Microcystic adnexal carcinoma - Revision history

Michael: /* IHC */

2022-03-03T18:48:22Z

IHC

← Older revision		Revision as of 18:48, 3 March 2022
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	**Positive in DTE.		**Positive in DTE.
	**Negative in sclerosing BCC.		**Negative in sclerosing BCC.
	*EMA +ve		*EMA +ve.
	**Negative in sclerosing BCC and desmoplastic trichoepithelioma		**Negative in sclerosing BCC and desmoplastic trichoepithelioma.

	==See also==		==See also==

Michael: /* Images */

2022-03-03T18:47:37Z

Images

← Older revision		Revision as of 18:47, 3 March 2022
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	www:		www:
	*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref>		*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov).<ref name=pmid21606063/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov)].<ref name=pmid21606063/>

	==IHC==		==IHC==

Zlatica: /* IHC */

2018-02-26T15:01:59Z

IHC

← Older revision		Revision as of 15:01, 26 February 2018
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	**Positive in DTE.		**Positive in DTE.
	**Negative in sclerosing BCC.		**Negative in sclerosing BCC.
			*EMA +ve
			**Negative in sclerosing BCC and desmoplastic trichoepithelioma

	==See also==		==See also==

Michael at 16:23, 15 May 2016

2016-05-15T16:23:53Z

← Older revision		Revision as of 16:23, 15 May 2016
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	\| LMDDx = [[sclerosing basal cell carcinoma]], desmoplastic [[trichoepithelioma]], infiltrative [[squamous cell carcinoma]]		\| LMDDx = [[sclerosing basal cell carcinoma]], desmoplastic [[trichoepithelioma]], infiltrative [[squamous cell carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = Ber-EP4 -ve, CD15 -ve		\| IHC = [[Ber-EP4]] -ve, CD15 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	==IHC==		==IHC==
	Features:<ref name=pmid23398472 >{{Cite journal \| last1 = Sellheyer \| first1 = K. \| last2 = Nelson \| first2 = P. \| last3 = Kutzner \| first3 = H. \| last4 = Patel \| first4 = RM. \| title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. \| journal = J Cutan Pathol \| volume = 40 \| issue = 4 \| pages = 363-70 \| month = Apr \| year = 2013 \| doi = 10.1111/cup.12085 \| PMID = 23398472 }}</ref>		Features:<ref name=pmid23398472 >{{Cite journal \| last1 = Sellheyer \| first1 = K. \| last2 = Nelson \| first2 = P. \| last3 = Kutzner \| first3 = H. \| last4 = Patel \| first4 = RM. \| title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. \| journal = J Cutan Pathol \| volume = 40 \| issue = 4 \| pages = 363-70 \| month = Apr \| year = 2013 \| doi = 10.1111/cup.12085 \| PMID = 23398472 }}</ref>
	*BerEP4 -ve.		*[[BerEP4]] -ve.
	**Positive in [[sclerosing basal cell carcinoma]].		**Positive in [[sclerosing basal cell carcinoma]].
	*CK15 -ve.		*CK15 -ve.

Michael: /* References */ fix cat.

2013-10-16T02:26:08Z

References: fix cat.

← Older revision		Revision as of 02:26, 16 October 2013
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Dermatologic neoplasms]]		[[Category:Dermatologic neoplasms]]

