Lymphovascular invasion - Revision history

Michael at 18:55, 19 June 2025

2025-06-19T18:55:52Z

← Older revision		Revision as of 18:55, 19 June 2025
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	'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''.		'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''.

	~~The term~~ ''~~lymphovascular~~ invasion'' ~~was traditionally preferred to~~ ''~~[[vascular~~ invasion]]'', ~~as it is very difficult to differentiate morphologically small lymphatics and small vascular spaces~~, ~~without [[immunohistochemistry]]~~.		In some contexts, ''[[vascular invasion]]'' (also ''angioinvasion'') must be separated from ''lymphovascular invasion''.<ref>{{cite journal \|authors=Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG \|title=Overview of the 2022 WHO Classification of Adrenal Cortical Tumors \|journal=Endocr Pathol \|volume=33 \|issue=1 \|pages=155–196 \|date=March 2022 \|pmid=35288842 \|pmc=8920443 \|doi=10.1007/s12022-022-09710-8 \|url=}}</ref>

	~~In some contexts,~~ ''~~vascular~~ invasion'' ~~(angioinvasion) must be separated from~~ ''~~lymphovascular~~ invasion''~~.<ref>{{cite journal \|authors=Mete O~~, ~~Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M~~, ~~Papotti MG \|title=Overview of the 2022 WHO Classification of Adrenal Cortical Tumors \|journal=Endocr Pathol \|volume=33 \|issue=1 \|pages=155–196 \|date=March 2022 \|pmid=35288842 \|pmc=8920443 \|doi=10~~.~~1007/s12022-022-09710-8 \|url=}}</ref>~~		The term ''lymphovascular invasion'' was traditionally preferred to ''[[vascular invasion]]'', as it is difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]].

	==General==		==General==

Michael at 18:54, 19 June 2025

2025-06-19T18:54:15Z

← Older revision		Revision as of 18:54, 19 June 2025
Line 2:		Line 2:
	'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''.		'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''.

	The term ''lymphovascular invasion'' is preferred to ''[[vascular invasion]]'', as it is very difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]].		The term ''lymphovascular invasion'' was traditionally preferred to ''[[vascular invasion]]'', as it is very difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]].

			In some contexts, ''vascular invasion'' (angioinvasion) must be separated from ''lymphovascular invasion''.<ref>{{cite journal \|authors=Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG \|title=Overview of the 2022 WHO Classification of Adrenal Cortical Tumors \|journal=Endocr Pathol \|volume=33 \|issue=1 \|pages=155–196 \|date=March 2022 \|pmid=35288842 \|pmc=8920443 \|doi=10.1007/s12022-022-09710-8 \|url=}}</ref>

	==General==		==General==

Michael: /* See also */

2020-03-05T15:58:18Z

Michael: /* Images */

2019-03-24T00:13:49Z

Images

← Older revision		Revision as of 00:13, 24 March 2019
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: CRC with LVI - elastin -- very low mag.jpg \| CRC with LVI - elastin - very low mag. (WC/Nephron)		Image: CRC with LVI - elastin -- very low mag.jpg \| [[colorectal carcinoma\|CRC]] with LVI - elastin - very low mag. (WC/Nephron)
	Image: CRC with LVI - elastin -- low mag.jpg \| CRC with LVI - elastin - low mag. (WC/Nephron)		Image: CRC with LVI - elastin -- low mag.jpg \| CRC with LVI - elastin - low mag. (WC/Nephron)
	Image: CRC with LVI - elastin -- intermed mag.jpg \| CRC with LVI - elastin - intermed. mag. (WC/Nephron)		Image: CRC with LVI - elastin -- intermed mag.jpg \| CRC with LVI - elastin - intermed. mag. (WC/Nephron)

Michael at 00:13, 24 March 2019

2019-03-24T00:13:32Z

← Older revision		Revision as of 00:13, 24 March 2019
Line 66:		Line 66:
	Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)		Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)
	Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)		Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)
	<gallery>		</gallery>

