Nephrotic syndrome - Revision history

Michael: /* Microscopic */

2014-08-20T21:35:41Z

Microscopic

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	*Nephr'''o'''tic syndrome (caused by) '''a'''utoimmune disorders, hepatitis '''B''', '''c'''ancer, '''d'''rugs (with), sub'''e'''pithelial deposits & '''s'''pikes.		*Nephr'''o'''tic syndrome (caused by) '''a'''utoimmune disorders, hepatitis '''B''', '''c'''ancer, '''d'''rugs (with), sub'''e'''pithelial deposits & '''s'''pikes.

	Images:		====Images====
	*www:		www:
	**[http://www.flickr.com/photos/jian-hua_qiao_md/3989875091/in/set-72157622411941607 MN - silver stain (flickr.com)].		*[http://www.flickr.com/photos/jian-hua_qiao_md/3989875091/in/set-72157622411941607 MN - silver stain (flickr.com)].
	*[[WC]]:		<gallery>
	**[http://commons.wikimedia.org/wiki/File:Membranous_nephropathy_-_he_-_very_high_mag.jpg MN - very high mag. (WC)].		Image:Membranous_nephropathy_-_he_-_very_high_mag.jpg \| MN - very high mag. (WC)
	**[http://commons.wikimedia.org/wiki/File:Membranous_nephropathy_-_pas_-_very_high_mag.jpg MN - PAS - very high mag. (WC)].		Image:Membranous_nephropathy_-_pas_-_very_high_mag.jpg \| MN - PAS - very high mag. (WC)
	**[http://commons.wikimedia.org/wiki/File:Membranous_nephropathy_-_mpas_-_very_high_mag.jpg MN - MPAS - very high mag. (WC)].		Image:Membranous_nephropathy_-_mpas_-_very_high_mag.jpg \| MN - MPAS - very high mag. (WC)
	**[http://commons.wikimedia.org/wiki/File:Membranous_nephropathy_-_cropped_-_mpas_-_very_high_mag.jpg MN - MPAS - very high mag. (WC)].		Image:Membranous_nephropathy_-_cropped_-_mpas_-_very_high_mag.jpg \| MN - MPAS - very high mag. (WC)
			</gallery>

	===IF===		===IF===

Michael: /* Membranous nephropathy */

2014-01-28T02:30:07Z

Membranous nephropathy

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	===General===		===General===
	*Presents as nephrotic syndrome.		*Presents as [[nephrotic syndrome]].
	*Variable course.		*Variable course.
	*Pathogenesis: autoantibodies directed against ''phospholipase A2 receptor 1'', abbreviated PLA2R.<ref name=pmid22388552>{{Cite journal \| last1 = Glassock \| first1 = RJ. \| title = The pathogenesis of membranous nephropathy: evolution and revolution. \| journal = Curr Opin Nephrol Hypertens \| volume = \| issue = \| pages = \| month = Mar \| year = 2012 \| doi = 10.1097/MNH.0b013e3283522ea8 \| PMID = 22388552 }}</ref><ref name=omim604939>{{OMIM\|604939}}</ref>		*Pathogenesis: autoantibodies directed against ''phospholipase A2 receptor 1'', abbreviated PLA2R.<ref name=pmid22388552>{{Cite journal \| last1 = Glassock \| first1 = RJ. \| title = The pathogenesis of membranous nephropathy: evolution and revolution. \| journal = Curr Opin Nephrol Hypertens \| volume = \| issue = \| pages = \| month = Mar \| year = 2012 \| doi = 10.1097/MNH.0b013e3283522ea8 \| PMID = 22388552 }}</ref><ref name=omim604939>{{OMIM\|604939}}</ref>

Michael: nl update

2012-08-10T02:19:14Z

nl update

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	'''Nephrotic syndrome''' is a constellation of clinical findings seen in a number of [[medical kidney diseases]]. This article deals with them. ~~An introduction to the medical kidney is in the~~ ''[[~~medical kidney diseases~~]]'' ~~article~~.		'''Nephrotic syndrome''' is a constellation of clinical findings seen in a number of [[medical kidney diseases]]. This article deals with them. It should '''not''' be confused with ''[[nephritic syndrome]]'' which has an almost identical spelling.

	In children nephrotic syndrome is assumed to be ''minimal change disease''. Biopsies are done only there is no response to ~~steriods~~.		An introduction to the medical kidney is in the ''[[medical kidney diseases]]'' article. In children nephrotic syndrome is assumed to be ''minimal change disease''. Biopsies are done only there is no response to steroids.

