Medullary thyroid carcinoma - Revision history

Brigitte: /* Images */

2018-04-26T12:49:25Z

Images

← Older revision		Revision as of 12:49, 26 April 2018
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	===Images===		===Images===
	www:		www:
	*[http://jcp.bmj.com/content/vol57/issue3/images/large/cp8474.f16.jpeg Medullary thyroid carcinoma (bmj.com)].
	*[http://www.nature.com/ki/journal/v70/n11/fig_tab/5001888f2.html C cell hyperplasia (nature.com)].
	*[http://lifesci.rutgers.edu/~babiarz/Review3/Lp6/scope8.htm C cell (rutgers.edu)].
	*[http://www.anatomyatlases.org/MicroscopicAnatomy/Images/Plate287.jpg Parafollicular cells (anatomyatlases.org)].		*[http://www.anatomyatlases.org/MicroscopicAnatomy/Images/Plate287.jpg Parafollicular cells (anatomyatlases.org)].
	<gallery>		<gallery>

Michael: /* Sign out */

2016-04-11T18:21:45Z

Sign out

← Older revision		Revision as of 18:21, 11 April 2016
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	Comment:		Comment:
	Stains/IHC ~~confirms~~ the ~~impression from~~ the ~~morphology and history; it~~ stains as follows:		Stains/IHC confirm the morphologic findings; the tumour stains as follows:
	POSITIVE: calcitonin, CEAp, synaptophysin, CD56, TTF-1 (focal, moderate), congo red (confirms the presence of amyloid).		POSITIVE: calcitonin, CEAp, synaptophysin, CD56, TTF-1 (focal, moderate), congo red (confirms the presence of amyloid).
	NEGATIVE: thyroglobulin, CDX2.		NEGATIVE: thyroglobulin, CDX2.

Michael: /* EM */

2016-04-11T18:20:19Z

← Older revision		Revision as of 18:20, 11 April 2016
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	Images: [http://pathhsw5m54.ucsf.edu/case7/image77.html Neurosecretory granules (ucsf.edu)].		Images: [http://pathhsw5m54.ucsf.edu/case7/image77.html Neurosecretory granules (ucsf.edu)].

			==Sign out==
			<pre>
			Lesion, Liver, Core Biopsy:
			- METASTATIC MEDULLARY THYROID CARCINOMA, see comment.

			Comment:
			Stains/IHC confirms the impression from the morphology and history; it stains as follows:
			POSITIVE: calcitonin, CEAp, synaptophysin, CD56, TTF-1 (focal, moderate), congo red (confirms the presence of amyloid).
			NEGATIVE: thyroglobulin, CDX2.
			</pre>

			===Micro===
			The sections show cells of intermediate size without apparent nucleoli, moderate eosinophilic cytoplasm, arranged in nests, focally associated with amorphous acellular cotton candy-like material.

			The cotton candy-like material has a light apple-green appearance when polarized.

	==See also==		==See also==

Michael: /* IHC */

2016-01-02T05:42:54Z

IHC

← Older revision		Revision as of 05:42, 2 January 2016
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	**[[Chromogranin A]].		**[[Chromogranin A]].
	**[[Synaptophysin]].		**[[Synaptophysin]].
	*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>		*[[CEA]] +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>
	*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>		*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>
	*TTF-1 +ve		*TTF-1 +ve

Michael at 05:42, 2 January 2016

2016-01-02T05:42:29Z

← Older revision		Revision as of 05:42, 2 January 2016
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	\| LMDDx =		\| LMDDx =
	\| Stains = congo red +ve (amyloid deposits)		\| Stains = congo red +ve (amyloid deposits)
	\| IHC = calcitonin +ve, CEA +ve, chromogranin A +ve, synaptophysin +ve, thyroglobulin -ve (usually)		\| IHC = calcitonin +ve, [[CEA]] +ve, chromogranin A +ve, synaptophysin +ve, thyroglobulin -ve (usually)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	DDx:		DDx:
	*Other thyroid ~~tumor~~		*Other thyroid tumours:
	**[[Anaplastic thyroid carcinoma]].		**[[Anaplastic thyroid carcinoma]].
	**[[Papillary thyroid carcinoma]].		**[[Papillary thyroid carcinoma]].
	**[[Hurthle cell carcinoma]]		**[[Hurthle cell carcinoma]]
	***The oncocytic variant of medullary carcinoma can be confused with Hurthle cell carcinoma. Clues to suggest medullary carcinoma:		***The oncocytic variant of medullary carcinoma can be confused with [[Hurthle cell carcinoma]]. Clues to suggest medullary carcinoma:
	****Cytoplasm is amphophilic as opposed to eosinophilic		****Cytoplasm is amphophilic as opposed to eosinophilic
	****Nests of tumour cells separated by fibrous septa		****Nests of tumour cells separated by fibrous septa
	**[[C-cell hyperplasia]]		*[[C-cell hyperplasia]].
	***Invasive medullary carcinoma shows fibrosis around tumor cells and stains more weakly for calcitonin.		**Invasive medullary carcinoma shows fibrosis around tumor cells and stains more weakly for calcitonin.
			*Other neuroendocrine tumours - primary or metastatic:
	*Other neuroendocrine ~~tumor (~~primary or metastatic)		**[[Paraganglioma]] - negative for keratin, calcitonin and [[CEA]].
	**[[Paraganglioma]] - ~~Negative~~ for keratin, calcitonin and CEA		**[[Carcinoid]] - negative for calcitonin.
	**[[Carcinoid]] - ~~Negative~~ for calcitonin		*Metastatic [[melanoma]].
			**Pigment.
	*And of course		**Melanoma markers positive, calcitonin and CEA negative.
	**Metastatic ~~Melanoma~~
	***Pigment -
	***Melanoma markers positive, calcitonin and CEA negative.


