Lymph nodes with isolated tumour cells - Revision history

Michael at 13:07, 16 September 2016

2016-09-16T13:07:06Z

← Older revision		Revision as of 13:07, 16 September 2016
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	'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' (abbreviated '''ITCs''') and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.		'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' (abbreviated '''ITCs''') and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.

	This article is ~~focus~~ on ''isolated tumour cells'' in [[breast pathology]].		This article is focused on ''isolated tumour cells'' in [[breast pathology]].

	==General==		==General==

Michael: /* Definition */

2016-09-16T13:00:00Z

Definition

← Older revision		Revision as of 13:00, 16 September 2016
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	==General==		==General==
	===Definition===		===Definition===
	*An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm ''or'' <200 tumour cells.<ref name=pmid19317993> {{Cite journal \| last1 = Reed \| first1 = J. \| last2 = Rosman \| first2 = M. \| last3 = Verbanac \| first3 = KM. \| last4 = Mannie \| first4 = A. \| last5 = Cheng \| first5 = Z. \| last6 = Tafra \| first6 = L. \| title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. \| journal = J Am Coll Surg \| volume = 208 \| issue = 3 \| pages = 333-40 \| month = Mar \| year = 2009 \| doi = 10.1016/j.jamcollsurg.2008.10.036 \| PMID = 19317993 }}</ref><ref>{{Cite journal \| last1 = Naidoo \| first1 = K. \| last2 = Pinder \| first2 = SE. \| title = Micro- and macro-metastasis in the axillary lymph node: A review. \| journal = Surgeon \| volume = \| issue = \| pages = \| month = Aug \| year = 2016 \| doi = 10.1016/j.surge.2016.07.002 \| PMID = 27498412 }}</ref>		*An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm ''or'' <=200 tumour cells.<ref name=pmid19317993> {{Cite journal \| last1 = Reed \| first1 = J. \| last2 = Rosman \| first2 = M. \| last3 = Verbanac \| first3 = KM. \| last4 = Mannie \| first4 = A. \| last5 = Cheng \| first5 = Z. \| last6 = Tafra \| first6 = L. \| title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. \| journal = J Am Coll Surg \| volume = 208 \| issue = 3 \| pages = 333-40 \| month = Mar \| year = 2009 \| doi = 10.1016/j.jamcollsurg.2008.10.036 \| PMID = 19317993 }}</ref><ref>{{Cite journal \| last1 = Naidoo \| first1 = K. \| last2 = Pinder \| first2 = SE. \| title = Micro- and macro-metastasis in the axillary lymph node: A review. \| journal = Surgeon \| volume = \| issue = \| pages = \| month = Aug \| year = 2016 \| doi = 10.1016/j.surge.2016.07.002 \| PMID = 27498412 }}</ref>

	===Significance===		===Significance===

Michael: /* See also */

2016-09-16T12:59:06Z

Michael at 12:58, 16 September 2016

2016-09-16T12:58:33Z

← Older revision		Revision as of 12:58, 16 September 2016
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	'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.		'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' (abbreviated '''ITCs''') and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.

	This article is focus on ''isolated tumour cells'' in [[breast pathology]].		This article is focus on ''isolated tumour cells'' in [[breast pathology]].

Michael at 12:57, 16 September 2016

2016-09-16T12:57:13Z

← Older revision		Revision as of 12:57, 16 September 2016
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	'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.		'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.

			This article is focus on ''isolated tumour cells'' in [[breast pathology]].

	==General==		==General==

Michael at 12:56, 16 September 2016

2016-09-16T12:56:07Z

← Older revision		Revision as of 12:56, 16 September 2016
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	{{reflist\|1}}		{{reflist\|1}}

	[[Category:Lymph ~~nodes~~]]		[[Category:Lymph node pathology]]

