Male infertility - Revision history

Michael: /* Hypospematogensis */ fix sp

2025-12-24T14:40:15Z

Hypospematogensis: fix sp

← Older revision		Revision as of 14:40, 24 December 2025
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	- Hypospematogensis (70% of biopsy) intermixed with histologically normal		- Hypospematogensis (70% of biopsy) intermixed with histologically normal
	test (30% of biopsy) with normal numbers of sperm.		test (30% of biopsy) with normal numbers of sperm.
	- NEGATIVE for significant ~~semineferous~~ tubule hyalinization.		- NEGATIVE for significant seminiferous tubule hyalinization.
			- NEGATIVE for significant inflammation.
			- NEGATIVE for germ cell neoplasia in situ.
			</pre>

			===Normal===
			<pre>
			A. Right Testis, Biopsy:
			- Testis within normal limits with spermatogenesis.
			- NEGATIVE for significant inter-tubular changes.
			- NEGATIVE for significant seminiferous tubule hyalinization.
	- NEGATIVE for significant inflammation.		- NEGATIVE for significant inflammation.
	- NEGATIVE for germ cell neoplasia in situ.		- NEGATIVE for germ cell neoplasia in situ.

Michael: /* Hypospematogensis */

2025-11-14T15:03:00Z

Hypospematogensis

← Older revision		Revision as of 15:03, 14 November 2025
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	test (30% of biopsy) with normal numbers of sperm.		test (30% of biopsy) with normal numbers of sperm.
	- NEGATIVE for significant semineferous tubule hyalinization.		- NEGATIVE for significant semineferous tubule hyalinization.
	- NEGATIVE for significant inflammation		- NEGATIVE for significant inflammation.
	- NEGATIVE for germ cell neoplasia in situ.		- NEGATIVE for germ cell neoplasia in situ.
	</pre>		</pre>

Michael: /* Sign out */

2025-11-14T15:02:27Z

Sign out

← Older revision		Revision as of 15:02, 14 November 2025
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	===Mixed pattern===		===Mixed pattern===
	<pre>		<pre>
	LEFT TESTIS, BIOPSY ~~FOR~~ SPERM RETRIEVAL:		LEFT TESTIS, BIOPSY WITH SPERM RETRIEVAL:
	- SERTOLI CELLS ONLY REGIONS (25% OF BIOPSY) INTERMIXED WITH		- SERTOLI CELLS ONLY REGIONS (25% OF BIOPSY) INTERMIXED WITH
	HISTOLOGICALLY NORMAL TESTIS (75% OF BIOPSY) WITH NORMAL NUMBERS		HISTOLOGICALLY NORMAL TESTIS (75% OF BIOPSY) WITH NORMAL NUMBERS
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	===Hypospematogensis===		===Hypospematogensis===
	<pre>		<pre>
	A. Left Testis, Biopsy:		A. Left Testis, Biopsy with Sperm Retrieval:
	- Hypospematogensis (70% of biopsy) intermixed with histologically normal		- Hypospematogensis (70% of biopsy) intermixed with histologically normal
	test (30% of biopsy) with normal numbers of sperm.		test (30% of biopsy) with normal numbers of sperm.

Michael: /* Mixed pattern */

2025-11-14T15:00:22Z

Mixed pattern

← Older revision		Revision as of 15:00, 14 November 2025
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	- NEGATIVE FOR SIGNIFICANT INFLAMMATION.		- NEGATIVE FOR SIGNIFICANT INFLAMMATION.
	- NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA).		- NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA).
			</pre>

			===Hypospematogensis===
			<pre>
			A. Left Testis, Biopsy:
			- Hypospematogensis (70% of biopsy) intermixed with histologically normal
			test (30% of biopsy) with normal numbers of sperm.
			- NEGATIVE for significant semineferous tubule hyalinization.
			- NEGATIVE for significant inflammation
			- NEGATIVE for germ cell neoplasia in situ.
	</pre>		</pre>

Michael: /* Mixed pattern */

2025-11-14T14:56:14Z

Mixed pattern

← Older revision		Revision as of 14:56, 14 November 2025
Line 70:		Line 70:
	<pre>		<pre>
	LEFT TESTIS, BIOPSY FOR SPERM RETRIEVAL:		LEFT TESTIS, BIOPSY FOR SPERM RETRIEVAL:
	- SERTOLI CELLS ONLY REGIONS (25% OF BIOPSY) ~~INTERMEIXED~~ WITH		- SERTOLI CELLS ONLY REGIONS (25% OF BIOPSY) INTERMIXED WITH
	HISTOLOGICALLY NORMAL TESTIS (75% OF BIOPSY) WITH NORMAL NUMBERS		HISTOLOGICALLY NORMAL TESTIS (75% OF BIOPSY) WITH NORMAL NUMBERS
	OF SPERM.		OF SPERM.

Michael: fix ref

2025-11-14T14:31:06Z

fix ref

← Older revision		Revision as of 14:31, 14 November 2025
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	*Infertility is a [[clinical diagnosis]].		*Infertility is a [[clinical diagnosis]].

