Localized cystic disease of the kidney - Revision history

Michael: /* See also */ +SO

2017-11-08T20:30:27Z

Michael: create

2017-10-30T19:20:36Z

create

← Older revision		Revision as of 19:20, 30 October 2017
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	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs = +/-hematuria		\| Signs = +/-hematuria (uncommon), often [[incidentaloma]]
	\| Symptoms = abdominal pain - due to mass effect		\| Symptoms = abdominal pain - due to mass effect
	\| Prevalence = very rare		\| Prevalence = very rare

Michael: +infobox

2017-10-30T19:18:44Z

+infobox

← Older revision		Revision as of 19:18, 30 October 2017
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro = cysts with cuboidal or flat lining epithelium - contiguous with renal collecting ducts;
			renal parenchyma (renal tubules or glomeruli) with in septations; +/-foamy histiocytes; +/-refractile material within the cysts
			\| Subtypes =
			\| LMDDx = cystic [[renal tumours]] (cystic [[clear cell renal cell carcinoma]], [[cystic nephroma]], [[multilocular cystic renal neoplasm of low malignant potential]]), hereditary [[cystic renal disease]] ([[autosomal dominant polycystic kidney disease]])
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[kidney]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = +/-hematuria
			\| Symptoms = abdominal pain - due to mass effect
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads = localized cystic disease, [[Bosniak classification]] 2 or 3
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = cystic [[renal cell carcinoma]]
			\| Tx = excision for diagnosis
			}}
	'''Localized cystic disease of the kidney''' is a rare benign entity that should be separated from hereditary [[cystic kidney diseases]] and cystic [[renal tumours]].<ref name=pmid23211292>{{Cite journal \| last1 = Ding \| first1 = Y. \| last2 = Chen \| first2 = L. \| last3 = Deng \| first3 = FM. \| last4 = Melamed \| first4 = J. \| last5 = Fan \| first5 = R. \| last6 = Bonsib \| first6 = S. \| last7 = Zhou \| first7 = M. \| title = Localized cystic disease of the kidney: distinction from cystic neoplasms and hereditary polycystic diseases. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 4 \| pages = 506-13 \| month = Apr \| year = 2013 \| doi = 10.1097/PAS.0b013e318271eff9 \| PMID = 23211292 }}</ref>		'''Localized cystic disease of the kidney''' is a rare benign entity that should be separated from hereditary [[cystic kidney diseases]] and cystic [[renal tumours]].<ref name=pmid23211292>{{Cite journal \| last1 = Ding \| first1 = Y. \| last2 = Chen \| first2 = L. \| last3 = Deng \| first3 = FM. \| last4 = Melamed \| first4 = J. \| last5 = Fan \| first5 = R. \| last6 = Bonsib \| first6 = S. \| last7 = Zhou \| first7 = M. \| title = Localized cystic disease of the kidney: distinction from cystic neoplasms and hereditary polycystic diseases. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 4 \| pages = 506-13 \| month = Apr \| year = 2013 \| doi = 10.1097/PAS.0b013e318271eff9 \| PMID = 23211292 }}</ref>

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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid23211292/>		Features:<ref name=pmid23211292/>
	*~~Cystis~~ with cuboidal or flat lining epithelium.		*Cysts with cuboidal or flat lining epithelium.
	**Contiguous with renal collecting ducts.		**Contiguous with renal collecting ducts.
	*Renal parenchyma (renal tubules or glomeruli) with in (cyst) septations.		*Renal parenchyma (renal tubules or glomeruli) with in (cyst) septations.

Michael: /* Microscopic */

2017-05-12T16:02:25Z

Microscopic

← Older revision		Revision as of 16:02, 12 May 2017
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	**Cystic [[clear cell renal cell carcinoma]].		**Cystic [[clear cell renal cell carcinoma]].
	**[[Cystic nephroma]].<ref name=pmid23132986>{{Cite journal \| last1 = Bhat \| first1 = S. \| last2 = Thomas \| first2 = A. \| title = Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. \| journal = Indian J Surg \| volume = 69 \| issue = 5 \| pages = 209-11 \| month = Oct \| year = 2007 \| doi = 10.1007/s12262-007-0025-1 \| PMID = 23132986 }}</ref>		**[[Cystic nephroma]].<ref name=pmid23132986>{{Cite journal \| last1 = Bhat \| first1 = S. \| last2 = Thomas \| first2 = A. \| title = Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. \| journal = Indian J Surg \| volume = 69 \| issue = 5 \| pages = 209-11 \| month = Oct \| year = 2007 \| doi = 10.1007/s12262-007-0025-1 \| PMID = 23132986 }}</ref>
	**[[Multilocular cystic renal cell carcinoma]].		**[[Multilocular cystic renal neoplasm of low malignant potential]] - previously known as ''[[multilocular cystic renal cell carcinoma]]''.
	*Hereditary [[cystic renal disease]], e.g. [[autosomal dominant polycystic kidney disease]].		*Hereditary [[cystic renal disease]], e.g. [[autosomal dominant polycystic kidney disease]].

