DL. \| last2 = Dupont \| first2 = WD. \| last3 = Rogers \| first3 = LW. \| title = Ductal involvement by cells of atypical~~ lobular hyperplasia ~~in the breast: a long-term follow-up study of cancer risk. \| journal = Hum Pathol \| volume = 19 \| issue = 2 \| pages = 201-7 \| month = Feb \| year = 1988 \| doi = \| PMID = 3343034~~ }}~~</ref>~~
	**ALH with DIALH has a risk of developing breast cancer that is similar to [[LCIS]].

	~~===Microscopic===~~
	~~Features:~~
	*Extent criterium: <50% of terminal duct lobular unit (TDLU) is involved.
	*See ''[[lobular carcinoma in situ]]'' for details.

	~~DDx:~~
	*[[Lobular carcinoma in situ]].
	*[[Lobular carcinoma]].

	~~===IHC===~~
	*E-cadherin -ve ''or'' incomplete membrane staining.

	==Lobular carcinoma in situ==		==Lobular carcinoma in situ==

Michael: /* Ductal carcinoma in situ */ split out

2016-05-01T04:00:47Z

Ductal carcinoma in situ: split out

← Older revision		Revision as of 04:00, 1 May 2016
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	==Ductal carcinoma in situ==		==Ductal carcinoma in situ==
	*Abbreviated ''DCIS''.		*Abbreviated ''DCIS''.
	~~===General===~~		{{Main\|Ductal carcinoma in situ}}
	*Diagnosis based on nuclear abnormalities ''and/or'' architecture.
	**Low-grade DCIS does '''not''' have a malignant cytology.
	*It is typically picked-up during radiologic screening.

	~~===Microscopic===~~
	~~Features:~~
	*Architectural changes:
	**Equal spacing of cells - "cookie cutter" look.
	**Cells line-up along lumen/glandular spaces - form "Roman briges".
	**Architecture suggestive of DCIS - see ''[[Subtypes of DCIS]]''.
	*Nuclear changes:
	**Nuclear enlargement - at least 2-3x size of [[RBC]] - '''key feature'''.
	***Compared to RBCs to grade DCIS - see ''[[Grading DCIS]]''.
	****Compare sizes of nuclei if you cannot find RBCs.
	**Nuclear pleomorphism - important feature.
	*+/-Mitoses.

	~~Note:~~
	*Apocrine changes of cytoplasm -- several sets of criteria exist -- any of the following:
	*#Nuclei should be ~4x RBC for low grade, 5x RBC for high grade.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html]. Accessed on: 4 August 2011.</ref>
	*#Nuclear enlargement of 3x +/- nucleolar enlargement.<ref name=pmid18171412/>
	*#Multiple nucleoli + nuclear size variation.<ref name=pmid18171412>{{~~Cite journal~~ \| last1 = O'Malley \| first1 = FP. \| last2 = Bane \| first2 = A. \| title = An update on apocrine lesions of the breast. \| journal = Histopathology \| volume = 52 \| issue = 1 \| pages = 3-10 \| month = Jan \| year = 2008 \| doi = 10.1111/j.1365-2559.2007.02888.x \| PMID = 18171412 }}</ref>

	~~====Subtypes of DCIS====~~
	~~The subtypes are based on architecture.~~

	~~Note:~~
	*''Comedonecrosis'' used to be considered a separate subtype. [[Necrosis]] is seen most often in the context of ''solid ductal carcinoma in situ''.
	~~=====Solid ductal carcinoma in situ=====~~
	~~Features:~~
	*Sheet of cells fills the duct
	*No spaces between cells.

