Lymphoma - Revision history

Maxwell: /* Lymphoplasmacytic lymphoma */

2025-07-13T21:07:55Z

Lymphoplasmacytic lymphoma

← Older revision		Revision as of 21:07, 13 July 2025
Line 404:		Line 404:

	Note:		Note:
	*''Waldenström macroglobulinemia'' ~~(WM)~~ is a type of lymphoplasmacytic lymphoma<ref name=pmid22507796>{{Cite journal \| last1 = Gertz \| first1 = MA. \| title = Waldenström macroglobulinemia. \| journal = Hematology \| volume = 17 Suppl 1 \| issue = \| pages = 112-6 \| month = Apr \| year = 2012 \| doi = 10.1179/102453312X13336169156212 \| PMID = 22507796 }}</ref> - it is characterized by:		*''Waldenström macroglobulinemia'' is a type of lymphoplasmacytic lymphoma<ref name=pmid22507796>{{Cite journal \| last1 = Gertz \| first1 = MA. \| title = Waldenström macroglobulinemia. \| journal = Hematology \| volume = 17 Suppl 1 \| issue = \| pages = 112-6 \| month = Apr \| year = 2012 \| doi = 10.1179/102453312X13336169156212 \| PMID = 22507796 }}</ref> - it is characterized by:
	**''Hyperviscosity syndrome''.		**''Hyperviscosity syndrome''.
	**Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8\|325}}</ref>		**Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8\|325}}</ref>

Maxwell: /* Lymphoplasmacytic lymphoma */

2025-07-13T21:02:54Z

Lymphoplasmacytic lymphoma

← Older revision		Revision as of 21:02, 13 July 2025
Line 404:		Line 404:

	Note:		Note:
	*''Waldenström macroglobulinemia'' is a type of lymphoplasmacytic lymphoma<ref name=pmid22507796>{{Cite journal \| last1 = Gertz \| first1 = MA. \| title = Waldenström macroglobulinemia. \| journal = Hematology \| volume = 17 Suppl 1 \| issue = \| pages = 112-6 \| month = Apr \| year = 2012 \| doi = 10.1179/102453312X13336169156212 \| PMID = 22507796 }}</ref> - it is characterized by:		*''Waldenström macroglobulinemia'' (WM) is a type of lymphoplasmacytic lymphoma<ref name=pmid22507796>{{Cite journal \| last1 = Gertz \| first1 = MA. \| title = Waldenström macroglobulinemia. \| journal = Hematology \| volume = 17 Suppl 1 \| issue = \| pages = 112-6 \| month = Apr \| year = 2012 \| doi = 10.1179/102453312X13336169156212 \| PMID = 22507796 }}</ref> - it is characterized by:
	**''Hyperviscosity syndrome''.		**''Hyperviscosity syndrome''.
	**Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8\|325}}</ref>		**Bony destruction (seen in [[multiple myeloma]]) is absent.<ref name=Ref_PCPBoD8_325>{{Ref PCPBoD8\|325}}</ref>
			**Over 90% of patients have the MYD88 L265P somatic mutation.<ref name=pmid=22931316>{{cite journal \|vauthors=Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR \|title=MYD88 L265P somatic mutation in Waldenström's macroglobulinemia \|journal=N Engl J Med \|volume=367 \|issue=9 \|pages=826–33 \|date=August 2012 \|pmid=22931316 \|doi=10.1056/NEJMoa1200710 \|url=}}</ref>

	====Clinical====		====Clinical====

Michael at 19:37, 31 July 2016

2016-07-31T19:37:33Z

← Older revision		Revision as of 19:37, 31 July 2016
Line 105:		Line 105:

	Others:		Others:
	*AE1/AE3 -- to r/o carcinoma.		*[[AE1/AE3]] -ve -- to r/o carcinoma.

	====T cell markers====		====T cell markers====

Michael at 21:52, 27 July 2015

2015-07-27T21:52:03Z

← Older revision		Revision as of 21:52, 27 July 2015
Line 86:		Line 86:
	====Histologic terms====		====Histologic terms====
	*Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma.		*Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma.
	*Auer rods = ~~Acute~~ myeloid leukemia.		*[[Auer rods]] = [[acute myeloid leukemia]].
	**Granular cytoplasmic rod (0.5-1 x4-6 micrometres).		**Granular cytoplasmic rod (0.5-1 x4-6 micrometres).
			**Not pathognomonic.
	*Reed-Sternberg cells = [[Hodgkin's lymphoma]].		*Reed-Sternberg cells = [[Hodgkin's lymphoma]].
	**Large cell - very large nucleus.		**Large cell - very large nucleus.

Michael: /* Angioimmunoblastic T-cell lymphoma */ wikify

2015-06-01T15:39:49Z

Angioimmunoblastic T-cell lymphoma: wikify

← Older revision		Revision as of 15:39, 1 June 2015
Line 326:		Line 326:
	Features:		Features:
	*Intermediate size cells with:		*Intermediate size cells with:
	**+/-Vesicular nuclei.		**+/-[[Vesicular nuclei]].
	**Clear, moderate cytoplasm.		**Clear, moderate cytoplasm.
	*"Empty" sinus; subcapsular sinuses "open".		*"Empty" sinus; subcapsular sinuses "open".

