Low-grade papillary urothelial carcinoma - Revision history

Michael: /* Sign out */

2016-04-27T13:31:20Z

Sign out

← Older revision		Revision as of 13:31, 27 April 2016
Line 108:		Line 108:
	- NEGATIVE for carcinoma in situ.		- NEGATIVE for carcinoma in situ.
	- Benign muscularis propria present.		- Benign muscularis propria present.
			</pre>

			<pre>
			Urinary Bladder Tumour, Transurethral Resection:
			- LOW-GRADE PAPILLARY UROTHELIAL CARCINOMA.
			-- NEGATIVE for lamina propria invasion.
			- NEGATIVE for carcinoma in situ.
			- Definite muscularis propria ABSENT.
	</pre>		</pre>

Michael: /* Microscopic */

2016-03-04T22:12:56Z

Microscopic

← Older revision		Revision as of 22:12, 4 March 2016
Line 75:		Line 75:
	**The three most predictive features of high-grade are ''architectural complexity'', ''nuclear size variation'', and ''absence of umbrella cells''.<ref name=pmid21980608>{{Cite journal \| last1 = Isfoss \| first1 = BL. \| last2 = Majak \| first2 = B. \| last3 = Busch \| first3 = C. \| last4 = Braathen \| first4 = GJ. \| title = Simplification of grading papillary urothelial neoplasia using a reduced set of diagnostic features. \| journal = Anal Quant Cytol Histol \| volume = 33 \| issue = 2 \| pages = 68-74 \| month = Apr \| year = 2011 \| doi = \| PMID = 21980608 }}</ref>		**The three most predictive features of high-grade are ''architectural complexity'', ''nuclear size variation'', and ''absence of umbrella cells''.<ref name=pmid21980608>{{Cite journal \| last1 = Isfoss \| first1 = BL. \| last2 = Majak \| first2 = B. \| last3 = Busch \| first3 = C. \| last4 = Braathen \| first4 = GJ. \| title = Simplification of grading papillary urothelial neoplasia using a reduced set of diagnostic features. \| journal = Anal Quant Cytol Histol \| volume = 33 \| issue = 2 \| pages = 68-74 \| month = Apr \| year = 2011 \| doi = \| PMID = 21980608 }}</ref>
	**Stanford criteria has a 5% rule -- if the high-grade component is <5% it is low-grade.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref>		**Stanford criteria has a 5% rule -- if the high-grade component is <5% it is low-grade.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref>
			***There is some evidence to suggest low-grade with <5% high-grade behaves similar to low-grade.<ref name=pmid26520419>{{Cite journal \| last1 = Reis \| first1 = LO. \| last2 = Taheri \| first2 = D. \| last3 = Chaux \| first3 = A. \| last4 = Guner \| first4 = G. \| last5 = Mendoza Rodriguez \| first5 = MA. \| last6 = Bivalacqua \| first6 = TJ. \| last7 = Schoenberg \| first7 = MP. \| last8 = Epstein \| first8 = JI. \| last9 = Netto \| first9 = GJ. \| title = Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder. \| journal = Hum Pathol \| volume = 47 \| issue = 1 \| pages = 20-5 \| month = Jan \| year = 2016 \| doi = 10.1016/j.humpath.2015.09.007 \| PMID = 26520419 }}></ref>
	*[[Inverted urothelial papilloma]] - often have peripheral palisading.		*[[Inverted urothelial papilloma]] - often have peripheral palisading.
	*[[Urothelial papilloma]].		*[[Urothelial papilloma]].

