Lung metastasis - Revision history

Michael at 05:25, 9 February 2016

2016-02-09T05:25:06Z

← Older revision		Revision as of 05:25, 9 February 2016
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = +/-hx of ~~cancer~~		\| Clinicalhx = +/-history of malignancy
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =

Michael at 15:31, 28 September 2015

2015-09-28T15:31:21Z

← Older revision		Revision as of 15:31, 28 September 2015
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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx = primary lung cancer		\| LMDDx = primary lung cancer ([[adenocarcinoma of the lung]], [[squamous cell carcinoma of the lung]], [[small cell carcinoma of the lung]]), [[pulmonary meningothelial-like nodule]], [[carcinoid tumourlet]], [[carcinoid lung tumour]]
	\| Stains =		\| Stains =
	\| IHC = TTF-1 (-ve useful if non-squamous), CK20 (+ve suggestive colorectal carcinoma), CK7 (-ve useful if non-squamous), GATA3 (+ve suggestive UCC)		\| IHC = TTF-1 (-ve useful if non-squamous), CK20 (+ve suggestive colorectal carcinoma), CK7 (-ve useful if non-squamous), GATA3 (+ve suggestive UCC)
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	\| Prognosis = usually poor		\| Prognosis = usually poor
	\| Other =		\| Other =
	\| ClinDDx = lung primary, abscess		\| ClinDDx = lung primary, abscess, multiple benign lung tumours as may be seen in [[DIPNECH]]
	\| Tx =		\| Tx = dependent on primary site, occasionally surgical
	}}		}}
	'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.		'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.
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	DDx:		DDx:
			*Primary lung tumour, e.g. [[lung adenocarcinoma]], [[lung squamous cell carcinoma]], [[small cell carcinoma of the lung]].
	*[[Pulmonary meningothelial-like nodule]].<ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>		*[[Pulmonary meningothelial-like nodule]].<ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>
	*[[Carcinoid tumourlet]].		*[[Carcinoid tumourlet]].

Michael: /* Microscopic */ +ddx

2015-09-28T15:27:17Z

Microscopic: +ddx

← Older revision		Revision as of 15:27, 28 September 2015
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	Features:		Features:
	*Variable - dependent on site of origin.		*Variable - dependent on site of origin.
			*[[Colorectal adenocarcinoma]] - usually distinctive morphologically:
			**Typically gland forming.
			***Ellipsoid/elongated pseudostratified nuclei with moderate [[nuclear atypia]].
			***+/-Dirty necrosis.
			*Others:
			**[[Urothelial carcinoma]] - may mimic [[squamous cell carcinoma of the lung]].
			**Upper GI adenocarcinoma (e.g. [[gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma]].
			**Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic [[lung adenocarcinoma]].

	~~[[Colorectal adenocarcinoma]] - usually distinctive morphologically~~:		DDx:
	*~~Typically gland forming.~~		*[[Pulmonary meningothelial-like nodule]].<ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>
	**Ellipsoid/elongated pseudostratified nuclei with moderate [[~~nuclear atypia~~]].		*[[Carcinoid tumourlet]].
	**+/-~~Dirty necrosis.~~		*[[Carcinoid lung tumour]].

	~~Others~~:
	*[[Urothelial carcinoma]] - may mimic [[squamous cell carcinoma of the ~~lung]]~~.
	*~~Upper GI adenocarcinoma (e.g.~~ [[~~gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma~~]].
	*~~Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic~~ [[lung ~~adenocarcinoma~~]].

	===Images===		===Images===
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	Image:Metastatic prostatic adenocarcinoma (5918338484).jpg \| Prostate carcinoma. (WC/Rosen)		Image:Metastatic prostatic adenocarcinoma (5918338484).jpg \| Prostate carcinoma. (WC/Rosen)
	</gallery>		</gallery>

	==IHC==		==IHC==
	*TTF-1 -ve/+ve.		*TTF-1 -ve/+ve.