	==Stains==		==Stains==
	*[[Movat stain]] - especially useful in [[colorectal carcinoma]] so one can readily identify [[blood vessel]]s.<ref name=pmid19861561>{{Cite journal \| last1 = Howlett \| first1 = CJ. \| last2 = Tweedie \| first2 = EJ. \| last3 = Driman \| first3 = DK. \| title = Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factor. \| journal = J Clin Pathol \| volume = 62 \| issue = 11 \| pages = 1021-5 \| month = Nov \| year = 2009 \| doi = 10.1136/jcp.2009.065615 \| PMID = 19861561 }}</ref>		*[[Movat stain]] - especially useful in [[colorectal carcinoma]] so one can readily identify [[blood vessel]]s.<ref name=pmid19861561>{{Cite journal \| last1 = Howlett \| first1 = CJ. \| last2 = Tweedie \| first2 = EJ. \| last3 = Driman \| first3 = DK. \| title = Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factor. \| journal = J Clin Pathol \| volume = 62 \| issue = 11 \| pages = 1021-5 \| month = Nov \| year = 2009 \| doi = 10.1136/jcp.2009.065615 \| PMID = 19861561 }}</ref>
	*Elastin stain.		*Elastin stain.
			===Images===
			<gallery>
			Image: CRC with LVI - elastin -- very low mag.jpg \| CRC with LVI - elastin - very low mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- low mag.jpg \| CRC with LVI - elastin - low mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- intermed mag.jpg \| CRC with LVI - elastin - intermed. mag. (WC/Nephron)
			Image: CRC with LVI - elastin - alt -- high mag.jpg \| CRC with LVI - elastin - high mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- very high mag.jpg \| CRC with LVI - elastin - very high mag. (WC/Nephron)
			</gallery>

	==IHC==		==IHC==

Michael: /* Images */

2019-03-24T00:13:02Z

Images

← Older revision		Revision as of 00:13, 24 March 2019
Line 66:		Line 66:
	Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)		Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)
	Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)		Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)
			<gallery>
	~~Image: CRC with LVI - elastin -- very low mag.jpg \| CRC with LVI - elastin - very low mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin -- low mag.jpg \| CRC with LVI - elastin - low mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin -- intermed mag.jpg \| CRC with LVI - elastin - intermed. mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin - alt -- high mag.jpg \| CRC with LVI - elastin - high mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin -- very high mag.jpg \| CRC with LVI - elastin - very high mag. (WC/Nephron)~~
	</gallery>

	==Stains==		==Stains==

Michael: /* Images */ +elastin in CRC

2019-03-24T00:12:27Z

Images: +elastin in CRC

← Older revision		Revision as of 00:12, 24 March 2019
Line 57:		Line 57:
	<gallery>		<gallery>
	Image:Merkel_cell_carcinoma_-_high_mag.jpg \| Small focus of LVI in a [[merkel cell carcinoma]]. (WC/Nephron)		Image:Merkel_cell_carcinoma_-_high_mag.jpg \| Small focus of LVI in a [[merkel cell carcinoma]]. (WC/Nephron)
	~~Image:Tumor invasion into vein in a case of colorectal cancer, Elastica stain 2.jpg \| LVI in [[CRC]]. (WC)~~
	Image: Seminoma LVI -- low mag.jpg \| [[LVI]] - low mag. (WC/Nephron)		Image: Seminoma LVI -- low mag.jpg \| [[LVI]] - low mag. (WC/Nephron)
	Image: Seminoma LVI -- intermed mag.jpg \| LVI - intermed. mag. (WC/Nephron)		Image: Seminoma LVI -- intermed mag.jpg \| LVI - intermed. mag. (WC/Nephron)
			</gallery>
			<gallery>
			Image: CRC with LVI - HE -- very low mag.jpg \| [[colorectal carcinoma\|CRC]] with LVI - very low mag. (WC/Nephron)
			Image: CRC with LVI - HE -- low mag.jpg \| CRC with LVI - low mag. (WC/Nephron)
			Image: CRC with LVI - HE -- intermed mag.jpg \| CRC with LVI - intermed. mag. (WC/Nephron)
			Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)
			Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)

			Image: CRC with LVI - elastin -- very low mag.jpg \| CRC with LVI - elastin - very low mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- low mag.jpg \| CRC with LVI - elastin - low mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- intermed mag.jpg \| CRC with LVI - elastin - intermed. mag. (WC/Nephron)
			Image: CRC with LVI - elastin - alt -- high mag.jpg \| CRC with LVI - elastin - high mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- very high mag.jpg \| CRC with LVI - elastin - very high mag. (WC/Nephron)
	</gallery>		</gallery>

Michael: /* Stains */

2016-11-24T21:09:14Z

Stains

← Older revision		Revision as of 21:09, 24 November 2016
Line 64:		Line 64:
	==Stains==		==Stains==
	*[[Movat stain]] - especially useful in [[colorectal carcinoma]] so one can readily identify [[blood vessel]]s.<ref name=pmid19861561>{{Cite journal \| last1 = Howlett \| first1 = CJ. \| last2 = Tweedie \| first2 = EJ. \| last3 = Driman \| first3 = DK. \| title = Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factor. \| journal = J Clin Pathol \| volume = 62 \| issue = 11 \| pages = 1021-5 \| month = Nov \| year = 2009 \| doi = 10.1136/jcp.2009.065615 \| PMID = 19861561 }}</ref>		*[[Movat stain]] - especially useful in [[colorectal carcinoma]] so one can readily identify [[blood vessel]]s.<ref name=pmid19861561>{{Cite journal \| last1 = Howlett \| first1 = CJ. \| last2 = Tweedie \| first2 = EJ. \| last3 = Driman \| first3 = DK. \| title = Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factor. \| journal = J Clin Pathol \| volume = 62 \| issue = 11 \| pages = 1021-5 \| month = Nov \| year = 2009 \| doi = 10.1136/jcp.2009.065615 \| PMID = 19861561 }}</ref>
	*[[Elastin stain]].		*Elastin stain.