Michael at 02:34, 28 January 2016

2016-01-28T02:34:51Z

← Older revision		Revision as of 02:34, 28 January 2016
Line 13:		Line 13:
	\| IF =		\| IF =
	\| Gross = exophytic lesion, frond-like appearance, friable		\| Gross = exophytic lesion, frond-like appearance, friable
	\| Grossing =		\| Grossing = [[radical cystectomy grossing]], [[cystoprostatectomy grossing]], [[nephroureterectomy grossing]]
			\| Staging = [[bladder cancer staging]]
	\| Site = [[urothelium]]		\| Site = [[urothelium]]
	\| Assdx =		\| Assdx =

Michael: /* Sign out */ +SO more

2015-09-09T20:39:32Z

Sign out: +SO more

← Older revision		Revision as of 20:39, 9 September 2015
Line 100:		Line 100:

	==Sign out==		==Sign out==
			<pre>
			Urinary Bladder Tumour, Transurethral Resection:
			- LOW GRADE PAPILLARY UROTHELIAL CARCINOMA.
			-- NEGATIVE for lamina propria invasion.
			- NEGATIVE for carcinoma in situ.
			- Benign muscularis propria present.
			</pre>

			====Block letters====
	<pre>		<pre>
	URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION:		URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION:

Michael: /* Image */

2014-06-04T01:54:07Z

Image

← Older revision		Revision as of 01:54, 4 June 2014
Line 80:		Line 80:
	<gallery>		<gallery>
	Image: Low-grade papillary urothelial carcinoma -- intermed mag.jpg \| LGPUC - intermed. mag.		Image: Low-grade papillary urothelial carcinoma -- intermed mag.jpg \| LGPUC - intermed. mag.
	Image: Low-grade papillary urothelial carcinoma -- high mag.jpg \| LGPUC - ~~intermed.~~ mag.		Image: Low-grade papillary urothelial carcinoma -- high mag.jpg \| LGPUC - high mag.
	Image: Low-grade papillary urothelial carcinoma - alt -- high mag.jpg \| LGPUC - ~~intermed.~~ mag.		Image: Low-grade papillary urothelial carcinoma - alt -- high mag.jpg \| LGPUC - high mag.
	</gallery>		</gallery>

Michael: /* Sign out */

2014-03-10T15:49:56Z

Sign out

← Older revision		Revision as of 15:49, 10 March 2014
Line 114:		Line 114:
	- BENIGN MUSCULARIS PROPRIA PRESENT.		- BENIGN MUSCULARIS PROPRIA PRESENT.
	</pre>		</pre>

			===Micro===
			The sections show urothelial mucosa with a tumour with fibrovascular cores. The nuclei are of uniform size (2-3 times a resting lymphocytes). Rare foci of degenerative cells are seen. The papillary structures are thick and appear to compress the lamina propria. Rare mitotic figures are identified. No atypical mitoses are apparent. No lamina propria invasion is identified. No muscularis propria is identified.

