Lung tumours - Revision history

Michael: /* Epidemiology */

2019-03-17T23:44:52Z

Epidemiology

← Older revision		Revision as of 23:44, 17 March 2019
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	Children:		Children:
	*Most common lung tumour in children: metastasis (~85%).		*Most common lung tumour in children: metastasis (80-85% of lung tumours in children<ref name=pmid>{{Cite journal \| last1 = Dishop \| first1 = MK. \| last2 = Kuruvilla \| first2 = S. \| title = Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children's hospital. \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 7 \| pages = 1079-103 \| month = Jul \| year = 2008 \| doi = 10.1043/1543-2165(2008)132[1079:PAMLTI]2.0.CO;2 \| PMID = 18605764 }}</ref>
	**Most common primary tumours in children: [[inflammatory myofibroblastic tumour]], [[pleuropulmonary blastoma]], [[lung carcinoid]].<ref name=pmid26971789>{{Cite journal \| last1 = Giuseppucci \| first1 = C. \| last2 = Reusmann \| first2 = A. \| last3 = Giubergia \| first3 = V. \| last4 = Barrias \| first4 = C. \| last5 = Krüger \| first5 = A. \| last6 = Siminovich \| first6 = M. \| last7 = Botto \| first7 = H. \| last8 = Cadario \| first8 = M. \| last9 = Boglione \| first9 = M. \| title = Primary lung tumors in children: 24 years of experience at a referral center. \| journal = Pediatr Surg Int \| volume = 32 \| issue = 5 \| pages = 451-7 \| month = May \| year = 2016 \| doi = 10.1007/s00383-016-3884-3 \| PMID = 26971789 }}</ref>		**Most common primary tumours in children: [[inflammatory myofibroblastic tumour]], [[pleuropulmonary blastoma]], [[lung carcinoid]].<ref name=pmid26971789>{{Cite journal \| last1 = Giuseppucci \| first1 = C. \| last2 = Reusmann \| first2 = A. \| last3 = Giubergia \| first3 = V. \| last4 = Barrias \| first4 = C. \| last5 = Krüger \| first5 = A. \| last6 = Siminovich \| first6 = M. \| last7 = Botto \| first7 = H. \| last8 = Cadario \| first8 = M. \| last9 = Boglione \| first9 = M. \| title = Primary lung tumors in children: 24 years of experience at a referral center. \| journal = Pediatr Surg Int \| volume = 32 \| issue = 5 \| pages = 451-7 \| month = May \| year = 2016 \| doi = 10.1007/s00383-016-3884-3 \| PMID = 26971789 }}</ref>

Michael: /* Epidemiology */

2019-03-17T23:43:44Z

Epidemiology

← Older revision		Revision as of 23:43, 17 March 2019
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	Children:		Children:
	*Most common lung tumour in children: metastasis (~85%).		*Most common lung tumour in children: metastasis (~85%).
	**Most common primary ~~tumour~~ in children: [[lung carcinoid]] ~~(~50%)~~.		**Most common primary tumours in children: [[inflammatory myofibroblastic tumour]], [[pleuropulmonary blastoma]], [[lung carcinoid]].<ref name=pmid26971789>{{Cite journal \| last1 = Giuseppucci \| first1 = C. \| last2 = Reusmann \| first2 = A. \| last3 = Giubergia \| first3 = V. \| last4 = Barrias \| first4 = C. \| last5 = Krüger \| first5 = A. \| last6 = Siminovich \| first6 = M. \| last7 = Botto \| first7 = H. \| last8 = Cadario \| first8 = M. \| last9 = Boglione \| first9 = M. \| title = Primary lung tumors in children: 24 years of experience at a referral center. \| journal = Pediatr Surg Int \| volume = 32 \| issue = 5 \| pages = 451-7 \| month = May \| year = 2016 \| doi = 10.1007/s00383-016-3884-3 \| PMID = 26971789 }}</ref>

	===Distribution===		===Distribution===

Michael: /* Epidemiology */

2019-03-17T12:55:36Z

Epidemiology

← Older revision		Revision as of 12:55, 17 March 2019
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	*Adenocarcinoma is the most common (primary lung cancer).<ref>{{cite journal \|author=Lutschg JH \|title=Lung cancer \|journal=N. Engl. J. Med. \|volume=360 \|issue=1 \|pages=87-8; author reply 88 \|year=2009 \|month=January \|pmid=19118313 \|doi=10.1056/NEJMc082208 \|url=}}</ref>		*Adenocarcinoma is the most common (primary lung cancer).<ref>{{cite journal \|author=Lutschg JH \|title=Lung cancer \|journal=N. Engl. J. Med. \|volume=360 \|issue=1 \|pages=87-8; author reply 88 \|year=2009 \|month=January \|pmid=19118313 \|doi=10.1056/NEJMc082208 \|url=}}</ref>
	*Adenocarcinoma is the non-smoker tumour - SCLC and squamous are more strongly associated with [[smoking]].		*Adenocarcinoma is the non-smoker tumour - SCLC and squamous are more strongly associated with [[smoking]].