Michael: tweak

2013-10-16T01:57:00Z

tweak

← Older revision		Revision as of 01:57, 16 October 2013
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[skin]] - ~~usu.~~ head and neck		\| Site = [[skin]] - usually head and neck
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
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	*Adults.		*Adults.
	*Very rare<ref name=pmid21606063>{{Cite journal \| last1 = Tawfik \| first1 = AM. \| last2 = Kreft \| first2 = A. \| last3 = Wagner \| first3 = W. \| last4 = Vogl \| first4 = TJ. \| title = MRI of a microcystic adnexal carcinoma of the skin mimicking a fibrous tumour: case report and literature review. \| journal = Br J Radiol \| volume = 84 \| issue = 1002 \| pages = e114-7 \| month = Jun \| year = 2011 \| doi = 10.1259/bjr/44068180 \| PMID = 21606063 }}</ref> ~ 150 cases in world literature in 2001.<ref name=pmid11298716/>		*Very rare<ref name=pmid21606063>{{Cite journal \| last1 = Tawfik \| first1 = AM. \| last2 = Kreft \| first2 = A. \| last3 = Wagner \| first3 = W. \| last4 = Vogl \| first4 = TJ. \| title = MRI of a microcystic adnexal carcinoma of the skin mimicking a fibrous tumour: case report and literature review. \| journal = Br J Radiol \| volume = 84 \| issue = 1002 \| pages = e114-7 \| month = Jun \| year = 2011 \| doi = 10.1259/bjr/44068180 \| PMID = 21606063 }}</ref> ~ 150 cases in world literature in 2001.<ref name=pmid11298716/>
	*Uncommonly metastases.		*Uncommonly metastases.<ref name=pmid11298716/>
	==Gross==		==Gross==
	*Typical location: head and neck.<ref name=pmid11298716/><ref name=pmid16549917>{{Cite journal \| last1 = Gabillot-Carré \| first1 = M. \| last2 = Weill \| first2 = F. \| last3 = Mamelle \| first3 = G. \| last4 = Kolb \| first4 = F. \| last5 = Boitier \| first5 = F. \| last6 = Petrow \| first6 = P. \| last7 = Ortoli \| first7 = JC. \| last8 = Margulis \| first8 = A. \| last9 = Souteyrand \| first9 = P. \| title = Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. \| journal = Dermatology \| volume = 212 \| issue = 3 \| pages = 221-8 \| month = \| year = 2006 \| doi = 10.1159/000091248 \| PMID = 16549917 }}</ref>		*Typical location: head and neck.<ref name=pmid11298716/><ref name=pmid16549917>{{Cite journal \| last1 = Gabillot-Carré \| first1 = M. \| last2 = Weill \| first2 = F. \| last3 = Mamelle \| first3 = G. \| last4 = Kolb \| first4 = F. \| last5 = Boitier \| first5 = F. \| last6 = Petrow \| first6 = P. \| last7 = Ortoli \| first7 = JC. \| last8 = Margulis \| first8 = A. \| last9 = Souteyrand \| first9 = P. \| title = Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. \| journal = Dermatology \| volume = 212 \| issue = 3 \| pages = 221-8 \| month = \| year = 2006 \| doi = 10.1159/000091248 \| PMID = 16549917 }}</ref>
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	*Infiltrative [[squamous cell carcinoma]].		*Infiltrative [[squamous cell carcinoma]].

	~~Image~~:		===Images===
			www:
	*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref>		*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov).<ref name=pmid21606063/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov).<ref name=pmid21606063/>

Michael: fix infobox

2013-10-16T01:55:15Z

fix infobox

← Older revision		Revision as of 01:55, 16 October 2013
Line 14:		Line 14:
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[skin] - usu. head and neck		\| Site = [[skin]] - usu. head and neck
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =

Michael: split out, +infobox

2013-10-16T01:54:55Z

split out, +infobox

← Older revision		Revision as of 01:54, 16 October 2013
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	~~#redirect~~ [[~~Dermatologic_neoplasms#Microcystic_adnexal_carcinoma~~]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Micro = small basaloid cells - often forming small cystic spaces, usu. very bland cytology, fibrotic stroma
			\| Subtypes =
			\| LMDDx = [[sclerosing basal cell carcinoma]], desmoplastic [[trichoepithelioma]], infiltrative [[squamous cell carcinoma]]
			\| Stains =
			\| IHC = Ber-EP4 -ve, CD15 -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[skin] - usu. head and neck
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = adults
			\| Signs =
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good
			\| Other =
			\| ClinDDx =
			}}
			'''Microcystic adnexal carcinoma''', also known as ''syringomatous carcinoma'' and ''sclerosing sweat duct carcinoma'',<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref> is rare malignant [[dermatologic neoplasm\|tumour of the skin]] that can have a deceptively bland appearance.
			==General==
			*Low-grade tumour.
			*Adults.
			*Very rare<ref name=pmid21606063>{{Cite journal \| last1 = Tawfik \| first1 = AM. \| last2 = Kreft \| first2 = A. \| last3 = Wagner \| first3 = W. \| last4 = Vogl \| first4 = TJ. \| title = MRI of a microcystic adnexal carcinoma of the skin mimicking a fibrous tumour: case report and literature review. \| journal = Br J Radiol \| volume = 84 \| issue = 1002 \| pages = e114-7 \| month = Jun \| year = 2011 \| doi = 10.1259/bjr/44068180 \| PMID = 21606063 }}</ref> ~ 150 cases in world literature in 2001.<ref name=pmid11298716/>
			*Uncommonly metastases.
			==Gross==
			*Typical location: head and neck.<ref name=pmid11298716/><ref name=pmid16549917>{{Cite journal \| last1 = Gabillot-Carré \| first1 = M. \| last2 = Weill \| first2 = F. \| last3 = Mamelle \| first3 = G. \| last4 = Kolb \| first4 = F. \| last5 = Boitier \| first5 = F. \| last6 = Petrow \| first6 = P. \| last7 = Ortoli \| first7 = JC. \| last8 = Margulis \| first8 = A. \| last9 = Souteyrand \| first9 = P. \| title = Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. \| journal = Dermatology \| volume = 212 \| issue = 3 \| pages = 221-8 \| month = \| year = 2006 \| doi = 10.1159/000091248 \| PMID = 16549917 }}</ref>
			*Usu. a firm subcutaneous nodule.<ref name=pmid11298716>{{Cite journal \| last1 = Snow \| first1 = S. \| last2 = Madjar \| first2 = DD. \| last3 = Hardy \| first3 = S. \| last4 = Bentz \| first4 = M. \| last5 = Lucarelli \| first5 = MJ. \| last6 = Bechard \| first6 = R. \| last7 = Aughenbaugh \| first7 = W. \| last8 = McFadden \| first8 = T. \| last9 = Sharata \| first9 = H. \| title = Microcystic adnexal carcinoma: report of 13 cases and review of the literature. \| journal = Dermatol Surg \| volume = 27 \| issue = 4 \| pages = 401-8 \| month = Apr \| year = 2001 \| doi = \| PMID = 11298716 }}</ref>

			==Microscopic==
			Features:<ref>{{Ref Derm\|412}}</ref>
			*Small basaloid cells - often forming small cystic spaces - '''key feature'''.
			**Very bland cytology.
			*Fibrotic stroma.

			Notes:
			*Margins typically positive - as MAC typically extends well beyond what is suspected clinically.<ref name=pmid11298716/>

			DDx:
			*[[Sclerosing basal cell carcinoma]].
			*Desmoplastic [[trichoepithelioma]] (DTE).<ref name=pmid22366669>{{Cite journal \| last1 = Kirzhner \| first1 = M. \| last2 = Jakobiec \| first2 = FA. \| last3 = Borodic \| first3 = G. \| title = Desmoplastic trichoepithelioma: report of a unique periocular case. \| journal = Ophthal Plast Reconstr Surg \| volume = 28 \| issue = 5 \| pages = e121-3 \| month = \| year = \| doi = 10.1097/IOP.0b013e318245535a \| PMID = 22366669 }}</ref>
			*Infiltrative [[squamous cell carcinoma]].

			Image:
			*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref>
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov).<ref name=pmid21606063/>

			==IHC==
			Features:<ref name=pmid23398472 >{{Cite journal \| last1 = Sellheyer \| first1 = K. \| last2 = Nelson \| first2 = P. \| last3 = Kutzner \| first3 = H. \| last4 = Patel \| first4 = RM. \| title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. \| journal = J Cutan Pathol \| volume = 40 \| issue = 4 \| pages = 363-70 \| month = Apr \| year = 2013 \| doi = 10.1111/cup.12085 \| PMID = 23398472 }}</ref>
			*BerEP4 -ve.
			**Positive in [[sclerosing basal cell carcinoma]].
			*CK15 -ve.
			**Positive in DTE.
			**Negative in sclerosing BCC.

			==See also==
			*[[Dermatologic neoplasms]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Dermatologic neoplasms]]

Michael: +cat.

2011-10-22T05:39:28Z

+cat.

← Older revision		Revision as of 05:39, 22 October 2011
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	#redirect [[Dermatologic_neoplasms#Microcystic_adnexal_carcinoma]]		#redirect [[Dermatologic_neoplasms#Microcystic_adnexal_carcinoma]]

			[[Category:Diagnosis]]

Michael: redirect

2011-09-16T19:12:26Z

redirect

New page

#redirect [[Dermatologic_neoplasms#Microcystic_adnexal_carcinoma]]