Myelodysplastic syndromes - Revision history

Michael: /* Dysmegakaryocytopoiesis */

2016-02-18T15:42:10Z

Dysmegakaryocytopoiesis

← Older revision		Revision as of 15:42, 18 February 2016
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	*Non-lobated nuclei of any size.		*Non-lobated nuclei of any size.
	*Multiple widely separated nuclear lobes.		*Multiple widely separated nuclear lobes.

			Image:
			*[http://www.atlasbloodcells.es/ficha.php?codigo=410&codigo2=499&indice=410 Dysmegakaryocytopoiesis (atlasbloodcells.es)].

	=IHC=		=IHC=

2016-02-18T15:40:06Z

Dysmegakaryocytopoiesis

← Older revision		Revision as of 15:40, 18 February 2016
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	===Histology===		===Histology===
	Features:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref>		Features:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref>
	*Micromegakaryoctes with ~~ypolobated~~ nuclei.		*Micromegakaryoctes with hypolobated nuclei.
	*Non-lobated nuclei of any size.		*Non-lobated nuclei of any size.
	*Multiple widely separated nuclear lobes.		*Multiple widely separated nuclear lobes.

	=IHC=		=IHC=
	Typical [[IHC]] in work-up of MDS:		Typical [[IHC]] in work-up of MDS:

2015-07-27T21:12:49Z

wiify

← Older revision		Revision as of 21:12, 27 July 2015
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	=Histologic features=		=Histologic features=
	*Auer rods - '''used to be''' diagnostic of MDS regardless of blast count.		*[[Auer rods]] - '''used to be''' diagnostic of MDS regardless of blast count.

	==Dyserythropoiesis==		==Dyserythropoiesis==

2012-05-05T19:58:54Z

WHO classification (2008)

← Older revision		Revision as of 19:58, 5 May 2012
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	*#Thrombocytopenia.		*#Thrombocytopenia.
	*Refractory anemia with ringed sideroblasts (RARS).		*Refractory anemia with ringed sideroblasts (RARS).
	#Refractory cytopenia with multilineage dysplasia (RCMD).<ref name=pmid8558932>{{Cite journal \| last1 = Rosati \| first1 = S. \| last2 = Mick \| first2 = R. \| last3 = Xu \| first3 = F. \| last4 = Stonys \| first4 = E. \| last5 = Le Beau \| first5 = MM. \| last6 = Larson \| first6 = R. \| last7 = Vardiman \| first7 = JW. \| title = Refractory cytopenia with multilineage dysplasia: further characterization of an 'unclassifiable' myelodysplastic syndrome. \| journal = Leukemia \| volume = 10 \| issue = 1 \| pages = 20-6 \| month = Jan \| year = 1996 \| doi = \| PMID = 8558932 }}</ref>		*Refractory cytopenia with multilineage dysplasia (RCMD).<ref name=pmid8558932>{{Cite journal \| last1 = Rosati \| first1 = S. \| last2 = Mick \| first2 = R. \| last3 = Xu \| first3 = F. \| last4 = Stonys \| first4 = E. \| last5 = Le Beau \| first5 = MM. \| last6 = Larson \| first6 = R. \| last7 = Vardiman \| first7 = JW. \| title = Refractory cytopenia with multilineage dysplasia: further characterization of an 'unclassifiable' myelodysplastic syndrome. \| journal = Leukemia \| volume = 10 \| issue = 1 \| pages = 20-6 \| month = Jan \| year = 1996 \| doi = \| PMID = 8558932 }}</ref>
	*Refractory anemia with excess blasts (RAEB).		*Refractory anemia with excess blasts (RAEB).
	**RAEB-1.		**RAEB-1.