	=Clinical definition=		=Clinical definition=

Michael: /* Overview */

2012-07-09T20:40:45Z

Overview

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	#[[MN]].		#[[MN]].
	#[[IgA nephropathy]].<ref name=pmid7849391>{{Cite journal \| last1 = Komatsuda \| first1 = A. \| last2 = Wakui \| first2 = H. \| last3 = Yasuda \| first3 = T. \| last4 = Imai \| first4 = H. \| last5 = Miura \| first5 = AB. \| last6 = Tsuda \| first6 = A. \| last7 = Nakamoto \| first7 = Y. \| title = Successful delivery in a pregnant women with crescentic IgA nephropathy. \| journal = Intern Med \| volume = 33 \| issue = 11 \| pages = 723-6 \| month = Nov \| year = 1994 \| doi = \| PMID = 7849391 }}</ref><ref name=pmid22322610>{{Cite journal \| last1 = Kim \| first1 = JK. \| last2 = Kim \| first2 = JH. \| last3 = Lee \| first3 = SC. \| last4 = Kang \| first4 = EW. \| last5 = Chang \| first5 = TI. \| last6 = Moon \| first6 = SJ. \| last7 = Yoon \| first7 = SY. \| last8 = Yoo \| first8 = TH. \| last9 = Kang \| first9 = SW. \| title = Clinical features and outcomes of IgA nephropathy with nephrotic syndrome. \| journal = Clin J Am Soc Nephrol \| volume = 7 \| issue = 3 \| pages = 427-36 \| month = Mar \| year = 2012 \| doi = 10.2215/CJN.04820511 \| PMID = 22322610 }}</ref>		#[[IgA nephropathy]].<ref name=pmid7849391>{{Cite journal \| last1 = Komatsuda \| first1 = A. \| last2 = Wakui \| first2 = H. \| last3 = Yasuda \| first3 = T. \| last4 = Imai \| first4 = H. \| last5 = Miura \| first5 = AB. \| last6 = Tsuda \| first6 = A. \| last7 = Nakamoto \| first7 = Y. \| title = Successful delivery in a pregnant women with crescentic IgA nephropathy. \| journal = Intern Med \| volume = 33 \| issue = 11 \| pages = 723-6 \| month = Nov \| year = 1994 \| doi = \| PMID = 7849391 }}</ref><ref name=pmid22322610>{{Cite journal \| last1 = Kim \| first1 = JK. \| last2 = Kim \| first2 = JH. \| last3 = Lee \| first3 = SC. \| last4 = Kang \| first4 = EW. \| last5 = Chang \| first5 = TI. \| last6 = Moon \| first6 = SJ. \| last7 = Yoon \| first7 = SY. \| last8 = Yoo \| first8 = TH. \| last9 = Kang \| first9 = SW. \| title = Clinical features and outcomes of IgA nephropathy with nephrotic syndrome. \| journal = Clin J Am Soc Nephrol \| volume = 7 \| issue = 3 \| pages = 427-36 \| month = Mar \| year = 2012 \| doi = 10.2215/CJN.04820511 \| PMID = 22322610 }}</ref>
			Other:
			*Pre-eclampsia.<ref name=pmid20033418>{{Cite journal \| last1 = Wei \| first1 = Q. \| last2 = Zhang \| first2 = L. \| last3 = Liu \| first3 = X. \| title = Outcome of severe preeclampsia manifested as nephrotic syndrome. \| journal = Arch Gynecol Obstet \| volume = 283 \| issue = 2 \| pages = 201-4 \| month = Feb \| year = 2011 \| doi = 10.1007/s00404-009-1338-z \| PMID = 20033418 }}</ref>

	=Specific entities=		=Specific entities=

Michael: /* Overview */

2012-07-08T21:46:24Z

Overview

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	Immune complex positive:		Immune complex positive:
	#[[MN]].		#[[MN]].
	#[[IgA nephropathy]].<ref name=pmid7849391>{{Cite journal \| last1 = Komatsuda \| first1 = A. \| last2 = Wakui \| first2 = H. \| last3 = Yasuda \| first3 = T. \| last4 = Imai \| first4 = H. \| last5 = Miura \| first5 = AB. \| last6 = Tsuda \| first6 = A. \| last7 = Nakamoto \| first7 = Y. \| title = Successful delivery in a pregnant women with crescentic IgA nephropathy. \| journal = Intern Med \| volume = 33 \| issue = 11 \| pages = 723-6 \| month = Nov \| year = 1994 \| doi = \| PMID = 7849391 }}</ref>		#[[IgA nephropathy]].<ref name=pmid7849391>{{Cite journal \| last1 = Komatsuda \| first1 = A. \| last2 = Wakui \| first2 = H. \| last3 = Yasuda \| first3 = T. \| last4 = Imai \| first4 = H. \| last5 = Miura \| first5 = AB. \| last6 = Tsuda \| first6 = A. \| last7 = Nakamoto \| first7 = Y. \| title = Successful delivery in a pregnant women with crescentic IgA nephropathy. \| journal = Intern Med \| volume = 33 \| issue = 11 \| pages = 723-6 \| month = Nov \| year = 1994 \| doi = \| PMID = 7849391 }}</ref><ref name=pmid22322610>{{Cite journal \| last1 = Kim \| first1 = JK. \| last2 = Kim \| first2 = JH. \| last3 = Lee \| first3 = SC. \| last4 = Kang \| first4 = EW. \| last5 = Chang \| first5 = TI. \| last6 = Moon \| first6 = SJ. \| last7 = Yoon \| first7 = SY. \| last8 = Yoo \| first8 = TH. \| last9 = Kang \| first9 = SW. \| title = Clinical features and outcomes of IgA nephropathy with nephrotic syndrome. \| journal = Clin J Am Soc Nephrol \| volume = 7 \| issue = 3 \| pages = 427-36 \| month = Mar \| year = 2012 \| doi = 10.2215/CJN.04820511 \| PMID = 22322610 }}</ref>