	~~<gallery>~~
	~~Image:Breast DCIS Solid IntermediateGrade SNP.jpg\|Breast - Ductal carcinoma in situ - Solid variant- Intermediate grade - Medium power (SKB)~~
	~~Image:Breast DCIS Solid SNP.jpg\|Breast - Ductal carcinoma in situ - Solid variant- Intermediate grade - Low power (SKB)~~
	~~Image:Breast DCIS Solid PA.JPG\|Breast - Ductal carcinoma in situ - Solid variant - Medium power (SKB)~~
	~~Image:Breast DCIS Comedonecrotic 2 PA.JPG\|Breast - Ductal carcinoma in situ - Solid variant - Comedonecrosis (SKB)~~
	~~Image:Breast DCIS Comedonecrosis MP PA.JPG\|Breast - Ductal carcinoma in situ - Solid variant - Comedonecrosis (SKB)~~
	~~</gallery>~~

	~~DDx:~~
	*[[LCIS]].
	**May show dyscohesion
	**More monomorphic population of cells

	~~=====Cribriform ductal carcinoma in situ=====~~
	~~Features:~~
	*Honeycomb-like appearance: circular holes.
	*"Cookie cutter" appearance/"punched-out" appearance/"Roman bridges" -- cells surround the circular holes.

	~~<gallery>~~
	~~Image:Breast DCIS Cribriform MP CTR.jpg\|Breast - Ductal carcinoma in situ - cribriform varient - medium power (SKB)~~
	~~Image:Breast DCIS Cribriform PA.JPG\|Breast - Ductal carcinoma in situ - cribriform varient - medium power (SKB)~~
	~~</gallery>~~

	~~DDx:~~
	*[[Collagenous spherulosis]].
	*[[Adenoid cystic carcinoma of the breast]].
	*Invasive cribriform carcinoma of the breast

	~~=====Papillary ductal carcinoma in situ=====~~
	~~Features:~~
	*Papillae with fibrovascular cores.
	*Papillae lack a myoepithelial layer
	*Papillae are lined by atypical cells.
	*Papillae within a ductal space lined by myoepithelial cells.

	~~<gallery>~~
	~~Image:Breast DCIS PapillaryVariant LP PA.JPG\|Breast - Ductal carcinoma in situ - Papillary variant - low power (SKB)~~
	~~Image:Breast DCIS Papillary PA.JPG\|Breast - Ductal carcinoma in situ - Papillary variant - Medium power (SKB)~~
	~~</gallery>~~

	~~DDX:~~

	*[[Intraductal papilloma]]
	*Ductal carcinoma in situ arising within an intraductal papilloma
	*[[Intracystic papillary breast carcinoma]]
	*[[Invasive papillary breast carcinoma]]

	~~=====Micropapillary ductal carcinoma in situ=====~~
	~~Features:~~
	*Small papillae without fibrovascular cores.
	*Have "drum stick" shape.

	~~DDx:~~
	*[[Gynecomastoid hyperplasia]].

	~~<gallery>~~
	~~Image:Breast DCIS MicropapillaryType MP CTR.jpg\|Breast -~~ Ductal carcinoma in situ ~~- micropapillary variant - Medium power - (SKB)~~
	~~Image:Breast DCIS Micropapillary SNP.jpg\|Breast - Ductal carcinoma in situ - micropapillary variant - High power - (SKB)~~
	~~Image:Breast DCIS Apocrine PA.JPG\|Breast - Ductal carcinoma in situ - Micropapillary type with apocrine features - High power - (SKB)~~
	~~</gallery>~~

	~~====Grading DCIS====~~
	Graded 1-3 (low-high)<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/ http://surgpathcriteria.stanford.edu/breast/dcis/]. Accessed on: 4 August 2011.</ref> - compare lesional nuclei to one another.
	*Grade 1:
	**Nuclei 2-3x size of [[RBC]].
	**No necrosis.
	*Grade 2:
	**Nuclei 2-3x size of RBC.
	**+/-[[Necrosis]].
	*Grade 3:
	**Nuclei >3x size of RBC.
	**Necrosis usually present.

	~~Notes:~~
	*It is often hard to find RBCs when you want 'em. DCIS is pleomorphic.
	*If no RBCs are present to compare with compare the nuclei to one another.
	*If you see nuclei >3x larger than their neigbour you're ready to call DCIS Grade 3.