			Children:
			*Most common lung tumour in children: metastasis (~85%).
			**Most common primary tumour in children: [[lung carcinoid]] (~50%).

	===Distribution===		===Distribution===

Arti: nuclear staining with TTF-1 in a primary lung adenocarcinoma

2018-02-03T01:23:20Z

nuclear staining with TTF-1 in a primary lung adenocarcinoma

← Older revision		Revision as of 01:23, 3 February 2018
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	*TTF-1 - should be nuclear staining; cytoplasmic staining is non-specific.<ref name=pmid15861215>{{cite journal \|author=Compérat E, Zhang F, Perrotin C, ''et al.'' \|title=Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin \|journal=Mod. Pathol. \|volume=18 \|issue=10 \|pages=1371–6 \|year=2005 \|month=October \|pmid=15861215 \|doi=10.1038/modpathol.3800422 \|url=http://www.nature.com/modpathol/journal/v18/n10/full/3800422a.html}}</ref>		*TTF-1 - should be nuclear staining; cytoplasmic staining is non-specific.<ref name=pmid15861215>{{cite journal \|author=Compérat E, Zhang F, Perrotin C, ''et al.'' \|title=Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin \|journal=Mod. Pathol. \|volume=18 \|issue=10 \|pages=1371–6 \|year=2005 \|month=October \|pmid=15861215 \|doi=10.1038/modpathol.3800422 \|url=http://www.nature.com/modpathol/journal/v18/n10/full/3800422a.html}}</ref>
	**Image: [http://commons.wikimedia.org/w/index.php?title=File:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg Nuclear staining with TTF-1 in a ~~metastatic~~ lung adenocarcinoma (WC)].		**Image: [http://commons.wikimedia.org/w/index.php?title=File:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg Nuclear staining with TTF-1 in a primary lung adenocarcinoma (WC)].

	==Neuroendocrine tumours==		==Neuroendocrine tumours==

Michael: /* Clear cell sugar tumour of the lung */ split out

2017-10-23T18:06:00Z

Clear cell sugar tumour of the lung: split out

← Older revision		Revision as of 18:06, 23 October 2017
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	*[[AKA]] ''clear cell sugar tumour''.		*[[AKA]] ''clear cell sugar tumour''.
	**Abbreviated ''CCST''.		**Abbreviated ''CCST''.
	~~===General===~~		{{Main\|Clear cell sugar tumour of the lung}}
	*A [[PEComa]].
	*Benign.<ref name=pmid19119463>{{~~Cite journal~~ \| last1 = Kim \| first1 = WJ. \| last2 = Kim \| first2 = SR. \| last3 = Choe \| first3 = YH. \| last4 = Lee \| first4 = KY. \| last5 = Park \| first5 = SJ. \| last6 = Lee \| first6 = HB. \| last7 = Chung \| first7 = MJ. \| last8 = Jin \| first8 = GY. \| last9 = Lee \| first9 = YC. \| title = Clear cell "sugar~~" tumor~~ of the lung: a well-enhanced mass with an early washout pattern on dynamic contrast-enhanced computed tomography. \| journal = J Korean Med Sci \| volume = 23 \| issue = 6 \| pages = 1121-4 \| month = Dec \| year = 2008 \| doi = 10.3346/jkms.2008.23.6.1121 \| PMID = 19119463 \| PMC = 2610653 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/?tool=pubmed }}~~</ref>~~

	~~===Microscopic===~~
	~~Features:<ref name=pmid19119463/>~~
	*Sheets or trabeculae.
	*Irregular epithelioid cells with:
	**Focally clear cytoplasm.

	~~Images:~~
	*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170404452 Clear cell sugar tumour of the lung (surgicalpathologyatlas.com)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/figure/F3/ CCST (nih.gov)].<ref name=pmid19119463/>

	~~===IHC===~~
	*HMB-45 +ve (nuclear & cytoplasmic).

	=See also=		=See also=

Michael: /* Benign tumours */ +PAC

2017-10-23T18:03:37Z

Benign tumours: +PAC

← Older revision		Revision as of 18:03, 23 October 2017
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	=Benign tumours=		=Benign tumours=
			==Pulmonary apical cap==
			{{Main\|Pulmonary apical cap}}
			A lesion that can mimic a lung neoplasm.

	==Pulmonary carcinoid tumourlet==		==Pulmonary carcinoid tumourlet==
	*[[AKA]] ''carcinoid tumourlet''.		*[[AKA]] ''carcinoid tumourlet''.