	It can be divided into:<ref name=pmid20670143>{{~~Cite~~ journal \| ~~last1~~ = Cerilli ~~\| first1 =~~ LA~~. \| last2 =~~ Kuang ~~\| first2 =~~ W~~. \| last3 =~~ Rogers ~~\| first3 =~~ D. \| title = A practical approach to testicular biopsy interpretation for male infertility. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 8 \| pages = ~~1197-204~~ \| ~~month~~ = ~~Aug~~ \| ~~year~~ = ~~2010~~ \| doi = 10.~~1043~~/2009-0379-RA.1 \| ~~PMID~~ = ~~20670143~~ }}</ref>		It can be divided into:<ref name=pmid20670143>{{cite journal \|authors=Cerilli LA, Kuang W, Rogers D \|title=A practical approach to testicular biopsy interpretation for male infertility \|journal=Arch Pathol Lab Med \|volume=134 \|issue=8 \|pages=1197–204 \|date=August 2010 \|pmid=20670143 \|doi=10.5858/2009-0379-RA.1 \|url=}}</ref>
	*Pre-testicular - e.g. hormonal, [[pituitary gland\|pituitary]].		*Pre-testicular - e.g. hormonal, [[pituitary gland\|pituitary]].
	*Testicular.		*Testicular.

Michael: ITGCN --> GCNIS

2016-03-15T23:50:16Z

ITGCN --> GCNIS

← Older revision		Revision as of 23:50, 15 March 2016
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	\| Micro = various patterns - see ''microscopic''		\| Micro = various patterns - see ''microscopic''
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[~~intratubular~~ germ cell neoplasia]], [[germ cell tumour]], inflammation of the testis		\| LMDDx = [[germ cell neoplasia in situ]], [[germ cell tumour]], inflammation of the testis
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
Line 52:		Line 52:

	DDx:		DDx:
	*[[~~Intratubular germ~~ cell neoplasia]].		*[[Germ cell neoplasia in situ]] (GCNIS).
	*[[Germ cell tumour]].		*[[Germ cell tumour]].
	*[[Testicular adrenal rest tumour]] in the context of congenital adrenal hyperplasia - case report.<ref name=pmid23342900>{{Cite journal \| last1 = Niedziela \| first1 = M. \| last2 = Joanna \| first2 = T. \| last3 = Piotr \| first3 = J. \| title = Testicular adrenal rest tumors (TARTs) as a male infertility factor. Case report. \| journal = Ginekol Pol \| volume = 83 \| issue = 9 \| pages = 700-2 \| month = Sep \| year = 2012 \| doi = \| PMID = 23342900 }}</ref>		*[[Testicular adrenal rest tumour]] in the context of congenital adrenal hyperplasia - case report.<ref name=pmid23342900>{{Cite journal \| last1 = Niedziela \| first1 = M. \| last2 = Joanna \| first2 = T. \| last3 = Piotr \| first3 = J. \| title = Testicular adrenal rest tumors (TARTs) as a male infertility factor. Case report. \| journal = Ginekol Pol \| volume = 83 \| issue = 9 \| pages = 700-2 \| month = Sep \| year = 2012 \| doi = \| PMID = 23342900 }}</ref>
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	*Hyalinization of the tubules.		*Hyalinization of the tubules.
	*Inflammation.		*Inflammation.
	*Absence of [[~~intratubular~~ germ cell neoplasia]].		*Absence of [[germ cell neoplasia in situ]].

	===Mixed pattern===		===Mixed pattern===
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	- NEGATIVE FOR SIGNIFICANT SEMINIFEROUS TUBULE HYALINIZATION.		- NEGATIVE FOR SIGNIFICANT SEMINIFEROUS TUBULE HYALINIZATION.
	- NEGATIVE FOR SIGNIFICANT INFLAMMATION.		- NEGATIVE FOR SIGNIFICANT INFLAMMATION.
	- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.		- NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA).
	</pre>		</pre>

Michael: /* Microscopic */

2015-07-15T04:15:05Z

Microscopic

← Older revision		Revision as of 04:15, 15 July 2015
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	#Sertoli cells only.		#Sertoli cells only.
	#Seminiferous tubule hyalinization		#Seminiferous tubule hyalinization
	#A combination of the above.		#Some combination of the above patterns.

	DDx:		DDx:

Michael: /* Microscopic */

2015-07-15T04:04:21Z

Microscopic

← Older revision		Revision as of 04:04, 15 July 2015
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	*[[Intratubular germ cell neoplasia]].		*[[Intratubular germ cell neoplasia]].
	*[[Germ cell tumour]].		*[[Germ cell tumour]].
			*[[Testicular adrenal rest tumour]] in the context of congenital adrenal hyperplasia - case report.<ref name=pmid23342900>{{Cite journal \| last1 = Niedziela \| first1 = M. \| last2 = Joanna \| first2 = T. \| last3 = Piotr \| first3 = J. \| title = Testicular adrenal rest tumors (TARTs) as a male infertility factor. Case report. \| journal = Ginekol Pol \| volume = 83 \| issue = 9 \| pages = 700-2 \| month = Sep \| year = 2012 \| doi = \| PMID = 23342900 }}</ref>
	*Inflammation of the testis.		*Inflammation of the testis.

Michael: touch

2015-06-11T05:40:45Z

touch

← Older revision		Revision as of 05:40, 11 June 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Male infertility -- intermed mag.jpg		\| Image = Male infertility -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption = Mixed pattern male infertility (Sertoli cells only mixed with hypospermatogensis). [[H&E stain]].		\| Caption = Mixed pattern male infertility (Sertoli cells only mixed with hypospermatogensis). [[H&E stain]].