	==See also==		==See also==

Michael: /* Microscopic */

2014-01-27T19:59:03Z

Microscopic

← Older revision		Revision as of 19:59, 27 January 2014
Line 73:		Line 73:
	**Often under-diagnosed (~15% in one series) when reassessed by experts.<ref name=pmid20670136>{{Cite journal \| last1 = Miyamoto \| first1 = H. \| last2 = Brimo \| first2 = F. \| last3 = Schultz \| first3 = L. \| last4 = Ye \| first4 = H. \| last5 = Miller \| first5 = JS. \| last6 = Fajardo \| first6 = DA. \| last7 = Lee \| first7 = TK. \| last8 = Epstein \| first8 = JI. \| last9 = Netto \| first9 = GJ. \| title = Low-grade papillary urothelial carcinoma of the urinary bladder: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 8 \| pages = 1160-3 \| month = Aug \| year = 2010 \| doi = 10.1043/2009-0403-OA.1 \| PMID = 20670136 }}</ref>		**Often under-diagnosed (~15% in one series) when reassessed by experts.<ref name=pmid20670136>{{Cite journal \| last1 = Miyamoto \| first1 = H. \| last2 = Brimo \| first2 = F. \| last3 = Schultz \| first3 = L. \| last4 = Ye \| first4 = H. \| last5 = Miller \| first5 = JS. \| last6 = Fajardo \| first6 = DA. \| last7 = Lee \| first7 = TK. \| last8 = Epstein \| first8 = JI. \| last9 = Netto \| first9 = GJ. \| title = Low-grade papillary urothelial carcinoma of the urinary bladder: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 8 \| pages = 1160-3 \| month = Aug \| year = 2010 \| doi = 10.1043/2009-0403-OA.1 \| PMID = 20670136 }}</ref>
	**The three most predictive features of high-grade are ''architectural complexity'', ''nuclear size variation'', and ''absence of umbrella cells''.<ref name=pmid21980608>{{Cite journal \| last1 = Isfoss \| first1 = BL. \| last2 = Majak \| first2 = B. \| last3 = Busch \| first3 = C. \| last4 = Braathen \| first4 = GJ. \| title = Simplification of grading papillary urothelial neoplasia using a reduced set of diagnostic features. \| journal = Anal Quant Cytol Histol \| volume = 33 \| issue = 2 \| pages = 68-74 \| month = Apr \| year = 2011 \| doi = \| PMID = 21980608 }}</ref>		**The three most predictive features of high-grade are ''architectural complexity'', ''nuclear size variation'', and ''absence of umbrella cells''.<ref name=pmid21980608>{{Cite journal \| last1 = Isfoss \| first1 = BL. \| last2 = Majak \| first2 = B. \| last3 = Busch \| first3 = C. \| last4 = Braathen \| first4 = GJ. \| title = Simplification of grading papillary urothelial neoplasia using a reduced set of diagnostic features. \| journal = Anal Quant Cytol Histol \| volume = 33 \| issue = 2 \| pages = 68-74 \| month = Apr \| year = 2011 \| doi = \| PMID = 21980608 }}</ref>
			**Stanford criteria has a 5% rule -- if the high-grade component is <5% it is low-grade.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref>
	*[[Inverted urothelial papilloma]] - often have peripheral palisading.		*[[Inverted urothelial papilloma]] - often have peripheral palisading.
