Leydig cell tumour - Revision history

Michael: /* IHC */

2022-01-31T20:31:06Z

IHC

← Older revision		Revision as of 20:31, 31 January 2022
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	**Expressed in [[melanoma]], [[adrenal gland\|adrenal tissue]], steroid-secreting tumours.		**Expressed in [[melanoma]], [[adrenal gland\|adrenal tissue]], steroid-secreting tumours.
	*Vimentin +ve.<ref name=pmid17284120/>		*Vimentin +ve.<ref name=pmid17284120/>
			*[[SALL4]] -ve (10 of 10 cases).<ref name=pmid19390421>{{cite journal \|authors=Cao D, Li J, Guo CC, Allan RW, Humphrey PA \|title=SALL4 is a novel diagnostic marker for testicular germ cell tumors \|journal=Am J Surg Pathol \|volume=33 \|issue=7 \|pages=1065–77 \|date=July 2009 \|pmid=19390421 \|doi=10.1097/PAS.0b013e3181a13eef \|url=}}</ref>

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2016-05-26T13:25:00Z

← Older revision		Revision as of 13:25, 26 May 2016
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	\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei		\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei
	\| Subtypes = benign (common), malignant (rare)		\| Subtypes = benign (common), malignant (rare)
	\| LMDDx = [[spermatocytic tumour]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]]		\| LMDDx = [[spermatocytic tumour]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]], [[Leydig cell hyperplasia]]
	\| Stains =		\| Stains =
	\| IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve		\| IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve
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	*[[Spermatocytic tumour]] (previously ''spermatocytic seminoma'') - may have eosinophilic cytoplasm.		*[[Spermatocytic tumour]] (previously ''spermatocytic seminoma'') - may have eosinophilic cytoplasm.
	*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies.		*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies.
	*Leydig cell hyperplasia.		*[[Leydig cell hyperplasia]].
	*[[Granular cell tumour]].<ref name=pmid17284120/>		*[[Granular cell tumour]].<ref name=pmid17284120/>

2016-03-15T16:11:41Z

update name

← Older revision		Revision as of 16:11, 15 March 2016
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	\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei		\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei
	\| Subtypes = benign (common), malignant (rare)		\| Subtypes = benign (common), malignant (rare)
	\| LMDDx = [[spermatocytic ~~seminoma~~]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]]		\| LMDDx = [[spermatocytic tumour]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]]
	\| Stains =		\| Stains =
	\| IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve		\| IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve
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	DDx:		DDx:
	*[[Spermatocytic ~~seminoma~~]] - may have eosinophilic cytoplasm.		*[[Spermatocytic tumour]] (previously ''spermatocytic seminoma'') - may have eosinophilic cytoplasm.
	*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies.		*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies.
	*Leydig cell hyperplasia.		*Leydig cell hyperplasia.

2015-05-30T17:28:56Z

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← Older revision		Revision as of 17:28, 30 May 2015
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	Comment:		Comment:
	The tumour consists of polygonal cells with abundant eosinophilic		The tumour consists of polygonal cells with abundant eosinophilic
	cytoplasm, round nuclei with prominent nucleoli.		cytoplasm, round nuclei with prominent nucleoli.

			Features suggestive of malignancy are absent.

	The tumour stains with calretinin, Melan A and inhibin. It is		The tumour stains with calretinin, Melan A and inhibin. It is

2015-05-30T17:27:04Z

← Older revision		Revision as of 17:27, 30 May 2015
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	\| Synonyms = interstitial cell tumour		\| Synonyms = interstitial cell tumour
	\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei		\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei
	\| Subtypes =		\| Subtypes = benign (common), malignant (rare)
	\| LMDDx = [[spermatocytic seminoma]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]]		\| LMDDx = [[spermatocytic seminoma]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]]
	\| Stains =		\| Stains =
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = usu. benign		\| Prognosis = usu. benign, occasionally malignant
	\| Other =		\| Other =
	\| ClinDDx = other testicular tumours		\| ClinDDx = other testicular tumours

2015-05-30T17:26:26Z

← Older revision		Revision as of 17:26, 30 May 2015
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	\| Width =		\| Width =
	\| Caption = Leydig cell tumour. [[H&E stain]].		\| Caption = Leydig cell tumour. [[H&E stain]].
			\| Synonyms = interstitial cell tumour
	\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei		\| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei
	\| Subtypes =		\| Subtypes =

2015-05-30T17:25:45Z

← Older revision		Revision as of 17:25, 30 May 2015
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	\| ClinDDx = other testicular tumours		\| ClinDDx = other testicular tumours
	}}		}}
	'''Leydig cell tumour''', also known as '''interstitial cell tumour''', is an uncommon benign sex cord-stromal tumour, typically seen in the [[testis]].		'''Leydig cell tumour''' (abbreviated '''LCT'''), also known as '''interstitial cell tumour''', is an uncommon benign sex cord-stromal tumour, typically seen in the [[testis]].

	''Interstitial cell tumour'' should '''not''' be confused with ''[[renomedullary interstitial cell tumour]]''.		''Interstitial cell tumour'' should '''not''' be confused with ''[[renomedullary interstitial cell tumour]]''.

2015-05-29T21:27:35Z

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2015-05-29T21:26:40Z

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2015-05-29T21:25:24Z

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