Medullary breast carcinoma - Revision history

Michael at 11:36, 8 September 2016

2016-09-08T11:36:14Z

← Older revision		Revision as of 11:36, 8 September 2016
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing = [[~~mastectomy~~ grossing]]		\| Grossing = [[breast grossing]]
	\| Staging = [[breast cancer staging]]		\| Staging = [[breast cancer staging]]
	\| Site = [[breast]] - see ''[[invasive breast cancer]]''		\| Site = [[breast]] - see ''[[invasive breast cancer]]''

Michael at 04:12, 1 May 2016

2016-05-01T04:12:26Z

← Older revision		Revision as of 04:12, 1 May 2016
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing = [[mastectomy grossing]]
			\| Staging = [[breast cancer staging]]
	\| Site = [[breast]] - see ''[[invasive breast cancer]]''		\| Site = [[breast]] - see ''[[invasive breast cancer]]''
	\| Assdx =		\| Assdx =

Sarah: /* Images */

2015-03-28T04:25:07Z

Images

← Older revision		Revision as of 04:25, 28 March 2015
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	==Images==		==Images==
	<gallery>		<gallery>
	Image:Breast MedullaryCarcinoma (2) PA.JPG~~\|thumb~~\|Breast - Medullary Carcinoma - low power (SKB)		Image:Breast MedullaryCarcinoma (2) PA.JPG\|Breast - Medullary Carcinoma - low power (SKB)
	Image:Breast MedullaryCarcinoma TripleNegative LP PA.JPG~~\|thumb~~\|Breast - Medullary Carcinoma - medium power (SKB)		Image:Breast MedullaryCarcinoma TripleNegative LP PA.JPG\|Breast - Medullary Carcinoma - medium power (SKB)
	Image:Breast MedullaryCarcinoma TripleNegative HP PA.JPG~~\|thumb~~\|Breast - Medullary Carcinoma - high power (SKB)		Image:Breast MedullaryCarcinoma TripleNegative HP PA.JPG\|Breast - Medullary Carcinoma - high power (SKB)
	</gallery>		</gallery>

Sarah: /* Microscopic */

2015-03-28T04:22:15Z

Microscopic

← Older revision		Revision as of 04:22, 28 March 2015
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	DDx:		DDx:
	*[[Invasive ductal carcinoma of the breast\|Invasive ductal carcinoma]] with medullary features.		*[[Invasive ductal carcinoma of the breast\|Invasive ductal carcinoma]] with medullary features.

			==Images==
			<gallery>
			Image:Breast MedullaryCarcinoma (2) PA.JPG\|thumb\|Breast - Medullary Carcinoma - low power (SKB)
			Image:Breast MedullaryCarcinoma TripleNegative LP PA.JPG\|thumb\|Breast - Medullary Carcinoma - medium power (SKB)
			Image:Breast MedullaryCarcinoma TripleNegative HP PA.JPG\|thumb\|Breast - Medullary Carcinoma - high power (SKB)
			</gallery>

	==IHC==		==IHC==

Michael: /* General */

2014-05-27T15:52:14Z

General

← Older revision		Revision as of 15:52, 27 May 2014
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	Epidemiology:		Epidemiology:
	*Thought to have a better prognosis that no special type (NST).		*Thought to have a better prognosis that no special type (NST).
	*May be associated with a BRCA1 mutation.		*May be associated with a [[BRCA1]] mutation.

	==Gross==		==Gross==

Michael at 19:18, 14 February 2014

2014-02-14T19:18:15Z

← Older revision		Revision as of 19:18, 14 February 2014
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	\| Caption =		\| Caption =
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = all required: (1) lesion has well-circumscribed border, (2) syncytial growth pattern, (3) lymphocytic infiltrate, (4) high nuclear grade (as per Nottingham grading system), (5) no tubule formation
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[Invasive ductal carcinoma of the breast\|Invasive ductal carcinoma]] with medullary features
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = ER -ve, PR -ve, HER2 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 18:56, 14 February 2014

2014-02-14T18:56:50Z

← Older revision		Revision as of 18:56, 14 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[breast]] - see ''[[invasive breast cancer]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = better than NST
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Medullary breast carcinoma''' is an uncommon form of [[invasive breast carcinoma]].		'''Medullary breast carcinoma''' is an uncommon form of [[invasive breast carcinoma]].