	=Specific entities=		=Specific entities=

Michael: /* Overview */ +ref.

2012-07-08T21:42:17Z

Overview: +ref.

← Older revision		Revision as of 21:42, 8 July 2012
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	Immune complex positive:		Immune complex positive:
	#[[MN]].		#[[MN]].
	#[[IgA nephropathy]].		#[[IgA nephropathy]].<ref name=pmid7849391>{{Cite journal \| last1 = Komatsuda \| first1 = A. \| last2 = Wakui \| first2 = H. \| last3 = Yasuda \| first3 = T. \| last4 = Imai \| first4 = H. \| last5 = Miura \| first5 = AB. \| last6 = Tsuda \| first6 = A. \| last7 = Nakamoto \| first7 = Y. \| title = Successful delivery in a pregnant women with crescentic IgA nephropathy. \| journal = Intern Med \| volume = 33 \| issue = 11 \| pages = 723-6 \| month = Nov \| year = 1994 \| doi = \| PMID = 7849391 }}</ref>

	=Specific entities=		=Specific entities=

Michael: /* Focal segmental glomerulosclerosis */

2012-07-08T21:36:58Z

Focal segmental glomerulosclerosis

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	===General===		===General===
	*Presents as nephrotic syndrome.		*Presents as nephrotic syndrome.
	*Does not respond to steroids (unlike MCD).		*Does not respond to steroids (unlike [[MCD]]).
	*Usually less rapid onset than MCD.		*Usually less rapid onset than MCD.
	**~~How to remember? A.~~ Fibrosis takes some time.		**Fibrosis usually takes some time.

	====Etiology====		====Etiology====

Michael: /* Specific entities */

2012-07-08T21:34:34Z

Specific entities

← Older revision		Revision as of 21:34, 8 July 2012
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	*Presents as nephrotic syndrome.		*Presents as nephrotic syndrome.
	*Does not respond to steroids (unlike MCD).		*Does not respond to steroids (unlike MCD).
			*Usually less rapid onset than MCD.
			**How to remember? A. Fibrosis takes some time.

	====Etiology====		====Etiology====

Michael: /* Focal segmental glomerulosclerosis */ +links to micrographs

2012-05-19T02:46:42Z

Focal segmental glomerulosclerosis: +links to micrographs

← Older revision		Revision as of 02:46, 19 May 2012
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	*[[C1q nephropathy]].		*[[C1q nephropathy]].

	~~Image~~:		Images:
	*[http://library.med.utah.edu/WebPath/jpeg1/RENAL083.jpg FSGS (utah.edu)].		*www:
			**[http://library.med.utah.edu/WebPath/jpeg1/RENAL083.jpg FSGS (utah.edu)].
			*[[WC]]:
			**[http://commons.wikimedia.org/wiki/File:Focal_segmental_glomerulosclerosis_-_high_mag.jpg FSGS - high mag. (WC)].
			**[http://commons.wikimedia.org/wiki/File:Collapsing_glomerulopathy_-_high_mag.jpg Collapsing glomerulopathy - high mag. (WC)].
			**[http://commons.wikimedia.org/wiki/File:Collapsing_glomerulopathy_-_very_high_mag.jpg Collapsing glomerulopathy - very high mag. (WC)].

	====Histologic classification====		====Histologic classification====

Michael: /* EM */ more

2012-04-02T04:45:44Z

EM: more

← Older revision		Revision as of 04:45, 2 April 2012
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	===EM===		===EM===
	*Diffuse subepithelial deposits - spike forming.		*Diffuse subepithelial deposits - spike forming.
			**The size of the deposits measured perpendicular to the basement membrane is smaller than seen in [[post-infectious glomerulonephritis]] (PIGN), and more diffuse. In other words, MN has a thin band-like deposits. PIGN has scattered tombstone-like ones.

			Image:
			*[http://missinglink.ucsf.edu/lm/IDS_102_cases_glomerular/images/membranous_EM.jpg MN (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/IDS_102_cases_glomerular/Nephrotic_syndrome.htm http://missinglink.ucsf.edu/lm/IDS_102_cases_glomerular/Nephrotic_syndrome.htm]. Accessed on: 2 April 2012.</ref>

	==C1q nephropathy==		==C1q nephropathy==