	~~====Size criteria for low-grade DCIS====~~
	~~ADH is diagnosed if the lesion is small - specifically:<ref name=Ref_BP168>{{Ref BP\|168}}</ref><ref>{{Ref DCHH\|258}}</ref>~~
	~~# < Two membrane-bound spaces.~~
	~~# < 2 mm extent. ‡~~

	~~The treatment is similar; ADH and DCIS are both excised.~~

	~~The differences are:~~
	*DCIS is cancer, i.e. this has life insurance implications.
	*Radiation treatment - DCIS is irradiated; ADH does ''not'' get radiation.

	~~Notes:~~
	* ‡ 3 mm is used in papillary lesions.{{fact}}

	~~====Micrometastasis in DCIS====~~
	Micrometastasis in DCIS - not significant.<ref name=pmid14601079>{{Cite journal \| last1 = Lara \| first1 = JF. \| last2 = Young \| first2 = SM. \| last3 = Velilla \| first3 = RE. \| last4 = Santoro \| first4 = EJ. \| last5 = Templeton \| first5 = SF. \| title = The relevance of occult axillary micrometastasis in ductal carcinoma in situ: a clinicopathologic study with long-term follow-up. \| journal = Cancer \| volume = 98 \| issue = 10 \| pages = 2105-13 \| month = Nov \| year = 2003 \| doi = 10.1002/cncr.11761 \| PMID = 14601079 }}</ref><ref name=pmid16569492>{{Cite journal \| last1 = Broekhuizen \| first1 = LN. \| last2 = Wijsman \| first2 = JH. \| last3 = Peterse \| first3 = JL. \| last4 = Rutgers \| first4 = EJ. \| title = The incidence and significance of micrometastases in lymph nodes of patients with ductal carcinoma in situ and T1a carcinoma of the breast. \| journal = Eur J Surg Oncol \| volume = 32 \| issue = 5 \| pages = 502-6 \| month = Jun \| year = 2006 \| doi = 10.1016/j.ejso.2006.02.006 \| PMID = 16569492 }}~~</ref>~~

	=Lobular neoplasia=		=Lobular neoplasia=

Michael: /* Atypical ductal hyperplasia */

2016-04-28T15:28:34Z

Atypical ductal hyperplasia

← Older revision		Revision as of 15:28, 28 April 2016
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	==Atypical ductal hyperplasia==		==Atypical ductal hyperplasia==
	*Abbreviated ''ADH''.		*Abbreviated ''ADH''.
	{{Main\|Atypical ductal hyperplasia}} ~~and~~		{{Main\|Atypical ductal hyperplasia}}