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	#High nuclear grade (as per Nottingham grading system).		#High nuclear grade (as per Nottingham grading system).
	#No tubule formation.		#No tubule formation.

			DDx:
			*[[Invasive ductal carcinoma of the breast\|Invasive ductal carcinoma]] with medullary features.

	==IHC==		==IHC==

Michael: /* References */

2014-02-14T11:06:10Z

References

← Older revision		Revision as of 11:06, 14 February 2014
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	{{Reflist\|2}}		{{Reflist\|2}}

	[[Category:Invasive breast ~~carcinoma~~]]		[[Category:Invasive breast cancer]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: /* See also */

2014-02-14T11:05:20Z

Michael: split out

2014-02-14T11:04:16Z

split out

← Older revision		Revision as of 11:04, 14 February 2014
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	~~#redirect~~ [[~~Invasive_breast_cancer#Medullary_breast_carcinoma~~]]		'''Medullary breast carcinoma''' is an uncommon form of [[invasive breast carcinoma]].

			It is also known as '''medullary carcinoma of the breast'''.

			==General==
			*Uncommon breast cancer subtype.
			*Some pathologists very rarely make the diagnosis.{{fact}}

			Epidemiology:
			*Thought to have a better prognosis that no special type (NST).
			*May be associated with a BRCA1 mutation.

			==Gross==
			*Well-circumscribed border.<ref name=pmid21071383>{{Cite journal \| last1 = Yoo \| first1 = JL. \| last2 = Woo \| first2 = OH. \| last3 = Kim \| first3 = YK. \| last4 = Cho \| first4 = KR. \| last5 = Yong \| first5 = HS. \| last6 = Seo \| first6 = BK. \| last7 = Kim \| first7 = A. \| last8 = Kang \| first8 = EY. \| title = Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas? \| journal = Radiographics \| volume = 30 \| issue = 6 \| pages = 1689-702 \| month = Oct \| year = 2010 \| doi = 10.1148/rg.306105511 \| PMID = 21071383 }}</ref>

			Aside - malignant well-circumscribed breast masses - radiologic DDx:<ref name=pmid21071383/>
			*Medullary breast carcinoma.
			*[[Mucinous breast carcinoma]].
			*[[Phyllodes tumour\|Malignant phyllodes tumour]].
			*[[Invasive papillary carcinoma of the breast]].

			==Microscopic==
			Features:
			#Lesion has well-circumscribed border.
			#Syncytial growth pattern = clumps of cells with poorly defined cell borders.
			#Lymphocytic infiltrate.
			#High nuclear grade (as per Nottingham grading system).
			#No tubule formation.

			==IHC==
			Features - typical:<ref>{{Cite journal \| last1 = Matkovic \| first1 = B. \| last2 = Juretic \| first2 = A. \| last3 = Separovic \| first3 = V. \| last4 = Novosel \| first4 = I. \| last5 = Separovic \| first5 = R. \| last6 = Gamulin \| first6 = M. \| last7 = Kruslin \| first7 = B. \| title = Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer. \| journal = Tumori \| volume = 94 \| issue = 6 \| pages = 838-44 \| month = \| year = \| doi = \| PMID = 19267102 }}</ref>
			*ER -ve.
			*PR -ve.
			*HER2 -ve.

			==See also==
			*[[Invasive breast carcinoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Invasive breast carcinoma]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

← Older revision		Revision as of 11:05, 14 February 2014
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	==See also==		==See also==
	*[[Invasive breast carcinoma]].		*[[Invasive breast carcinoma]].
			*[[Medullary carcinoma]].

	==References==		==References==