Michael: /* Gross */

2014-11-17T05:57:54Z

Gross

← Older revision		Revision as of 05:57, 17 November 2014
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	==Gross==		==Gross==
	*Typically peripheral, multiple, well-circumscribed & white/tan masses.		*Typically peripheral, multiple, well-circumscribed & white/tan masses.
	*May be diffuse without obvious mass +/- septal thickening.		*May be diffuse without an obvious mass +/- septal thickening.

	<gallery>		<gallery>

Michael: /* Gross */

2014-11-17T05:54:44Z

Gross

← Older revision		Revision as of 05:54, 17 November 2014
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	<gallery>		<gallery>
	Image~~: File~~:Metastatic_prostatic_adenocarcinoma_(3944215449).jpg \| Prostate carcinoma. (WC/Rosen)		Image: Metastatic_prostatic_adenocarcinoma_(3944215449).jpg \| Prostate carcinoma. (WC/Rosen)
	</gallery>		</gallery>

	==Microscopic==		==Microscopic==
	Features:		Features:

Michael: +nice Rosen images

2014-11-17T05:47:58Z

+nice Rosen images

← Older revision		Revision as of 05:47, 17 November 2014
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	*Relatively common.		*Relatively common.

			==Gross==
			*Typically peripheral, multiple, well-circumscribed & white/tan masses.
			*May be diffuse without obvious mass +/- septal thickening.

			<gallery>
			Image: File:Metastatic_prostatic_adenocarcinoma_(3944215449).jpg \| Prostate carcinoma. (WC/Rosen)
			</gallery>
	==Microscopic==		==Microscopic==
	Features:		Features:
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:Ewing sarcoma - intermed mag.jpg \| Lung metastasis ([[Ewing sarcoma\|ES]]) - intermed. mag.		Image:Ewing sarcoma - intermed mag.jpg \| Lung metastasis ([[Ewing sarcoma\|ES]]) - intermed. mag. (WC/Nephron)
	Image:Ewing sarcoma - high mag.jpg \| Lung metastasis (ES) - high mag.		Image:Ewing sarcoma - high mag.jpg \| Lung metastasis (ES) - high mag. (WC/Nephron)
	Image:Ewing sarcoma - very high mag.jpg \| Lung metastasis (ES) - very high mag.		Image:Ewing sarcoma - very high mag.jpg \| Lung metastasis (ES) - very high mag. (WC/Nephron)
			</gallery>
			<gallery>
			Image:Metastatic prostatic adenocarcinoma (5917779709).jpg \| Prostate carcinoma. (WC/Rosen)
			Image:Metastatic prostatic adenocarcinoma (5918338484).jpg \| Prostate carcinoma. (WC/Rosen)
	</gallery>		</gallery>

	==IHC==		==IHC==
	*TTF-1 -ve/+ve.		*TTF-1 -ve/+ve.

Michael at 05:42, 17 November 2014

2014-11-17T05:42:57Z

← Older revision		Revision as of 05:42, 17 November 2014
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	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross =		\| Gross = lung nodules - typically multiple and peripheral
	\| Grossing =		\| Grossing =
	\| Site = [[lung]]		\| Site = [[lung]]
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	\| Prevalence = relatively common		\| Prevalence = relatively common
	\| Bloodwork =		\| Bloodwork =
	\| Rads = peripheral lung lesions, multiple		\| Rads = peripheral lung lesions, typically multiple
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = usually poor		\| Prognosis = usually poor

Michael: tweak

2014-10-29T05:44:44Z

tweak

← Older revision		Revision as of 05:44, 29 October 2014
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	[[Image:Ewing sarcoma - intermed mag.jpg\|~~thumb\|right\|250px~~\|Lung metastasis ([[Ewing sarcoma]]). [[H&E stain]].]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Ewing sarcoma - intermed mag.jpg
			\| Width =
			\| Caption = Lung metastasis ([[Ewing sarcoma]]). [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = primary lung cancer
			\| Stains =
			\| IHC = TTF-1 (-ve useful if non-squamous), CK20 (+ve suggestive colorectal carcinoma), CK7 (-ve useful if non-squamous), GATA3 (+ve suggestive UCC)
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[lung]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = +/-hx of cancer
			\| Signs =
			\| Symptoms =
			\| Prevalence = relatively common
			\| Bloodwork =
			\| Rads = peripheral lung lesions, multiple
			\| Endoscopy =
			\| Prognosis = usually poor
			\| Other =
			\| ClinDDx = lung primary, abscess
			\| Tx =
			}}
	'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.		'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.

