Mastocytosis - Revision history

Michael: /* Microscopic */

2018-03-20T03:19:54Z

Microscopic

← Older revision		Revision as of 03:19, 20 March 2018
Line 59:		Line 59:
	DDx:		DDx:
	*[[Intradermal nevus]].		*[[Intradermal nevus]].
	*~~Aggressive systemic mastocytosis - may have marked atypia and mimic~~ [[~~pleomorphic~~ undifferentiated sarcoma]], [[Langerhans cell histiocytosis]] and other [[pleomorphic tumours]].		*[[Pleomorphic undifferentiated sarcoma]], [[Langerhans cell histiocytosis]] and other [[pleomorphic tumours]] - for ''aggressive systemic mastocytosis''.

	===Images===		===Images===

Michael: /* Microscopic */

2018-03-20T03:18:01Z

Microscopic

← Older revision		Revision as of 03:18, 20 March 2018
Line 59:		Line 59:
	DDx:		DDx:
	*[[Intradermal nevus]].		*[[Intradermal nevus]].
	*Aggressive systemic mastocytosis - may have marked atypia and mimic [[pleomorphic undifferentiated sarcoma]], [[Langerhans cell histiocytosis]] and other [[pleomorphic ~~neoplasms~~]].		*Aggressive systemic mastocytosis - may have marked atypia and mimic [[pleomorphic undifferentiated sarcoma]], [[Langerhans cell histiocytosis]] and other [[pleomorphic tumours]].

	===Images===		===Images===

Michael: /* Microscopic */

2018-03-20T03:17:30Z

Microscopic

← Older revision		Revision as of 03:17, 20 March 2018
Line 56:		Line 56:
	*Lymphocyte versus mast cell:		*Lymphocyte versus mast cell:
	**Lymphocytes = round; mast cells = ovoid.		**Lymphocytes = round; mast cells = ovoid.
	*Aggressive systemic mastocytosis - may have marked atypia and mimic ''[[pleomorphic undifferentiated sarcoma]]''.

	DDx:		DDx:
	*[[Intradermal nevus]].		*[[Intradermal nevus]].
			*Aggressive systemic mastocytosis - may have marked atypia and mimic [[pleomorphic undifferentiated sarcoma]], [[Langerhans cell histiocytosis]] and other [[pleomorphic neoplasms]].

	===Images===		===Images===

Michael: /* Microscopic */

2018-03-20T03:12:08Z

Microscopic

← Older revision		Revision as of 03:12, 20 March 2018
Line 56:		Line 56:
	*Lymphocyte versus mast cell:		*Lymphocyte versus mast cell:
	**Lymphocytes = round; mast cells = ovoid.		**Lymphocytes = round; mast cells = ovoid.
			*Aggressive systemic mastocytosis - may have marked atypia and mimic ''[[pleomorphic undifferentiated sarcoma]]''.

	DDx:		DDx:

Michael: /* Stains */

2014-06-19T19:39:23Z

Stains

← Older revision		Revision as of 19:39, 19 June 2014
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	==Stains==		==Stains==
	*[[Toluidine blue stain\|Toluidine blue]] -- highlights the granules.		*[[Toluidine blue stain\|Toluidine blue]] -- highlights the granules.
			*[[Giemsa stain]] +ve

	==IHC==		==IHC==

Michael: /* Images */

2014-06-19T19:38:48Z

Images

← Older revision		Revision as of 19:38, 19 June 2014
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	Image:Mastocytosis - intermed mag.jpg \| Mastocytosis - intermed. mag. (WC)		Image:Mastocytosis - intermed mag.jpg \| Mastocytosis - intermed. mag. (WC)
	Image:Mastocytosis_-_high_mag.jpg \| Mastocytosis - high mag. (WC)		Image:Mastocytosis_-_high_mag.jpg \| Mastocytosis - high mag. (WC)
			Image:Mastocytosis_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)
	Image:Mastocytosis_-_cropped_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)		Image:Mastocytosis_-_cropped_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)
	</gallery>		</gallery>

Michael: /* Images */

2014-06-19T19:37:39Z

Images

← Older revision		Revision as of 19:37, 19 June 2014
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	*[http://path.upmc.edu/cases/case409.html Systemic mastocytosis - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case409.html Systemic mastocytosis - several images (upmc.edu)].
	<gallery>		<gallery>
			Image:Mastocytosis - intermed mag.jpg \| Mastocytosis - intermed. mag. (WC)
	Image:Mastocytosis_-_high_mag.jpg \| Mastocytosis - high mag. (WC)		Image:Mastocytosis_-_high_mag.jpg \| Mastocytosis - high mag. (WC)
	Image:Mastocytosis_-_cropped_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)		Image:Mastocytosis_-_cropped_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)

Michael: +template

2014-06-19T19:36:31Z

+template

← Older revision		Revision as of 19:36, 19 June 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Mastocytosis_-_cropped_-_very_high_mag.jpg
			\| Width =
			\| Caption = Mastocytosis. [[H&E stain]].
			\| Synonyms =
			\| Micro = mast cells (cells in the superficial/mid dermis that are: lymphocyte-like with more cytoplasm that is granular; cells may have spindled or stellate morphology); +/-eosinophils (common)
			\| Subtypes =
			\| LMDDx = [[intradermal nevus]]
			\| Stains = [[Giemsa stain]] +ve
			\| IHC = CD117 +ve, tryptase +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[skin]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = not very common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = dependent on underlying cause
			\| Other =
			\| ClinDDx =
			\| Tx = dependent on underlying cause
			}}
	'''Mastocytosis''' is the abundance of [[mast cells]]. It can be due to a number of causes.		'''Mastocytosis''' is the abundance of [[mast cells]]. It can be due to a number of causes.

