Miscellaneous ovarian tumours - Revision history

Michael: /* Ovarian small cell carcinoma of the hypercalcemic type */

2016-06-07T03:27:28Z

Ovarian small cell carcinoma of the hypercalcemic type

← Older revision		Revision as of 03:27, 7 June 2016
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	*Abbreviated ''OSSCHT''.		*Abbreviated ''OSSCHT''.
	*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.		*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.
	*''Malignant rhabdoid tumour of the ovary'', ~~abbreiated~~ ''MRTO'', is a proposed name.<ref name=pmid24752781>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>		*''Malignant rhabdoid tumour of the ovary'', abbreviated ''MRTO'', is a proposed name.<ref name=pmid24752781>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>
	{{Main\|Ovarian small cell carcinoma of the hypercalcemic type}}		{{Main\|Ovarian small cell carcinoma of the hypercalcemic type}}

Michael: /* Ovarian small cell carcinoma of the hypercalcemic type */

2016-06-07T03:27:17Z

Ovarian small cell carcinoma of the hypercalcemic type

← Older revision		Revision as of 03:27, 7 June 2016
Line 8:		Line 8:
	*Abbreviated ''OSSCHT''.		*Abbreviated ''OSSCHT''.
	*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.		*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.
	*''Malignant rhabdoid tumour of the ovary'', abbreiated ''MRTO)'', is a proposed name.<ref name=pmid24752781>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>		*''Malignant rhabdoid tumour of the ovary'', abbreiated ''MRTO'', is a proposed name.<ref name=pmid24752781>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>
	{{Main\|Ovarian small cell carcinoma of the hypercalcemic type}}		{{Main\|Ovarian small cell carcinoma of the hypercalcemic type}}

Michael: /* Ovarian small cell carcinoma of the hypercalcemic type */

2016-06-07T03:27:09Z

Ovarian small cell carcinoma of the hypercalcemic type

← Older revision		Revision as of 03:27, 7 June 2016
Line 8:		Line 8:
	*Abbreviated ''OSSCHT''.		*Abbreviated ''OSSCHT''.
	*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.		*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.
	*~~Proposed name:~~ ''Malignant rhabdoid tumour of the ovary (MRTO)''. <ref>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>		*''Malignant rhabdoid tumour of the ovary'', abbreiated ''MRTO)'', is a proposed name.<ref name=pmid24752781>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>
	{{Main\|Ovarian small cell carcinoma of the hypercalcemic type}}		{{Main\|Ovarian small cell carcinoma of the hypercalcemic type}}

Michael: /* Ovarian small cell carcinoma of the pulmonary type */

2016-06-07T03:25:29Z

Ovarian small cell carcinoma of the pulmonary type

← Older revision		Revision as of 03:25, 7 June 2016
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	==Ovarian small cell carcinoma of the pulmonary type==		==Ovarian small cell carcinoma of the pulmonary type==
			*Abbreviated ''OSSCPT''.
	:See: ''[[Small cell carcinoma]]''.		:See: ''[[Small cell carcinoma]]''.

Michael: /* Ovarian small cell carcinoma of the hypercalcemic type */ split out

2016-06-06T14:07:22Z

Ovarian small cell carcinoma of the hypercalcemic type: split out

← Older revision		Revision as of 14:07, 6 June 2016
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	*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.		*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.
	*Proposed name: ''Malignant rhabdoid tumour of the ovary (MRTO)''. <ref>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>		*Proposed name: ''Malignant rhabdoid tumour of the ovary (MRTO)''. <ref>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>
			{{Main\|Ovarian small cell carcinoma of the hypercalcemic type}}
	~~===General===~~
	*Hypercalcemia.<ref name=pmid7943531>{{~~Cite journal~~ \| last1 = Young \| first1 = RH. \| last2 = Oliva \| first2 = E. \| last3 = Scully \| first3 = RE. \| title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 11 \| pages = 1102-16 \| month = Nov \| year = 1994 \| doi = \| PMID = 7943531 }}</ref>
	*Very rare.
	*Most common undifferentiated ovarian malignancy in individuals less than 40 years old.<ref name=pmid24658002/>
	*Associated with SMARCA4 mutations - may be familial.<ref name=pmid24658002>{{cite journal \|author=Witkowski L, Carrot-Zhang J, Albrecht S, ''et al.'' \|title=Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ~~ovary,~~ hypercalcemic type ~~\|journal=Nat. Genet. \|volume=46 \|issue=5 \|pages=438–43 \|year=2014 \|month=May \|pmid=24658002 \|doi=10.1038/ng.2931 \|url=}}</ref>~~

	~~===Microscopic===~~
	~~Features:<ref name=pmid7943531/>~~
	*Small cell carcinoma.
	*Follicle-like spaces.

