Leydig cell hyperplasia - Revision history

Michael: /* General */

2016-06-25T11:40:13Z

General

← Older revision		Revision as of 11:40, 25 June 2016
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	***Advanced age.		***Advanced age.
	**Endocrine-related:		**Endocrine-related:
	***[[Adrenal hyperplasia]].		***Adrenal hyperplasia.
	***Excess hCG - exogenous or tumour.		***Excess hCG - exogenous or tumour.

Michael: /* General */

2016-06-25T11:38:41Z

General

← Older revision		Revision as of 11:38, 25 June 2016
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	**Endocrine-related:		**Endocrine-related:
	***[[Adrenal hyperplasia]].		***[[Adrenal hyperplasia]].
	***Excess hCG (exogenous or tumour).		***Excess hCG - exogenous or tumour.

	Other associations:<ref name=pmid9488073/>		Other associations:<ref name=pmid9488073/>

Michael: /* General */

2016-06-25T11:38:06Z

General

← Older revision		Revision as of 11:38, 25 June 2016
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	*Secondary causes:		*Secondary causes:
	**Germ cell loss/decrease:		**Germ cell loss/decrease:
	***[[~~Cryptorchism~~]].		***[[Cryptorchidism]].
	***Advanced age.		***Advanced age.
	**Endocrine-related:		**Endocrine-related:

Michael: /* General */

2016-06-25T11:37:19Z

General

← Older revision		Revision as of 11:37, 25 June 2016
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	Other associations:<ref name=pmid9488073/>		Other associations:<ref name=pmid9488073/>
	*[[Klinefelter's syndrome]].<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>		*[[Klinefelter's syndrome]].<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>
	*Pernicious anemia.		*[[Pernicious anemia]].
	*[[Alcoholism]].		*[[Alcoholism]].
	*Infection - syphilis, tuberculosis.		*Infection - [[syphilis]], [[tuberculosis]].

	==Gross==		==Gross==

Michael: /* General */

2016-06-25T11:36:52Z

General

← Older revision		Revision as of 11:36, 25 June 2016
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	Other associations:<ref name=pmid9488073/>		Other associations:<ref name=pmid9488073/>
	*[[~~Kinefelter~~'s syndrome]].<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>		*[[Klinefelter's syndrome]].<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>
	*Pernicious anemia.		*Pernicious anemia.
	*[[Alcoholism]].		*[[Alcoholism]].

Michael: /* General */

2016-06-25T11:35:33Z

General

← Older revision		Revision as of 11:35, 25 June 2016
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	*Benign.		*Benign.
	*Uncommonly seen in isolation by pathology.		*Uncommonly seen in isolation by pathology.
	*~~May be seen in the context of ''~~[[~~Klinefelter~~ syndrome]]''.<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>
			A longer list of causes:<ref name=pmid9488073>{{Cite journal \| last1 = Naughton \| first1 = CK. \| last2 = Nadler \| first2 = RB. \| last3 = Basler \| first3 = JW. \| last4 = Humphrey \| first4 = PA. \| title = Leydig cell hyperplasia. \| journal = Br J Urol \| volume = 81 \| issue = 2 \| pages = 282-9 \| month = Feb \| year = 1998 \| doi = 10.1046/j.1464-410X.1998.00503.x \| PMID = 9488073 }}</ref>
			*Congenital (primary).
			*Secondary causes:
			**Germ cell loss/decrease:
			***[[Cryptorchism]].
			***Advanced age.
			**Endocrine-related:
			***[[Adrenal hyperplasia]].
			***Excess hCG (exogenous or tumour).

			Other associations:<ref name=pmid9488073/>
			*[[Kinefelter's syndrome]].<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>
			*Pernicious anemia.
			*[[Alcoholism]].
			*Infection - syphilis, tuberculosis.

	==Gross==		==Gross==

Michael: /* General */

2016-06-23T14:26:29Z

General

← Older revision		Revision as of 14:26, 23 June 2016
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	==General==		==General==
	*Benign.		*Benign.
	*Uncommonly seen in pathology.		*Uncommonly seen in isolation by pathology.
	*May be seen in the context of ''[[Klinefelter syndrome]]''.<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>		*May be seen in the context of ''[[Klinefelter syndrome]]''.<ref name=pmid26209412>{{Cite journal \| last1 = Sterbis \| first1 = J. \| last2 = E-Nunu \| first2 = T. \| title = Leydig cell hyperplasia in the setting of Klinefelter syndrome. \| journal = BMJ Case Rep \| volume = 2015 \| issue = \| pages = \| month = \| year = 2015 \| doi = 10.1136/bcr-2015-209805 \| PMID = 26209412 }}</ref>

Michael: /* Gross */

2016-06-23T14:25:39Z

Gross

← Older revision		Revision as of 14:25, 23 June 2016
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	==Gross==		==Gross==
	*Unremarkable gross appearance		Features:
			*Unremarkable gross appearance of parenchyma. (???)
			*Normal or small testis. (???)

	Note:		Note:

Michael: /* Microscopic */

2016-06-23T12:11:48Z

Microscopic

← Older revision		Revision as of 12:11, 23 June 2016
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	DDx:		DDx:
	*[[Leydig cell tumour]].		*[[Leydig cell tumour]].
			*[[Testicular adrenal rest tumour]].

	===Images===		===Images===

Michael: /* Sign out */

2016-06-23T12:10:40Z

Sign out

← Older revision		Revision as of 12:10, 23 June 2016
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	The Leydig cells are POSITIVE for inhibin, calretinin and melan A. The section is		The Leydig cells are POSITIVE for inhibin, calretinin and melan A. The section is
	NEGATIVE for PLAP.		NEGATIVE for PLAP and has a benign pattern for D2-40.
	</pre>		</pre>