	*[[Urothelial papilloma]].		*[[Urothelial papilloma]].

Michael: /* IHC */

2014-01-27T17:01:17Z

IHC

← Older revision		Revision as of 17:01, 27 January 2014
Line 87:		Line 87:
	**Rajcani ''et al.'':<ref name=pmid23944616>{{Cite journal \| last1 = Rajcani \| first1 = J. \| last2 = Kajo \| first2 = K. \| last3 = Adamkov \| first3 = M. \| last4 = Moravekova \| first4 = E. \| last5 = Lauko \| first5 = L. \| last6 = Felcanova \| first6 = D. \| last7 = Bencat \| first7 = M. \| title = Immunohistochemical characterization of urothelial carcinoma. \| journal = Bratisl Lek Listy \| volume = 114 \| issue = 8 \| pages = 431-8 \| month = \| year = 2013 \| doi = \| PMID = 23944616 }}</ref> <25% of tumour cells for low-grade versus >50% tumour cell for high-grade.		**Rajcani ''et al.'':<ref name=pmid23944616>{{Cite journal \| last1 = Rajcani \| first1 = J. \| last2 = Kajo \| first2 = K. \| last3 = Adamkov \| first3 = M. \| last4 = Moravekova \| first4 = E. \| last5 = Lauko \| first5 = L. \| last6 = Felcanova \| first6 = D. \| last7 = Bencat \| first7 = M. \| title = Immunohistochemical characterization of urothelial carcinoma. \| journal = Bratisl Lek Listy \| volume = 114 \| issue = 8 \| pages = 431-8 \| month = \| year = 2013 \| doi = \| PMID = 23944616 }}</ref> <25% of tumour cells for low-grade versus >50% tumour cell for high-grade.
	**Pich ''et al.'':<ref name=pmid7910097>{{Cite journal \| last1 = Pich \| first1 = A. \| last2 = Chiusa \| first2 = L. \| last3 = Comino \| first3 = A. \| last4 = Navone \| first4 = R. \| title = Cell proliferation indices, morphometry and DNA flow cytometry provide objective criteria for distinguishing low and high grade bladder carcinomas. \| journal = Virchows Arch \| volume = 424 \| issue = 2 \| pages = 143-8 \| month = \| year = 1994 \| doi = \| PMID = 7910097 }}</ref> 11%/17% for G1/G2 versus 34% for G3.		**Pich ''et al.'':<ref name=pmid7910097>{{Cite journal \| last1 = Pich \| first1 = A. \| last2 = Chiusa \| first2 = L. \| last3 = Comino \| first3 = A. \| last4 = Navone \| first4 = R. \| title = Cell proliferation indices, morphometry and DNA flow cytometry provide objective criteria for distinguishing low and high grade bladder carcinomas. \| journal = Virchows Arch \| volume = 424 \| issue = 2 \| pages = 143-8 \| month = \| year = 1994 \| doi = \| PMID = 7910097 }}</ref> 11%/17% for G1/G2 versus 34% for G3.
			**Mai ''et al.'' suggest there is overlap:<ref name=pmid23913166>{{Cite journal \| last1 = Mai \| first1 = KT. \| last2 = Flood \| first2 = TA. \| last3 = Williams \| first3 = P. \| last4 = Kos \| first4 = Z. \| last5 = Belanger \| first5 = EC. \| title = Mixed low- and high-grade papillary urothelial carcinoma: histopathogenetic and clinical significance. \| journal = Virchows Arch \| volume = 463 \| issue = 4 \| pages = 575-81 \| month = Oct \| year = 2013 \| doi = 10.1007/s00428-013-1456-7 \| PMID = 23913166 }}</ref> 10-30% for low-grade versus 20-50% for high-grade.

	==Molecular==		==Molecular==

Michael at 03:13, 12 December 2013

2013-12-12T03:13:12Z

← Older revision		Revision as of 03:13, 12 December 2013
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Bladder_urothelial_carcinoma_(1)_pT1~~.~~JPG~~		\| Image = Low-grade papillary urothelial carcinoma -- high mag.jpg
	\| Width =		\| Width =
	\| Caption = Low-grade papillary urothelial carcinoma. [[H&E stain]].		\| Caption = Low-grade papillary urothelial carcinoma. [[H&E stain]].
Line 76:		Line 76:
	*[[Urothelial papilloma]].		*[[Urothelial papilloma]].

	===IHC===		===Image===
			<gallery>
			Image: Low-grade papillary urothelial carcinoma -- intermed mag.jpg \| LGPUC - intermed. mag.
			Image: Low-grade papillary urothelial carcinoma -- high mag.jpg \| LGPUC - intermed. mag.
			Image: Low-grade papillary urothelial carcinoma - alt -- high mag.jpg \| LGPUC - intermed. mag.
			</gallery>

			==IHC==
	*Ki-67:		*Ki-67:
	**Rajcani ''et al.'':<ref name=pmid23944616>{{Cite journal \| last1 = Rajcani \| first1 = J. \| last2 = Kajo \| first2 = K. \| last3 = Adamkov \| first3 = M. \| last4 = Moravekova \| first4 = E. \| last5 = Lauko \| first5 = L. \| last6 = Felcanova \| first6 = D. \| last7 = Bencat \| first7 = M. \| title = Immunohistochemical characterization of urothelial carcinoma. \| journal = Bratisl Lek Listy \| volume = 114 \| issue = 8 \| pages = 431-8 \| month = \| year = 2013 \| doi = \| PMID = 23944616 }}</ref> <25% of tumour cells for low-grade versus >50% tumour cell for high-grade.		**Rajcani ''et al.'':<ref name=pmid23944616>{{Cite journal \| last1 = Rajcani \| first1 = J. \| last2 = Kajo \| first2 = K. \| last3 = Adamkov \| first3 = M. \| last4 = Moravekova \| first4 = E. \| last5 = Lauko \| first5 = L. \| last6 = Felcanova \| first6 = D. \| last7 = Bencat \| first7 = M. \| title = Immunohistochemical characterization of urothelial carcinoma. \| journal = Bratisl Lek Listy \| volume = 114 \| issue = 8 \| pages = 431-8 \| month = \| year = 2013 \| doi = \| PMID = 23944616 }}</ref> <25% of tumour cells for low-grade versus >50% tumour cell for high-grade.
	**Pich ''et al.'':<ref name=pmid7910097>{{Cite journal \| last1 = Pich \| first1 = A. \| last2 = Chiusa \| first2 = L. \| last3 = Comino \| first3 = A. \| last4 = Navone \| first4 = R. \| title = Cell proliferation indices, morphometry and DNA flow cytometry provide objective criteria for distinguishing low and high grade bladder carcinomas. \| journal = Virchows Arch \| volume = 424 \| issue = 2 \| pages = 143-8 \| month = \| year = 1994 \| doi = \| PMID = 7910097 }}</ref> 11%/17% for G1/G2 versus 34% for G3.		**Pich ''et al.'':<ref name=pmid7910097>{{Cite journal \| last1 = Pich \| first1 = A. \| last2 = Chiusa \| first2 = L. \| last3 = Comino \| first3 = A. \| last4 = Navone \| first4 = R. \| title = Cell proliferation indices, morphometry and DNA flow cytometry provide objective criteria for distinguishing low and high grade bladder carcinomas. \| journal = Virchows Arch \| volume = 424 \| issue = 2 \| pages = 143-8 \| month = \| year = 1994 \| doi = \| PMID = 7910097 }}</ref> 11%/17% for G1/G2 versus 34% for G3.

	===Molecular===		==Molecular==
	Molecular changes:<ref name=pmid19468362>{{Cite journal \| last1 = Ehdaie \| first1 = B. \| last2 = Theodorescu \| first2 = D. \| title = Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis. \| journal = Indian J Urol \| volume = 24 \| issue = 1 \| pages = 61-7 \| month = Jan \| year = 2008 \| doi = 10.4103/0970-1591.38606 \| PMID = 19468362 \| PMC = 2684226}}</ref>		Molecular changes:<ref name=pmid19468362>{{Cite journal \| last1 = Ehdaie \| first1 = B. \| last2 = Theodorescu \| first2 = D. \| title = Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis. \| journal = Indian J Urol \| volume = 24 \| issue = 1 \| pages = 61-7 \| month = Jan \| year = 2008 \| doi = 10.4103/0970-1591.38606 \| PMID = 19468362 \| PMC = 2684226}}</ref>
	*FGFR3		*FGFR3

Michael: /* Microscopic */

2013-11-18T15:20:04Z

Microscopic

← Older revision		Revision as of 15:20, 18 November 2013
Line 56:		Line 56:
	**Basal location.		**Basal location.

	Criteria for invasion:<ref name=pmid22510761>{{Cite journal \| last1 = Toll \| first1 = AD. \| last2 = Epstein \| first2 = JI. \| title = Invasive low-grade papillary urothelial carcinoma: a clinicopathologic analysis of 41 cases. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 7 \| pages = 1081-6 \| month = Jul \| year = 2012 \| doi = 10.1097/PAS.0b013e318253d6e0 \| PMID = 22510761 }}</ref>		Criteria for invasion (mnemonic ''PISS-R''):<ref name=pmid22510761>{{Cite journal \| last1 = Toll \| first1 = AD. \| last2 = Epstein \| first2 = JI. \| title = Invasive low-grade papillary urothelial carcinoma: a clinicopathologic analysis of 41 cases. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 7 \| pages = 1081-6 \| month = Jul \| year = 2012 \| doi = 10.1097/PAS.0b013e318253d6e0 \| PMID = 22510761 }}</ref>
	*[[Stromal reaction]].		*[[Stromal reaction]].
	*Infiltrating single cells.		*Infiltrating single cells.
Line 89:		Line 89:
	Note:		Note:
	*Not currently used diagnostically.		*Not currently used diagnostically.

	==Sign out==		==Sign out==
	<pre>		<pre>