	==IHC==		==IHC==

Michael: /* See also */

2016-11-24T21:09:05Z

Michael at 21:05, 24 November 2016

2016-11-24T21:05:12Z

← Older revision		Revision as of 21:05, 24 November 2016
Line 2:		Line 2:
	'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''.		'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''.

	The term ''lymphovascular invasion'' is preferred to ''vascular invasion'', as it is very difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]].		The term ''lymphovascular invasion'' is preferred to ''[[vascular invasion]]'', as it is very difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]].

	==General==		==General==

← Older revision		Revision as of 15:58, 5 March 2020
Line 93:		Line 93:
	*[[Perineural invasion]].		*[[Perineural invasion]].
	*[[Angioinvasion]].		*[[Angioinvasion]].
			*[[MELF]].

	==References==		==References==

← Older revision		Revision as of 00:13, 24 March 2019
Line 66:		Line 66:
	Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)		Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)
	Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)		Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)
			<gallery>
	~~Image: CRC with LVI - elastin -- very low mag.jpg \| CRC with LVI - elastin - very low mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin -- low mag.jpg \| CRC with LVI - elastin - low mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin -- intermed mag.jpg \| CRC with LVI - elastin - intermed. mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin - alt -- high mag.jpg \| CRC with LVI - elastin - high mag. (WC/Nephron)~~
	~~Image: CRC with LVI - elastin -- very high mag.jpg \| CRC with LVI - elastin - very high mag. (WC/Nephron)~~
	</gallery>

	==Stains==		==Stains==

← Older revision		Revision as of 00:12, 24 March 2019
Line 57:		Line 57:
	<gallery>		<gallery>
	Image:Merkel_cell_carcinoma_-_high_mag.jpg \| Small focus of LVI in a [[merkel cell carcinoma]]. (WC/Nephron)		Image:Merkel_cell_carcinoma_-_high_mag.jpg \| Small focus of LVI in a [[merkel cell carcinoma]]. (WC/Nephron)
	~~Image:Tumor invasion into vein in a case of colorectal cancer, Elastica stain 2.jpg \| LVI in [[CRC]]. (WC)~~
	Image: Seminoma LVI -- low mag.jpg \| [[LVI]] - low mag. (WC/Nephron)		Image: Seminoma LVI -- low mag.jpg \| [[LVI]] - low mag. (WC/Nephron)
	Image: Seminoma LVI -- intermed mag.jpg \| LVI - intermed. mag. (WC/Nephron)		Image: Seminoma LVI -- intermed mag.jpg \| LVI - intermed. mag. (WC/Nephron)
			</gallery>
			<gallery>
			Image: CRC with LVI - HE -- very low mag.jpg \| [[colorectal carcinoma\|CRC]] with LVI - very low mag. (WC/Nephron)
			Image: CRC with LVI - HE -- low mag.jpg \| CRC with LVI - low mag. (WC/Nephron)
			Image: CRC with LVI - HE -- intermed mag.jpg \| CRC with LVI - intermed. mag. (WC/Nephron)
			Image: CRC with LVI - HE - alt -- high mag.jpg \| CRC with LVI - high mag. (WC/Nephron)
			Image: CRC with LVI - HE -- very high mag.jpg \| CRC with LVI - very high mag. (WC/Nephron)

			Image: CRC with LVI - elastin -- very low mag.jpg \| CRC with LVI - elastin - very low mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- low mag.jpg \| CRC with LVI - elastin - low mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- intermed mag.jpg \| CRC with LVI - elastin - intermed. mag. (WC/Nephron)
			Image: CRC with LVI - elastin - alt -- high mag.jpg \| CRC with LVI - elastin - high mag. (WC/Nephron)
			Image: CRC with LVI - elastin -- very high mag.jpg \| CRC with LVI - elastin - very high mag. (WC/Nephron)
	</gallery>		</gallery>

← Older revision		Revision as of 21:09, 24 November 2016
Line 78:		Line 78:
	*[[Intravascular lymphoma]].		*[[Intravascular lymphoma]].
	*[[Perineural invasion]].		*[[Perineural invasion]].
			*[[Angioinvasion]].

	==References==		==References==