Michael: /* Extranodal NK/T-cell lymphoma, nasal type */

2015-03-18T15:46:57Z

Extranodal NK/T-cell lymphoma, nasal type

← Older revision		Revision as of 15:46, 18 March 2015
Line 477:		Line 477:
	*[[AKA]] ''extranodal natural kill lymphoma''		*[[AKA]] ''extranodal natural kill lymphoma''
	*[[AKA]] ''angiocentric lymphoma''.		*[[AKA]] ''angiocentric lymphoma''.
			{{Main\|Extranodal NK/T-cell lymphoma, nasal type}}
	~~===General===~~
	*Common in east Asia.<ref name=pmid18283711>{{~~Cite journal~~ \| last1 = Suzuki \| first1 = R. \| last2 = Takeuchi \| first2 = K. \| last3 = Ohshima \| first3 = K. \| last4 = Nakamura \| first4 = S. \| title = Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. \| journal = Hematol Oncol \| volume = 26 \| issue = 2 \| pages = 66-72 \| month = Jun \| year = 2008 \| doi = 10.1002/hon.847 \| PMID = 18283711 }}</ref>
	*Strong association with [[EBV]].

	~~===Microscopic===~~
	~~Features:~~
	*Atypical lymphoid cells:
	**[[Nucleoli]].
	**[[Nuclear pleomorphism]].
	**Cells centered around vessels (angiocentric).
	***May destroy small and medium sized arterioles.

	~~Images:~~
	*[http://path.upmc.edu/cases/case231/micro.html Extranodal NK/T-cell lymphoma, nasal type - case 1 - several images (upmc.edu)].
	*[http://path.upmc.edu/cases/case310.html Extranodal NK/T-cell lymphoma, nasal type ~~- case 2 - several images (upmc.edu)].~~

	~~===IHC===~~
	Features:<ref name=pmid17064952>{{Cite journal \| last1 = Al-Hakeem \| first1 = DA. \| last2 = Fedele \| first2 = S. \| last3 = Carlos \| first3 = R. \| last4 = Porter \| first4 = S. \| title = Extranodal NK/T-cell lymphoma, nasal type. \| journal = Oral Oncol \| volume = 43 \| issue = 1 \| pages = 4-14 \| month = Jan \| year = 2007 \| doi = 10.1016/j.oraloncology.2006.03.011 \| PMID = 17064952 }}~~</ref>~~
	*CD2 +ve.
	*CD3 +ve (cytoplasmic).
	*[[CD56]] +ve.

	~~Others:<ref>URL: [http://path.upmc.edu/cases/case310.html http://path.upmc.edu/cases/case310.html]. Accessed on: 14 January 2012.</ref>~~
	*TIA-1 +ve.
	*CD7 +ve.
	*EBER +ve.

	==Table of lymphoma==		==Table of lymphoma==

Michael at 00:38, 26 December 2014

2014-12-26T00:38:36Z

← Older revision		Revision as of 00:38, 26 December 2014
Line 1:		Line 1:
	[[Image:Lymphoma macro.jpg \| thumb \| 200px \| right \| Lymphoma at ~~gross~~. (WC/Emmanuelm)]]		[[Image:Lymphoma macro.jpg \| thumb \| 200px \| right \| Lymphoma at [[cut-up]]. (WC/Emmanuelm)]]
	'''Lymphoma''' is almost a specialty for itself. It can be subclassified a number of ways.		'''Lymphoma''' is almost a specialty for itself. It can be subclassified a number of ways.

Michael at 00:37, 26 December 2014

2014-12-26T00:37:59Z

← Older revision		Revision as of 00:37, 26 December 2014
Line 1:		Line 1:
			[[Image:Lymphoma macro.jpg \| thumb \| 200px \| right \| Lymphoma at gross. (WC/Emmanuelm)]]
	'''Lymphoma''' is almost a specialty for itself. It can be subclassified a number of ways.		'''Lymphoma''' is almost a specialty for itself. It can be subclassified a number of ways.

Michael: /* IHC */

2014-09-13T08:07:44Z

IHC

← Older revision		Revision as of 08:07, 13 September 2014
Line 497:		Line 497:
	*CD2 +ve.		*CD2 +ve.
	*CD3 +ve (cytoplasmic).		*CD3 +ve (cytoplasmic).
	*CD56 +ve.		*[[CD56]] +ve.

	Others:<ref>URL: [http://path.upmc.edu/cases/case310.html http://path.upmc.edu/cases/case310.html]. Accessed on: 14 January 2012.</ref>		Others:<ref>URL: [http://path.upmc.edu/cases/case310.html http://path.upmc.edu/cases/case310.html]. Accessed on: 14 January 2012.</ref>

Michael: /* Intravascular lymphoma */

2014-03-09T04:07:32Z

Intravascular lymphoma

← Older revision		Revision as of 04:07, 9 March 2014
Line 259:		Line 259:
	*Usually B-cell lineage (see ''[[intravascular large B-cell lymphoma]]'').		*Usually B-cell lineage (see ''[[intravascular large B-cell lymphoma]]'').
	**May be T-cell lineage.<ref name=pmid20337769>{{cite journal \|author=Wang L, Li C, Gao T \|title=Cutaneous intravascular anaplastic large cell lymphoma \|journal=J Cutan Pathol \|volume= \|issue= \|pages= \|year=2010 \|month=March \|pmid=20337769 \|doi=10.1111/j.1600-0560.2010.01538.x \|url=}}</ref>		**May be T-cell lineage.<ref name=pmid20337769>{{cite journal \|author=Wang L, Li C, Gao T \|title=Cutaneous intravascular anaplastic large cell lymphoma \|journal=J Cutan Pathol \|volume= \|issue= \|pages= \|year=2010 \|month=March \|pmid=20337769 \|doi=10.1111/j.1600-0560.2010.01538.x \|url=}}</ref>

	~~===Intravascular large B-cell lymphoma===.~~
	~~{{Main\|Intravascular large B-cell lymphoma}}~~

	==Burkitt's lymphoma==		==Burkitt's lymphoma==