2012-02-10T00:26:46Z

Histology

← Older revision		Revision as of 00:26, 10 February 2012
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	===Histology===		===Histology===
	Features:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref>		Features:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref>
	*Nuclear hypolobation (pseudo-Pelger-~~Huet~~).		*Nuclear hypolobation (pseudo Pelger-Huët).
	*Hypersegmentation.		*Hypersegmentation.
	**May be seen in vitamin B12 deficiency, Rx.		**May be seen in vitamin B12 deficiency, Rx.

2012-02-10T00:25:05Z

Overview

← Older revision		Revision as of 00:25, 10 February 2012
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	=Overview=		=Overview=
	==Lab ~~fidnings~~==		==Lab findings==
	*+/-[[Anemia]].		*+/-[[Anemia]].
	*+/-Neutropenia.		*+/-Neutropenia.
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	#*Congenital hematopoietic disorder.		#*Congenital hematopoietic disorder.
	#**Congenital dyserythropoietic anemia.		#**Congenital dyserythropoietic anemia.



	=Bone marrow specimens=		=Bone marrow specimens=

2011-09-07T20:16:56Z

IHC

← Older revision		Revision as of 20:16, 7 September 2011
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	Typical [[IHC]] in work-up of MDS:		Typical [[IHC]] in work-up of MDS:
	*CD34 - (myeloid) progenitor/precursor cells.		*CD34 - (myeloid) progenitor/precursor cells.
	*CD117 - (myeloid) progenitor/precursor cells, mast ~~cells~~.		*CD117 - (myeloid) progenitor/precursor cells, [[mast cell]]s.
	*Tryptase - mast cells, immature basophils.		*Tryptase - mast cells, immature basophils.
	**Uncommonly done.		**Uncommonly done.

2011-05-29T18:20:56Z

2011-05-29T17:27:08Z

WHO classification (2008): more

← Older revision		Revision as of 17:27, 29 May 2011
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	*#Thrombocytopenia.		*#Thrombocytopenia.
	*Refractory anemia with ringed sideroblasts (RARS).		*Refractory anemia with ringed sideroblasts (RARS).
			#Refractory cytopenia with multilineage dysplasia (RCMD).<ref name=pmid8558932>{{Cite journal \| last1 = Rosati \| first1 = S. \| last2 = Mick \| first2 = R. \| last3 = Xu \| first3 = F. \| last4 = Stonys \| first4 = E. \| last5 = Le Beau \| first5 = MM. \| last6 = Larson \| first6 = R. \| last7 = Vardiman \| first7 = JW. \| title = Refractory cytopenia with multilineage dysplasia: further characterization of an 'unclassifiable' myelodysplastic syndrome. \| journal = Leukemia \| volume = 10 \| issue = 1 \| pages = 20-6 \| month = Jan \| year = 1996 \| doi = \| PMID = 8558932 }}</ref>
	*Refractory anemia with excess blasts (RAEB).		*Refractory anemia with excess blasts (RAEB).
	**RAEB-1.		**RAEB-1.

2011-05-29T17:24:13Z

Cytogenetics

← Older revision		Revision as of 17:24, 29 May 2011
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	</ref> abbreviated ''IPSS'':		</ref> abbreviated ''IPSS'':
	*Higher score = worse outcome.		*Higher score = worse outcome.

			=WHO classification (2008)=
			*Refractory cytopenia with unilineage dysplasia (RCUD).
			*#Anemia.
			*#Neutropenia
			*#Thrombocytopenia.
			*Refractory anemia with ringed sideroblasts (RARS).
			*Refractory anemia with excess blasts (RAEB).
			**RAEB-1.
			**RAEB-2: Auer rods ''or'' >= 10% blasts.
			*MDS with isolated del(5q).
			*MDS unclassifiable.

	=See also=		=See also=

← Older revision		Revision as of 18:20, 29 May 2011
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	*[[Haematopathology]].		*[[Haematopathology]].
	*[[Myeloproliferative neoplasms]].		*[[Myeloproliferative neoplasms]].
			*[[Leukemia]].

	=References=		=References=