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	Notes:		Notes:
	*Lymphocyte ~~vs.~~ mast cell:		*Lymphocyte versus mast cell:
	**Lymphocytes = round; mast cells = ovoid.		**Lymphocytes = round; mast cells = ovoid.

			DDx:
			*[[Intradermal nevus]].

	===Images===		===Images===

Michael at 04:56, 31 December 2013

2013-12-31T04:56:52Z

← Older revision		Revision as of 04:56, 31 December 2013
Line 1:		Line 1:
	'''Mastocytosis''' is the abundance of [[mast cells]].		'''Mastocytosis''' is the abundance of [[mast cells]]. It can be due to a number of causes.

	==General==		==General==

Michael: more

2013-12-31T04:56:20Z

← Older revision		Revision as of 04:56, 31 December 2013
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	#~~redirect~~ [[Non-~~malignant_skin_disease#Mastocytosis~~]]		'''Mastocytosis''' is the abundance of [[mast cells]].

			==General==
			*Abundance of [[mast cell]]s.

			Classification:<ref name=pmid21083038>{{Cite journal \| last1 = Arock \| first1 = M. \| last2 = Valent \| first2 = P. \| title = Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives. \| journal = Expert Rev Hematol \| volume = 3 \| issue = 4 \| pages = 497-516 \| month = Aug \| year = 2010 \| doi = 10.1586/ehm.10.42 \| PMID = 21083038 }}</ref>
			#Cutaneous (only) - usually children.
			#*Urticaria pigmentosa.
			#*Others.
			#Systemic - usually adults.
			#*Indolent subvariant.
			#*Aggressive subvariant.
			#*Leukemic subvariant.

			==Microscopic==
			Features:<ref name=Ref_PBoD8\|1185>{{Ref PBoD8\|1185}}</ref>
			*Cells in the superficial/mid dermis that are:
			**Lymphocyte-like with more cytoplasm that is granular.
			***Cells may have spindled or stellate morphology.
			***Tend to be more abundant around vessels.
			*+/-Eosinophils (common).
			*+/-Edema - often prominent; gives cells a white halo.

			Notes:
			*Lymphocyte vs. mast cell:
			**Lymphocytes = round; mast cells = ovoid.

			===Images===
			www:
			*[http://www.jameswpattersonmd.com/case_studies/index.cfm?CFID=387434 Mastocytosis - low res. (jameswpattersonmd.com)].
			*[http://path.upmc.edu/cases/case366.html Mastocytosis - bone marrow - several images (upmc.edu)].
			*[http://path.upmc.edu/cases/case409.html Systemic mastocytosis - several images (upmc.edu)].
			<gallery>
			Image:Mastocytosis_-_high_mag.jpg \| Mastocytosis - high mag. (WC)
			Image:Mastocytosis_-_cropped_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)
			</gallery>

			==Stains==
			*[[Toluidine blue stain\|Toluidine blue]] -- highlights the granules.

			==IHC==
			*CD117 +ve.
			*Tryptase +ve.<ref name=pmid21866466>{{Cite journal \| last1 = Rudzki \| first1 = Z. \| last2 = Sotlar \| first2 = K. \| last3 = Kudela \| first3 = A. \| last4 = Starzak-Gwóźdź \| first4 = J. \| last5 = Horny \| first5 = HP. \| title = Systemic mastocytosis (SM) and associated malignant bone marrow histiocytosis - a hitherto undescribed form of SM-AHNMD. \| journal = Pol J Pathol \| volume = 62 \| issue = 2 \| pages = 101-4 \| month = \| year = 2011 \| doi = \| PMID = 21866466 }}
			</ref>

			==See also==
			*[[Non-malignant skin disease]].
			*[[Mast cell]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Non-malignant skin disease]]

← Older revision		Revision as of 19:38, 19 June 2014
Line 68:		Line 68:
	Image:Mastocytosis - intermed mag.jpg \| Mastocytosis - intermed. mag. (WC)		Image:Mastocytosis - intermed mag.jpg \| Mastocytosis - intermed. mag. (WC)
	Image:Mastocytosis_-_high_mag.jpg \| Mastocytosis - high mag. (WC)		Image:Mastocytosis_-_high_mag.jpg \| Mastocytosis - high mag. (WC)
			Image:Mastocytosis_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)
	Image:Mastocytosis_-_cropped_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)		Image:Mastocytosis_-_cropped_-_very_high_mag.jpg \| Mastocytosis - very high mag. (WC)
	</gallery>		</gallery>