	~~DDx:~~
	*[[Small cell carcinoma of the lung]].
	*[[Small cell carcinoma of the cervix]].
	*[[Sertoli-Leydig cell tumour]].
	*[[Juvenile granulosa cell tumour]].

	~~====Images====~~
	~~www:~~
	*[http://webpathology.com/image.asp?n=6&Case=531 OSSCHT - low mag. (webpathology.com)].
	*[http://webpathology.com/image.asp?case=531&n=5 OSSCHT - high mag. (webpathology.com)].
	~~<gallery>~~
	~~Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_low_mag.jpg \| OSSCHT - low mag. (WC)~~
	~~Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_intermed_mag.jpg \| OSSCHT - intermed. mag. (WC)~~
	~~Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_high_mag.jpg \| OSSCHT - high mag. (WC)~~
	~~Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_very_high_mag.jpg \| OSSCHT - very high mag. (WC)~~
	~~</gallery>~~

	~~===IHC===~~
	Features:<ref name=pmid17727473>{{Cite journal \| last1 = Carlson \| first1 = JW. \| last2 = Nucci \| first2 = MR. \| last3 = Brodsky \| first3 = J. \| last4 = Crum \| first4 = CP. \| last5 = Hirsch \| first5 = MS. \| title = Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. \| journal = Histopathology \| volume = 51 \| issue = 3 \| pages = 305-12 \| month = Sep \| year = 2007 \| doi = 10.1111/j.1365-2559.2007.02790.x \| PMID = 17727473 }}~~</ref>~~
	*WT-1 +ve.
	*TTF-1 -ve.
	*HPV -ve.
	*p16 +ve/-ve.

	=See also=		=See also=

Jensflorian: /* Ovarian small cell carcinoma of the hypercalcemic type */ +proposal and link

2015-04-01T08:12:44Z

Ovarian small cell carcinoma of the hypercalcemic type: +proposal and link

← Older revision		Revision as of 08:12, 1 April 2015
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	*Abbreviated ''OSSCHT''.		*Abbreviated ''OSSCHT''.
	*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.		*[[AKA]] ''small cell carcinoma, hypercalcemic type'', [[AKA]] ''small cell carcinoma of the ovary, hypercalcemic type''.
			*Proposed name: ''Malignant rhabdoid tumour of the ovary (MRTO)''. <ref>{{Cite journal \| last1 = Foulkes \| first1 = WD. \| last2 = Clarke \| first2 = BA. \| last3 = Hasselblatt \| first3 = M. \| last4 = Majewski \| first4 = J. \| last5 = Albrecht \| first5 = S. \| last6 = McCluggage \| first6 = WG. \| title = No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. \| journal = J Pathol \| volume = 233 \| issue = 3 \| pages = 209-14 \| month = Jul \| year = 2014 \| doi = 10.1002/path.4362 \| PMID = 24752781 }}</ref>

	===General===		===General===
	*Hypercalcemia.<ref name=pmid7943531>{{Cite journal \| last1 = Young \| first1 = RH. \| last2 = Oliva \| first2 = E. \| last3 = Scully \| first3 = RE. \| title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 11 \| pages = 1102-16 \| month = Nov \| year = 1994 \| doi = \| PMID = 7943531 }}</ref>		*Hypercalcemia.<ref name=pmid7943531>{{Cite journal \| last1 = Young \| first1 = RH. \| last2 = Oliva \| first2 = E. \| last3 = Scully \| first3 = RE. \| title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 11 \| pages = 1102-16 \| month = Nov \| year = 1994 \| doi = \| PMID = 7943531 }}</ref>