	==Ductal carcinoma in situ==		==Ductal carcinoma in situ==

Michael: /* Atypical ductal hyperplasia */ split

2016-04-28T15:28:24Z

Atypical ductal hyperplasia: split

← Older revision		Revision as of 15:28, 28 April 2016
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	==Atypical ductal hyperplasia==		==Atypical ductal hyperplasia==
	*Abbreviated ''ADH''.		*Abbreviated ''ADH''.
	~~===General===~~		{{Main\|Atypical ductal hyperplasia}} and
	*Molecular studies have shown it is the same thing as low-grade DCIS; thus, some have called for abolition of the term.<ref>{{~~Cite journal~~ \| last1 = Ghofrani \| first1 = M. \| last2 = Tapia \| first2 = B. \| last3 = Tavassoli \| first3 = FA. \| title = Discrepancies in the diagnosis of intraductal proliferative lesions of the breast and its management implications: results of a multinational survey. \| journal = Virchows Arch \| volume = 449 \| issue = 6 \| pages = 609-16 \| month = Dec \| year = 2006 \| doi = 10.1007/s00428-006-0245-y \| PMID = 17058097 }}</ref>
	*ADH is considered an indication for a lumpectomy.<ref name=pmid7717215>{{cite journal \|author=Liberman L, Cohen MA, Dershaw DD, Abramson AF, Hann LE, Rosen PP \|title=Atypical ductal hyperplasia diagnosed at stereotaxic core biopsy of breast lesions: an indication for surgical biopsy \|journal=AJR Am J Roentgenol \|volume=164 \|issue=5 \|pages=1111–3 \|year=1995 \|month=May \|pmid=7717215 \|doi= \|url=http://www.ajronline.org/cgi/pmidlookup?view=long&pmid=7717215}}~~</ref>~~
	**Two large studies suggest the conversion of an ADH on core biopsy to breast cancer on surgical excision, known as "up-grading", is approximately 30%.<ref name=pmid20619647>{{Cite journal \| last1 = Deshaies \| first1 = I. \| last2 = Provencher \| first2 = L. \| last3 = Jacob \| first3 = S. \| last4 = Côté \| first4 = G. \| last5 = Robert \| first5 = J. \| last6 = Desbiens \| first6 = C. \| last7 = Poirier \| first7 = B. \| last8 = Hogue \| first8 = JC. \| last9 = Vachon \| first9 = E. \| title = Factors associated with upgrading to malignancy at surgery of atypical ductal hyperplasia diagnosed on core biopsy. \| journal = Breast \| volume = 20 \| issue = 1 \| pages = 50-5 \| month = Feb \| year = 2011 \| doi = 10.1016/j.breast.2010.06.004 \| PMID = 20619647 }}</ref><ref name=pmid16978969>{{Cite journal \| last1 = Margenthaler \| first1 = JA. \| last2 = Duke \| first2 = D. \| last3 = Monsees \| first3 = BS. \| last4 = Barton \| first4 = PT. \| last5 = Clark \| first5 = C. \| last6 = Dietz \| first6 = JR. \| title = Correlation between core biopsy and excisional biopsy in breast high-risk lesions. \| journal = Am J Surg \| volume = 192 \| issue = 4 \| pages = 534-7 \| month = Oct \| year = 2006 \| doi = 10.1016/j.amjsurg.2006.06.003 \| PMID = 16978969 }}</ref>

	~~Epidemiology:~~
	*Relative risk of breast cancer, based on a median follow-up of 8 years, in a case control study of US registered nurses, is 3.7.<ref name=pmid1734106>{{Cite journal \| last1 = London \| first1 = SJ. \| last2 = Connolly \| first2 = JL. \| last3 = Schnitt \| first3 = SJ. \| last4 = Colditz \| first4 = GA. \| title = A prospective study of benign breast disease and the risk of breast cancer. \| journal = JAMA \| volume = 267 \| issue = 7 \| pages = 941-4 \| month = Feb \| year = 1992 \| doi = \| PMID = 1734106 }}</ref>

	~~===Microscopic===~~
	~~Features:~~
	*Cytologic and architectural feature of low-grade DCIS.
	**Cell spacing ~ equal.
	**Lumina round.
	**Architecture - classically ''cribriform'' or ''solid''; may be ''micropapillary'' or ''papillary''.
	**Small nuclei.
	***Small indistinct nucleoli.
	*Limited extent ([[diagnostic size cutoffs]]) - either:<ref>{{Ref DCHH\|258}}</ref>
	*#< Two complete ducts.
	*#< 2 mm. ‡

	~~DDx:~~
	*Low-grade [[DCIS]].
	*[[Florid epithelial hyperplasia of the usual type]] (FEHUT).

	~~Notes:~~
	*''High-grade DCIS'' is '''not''' in the [[DDx]] of ADH.
	* ‡ 3 mm is used in papillary lesions.{{fact}}

	~~====Images====~~
	~~<gallery>~~
	~~Image:Atypical_ductal_hyperplasia_-_very_low_mag.jpg\|ADH. Very low mag. (WC/Nephron)~~
	~~Image:Atypical_ductal_hyperplasia_-_high_mag.jpg\|ADH - high mag. (WC/Nephron)~~
	~~</gallery>~~
	~~===IHC===~~
	*CK5 <20% +ve.
	*ER +ve - diffusely.
	**Heterogenous in [[FEHUT]].

