Lentigo simplex - Revision history

Michael: /* Sign out */

2016-08-26T16:49:09Z

Sign out

← Older revision		Revision as of 16:49, 26 August 2016
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	==Sign out==		==Sign out==
			<pre>
			Left Hand Lesion, Radial, Biopsy:
			- Simple lentigo/early seborrheic keratosis.
			</pre>

			===Block letters===
	<pre>		<pre>
	SKIN LESION, LEFT ABDOMEN, BIOPSY:		SKIN LESION, LEFT ABDOMEN, BIOPSY:

Michael at 16:45, 26 August 2016

2016-08-26T16:45:30Z

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	\| Width =		\| Width =
	\| Caption = Simple lentigo. [[H&E stain]]. (WC)		\| Caption = Simple lentigo. [[H&E stain]]. (WC)
	\| Synonyms =		\| Synonyms = simple lentigo
	\| Micro = melanocytes in epidermis only - hyperpigmentation; no melanocytic nests; +/-mild/moderate elongation of the rete ridges		\| Micro = melanocytes in epidermis only - hyperpigmentation; no melanocytic nests; +/-mild/moderate elongation of the rete ridges
	\| Subtypes =		\| Subtypes =

Michael at 16:45, 26 August 2016

2016-08-26T16:45:06Z

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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Skin_Tumors-171.jpg
			\| Width =
			\| Caption = Simple lentigo. [[H&E stain]]. (WC)
			\| Synonyms =
			\| Micro = melanocytes in epidermis only - hyperpigmentation; no melanocytic nests; +/-mild/moderate elongation of the rete ridges
			\| Subtypes =
			\| LMDDx = [[solar lentigo]], [[ephelis]] (freckle), melanotic macule, [[lentiginous nevus]], early [[seborrheic keratosis]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[skin]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = usu. older than 40 years
			\| Signs =
			\| Symptoms =
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Lentigo simplex''' is a common benign [[melanocytic lesion]].		'''Lentigo simplex''' is a common benign [[melanocytic lesion]].

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	*Melanotic macule.		*Melanotic macule.
	*[[Lentiginous nevus]] - has melanocytic nests.		*[[Lentiginous nevus]] - has melanocytic nests.
			*Early [[seborrheic keratosis]].

	===Images===		===Images===

Michael: /* See also */

2016-08-26T16:41:59Z

Michael: /* General */

2016-08-26T16:41:46Z

General

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	*Benign.		*Benign.
	*Usually <40 years old.		*Usually <40 years old.
			*May be precursor to [[seborrheic keratosis]].<ref name=pmid15729860>{{Cite journal \| last1 = Sahin \| first1 = MT. \| last2 = Oztürkcan \| first2 = S. \| last3 = Ermertcan \| first3 = AT. \| last4 = Güneş \| first4 = AT. \| title = A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. \| journal = J Dermatol \| volume = 31 \| issue = 11 \| pages = 884-9 \| month = Nov \| year = 2004 \| doi = \| PMID = 15729860 }}</ref>

	Fits into the larger category of ''lentiginous melanocytic proliferations'' - these include:<ref name=Ref_Derm438>{{Ref Derm\|438}}</ref>		Fits into the larger category of ''lentiginous melanocytic proliferations'' - these include:<ref name=Ref_Derm438>{{Ref Derm\|438}}</ref>

Michael: split out

2016-08-26T16:37:34Z

split out

← Older revision		Revision as of 16:37, 26 August 2016
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	~~#redirect~~ [[~~Melanocytic_lesions#Lentigo_simplex~~]]		'''Lentigo simplex''' is a common benign [[melanocytic lesion]].

			It is also known as ''simple lentigo''.<ref>URL: [http://www.dermnetnz.org/lesions/lentigo-simplex.html http://www.dermnetnz.org/lesions/lentigo-simplex.html]. Accessed on: 27 March 2013.</ref>
			==General==
			*Benign.
			*Usually <40 years old.

			Fits into the larger category of ''lentiginous melanocytic proliferations'' - these include:<ref name=Ref_Derm438>{{Ref Derm\|438}}</ref>
			*[[Solar lentigo]].
			*Lentigo simplex.
			*[[Lentiginous nevus]].
			*Lentiginous [[melanoma in situ]].

			Associated syndromes:<ref name=dermamin_ls>URL: [http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html]. Accessed on: 17 December 2012.</ref>
			*[[Peutz-Jeghers syndrome]].
			*[[LEOPARD syndrome]].
			*[[LAMB syndrome]].

			==Gross==
			*Small flat pigmented lesion.<ref name=Ref_WMSP498>{{Ref WMSP\|498}}</ref>

			DDx - clinical:
			*[[Melanocytic nevus]].<ref name=pmid19536147>{{Cite journal \| last1 = Hafner \| first1 = C. \| last2 = Stoehr \| first2 = R. \| last3 = van Oers \| first3 = JM. \| last4 = Zwarthoff \| first4 = EC. \| last5 = Hofstaedter \| first5 = F. \| last6 = Klein \| first6 = C. \| last7 = Landthaler \| first7 = M. \| last8 = Hartmann \| first8 = A. \| last9 = Vogt \| first9 = T. \| title = The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo. \| journal = J Invest Dermatol \| volume = 129 \| issue = 11 \| pages = 2730-5 \| month = Nov \| year = 2009 \| doi = 10.1038/jid.2009.146 \| PMID = 19536147 }}</ref>

			==Microscopic==
			Features:<ref name=Ref_WMSP498>{{Ref WMSP\|498}}</ref>
			*Melanocytes in epidermis only.
			**Melanocytes basally located (normal location) with hyperpigmentation.
			*No melanocytic nests.
			*+/-Mild/moderate elongation of the rete ridges.<ref name=pmid19536147/>

			DDx:<ref name=humpath_ls/>
			*[[Solar lentigo]] - solar elastosis, usu. in sun exposed areas.
			*[[Ephelis]] (freckle) - change with UV light exposure.
			*Melanotic macule.
			*[[Lentiginous nevus]] - has melanocytic nests.

			===Images===
			*[http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html Lentigo simplex - several images (dermamin.com)].<ref name=dermamin_ls/>
			*[http://www.humpath.com/IMG/jpg/lentigo_simplex_20x.jpg Lentigo simplex (humpath.com)].<ref name=humpath_ls>URL: [http://www.humpath.com/?lentigo-simplex http://www.humpath.com/?lentigo-simplex]. Accessed on: 17 December 2012.</ref>
			<gallery>
			Image:Skin_Tumors-171.jpg \| Simple lentigo. (WC)
			</gallery>

			==Sign out==
			<pre>
			SKIN LESION, LEFT ABDOMEN, BIOPSY:
			- SIMPLE LENTIGO, COMPLETELY EXCISED IN THE PLANE OF SECTION.
			</pre>

			<pre>
			SKIN LESION, LEFT ABDOMEN, BIOPSY:
			- BENIGN SIMPLE LENTIGO.
			</pre>

			===Micro===
			The sections show skin with increased numbers of small pigmented melanocytes at the dermal-epidermal junction. The rete ridges are mildly elongated. No solar damage is apparent. No dermal melanocytes are identified. No melanocytic nests are identified. No nuclear atypia is apparent.

			==See also==
			*[[Melanocytic lesions]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2012-10-17T17:58:36Z

redirect

New page

#redirect [[Melanocytic_lesions#Lentigo_simplex]]

[[Category:Diagnosis]]

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	==See also==		==See also==
	*[[Melanocytic lesions]].		*[[Melanocytic lesions]].
			*[[Lentigo maligna]].

	==References==		==References==