Abraham: /* IHC */

2017-08-08T04:21:45Z

IHC

← Older revision		Revision as of 04:21, 8 August 2017
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	*CD56 - cytoplasmic.<ref>URL: [http://jcp.bmjjournals.com/content/58/9/978.full http://jcp.bmjjournals.com/content/58/9/978.full]. Accessed: 11 February 2010.</ref>		*CD56 - cytoplasmic.<ref>URL: [http://jcp.bmjjournals.com/content/58/9/978.full http://jcp.bmjjournals.com/content/58/9/978.full]. Accessed: 11 February 2010.</ref>

			===Adenocarcinoma===
			*[[TTF-1]] +ve.
			*[[Napsin]] +ve - sensitive.<ref name=pmid22288963>{{cite journal \|author=Turner BM, Cagle PT,Fukuoka J, ''et al'' \|title=Napsin A, a New Marker for Lung Adenocarcinoma, Is Complementary and More Sensitive and Specific Than Thyroid Transcription Factor 1 in the Differential Diagnosis of Primary Pulmonary Carcinoma: Evaluation of 1674 Cases by Tissue Microarray \|journal=Arch Pathol Lab Med. \|volume=136 \|issue=10 \|pages=163-71 \|year=2012 \|month=February\|pmid=22288963 \|doi: 10.5858/arpa.2011-0320-OA\|url=}}</ref>
			*[[CK7]] +ve, [[CK20]] -ve.

	===Squamous cell carcinoma===		===Squamous cell carcinoma===

Michael: /* IHC */ wikify

2016-12-20T17:14:42Z

IHC: wikify

← Older revision		Revision as of 17:14, 20 December 2016
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	===Small cell carcinoma===		===Small cell carcinoma===
	*TTF-1 +ve.		*[[TTF-1]] +ve.
	*[[CD56]] +ve - sensitive.<ref name=pmid16862075>{{cite journal \|author=Hiroshima K, Iyoda A, Shida T, ''et al'' \|title=Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis \|journal=Mod. Pathol. \|volume=19 \|issue=10 \|pages=1358-68 \|year=2006 \|month=October \|pmid=16862075 \|doi=10.1038/modpathol.3800659 \|url=}}</ref>		*[[CD56]] +ve - sensitive.<ref name=pmid16862075>{{cite journal \|author=Hiroshima K, Iyoda A, Shida T, ''et al'' \|title=Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis \|journal=Mod. Pathol. \|volume=19 \|issue=10 \|pages=1358-68 \|year=2006 \|month=October \|pmid=16862075 \|doi=10.1038/modpathol.3800659 \|url=}}</ref>
	*[[CK7]] -ve, [[CK20]] -ve.		*[[CK7]] -ve, [[CK20]] -ve.
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	===Squamous cell carcinoma===		===Squamous cell carcinoma===
	*CK7 -ve, CK20 -ve.		*[[CK7]] -ve, CK20 -ve.
	*HMWK +ve.		*HMWK +ve.
	*Usually TTF-1 -ve.<ref>{{cite journal \|author=Al-Zahrani IH \|title=The value of immunohistochemical expression of TTF-1, CK7 and CK20 in the diagnosis of primary and secondary lung carcinomas \|journal=Saudi Med J \|volume=29 \|issue=7 \|pages=957-61 \|year=2008 \|month=July \|pmid=18626520 \|doi= \|url=}}</ref>		*Usually TTF-1 -ve.<ref>{{cite journal \|author=Al-Zahrani IH \|title=The value of immunohistochemical expression of TTF-1, CK7 and CK20 in the diagnosis of primary and secondary lung carcinomas \|journal=Saudi Med J \|volume=29 \|issue=7 \|pages=957-61 \|year=2008 \|month=July \|pmid=18626520 \|doi= \|url=}}</ref>
	*p40 +ve.		*[[p40]] +ve.

	===Primary vs. secondary===		===Primary vs. secondary===

Michael: /* Poorly differentiated carcinoma */

2016-01-15T03:08:58Z

Poorly differentiated carcinoma

← Older revision		Revision as of 03:08, 15 January 2016
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	{{Main\|Malignant mesothelioma}}		{{Main\|Malignant mesothelioma}}

	==~~Poorly differentiated~~ carcinoma==		==Non-small cell lung carcinoma==
	{{Main\|~~Poorly differentiated~~ carcinoma ~~of the lung~~}}		*[[AKA]] ''poorly differentiated carcinoma of the lung''.
			{{Main\|Non-small cell lung carcinoma}}

	==Adenosquamous carcinoma of the lung==		==Adenosquamous carcinoma of the lung==

Michael: /* Poorly differentiated carcinoma */ link

2016-01-15T03:07:42Z

Poorly differentiated carcinoma: link

← Older revision		Revision as of 03:07, 15 January 2016
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	==Poorly differentiated carcinoma==		==Poorly differentiated carcinoma==
	{{Main\|Poorly differentiated carcinoma of the lung}}		{{Main\|Poorly differentiated carcinoma of the lung}}

			==Adenosquamous carcinoma of the lung==
			{{Main\|Adenosquamous carcinoma of the lung}}

	==Lung metastasis==		==Lung metastasis==