	==Ductal carcinoma in situ==		==Ductal carcinoma in situ==

Michael: /* General */

2016-03-01T14:18:22Z

General

← Older revision		Revision as of 14:18, 1 March 2016
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	*Management is currently some matter of debate.		*Management is currently some matter of debate.
	**''Association of Breast Surgery'' (UK) guidelines recommend excision of LCIS on biopsy,<ref name=pmid26492902/> as does a smaller (US) study.<ref name=pmid20637429>{{Cite journal \| last1 = O'Neil \| first1 = M. \| last2 = Madan \| first2 = R. \| last3 = Tawfik \| first3 = OW. \| last4 = Thomas \| first4 = PA. \| last5 = Fan \| first5 = F. \| title = Lobular carcinoma in situ/atypical lobular hyperplasia on breast needle biopsies: does it warrant surgical excisional biopsy? A study of 27 cases. \| journal = Ann Diagn Pathol \| volume = 14 \| issue = 4 \| pages = 251-5 \| month = Aug \| year = 2010 \| doi = 10.1016/j.anndiagpath.2010.04.002 \| PMID = 20637429 }}</ref>		**''Association of Breast Surgery'' (UK) guidelines recommend excision of LCIS on biopsy,<ref name=pmid26492902/> as does a smaller (US) study.<ref name=pmid20637429>{{Cite journal \| last1 = O'Neil \| first1 = M. \| last2 = Madan \| first2 = R. \| last3 = Tawfik \| first3 = OW. \| last4 = Thomas \| first4 = PA. \| last5 = Fan \| first5 = F. \| title = Lobular carcinoma in situ/atypical lobular hyperplasia on breast needle biopsies: does it warrant surgical excisional biopsy? A study of 27 cases. \| journal = Ann Diagn Pathol \| volume = 14 \| issue = 4 \| pages = 251-5 \| month = Aug \| year = 2010 \| doi = 10.1016/j.anndiagpath.2010.04.002 \| PMID = 20637429 }}</ref>
	**In the UK, most surgeons (~60%) excise LCIS seen on biopsy; however, significant minority considers followup appropriate.<ref name=pmid26492902>{{Cite journal \| last1 = Chester \| first1 = R. \| last2 = Bokinni \| first2 = O. \| last3 = Ahmed \| first3 = I. \| last4 = Kasem \| first4 = A. \| title = UK national survey of management of breast lobular carcinoma in situ. \| journal = Ann R Coll Surg Engl \| volume = 97 \| issue = 8 \| pages = 574-7 \| month = Nov \| year = 2015 \| doi = 10.1308/rcsann.2015.0037 \| PMID = 26492902 }}</ref>		**In the UK, most surgeons (~60%) excise LCIS seen on biopsy; however, a significant minority considers followup appropriate.<ref name=pmid26492902>{{Cite journal \| last1 = Chester \| first1 = R. \| last2 = Bokinni \| first2 = O. \| last3 = Ahmed \| first3 = I. \| last4 = Kasem \| first4 = A. \| title = UK national survey of management of breast lobular carcinoma in situ. \| journal = Ann R Coll Surg Engl \| volume = 97 \| issue = 8 \| pages = 574-7 \| month = Nov \| year = 2015 \| doi = 10.1308/rcsann.2015.0037 \| PMID = 26492902 }}</ref>
	*Not detected radiologically - it is an incidental pathologic finding.		*Not detected radiologically - it is an incidental pathologic finding.
	*The precursor to [[invasive ductal carcinoma of the breast]].		*The precursor to [[invasive ductal carcinoma of the breast]].

