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2015-05-02T06:07:07Z

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	#~~redirect~~ [[~~Ovarian_tumours~~#~~Mucinous_adenocarcinoma_of_the_ovary~~]]		'''Mucinous adenocarcinoma of the ovary''' is a [[malignant]] [[ovarian tumour]].

			It is also known as '''ovarian mucinous adenocarcinoma''' and '''ovarian mucinous carcinoma'''.

			==General==
			*Malignant.
			*May arise in [[endometriosis]].<ref name=Ref_PBoD1097>{{Ref PBoD \|1097}}</ref>
			*Poor response to chemotherapy vis-à-vis serous carcinoma.<ref name=pmid19275957>{{Cite journal \| last1 = Shimada \| first1 = M. \| last2 = Kigawa \| first2 = J. \| last3 = Ohishi \| first3 = Y. \| last4 = Yasuda \| first4 = M. \| last5 = Suzuki \| first5 = M. \| last6 = Hiura \| first6 = M. \| last7 = Nishimura \| first7 = R. \| last8 = Tabata \| first8 = T. \| last9 = Sugiyama \| first9 = T. \| title = Clinicopathological characteristics of mucinous adenocarcinoma of the ovary. \| journal = Gynecol Oncol \| volume = 113 \| issue = 3 \| pages = 331-4 \| month = Jun \| year = 2009 \| doi = 10.1016/j.ygyno.2009.02.010 \| PMID = 19275957 }}</ref>

			==Gross==
			Features:
			*Multiloculated.
			*Sticky, gelatinous fluid (glycoprotein).
			*+/-[[Necrosis]].
			*Typically unilateral.<ref name=pmid22885379>{{Cite journal \| last1 = Offman \| first1 = SL. \| last2 = Longacre \| first2 = TA. \| title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). \| journal = Adv Anat Pathol \| volume = 19 \| issue = 5 \| pages = 296-312 \| month = Sep \| year = 2012 \| doi = 10.1097/PAP.0b013e31826663b1 \| PMID = 22885379 }}</ref>

			==Microscopic==
			Features:
			*Mucinous differentiation.
			**Tall [[columnar cell]]s in glands with apical mucin.
			***May have an endocervical-like ''or'' intestinal-like appearance - see ''subtypes''.
			*Invasive morphology - one of the following:
			*#Back-to-back glands/confluent growth pattern.
			*#Desmoplastic stromal response.
			*#Cribriforming of glands.
			*Malignant characteristics:
			**+/-Nuclear atypia.
			**+/-Necrosis.
			**No cilia.

			DDx:
			*[[Mucinous borderline tumour of the ovary]].
			*[[Metastatic]] [[mucinous carcinoma]].

			===Subtypes===
			#''Endocervical type''.
			#*Less likely to be malignant.
			#*More common than malignant type.
			#''Intestinal type''.
			#*More likely to be malignant.
			#*+/-[[Goblet cell]]s.
			#**One large clear apical vacuole.
			#*If it doesn't look like intestine to you... it probably isn't.
			#*May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism).
			#**Image: [http://www.ispub.com/xml/journals/ijgo/vol9n1/papillary-fig4.jpg]

			Comparison of mucosa:
			*Normal endocervical mucosa: [http://pathology.mc.duke.edu/research/Histo_course/endocx.jpg endocervical mucosa (duke.edu)].
			*Normal colonic mucosa: [http://commons.wikimedia.org/wiki/File:Rectal_prolapse_-_intermed_mag.jpg colonic type mucosa (WC)].

			==IHC==
			*CK7 +ve.
			*[[CK20]] +ve.

			==See also==
			*[[Ovarian tumours]].
			*[[Mucinous adenocarcinoma]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Ovarian tumours]]

Michael: redirect

2012-03-29T00:40:38Z

redirect

New page

#redirect [[Ovarian_tumours#Mucinous_adenocarcinoma_of_the_ovary]]

[[Category:Diagnosis]]

Mucinous adenocarcinoma of the ovary - Revision history

Michael: split out

Michael: redirect