Michael: /* Ovarian small cell carcinoma of the hypercalcemic type */

2014-07-25T06:46:55Z

Ovarian small cell carcinoma of the hypercalcemic type

← Older revision		Revision as of 06:46, 25 July 2014
Line 9:		Line 9:
	===General===		===General===
	*Hypercalcemia.<ref name=pmid7943531>{{Cite journal \| last1 = Young \| first1 = RH. \| last2 = Oliva \| first2 = E. \| last3 = Scully \| first3 = RE. \| title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 11 \| pages = 1102-16 \| month = Nov \| year = 1994 \| doi = \| PMID = 7943531 }}</ref>		*Hypercalcemia.<ref name=pmid7943531>{{Cite journal \| last1 = Young \| first1 = RH. \| last2 = Oliva \| first2 = E. \| last3 = Scully \| first3 = RE. \| title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 11 \| pages = 1102-16 \| month = Nov \| year = 1994 \| doi = \| PMID = 7943531 }}</ref>
	*~~Rare~~.		*Very rare.
			*Most common undifferentiated ovarian malignancy in individuals less than 40 years old.<ref name=pmid24658002/>
			*Associated with SMARCA4 mutations - may be familial.<ref name=pmid24658002>{{cite journal \|author=Witkowski L, Carrot-Zhang J, Albrecht S, ''et al.'' \|title=Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type \|journal=Nat. Genet. \|volume=46 \|issue=5 \|pages=438–43 \|year=2014 \|month=May \|pmid=24658002 \|doi=10.1038/ng.2931 \|url=}}</ref>

	===Microscopic===		===Microscopic===

Michael: /* Images */

2014-07-25T06:33:08Z

Images

← Older revision		Revision as of 06:33, 25 July 2014
Line 28:		Line 28:
	<gallery>		<gallery>
	Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_low_mag.jpg \| OSSCHT - low mag. (WC)		Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_low_mag.jpg \| OSSCHT - low mag. (WC)
			Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_intermed_mag.jpg \| OSSCHT - intermed. mag. (WC)
	Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_high_mag.jpg \| OSSCHT - high mag. (WC)		Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_high_mag.jpg \| OSSCHT - high mag. (WC)
			Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_very_high_mag.jpg \| OSSCHT - very high mag. (WC)
	</gallery>		</gallery>

Michael: /* Ovarian small cell carcinoma of the hypercalcemic type */

2014-07-25T06:32:05Z

Ovarian small cell carcinoma of the hypercalcemic type

← Older revision		Revision as of 06:32, 25 July 2014
Line 19:		Line 19:
	*[[Small cell carcinoma of the lung]].		*[[Small cell carcinoma of the lung]].
	*[[Small cell carcinoma of the cervix]].		*[[Small cell carcinoma of the cervix]].
			*[[Sertoli-Leydig cell tumour]].
			*[[Juvenile granulosa cell tumour]].

	====Images====		====Images====

Michael: /* Images */

2013-12-22T03:41:22Z

Images

← Older revision		Revision as of 03:41, 22 December 2013
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	====Images====		====Images====
	*www:		www:
	**[http://webpathology.com/image.asp?n=6&Case=531 OSSCHT - low mag. (webpathology.com)].		*[http://webpathology.com/image.asp?n=6&Case=531 OSSCHT - low mag. (webpathology.com)].
	**[http://webpathology.com/image.asp?case=531&n=5 OSSCHT - high mag. (webpathology.com)].		*[http://webpathology.com/image.asp?case=531&n=5 OSSCHT - high mag. (webpathology.com)].
	<gallery>		<gallery>
	Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_low_mag.jpg \| OSSCHT - low mag. (WC)		Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_low_mag.jpg \| OSSCHT - low mag. (WC)
	Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_high_mag.jpg \| OSSCHT - high mag. (WC)		Image:Small_cell_carcinoma_of_the_ovary_hypercalcemic_type_-_high_mag.jpg \| OSSCHT - high mag. (WC)
	</gallery>		</gallery>

	===IHC===		===IHC===
	Features:<ref name=pmid17727473>{{Cite journal \| last1 = Carlson \| first1 = JW. \| last2 = Nucci \| first2 = MR. \| last3 = Brodsky \| first3 = J. \| last4 = Crum \| first4 = CP. \| last5 = Hirsch \| first5 = MS. \| title = Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. \| journal = Histopathology \| volume = 51 \| issue = 3 \| pages = 305-12 \| month = Sep \| year = 2007 \| doi = 10.1111/j.1365-2559.2007.02790.x \| PMID = 17727473 }}</ref>		Features:<ref name=pmid17727473>{{Cite journal \| last1 = Carlson \| first1 = JW. \| last2 = Nucci \| first2 = MR. \| last3 = Brodsky \| first3 = J. \| last4 = Crum \| first4 = CP. \| last5 = Hirsch \| first5 = MS. \| title = Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. \| journal = Histopathology \| volume = 51 \| issue = 3 \| pages = 305-12 \| month = Sep \| year = 2007 \| doi = 10.1111/j.1365-2559.2007.02790.x \| PMID = 17727473 }}</ref>