Michael: /* Lobular carcinoma in situ */

2016-03-01T14:17:48Z

Lobular carcinoma in situ

← Older revision		Revision as of 14:17, 1 March 2016
Line 284:		Line 284:
	===General===		===General===
	*Management is currently some matter of debate.		*Management is currently some matter of debate.
			**''Association of Breast Surgery'' (UK) guidelines recommend excision of LCIS on biopsy,<ref name=pmid26492902/> as does a smaller (US) study.<ref name=pmid20637429>{{Cite journal \| last1 = O'Neil \| first1 = M. \| last2 = Madan \| first2 = R. \| last3 = Tawfik \| first3 = OW. \| last4 = Thomas \| first4 = PA. \| last5 = Fan \| first5 = F. \| title = Lobular carcinoma in situ/atypical lobular hyperplasia on breast needle biopsies: does it warrant surgical excisional biopsy? A study of 27 cases. \| journal = Ann Diagn Pathol \| volume = 14 \| issue = 4 \| pages = 251-5 \| month = Aug \| year = 2010 \| doi = 10.1016/j.anndiagpath.2010.04.002 \| PMID = 20637429 }}</ref>
			**In the UK, most surgeons (~60%) excise LCIS seen on biopsy; however, significant minority considers followup appropriate.<ref name=pmid26492902>{{Cite journal \| last1 = Chester \| first1 = R. \| last2 = Bokinni \| first2 = O. \| last3 = Ahmed \| first3 = I. \| last4 = Kasem \| first4 = A. \| title = UK national survey of management of breast lobular carcinoma in situ. \| journal = Ann R Coll Surg Engl \| volume = 97 \| issue = 8 \| pages = 574-7 \| month = Nov \| year = 2015 \| doi = 10.1308/rcsann.2015.0037 \| PMID = 26492902 }}</ref>
	*Not detected radiologically - it is an incidental pathologic finding.		*Not detected radiologically - it is an incidental pathologic finding.
	*The precursor to [[invasive ductal carcinoma of the breast]].		*The precursor to [[invasive ductal carcinoma of the breast]].

Sarah: /* Papillary ductal carcinoma in situ */

2015-04-29T11:34:43Z

Papillary ductal carcinoma in situ

← Older revision		Revision as of 11:34, 29 April 2015
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	<gallery>		<gallery>
			Image:Breast DCIS PapillaryVariant LP PA.JPG\|Breast - Ductal carcinoma in situ - Papillary variant - low power (SKB)
	Image:Breast DCIS Papillary PA.JPG\|Breast - Ductal carcinoma in situ - Papillary variant - Medium power (SKB)		Image:Breast DCIS Papillary PA.JPG\|Breast - Ductal carcinoma in situ - Papillary variant - Medium power (SKB)
	</gallery>		</gallery>

Sarah: /* Papillary ductal carcinoma in situ */

2015-04-28T10:38:55Z

Papillary ductal carcinoma in situ

← Older revision		Revision as of 10:38, 28 April 2015
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	Features:		Features:
	*Papillae with fibrovascular cores.		*Papillae with fibrovascular cores.
			*Papillae lack a myoepithelial layer
			*Papillae are lined by atypical cells.
			*Papillae within a ductal space lined by myoepithelial cells.

	<gallery>		<gallery>

Sarah: /* Micropapillary ductal carcinoma in situ */

2015-04-28T10:31:58Z

Micropapillary ductal carcinoma in situ

← Older revision		Revision as of 10:31, 28 April 2015
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	Image:Breast DCIS MicropapillaryType MP CTR.jpg\|Breast - Ductal carcinoma in situ - micropapillary variant - Medium power - (SKB)		Image:Breast DCIS MicropapillaryType MP CTR.jpg\|Breast - Ductal carcinoma in situ - micropapillary variant - Medium power - (SKB)
	Image:Breast DCIS Micropapillary SNP.jpg\|Breast - Ductal carcinoma in situ - micropapillary variant - High power - (SKB)		Image:Breast DCIS Micropapillary SNP.jpg\|Breast - Ductal carcinoma in situ - micropapillary variant - High power - (SKB)
			Image:Breast DCIS Apocrine PA.JPG\|Breast - Ductal carcinoma in situ - Micropapillary type with apocrine features - High power - (SKB)
	</gallery>		</gallery>