Michael: /* Definition */

2016-09-16T12:55:54Z

Definition

← Older revision		Revision as of 12:55, 16 September 2016
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	==General==		==General==
	===Definition===		===Definition===
	*An isolated cluster of tumour cells within a lymph node measuring <= 0.2 mm ''or'' <200 tumour cells ~~in one section~~.<ref name=pmid19317993> {{Cite journal \| last1 = Reed \| first1 = J. \| last2 = Rosman \| first2 = M. \| last3 = Verbanac \| first3 = KM. \| last4 = Mannie \| first4 = A. \| last5 = Cheng \| first5 = Z. \| last6 = Tafra \| first6 = L. \| title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. \| journal = J Am Coll Surg \| volume = 208 \| issue = 3 \| pages = 333-40 \| month = Mar \| year = 2009 \| doi = 10.1016/j.jamcollsurg.2008.10.036 \| PMID = 19317993 }}</ref><ref>{{Cite journal \| last1 = Naidoo \| first1 = K. \| last2 = Pinder \| first2 = SE. \| title = Micro- and macro-metastasis in the axillary lymph node: A review. \| journal = Surgeon \| volume = \| issue = \| pages = \| month = Aug \| year = 2016 \| doi = 10.1016/j.surge.2016.07.002 \| PMID = 27498412 }}</ref>		*An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm ''or'' <200 tumour cells.<ref name=pmid19317993> {{Cite journal \| last1 = Reed \| first1 = J. \| last2 = Rosman \| first2 = M. \| last3 = Verbanac \| first3 = KM. \| last4 = Mannie \| first4 = A. \| last5 = Cheng \| first5 = Z. \| last6 = Tafra \| first6 = L. \| title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. \| journal = J Am Coll Surg \| volume = 208 \| issue = 3 \| pages = 333-40 \| month = Mar \| year = 2009 \| doi = 10.1016/j.jamcollsurg.2008.10.036 \| PMID = 19317993 }}</ref><ref>{{Cite journal \| last1 = Naidoo \| first1 = K. \| last2 = Pinder \| first2 = SE. \| title = Micro- and macro-metastasis in the axillary lymph node: A review. \| journal = Surgeon \| volume = \| issue = \| pages = \| month = Aug \| year = 2016 \| doi = 10.1016/j.surge.2016.07.002 \| PMID = 27498412 }}</ref>

	===Significance===		===Significance===

Michael: create

2016-09-16T12:54:27Z

create

New page

'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.

==General==
===Definition===
*An isolated cluster of tumour cells within a lymph node measuring <= 0.2 mm ''or'' <200 tumour cells in one section.<ref name=pmid19317993> {{Cite journal | last1 = Reed | first1 = J. | last2 = Rosman | first2 = M. | last3 = Verbanac | first3 = KM. | last4 = Mannie | first4 = A. | last5 = Cheng | first5 = Z. | last6 = Tafra | first6 = L. | title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. | journal = J Am Coll Surg | volume = 208 | issue = 3 | pages = 333-40 | month = Mar | year = 2009 | doi = 10.1016/j.jamcollsurg.2008.10.036 | PMID = 19317993 }}</ref><ref>{{Cite journal | last1 = Naidoo | first1 = K. | last2 = Pinder | first2 = SE. | title = Micro- and macro-metastasis in the axillary lymph node: A review. | journal = Surgeon | volume = | issue = | pages = | month = Aug | year = 2016 | doi = 10.1016/j.surge.2016.07.002 | PMID = 27498412 }}</ref>

===Significance===
*Not a significant predictor of outcome in breast pathology.<ref name=pmid24218025>{{Cite journal | last1 = Ahmed | first1 = SS. | last2 = Thike | first2 = AA. | last3 = Iqbal | first3 = J. | last4 = Yong | first4 = WS. | last5 = Tan | first5 = B. | last6 = Madhukumar | first6 = P. | last7 = Ong | first7 = KW. | last8 = Ho | first8 = GH. | last9 = Wong | first9 = CY. | title = Sentinel lymph nodes with isolated tumour cells and micrometastases in breast cancer: clinical relevance and prognostic significance. | journal = J Clin Pathol | volume = 67 | issue = 3 | pages = 243-50 | month = Mar | year = 2014 | doi = 10.1136/jclinpath-2013-201771 | PMID = 24218025 }}</ref>

==Sign out==
<pre>
Right Breast, Modified Radical Mastectomy:
- Two lymph nodes of six lymph nodes with ISOLATED TUMOR CELLS
(<100 tumour cells per lymph node).
-- All lymph nodes NEGATIVE for micrometatases and
NEGATIVE for macrometatases (0/4).
- Scar and therapy changes (hyalization, calcifications) compatible
with treated tumour.
- Florid epithelial hyperplasia of the usual type.
- Please see synoptic report.

Comment:
The isolated tumour cells were demonstrated with a CAM5.2 immunostain.
</pre>

==See also==
*[[Invasive breast cancer]].
*[[Lymph node metastasis]].

==References==
{{reflist|1}}

[[Category:Lymph nodes]]

← Older revision		Revision as of 12:59, 16 September 2016
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	==See also==		==See also==
	*[[Invasive breast cancer]].		*[[Invasive breast cancer]].
			*[[Breast cancer staging]].
	*[[Lymph node metastasis]].		*[[Lymph node metastasis]].