	===Images===		===Images===

Michael at 02:10, 18 November 2015

2015-11-18T02:10:52Z

← Older revision		Revision as of 02:10, 18 November 2015
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	\| Gross = usu. well-circumscribed, white, gray or yellow, gritty, firm		\| Gross = usu. well-circumscribed, white, gray or yellow, gritty, firm
	\| Grossing =		\| Grossing =
			\| Staging = [[thyroid cancer staging]]
	\| Site = [[thyroid gland]]		\| Site = [[thyroid gland]]
	\| Assdx = [[C-cell hyperplasia]]		\| Assdx = [[C-cell hyperplasia]]

Sarah: /* Microscopic */

2015-03-28T06:45:07Z

Microscopic

← Older revision		Revision as of 06:45, 28 March 2015
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	DDx:		DDx:
	Other thyroid tumor		*Other thyroid tumor
	*[[Anaplastic thyroid carcinoma]].		**[[Anaplastic thyroid carcinoma]].
	*[[Papillary thyroid carcinoma]].		**[[Papillary thyroid carcinoma]].
	*[[Hurthle cell carcinoma]]		**[[Hurthle cell carcinoma]]
	**The oncocytic variant of medullary carcinoma can be confused with Hurthle cell carcinoma. Clues to suggest medullary carcinoma:		***The oncocytic variant of medullary carcinoma can be confused with Hurthle cell carcinoma. Clues to suggest medullary carcinoma:
	***Cytoplasm is amphophilic as opposed to eosinophilic		****Cytoplasm is amphophilic as opposed to eosinophilic
	***Nests of tumour cells separated by fibrous septa		****Nests of tumour cells separated by fibrous septa
	*[[C-cell hyperplasia]]		**[[C-cell hyperplasia]]
	**Invasive medullary carcinoma shows fibrosis around tumor cells and stains more weakly for calcitonin.		***Invasive medullary carcinoma shows fibrosis around tumor cells and stains more weakly for calcitonin.

	Other neuroendocrine tumor (primary or metastatic)		*Other neuroendocrine tumor (primary or metastatic)
	*[[Paraganglioma]] - Negative for keratin, calcitonin and CEA		**[[Paraganglioma]] - Negative for keratin, calcitonin and CEA
	*[[Carcinoid]] - Negative for calcitonin		**[[Carcinoid]] - Negative for calcitonin

	And of course		*And of course
	*[[Melanoma~~]] -~~		**Metastatic Melanoma
	**Pigment -		***Pigment -
	**Melanoma markers positive, calcitonin and CEA negative.		***Melanoma markers positive, calcitonin and CEA negative.

Sarah: /* IHC */

2015-03-23T03:55:34Z

IHC

← Older revision		Revision as of 03:55, 23 March 2015
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	*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>		*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>
	*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>		*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>
	*[TTF]-1 +ve		*TTF-1 +ve

	==EM==		==EM==

Sarah: /* IHC */

2015-03-23T03:55:18Z

IHC

← Older revision		Revision as of 03:55, 23 March 2015
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	*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>		*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>
	*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>		*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>
	[TTF]-1 +ve		*[TTF]-1 +ve

	==EM==		==EM==

Sarah: /* IHC */

2015-03-23T03:54:48Z

IHC

← Older revision		Revision as of 03:54, 23 March 2015
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	*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>		*CEA +ve (often better staining than calcitonin).<ref>SB. 7 January 2010.</ref>
	*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>		*Thyroglobulin usu. -ve.<ref name=pmid8454270>{{Cite journal \| last1 = de Micco \| first1 = C. \| last2 = Chapel \| first2 = F. \| last3 = Dor \| first3 = AM. \| last4 = Garcia \| first4 = S. \| last5 = Ruf \| first5 = J. \| last6 = Carayon \| first6 = P. \| last7 = Henry \| first7 = JF. \| last8 = Lebreuil \| first8 = G. \| title = Thyroglobulin in medullary thyroid carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. \| journal = Hum Pathol \| volume = 24 \| issue = 3 \| pages = 256-62 \| month = Mar \| year = 1993 \| doi = \| PMID = 8454270 }}</ref>
			[TTF]-1 +ve

	==EM==		==EM==