Michael: /* References */

2016-04-23T04:36:25Z

References

← Older revision		Revision as of 04:36, 23 April 2016
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:~~Kidney tumours~~]]		[[Category:Genitourinary pathology]]

Michael: /* Gross */

2015-09-21T20:43:59Z

Gross

← Older revision		Revision as of 20:43, 21 September 2015
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	==Gross==		==Gross==
	Features:<ref name=pmid23211292/>		Features:<ref name=pmid23211292/>
	*~~Cystic~~ lesion(s) without a capsule - involving ~~part of~~ the ~~kidney~~.		*Focal cystic lesion(s) without a capsule involving the renal papillae +/-renal cortex.
	**Contain clear or light-yellow serous fluid.		**Contain clear or light-yellow serous fluid.

			Note:
			*''Focal'' - only part of the kidney should be involved.

	==Microscopic==		==Microscopic==

Michael: /* Gross */

2015-09-21T20:41:53Z

Gross

← Older revision		Revision as of 20:41, 21 September 2015
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	==Gross==		==Gross==
	Features:<ref name=pmid23211292/>		Features:<ref name=pmid23211292/>
	*Cystic lesion without capsule.		*Cystic lesion(s) without a capsule - involving part of the kidney.
	*Contain clear or light-yellow serous fluid.		**Contain clear or light-yellow serous fluid.

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2015-09-21T20:41:06Z

Microscopic

← Older revision		Revision as of 20:41, 21 September 2015
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid23211292/>		Features:<ref name=pmid23211292/>
	*~~Cuboidal~~ or flat lining epithelium ~~- contiguous~~ with renal collecting ducts.		*Cystis with cuboidal or flat lining epithelium.
			**Contiguous with renal collecting ducts.
			*Renal parenchyma (renal tubules or glomeruli) with in (cyst) septations.
			*+/-Foamy histiocytes.
			*+/-Refractile material within the cysts.

			Notes - negatives:
	*No significant inflammation.		*No significant inflammation.
			*No capsule.
			*No papillary hyperplasia.

	DDx:		DDx:

Michael: /* Gross */

2015-09-21T20:35:53Z

Gross

← Older revision		Revision as of 20:35, 21 September 2015
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	Features:<ref name=pmid23211292/>		Features:<ref name=pmid23211292/>
	*Cystic lesion without capsule.		*Cystic lesion without capsule.
	*Contain clear or yellow serous fluid.		*Contain clear or light-yellow serous fluid.

	==Microscopic==		==Microscopic==

Michael: /* Gross */

2015-09-21T20:35:30Z

Gross

← Older revision		Revision as of 20:35, 21 September 2015
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	Features:<ref name=pmid23211292/>		Features:<ref name=pmid23211292/>
	*Cystic lesion without capsule.		*Cystic lesion without capsule.
			*Contain clear or yellow serous fluid.

	==Microscopic==		==Microscopic==

← Older revision		Revision as of 20:30, 8 November 2017
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	**[[Multilocular cystic renal neoplasm of low malignant potential]] - previously known as ''[[multilocular cystic renal cell carcinoma]]''.		**[[Multilocular cystic renal neoplasm of low malignant potential]] - previously known as ''[[multilocular cystic renal cell carcinoma]]''.
	*Hereditary [[cystic renal disease]], e.g. [[autosomal dominant polycystic kidney disease]].		*Hereditary [[cystic renal disease]], e.g. [[autosomal dominant polycystic kidney disease]].

			==Sign out==
			<pre>
			Left Kidney, Radical Nephrectomy:
			- Localized cystic disease of the kidney, see microscopic description.
			- NEGATIVE for malignancy.
			</pre>

			===Micro===
			The sections show multiple large cortical cysts. There is relative sparing of the parenchyma in the lower pole. The cyst walls are fibrotic, contain parenchymal remnants and have foci of calcifications. The cyst lining consists of flatted epithelium without appreciable cytoplasm. No cyst lining cell atypia is present. The cyst lining cells are POSITIVE for AE1/AE3 and NEGATIVE for CD34.

			Comment:
			It is noted that the contralateral kidney is unremarkable on imaging. The findings are in keeping with localized cystic disease of the kidney, a rare benign finding that can mimic a tumour.[1]

			1. Am J Surg Pathol 37 (4): 506-13. doi:10.1097/PAS.0b013e318271eff9. PMID: 23211292.

	==See also==		==See also==