Michael at 05:37, 29 October 2014

2014-10-29T05:37:24Z

← Older revision		Revision as of 05:37, 29 October 2014
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			[[Image:Ewing sarcoma - intermed mag.jpg\|thumb\|right\|250px\|Lung metastasis ([[Ewing sarcoma]]). [[H&E stain]].]]
	'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.		'''Lung metastasis''', also '''pulmonary metastasis''' and '''metastatic lung disease''', is relatively common and generally carries a poor prognosis.

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	*Upper GI adenocarcinoma (e.g. [[gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma]].		*Upper GI adenocarcinoma (e.g. [[gastric adenocarcinoma]]) - may mimic [[lung adenocarcinoma]].
	*Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic [[lung adenocarcinoma]].		*Breast carcinoma - esp. [[ductal carcinoma of the breast]] - may mimic [[lung adenocarcinoma]].

			===Images===
			<gallery>
			Image:Ewing sarcoma - intermed mag.jpg \| Lung metastasis ([[Ewing sarcoma\|ES]]) - intermed. mag.
			Image:Ewing sarcoma - high mag.jpg \| Lung metastasis (ES) - high mag.
			Image:Ewing sarcoma - very high mag.jpg \| Lung metastasis (ES) - very high mag.
			</gallery>

	==IHC==		==IHC==

Michael: /* IHC */

2014-09-29T19:32:12Z

IHC

← Older revision		Revision as of 19:32, 29 September 2014
Line 19:		Line 19:

	==IHC==		==IHC==
	*TTF-1 -ve ~~(may be positive)~~.		*TTF-1 -ve/+ve.
	*CK20 +ve/-ve ~~(+ve~~ in colorectal carcinoma, -ve in lung primaries).		**Negative suggestive of metastasis... unless it is [[squamous carcinoma]].
	*GATA3 +ve/-ve ~~(usu~~. +ve in [[urothelial carcinoma]]~~, -ve~~ in lung primaries<ref>{{Cite journal \| last1 = Chang \| first1 = A. \| last2 = Amin \| first2 = A. \| last3 = Gabrielson \| first3 = E. \| last4 = Illei \| first4 = P. \| last5 = Roden \| first5 = RB. \| last6 = Sharma \| first6 = R. \| last7 = Epstein \| first7 = JI. \| title = Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 10 \| pages = 1472-6 \| month = Oct \| year = 2012 \| doi = 10.1097/PAS.0b013e318260cde7 \| PMID = 22982890 }}</ref>).		*CK20 +ve/-ve.
	*CK7 -ve/+ve ~~(typically positive~~ in lung adenocarcinoma and small carcinoma of the lung~~; positive~~ in a number of other tumours - breast, upper GI tract, thyroid, mesothelioma, [[salivary gland]]).		**Positive in colorectal carcinoma - very useful.
			**Negative in lung primaries.
			*GATA3 +ve/-ve.
			**Usu. +ve in [[urothelial carcinoma]].
			**Negative in lung primaries.<ref>{{Cite journal \| last1 = Chang \| first1 = A. \| last2 = Amin \| first2 = A. \| last3 = Gabrielson \| first3 = E. \| last4 = Illei \| first4 = P. \| last5 = Roden \| first5 = RB. \| last6 = Sharma \| first6 = R. \| last7 = Epstein \| first7 = JI. \| title = Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 10 \| pages = 1472-6 \| month = Oct \| year = 2012 \| doi = 10.1097/PAS.0b013e318260cde7 \| PMID = 22982890 }}</ref>
			*CK7 -ve/+ve.
			**Positive in lung adenocarcinoma and small carcinoma of the lung.
			**Positive in a number of other tumours - breast, upper GI tract, thyroid, mesothelioma, [[salivary gland]].
			**Negative in poorly differentiated carcinoma of the lung and squamous carcinoma of the lung.

	==See also==		==See also==