Metaphyseal fibrous defect - Revision history

Sarah: /* General */

2014-10-18T23:43:06Z

General

← Older revision		Revision as of 23:43, 18 October 2014
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	*Often small lesions discovered as an radiographic incidentaloma.		*Often small lesions discovered as an radiographic incidentaloma.
	*Rarely seen as a pathologic specimen (should not be biopsied).		*Rarely seen as a pathologic specimen (should not be biopsied).
	*May be seen in the context of ''Jaffe-Campanacci syndrome''.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref>		*May be seen in the context of ''Jaffe-Campanacci syndrome'' which may be a presentation of Neurofibromatosis Type 1.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref><ref>{{Cite journal \| last1 = Stewart \| first1 = DR. \| last2 = Brems \| first2 = H. \| last3 = Gomes \| first3 = AG. \| last4 = Ruppert \| first4 = SL. \| last5 = Callens \| first5 = T. \| last6 = Williams \| first6 = J. \| last7 = Claes \| first7 = K. \| last8 = Bober \| first8 = MB. \| last9 = Hachen \| first9 = R. \| title = Jaffe-Campanacci syndrome, revisited: detailed clinical and molecular analyses determine whether patients have neurofibromatosis type 1, coincidental manifestations, or a distinct disorder. \| journal = Genet Med \| volume = 16 \| issue = 6 \| pages = 448-59 \| month = Jun \| year = 2014 \| doi = 10.1038/gim.2013.163 \| PMID = 24232412 }}
			</ref>
	*Radiographic diagnosis.		*Radiographic diagnosis.

Michael at 06:01, 17 October 2014

2014-10-17T06:01:38Z

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	\| EHVSC_mult =		\| EHVSC_mult =
	\| pathprotocols =		\| pathprotocols =
	\| wikipedia =		\| wikipedia = Nonossifying fibroma
	\| pathoutlines = {{Pathologyoutlines\|topic/bonemetaphysealfibrousdefect}}		\| pathoutlines = {{Pathologyoutlines\|topic/bonemetaphysealfibrousdefect}}
	\| rosaicollection =		\| rosaicollection =
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	*Eccentric location.		*Eccentric location.

	~~Radiographic findings:~~		===Radiology===
	*Sharply demarcated, lucent, loculated, meta-diaphyseal lesion.		*Sharply demarcated, lucent, loculated, meta-diaphyseal lesion.
	*Surrounded by a rim of sclerotic bone.		*Surrounded by a rim of sclerotic bone.

			<gallery>
			Image:NOF 1.jpg\|Nonossifying fibroma. (WC)
			</gallery>

	==Microscopic==		==Microscopic==

Michael: /* External links */ fix

2014-10-17T05:56:26Z

External links: fix

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	*[http://njms2.umdnj.edu/tutorweb/case8.htm A case of MFD (umdnj.edu)].		*[http://njms2.umdnj.edu/tutorweb/case8.htm A case of MFD (umdnj.edu)].
	*[http://radiopaedia.org/articles/fibrous-cortical-defect Fibrous cortical defect (radiopaedia.org)].		*[http://radiopaedia.org/articles/fibrous-cortical-defect Fibrous cortical defect (radiopaedia.org)].
	*[http://radiopaedia.org/articles/non-ossifying-fibroma-1 Non-ossifying fibroma (radiopaedia.org)]/		*[http://radiopaedia.org/articles/non-ossifying-fibroma-1 Non-ossifying fibroma (radiopaedia.org)].

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Bone]]		[[Category:Bone]]

Michael at 05:45, 17 October 2014

2014-10-17T05:45:06Z

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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[giant cell tumour of bone]]		\| LMDDx = [[giant cell tumour of bone]], others
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael at 05:43, 17 October 2014

2014-10-17T05:43:49Z

← Older revision		Revision as of 05:43, 17 October 2014
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	*Long bones.		*Long bones.
	*Eccentric location.		*Eccentric location.

			Radiographic findings:
			*Sharply demarcated, lucent, loculated, meta-diaphyseal lesion.
			*Surrounded by a rim of sclerotic bone.

	==Microscopic==		==Microscopic==
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	==Molecular==		==Molecular==
	*Not relevant.		*Not relevant.

	~~==Radiographic findings==~~
	~~Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone~~

	==Sign out==		==Sign out==

Michael at 05:42, 17 October 2014

2014-10-17T05:42:11Z

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	\| ClinDDx =		\| ClinDDx =
	\| Tx = none		\| Tx = none
			}}
			{{ Infobox external links
			\| Name = {{PAGENAME}}
			\| EHVSC =
			\| EHVSC_mult =
			\| pathprotocols =
			\| wikipedia =
			\| pathoutlines = {{Pathologyoutlines\|topic/bonemetaphysealfibrousdefect}}
			\| rosaicollection =
	}}		}}
	'''Metaphyseal fibrous defect''', abbreviated '''MFD''', is a common benign abnormality of the [[metaphysis]], classically seen in children and young adults.		'''Metaphyseal fibrous defect''', abbreviated '''MFD''', is a common benign abnormality of the [[metaphysis]], classically seen in children and young adults.

Michael at 05:36, 17 October 2014

2014-10-17T05:36:50Z

← Older revision		Revision as of 05:36, 17 October 2014
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	*Rarely seen as a pathologic specimen (should not be biopsied).		*Rarely seen as a pathologic specimen (should not be biopsied).
	*May be seen in the context of ''Jaffe-Campanacci syndrome''.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref>		*May be seen in the context of ''Jaffe-Campanacci syndrome''.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref>
			*Radiographic diagnosis.

	Clinical history:		Clinical history:
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	*Pathologic fracture.		*Pathologic fracture.

