Nevoid basal cell carcinoma syndrome - Revision history

Michael: change tumour to cyst again (KOT was renamed to odontogenic keratocyst)

2022-05-26T17:17:20Z

change tumour to cyst again (KOT was renamed to odontogenic keratocyst)

← Older revision		Revision as of 17:17, 26 May 2022
Line 6:		Line 6:
	Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>		Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>
	*[[Basal cell carcinoma]] - on average have their first tumour in their 20s.<ref name=pmid9096761>{{Cite journal \| last1 = Kimonis \| first1 = VE. \| last2 = Goldstein \| first2 = AM. \| last3 = Pastakia \| first3 = B. \| last4 = Yang \| first4 = ML. \| last5 = Kase \| first5 = R. \| last6 = DiGiovanna \| first6 = JJ. \| last7 = Bale \| first7 = AE. \| last8 = Bale \| first8 = SJ. \| title = Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. \| journal = Am J Med Genet \| volume = 69 \| issue = 3 \| pages = 299-308 \| month = Mar \| year = 1997 \| doi = \| PMID = 9096761 }}</ref>		*[[Basal cell carcinoma]] - on average have their first tumour in their 20s.<ref name=pmid9096761>{{Cite journal \| last1 = Kimonis \| first1 = VE. \| last2 = Goldstein \| first2 = AM. \| last3 = Pastakia \| first3 = B. \| last4 = Yang \| first4 = ML. \| last5 = Kase \| first5 = R. \| last6 = DiGiovanna \| first6 = JJ. \| last7 = Bale \| first7 = AE. \| last8 = Bale \| first8 = SJ. \| title = Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. \| journal = Am J Med Genet \| volume = 69 \| issue = 3 \| pages = 299-308 \| month = Mar \| year = 1997 \| doi = \| PMID = 9096761 }}</ref>
	*[[~~Keratocystic odontogenic tumour~~]] ~ 80% individuals with NBCCS have had one by age 20.<ref name=pmid9096761/>		*[[Odontogenic keratocyst]] ~ 80% individuals with NBCCS have had one by age 20.<ref name=pmid9096761/>
	*Bony abnormalities: bifid ribs, scoliosis + others.		*Bony abnormalities: bifid ribs, scoliosis + others.
	*Falx cerebri calcification.		*Falx cerebri calcification.

Michael at 03:24, 2 April 2015

2015-04-02T03:24:15Z

← Older revision		Revision as of 03:24, 2 April 2015
Line 1:		Line 1:
			[[Image:Basal_cell_carcinoma_-_2_-_intermed_mag.jpg\|thumb\|right\|Basal cell carcinoma, a component of NBCCS. [[H&E stain]].]]
	'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and '''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation. The gene is ''patched'' and abbreviated ''PTCH1''.<ref name=omim601309>{{OMIM\|601309}}</ref>		'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and '''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation. The gene is ''patched'' and abbreviated ''PTCH1''.<ref name=omim601309>{{OMIM\|601309}}</ref>

Michael at 12:28, 24 October 2013

2013-10-24T12:28:02Z

← Older revision		Revision as of 12:28, 24 October 2013
Line 1:		Line 1:
	'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and '''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation. The gene is ''patched'' and abbreviated ''PTCH1''.<ref name=omim601309>{{OMIM\|601309}}</ref>		'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and '''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation. The gene is ''patched'' and abbreviated ''PTCH1''.<ref name=omim601309>{{OMIM\|601309}}</ref>

			It is abbreviated '''NBCCS'''.

	Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>		Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>

Michael at 12:27, 24 October 2013

2013-10-24T12:27:32Z

← Older revision		Revision as of 12:27, 24 October 2013
Line 2:		Line 2:

	Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>		Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>
	*[[Basal cell carcinoma]].		*[[Basal cell carcinoma]] - on average have their first tumour in their 20s.<ref name=pmid9096761>{{Cite journal \| last1 = Kimonis \| first1 = VE. \| last2 = Goldstein \| first2 = AM. \| last3 = Pastakia \| first3 = B. \| last4 = Yang \| first4 = ML. \| last5 = Kase \| first5 = R. \| last6 = DiGiovanna \| first6 = JJ. \| last7 = Bale \| first7 = AE. \| last8 = Bale \| first8 = SJ. \| title = Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. \| journal = Am J Med Genet \| volume = 69 \| issue = 3 \| pages = 299-308 \| month = Mar \| year = 1997 \| doi = \| PMID = 9096761 }}</ref>
	*[[Keratocystic odontogenic tumour]].		*[[Keratocystic odontogenic tumour]] ~ 80% individuals with NBCCS have had one by age 20.<ref name=pmid9096761/>
	*Bony abnormalities: bifid ribs, scoliosis + others.		*Bony abnormalities: bifid ribs, scoliosis + others.
	*Falx cerebri calcification.		*Falx cerebri calcification.

Michael: +gene

2012-05-31T01:54:02Z

+gene

← Older revision		Revision as of 01:54, 31 May 2012
Line 1:		Line 1:
	'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and '''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation.		'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and '''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation. The gene is ''patched'' and abbreviated ''PTCH1''.<ref name=omim601309>{{OMIM\|601309}}</ref>

	Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>		Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>

Michael: +images

2012-01-03T03:58:56Z

+images

← Older revision		Revision as of 03:58, 3 January 2012
Line 9:		Line 9:
	*[[Medulloblastoma]].<ref name=Ref_PBoD8_1181>{{Ref PBoD8\|1181}}</ref>		*[[Medulloblastoma]].<ref name=Ref_PBoD8_1181>{{Ref PBoD8\|1181}}</ref>
	*[[Ovarian fibroma]].<ref name=Ref_PBoD8_1181>{{Ref PBoD8\|1181}}</ref>		*[[Ovarian fibroma]].<ref name=Ref_PBoD8_1181>{{Ref PBoD8\|1181}}</ref>

			Images:
			*[http://path.upmc.edu/cases/case109/micro.html NBCCS (upmc.edu)].

	==See also==		==See also==

Michael: more tumours

2011-03-20T18:33:22Z

more tumours

← Older revision		Revision as of 18:33, 20 March 2011
Line 7:		Line 7:
	*Falx cerebri calcification.		*Falx cerebri calcification.
	*Characteristic faces.		*Characteristic faces.
			*[[Medulloblastoma]].<ref name=Ref_PBoD8_1181>{{Ref PBoD8\|1181}}</ref>
			*[[Ovarian fibroma]].<ref name=Ref_PBoD8_1181>{{Ref PBoD8\|1181}}</ref>

	==See also==		==See also==
Line 12:		Line 14:

	==References==		==References==
	{{reflist\|1}}		{{reflist\|2}}

	[[Category:Syndromes]]		[[Category:Syndromes]]

Michael: fix again

2010-10-06T21:05:16Z

fix again

← Older revision		Revision as of 21:05, 6 October 2010
Line 1:		Line 1:
	'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and ''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation.		'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and '''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation.

	Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>		Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>

Michael: fix format

2010-10-06T21:04:56Z

fix format

← Older revision		Revision as of 21:04, 6 October 2010
Line 1:		Line 1:
	'''Nevoid basal cell carcinoma syndrome''', also ''Gorlin syndrome''' and ''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation.		'''Nevoid basal cell carcinoma syndrome''', also '''Gorlin syndrome''' and ''Gorlin-Goltz syndrome''', is a constellation of findings due to an autosomal dominant genetic mutation.

	Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>		Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>

Michael: wikify

2010-09-10T20:53:27Z

wikify

← Older revision		Revision as of 20:53, 10 September 2010
Line 2:		Line 2:

	Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>		Features:<ref name=Ref_Derm435>{{Ref Derm\|435}}</ref>
	*Basal cell carcinoma.		*[[Basal cell carcinoma]].
	*[[Keratocystic odontogenic tumour]].		*[[Keratocystic odontogenic tumour]].
	*Bony abnormalities: bifid ribs, scoliosis + others.		*Bony abnormalities: bifid ribs, scoliosis + others.