	~~Prognosis~~:		Treatment:
	*~~Ideally should not be biopsied.~~		*None (spontaneously resolve by ossification).
	*Radiographically characteristic and benign.		**Diagnosis is part of the ''skeletal do not touch list''.<ref>URL: [http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1 http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1]. Accessed on: October 14, 2014.</ref>
	*Ideally should not be treated or even biopsied.
	*Spontaneously resolve by ossification.
	*~~May resolve into a~~ '~~bone island~~'.

	==~~Site~~==		Notes:
	*Metaphysis of distal femur or proximal tibia (80%).		*May resolve into a ''bone island''.

			Clinical DDx:
			*''FOG MACHINES'' acronym for radiographically lytic bone lesions.<ref>URL: [http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic]. Accessed on: October 14, 2014.</ref>

			==Gross==
			*Firm, granular, brown to yellow to red.

			Site:
			*[[Metaphysis]] of distal femur or proximal tibia (80%).
	*Cortical.		*Cortical.
	*[[Metaphysis]].		*Metaphysis.
	*Long bones.		*Long bones.
	*Eccentric location.		*Eccentric location.

	~~==Gross==~~
	*Firm, granular, brown to yellow to red.

	==Microscopic==		==Microscopic==
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	DDx (microscopic):		DDx (microscopic):
	*[[Giant cell tumour of bone]] - [[epiphysis\|epiphyseal]] location, occurs in adults.		*[[Giant cell tumour of bone]] - [[epiphysis\|epiphyseal]] location, occurs in adults.
			*Other [[giant cell lesions]] of bone.
	~~==Relevant Diagnostic Groups==~~		*[[Spindle cell lesion]]s of bone.
	*Clinical
	**~~FOG MACHINES - acronym for radiographically lytic bone lesions <ref>URL:~~ [~~http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic]. Accessed on: October 14, 2014.</ref>~~
	**'Skeletal do not touch list' <ref>URL: [~~http://radiopaedia.org/articles/skeletal-do-not-touch-~~lesions~~-1 http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1~~]~~. Accessed on: October 14, 2014.</ref>~~
	*Pathologic
	**Giant cell lesions of bone.
	**Spindle cell ~~lesions~~ of bone.

	==Images==		==Images==
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	==IHC==		==IHC==
	*Not relevant		*Not relevant.

	==Molecular==		==Molecular==
	*Not relevant		*Not relevant.

	==Radiographic findings==		==Radiographic findings==
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	==Sign out==		==Sign out==
	<pre>		<pre>
	BONE, CURETTAGE: METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.		BONE, CURETTAGE:
			- METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.
	</pre>		</pre>

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	==External links==		==External links==
	*http://njms2.umdnj.edu/tutorweb/case8.htm		*[http://njms2.umdnj.edu/tutorweb/case8.htm A case of MFD (umdnj.edu)].
	*http://www.~~pathologyoutlines.com/topic/bonemetaphysealfibrousdefect~~.~~html~~		*[http://radiopaedia.org/articles/fibrous-cortical-defect Fibrous cortical defect (radiopaedia.org)].
	*http://radiopaedia.org/articles/fibrous-cortical-defect		*[http://radiopaedia.org/articles/non-ossifying-fibroma-1 Non-ossifying fibroma (radiopaedia.org)]/
	*http://radiopaedia.org/articles/non-ossifying-fibroma-1

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Bone]]		[[Category:Bone]]

Michael at 06:54, 16 October 2014

2014-10-16T06:54:58Z

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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Bone]]

Michael at 06:52, 16 October 2014

2014-10-16T06:52:57Z

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	\| Width =		\| Width =
	\| Caption =		\| Caption =
	\| Synonyms = nonossifying fibroma		\| Synonyms = nonossifying fibroma, fibrous cortical defect, fibrous metaphyseal defect, fibroxanthoma of bone
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =

Michael: fill in infobox things...

2014-10-16T06:52:10Z

fill in infobox things...

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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = Metaphyseal fibrous defect		\| Name = Metaphyseal fibrous defect
	\| Image =		\| Image = Bone Metaphyseal Fibrous Defect High Power.JPG
	\| Width =		\| Width =
	\| Caption =		\| Caption =
	\| Synonyms = ~~Nonossifying~~ fibroma		\| Synonyms = nonossifying fibroma
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[giant cell tumour of bone]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site =		\| Site = [[metaphysis]] of [[bone]] - usu. lower extremity
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = ~~Incidental~~ radiograhic finding		\| Clinicalhx = incidental radiograhic finding
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = common
	\| Bloodwork =		\| Bloodwork =
	\| Rads = ~~Lucent~~ defect		\| Rads = lucent defect
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = benign
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
	\| Tx =		\| Tx = none
	}}		}}
	'''Metaphyseal fibrous defect''', abbreviated '''MFD''', is a common benign abnormality of the [[metaphysis]], classically seen in children and young adults.		'''Metaphyseal fibrous defect''', abbreviated '''MFD''', is a common benign abnormality of the [[metaphysis]], classically seen in children and young adults.
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	==Images==		==Images==
	<gallery>		<gallery>
	Image:Bone Metaphyseal Fibrous Defect Medium Power.JPG\|Metaphyseal fibrous defect - intermediate magnification.]]		Image:Bone Metaphyseal Fibrous Defect Medium Power.JPG\|Metaphyseal fibrous defect - intermediate magnification.
	Image:Bone Metaphyseal Fibrous Defect High Power.JPG\|Metaphyseal fibrous defect - high magnification.]]		Image:Bone Metaphyseal Fibrous Defect High Power.JPG\|Metaphyseal fibrous defect - high magnification.
	</gallery>		</gallery>
	www:		www: