Leiomyoma - Revision history

Michael at 15:39, 13 May 2016

2016-05-13T15:39:37Z

← Older revision		Revision as of 15:39, 13 May 2016
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	\| Micro = spindle cells arranged in fascicles, +/-nuclear atypia, rare mitoses (allowable mitotic rate dependent on specific site)		\| Micro = spindle cells arranged in fascicles, +/-nuclear atypia, rare mitoses (allowable mitotic rate dependent on specific site)
	\| Subtypes = lipoleiomyoma, hypercellular leiomyoma, atypical leiomyoma (symplastic leiomyoma), benign metastasizing leiomyoma		\| Subtypes = lipoleiomyoma, hypercellular leiomyoma, atypical leiomyoma (symplastic leiomyoma), benign metastasizing leiomyoma
	\| LMDDx = [[leiomyosarcoma]], [[STUMP]], [[dermatomyofibroma]]		\| LMDDx = [[leiomyosarcoma]], [[STUMP]], [[dermatomyofibroma]], [[adenomatoid tumour]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael: /* Microscopic */

2016-05-13T15:39:24Z

Microscopic

← Older revision		Revision as of 15:39, 13 May 2016
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	*Dermatomyofibroma.<ref name=Ref_Derm533>{{Ref Derm\|533}}</ref>		*Dermatomyofibroma.<ref name=Ref_Derm533>{{Ref Derm\|533}}</ref>
	*[[Myopericytoma]] / [[myofibroma]].		*[[Myopericytoma]] / [[myofibroma]].
			*[[Adenomatoid tumour]] - esp. for lipoleiomyoma.
	*[[Smooth muscle tumour of uncertain malignant potential]] (STUMP) - do not fulfill criteria for leiomyosarcoma.		*[[Smooth muscle tumour of uncertain malignant potential]] (STUMP) - do not fulfill criteria for leiomyosarcoma.
	*[[Epstein-Barr virus-associated smooth muscle tumour]] - very rare.		*[[Epstein-Barr virus-associated smooth muscle tumour]] - very rare.

Michael: /* General */

2015-01-02T22:52:36Z

General

← Older revision		Revision as of 22:52, 2 January 2015
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	===Colonic leiomyoma===		===Colonic leiomyoma===
	{{Main\|Colonic leiomyoma}}		{{Main\|Colonic leiomyoma}}

			===Renal leiomyoma===
			{{Main\|Renal leiomyoma}}

	==Gross==		==Gross==

Michael: /* Uterine leiomyoma */

2014-10-27T16:01:45Z

Uterine leiomyoma

← Older revision		Revision as of 16:01, 27 October 2014
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	*Large & multiple leiomyomas are associated with infertility.		*Large & multiple leiomyomas are associated with infertility.
	*May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC).		*May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC).
	**In one series, 50% with HLRCC were ~~symptomatic~~ at age <=30 years.<ref name=pmid16597677>{{Cite journal \| last1 = Pithukpakorn \| first1 = M. \| last2 = Wei \| first2 = MH. \| last3 = Toure \| first3 = O. \| last4 = Steinbach \| first4 = PJ. \| last5 = Glenn \| first5 = GM. \| last6 = Zbar \| first6 = B. \| last7 = Linehan \| first7 = WM. \| last8 = Toro \| first8 = JR. \| title = Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer. \| journal = J Med Genet \| volume = 43 \| issue = 9 \| pages = 755-62 \| month = Sep \| year = 2006 \| doi = 10.1136/jmg.2006.041087 \| PMID = 16597677 }}		**In one series, 68% with HLRCC were diagnosed at age <=30 years.<ref name=pmid16597677>{{Cite journal \| last1 = Pithukpakorn \| first1 = M. \| last2 = Wei \| first2 = MH. \| last3 = Toure \| first3 = O. \| last4 = Steinbach \| first4 = PJ. \| last5 = Glenn \| first5 = GM. \| last6 = Zbar \| first6 = B. \| last7 = Linehan \| first7 = WM. \| last8 = Toro \| first8 = JR. \| title = Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer. \| journal = J Med Genet \| volume = 43 \| issue = 9 \| pages = 755-62 \| month = Sep \| year = 2006 \| doi = 10.1136/jmg.2006.041087 \| PMID = 16597677 }}
	</ref>		</ref>

Michael: /* Uterine leiomyoma */

2014-10-27T15:43:41Z

Uterine leiomyoma

← Older revision		Revision as of 15:43, 27 October 2014
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	*Large & multiple leiomyomas are associated with infertility.		*Large & multiple leiomyomas are associated with infertility.
	*May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC).		*May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC).
			**In one series, 50% with HLRCC were symptomatic at age <=30 years.<ref name=pmid16597677>{{Cite journal \| last1 = Pithukpakorn \| first1 = M. \| last2 = Wei \| first2 = MH. \| last3 = Toure \| first3 = O. \| last4 = Steinbach \| first4 = PJ. \| last5 = Glenn \| first5 = GM. \| last6 = Zbar \| first6 = B. \| last7 = Linehan \| first7 = WM. \| last8 = Toro \| first8 = JR. \| title = Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer. \| journal = J Med Genet \| volume = 43 \| issue = 9 \| pages = 755-62 \| month = Sep \| year = 2006 \| doi = 10.1136/jmg.2006.041087 \| PMID = 16597677 }}
			</ref>

	===Colonic leiomyoma===		===Colonic leiomyoma===

Michael at 17:38, 6 September 2014

2014-09-06T17:38:56Z

← Older revision		Revision as of 17:38, 6 September 2014
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	*[[Myopericytoma]] / [[myofibroma]].		*[[Myopericytoma]] / [[myofibroma]].
	*[[Smooth muscle tumour of uncertain malignant potential]] (STUMP) - do not fulfill criteria for leiomyosarcoma.		*[[Smooth muscle tumour of uncertain malignant potential]] (STUMP) - do not fulfill criteria for leiomyosarcoma.
			*[[Epstein-Barr virus-associated smooth muscle tumour]] - very rare.

	===Variants===		===Variants===

Michael at 06:38, 25 July 2014

2014-07-25T06:38:32Z

← Older revision		Revision as of 06:38, 25 July 2014
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	\| Site = [[skin]], [[uterus]], others		\| Site = [[skin]], [[uterus]], others
	\| Assdx =		\| Assdx =
	\| Syndromes = [[hereditary leiomyomatosis and renal cell cancer]] (cutaneous leiomyomas)		\| Syndromes = [[hereditary leiomyomatosis and renal cell cancer]] (cutaneous & uterine leiomyomas)
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =

Michael: /* Uterine leiomyoma */

2014-07-25T06:38:12Z

Uterine leiomyoma

← Older revision		Revision as of 06:38, 25 July 2014
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	*Can be a cause of [[AUB]] ([[abnormal uterine bleeding]]).		*Can be a cause of [[AUB]] ([[abnormal uterine bleeding]]).
	*Large & multiple leiomyomas are associated with infertility.		*Large & multiple leiomyomas are associated with infertility.
			*May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC).

	===Colonic leiomyoma===		===Colonic leiomyoma===

Michael at 06:36, 25 July 2014

2014-07-25T06:36:13Z

← Older revision		Revision as of 06:36, 25 July 2014
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	\| Site = [[skin]], [[uterus]], others		\| Site = [[skin]], [[uterus]], others
	\| Assdx =		\| Assdx =
	\| Syndromes = hereditary leiomyomatosis and renal cell cancer (cutaneous leiomyomas)		\| Syndromes = [[hereditary leiomyomatosis and renal cell cancer]] (cutaneous leiomyomas)
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =
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	===Cutaneous leiomyomas===		===Cutaneous leiomyomas===
	*May be part of ''~~Hereditary Leiomyomatosis~~ and ~~Renal Cell Cancer~~'' (HLRCC).<ref>URL: [http://www.ncbi.nlm.nih.gov/books/NBK1252/ http://www.ncbi.nlm.nih.gov/books/NBK1252/]. Accessed on: 2 September 2011.</ref><ref>URL: [http://ccr.cancer.gov/staff/gallery.asp?profileid=12822 http://ccr.cancer.gov/staff/gallery.asp?profileid=12822]. Accessed on: 2 September 2011.</ref>		*May be part of ''[[hereditary leiomyomatosis and renal cell cancer]]'' (HLRCC).<ref>URL: [http://www.ncbi.nlm.nih.gov/books/NBK1252/ http://www.ncbi.nlm.nih.gov/books/NBK1252/]. Accessed on: 2 September 2011.</ref><ref>URL: [http://ccr.cancer.gov/staff/gallery.asp?profileid=12822 http://ccr.cancer.gov/staff/gallery.asp?profileid=12822]. Accessed on: 2 September 2011.</ref>
	*[[Painful skin lesion]].		*[[Painful skin lesion]].

Michael: /* Sign out */

2014-03-25T12:05:12Z

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← Older revision		Revision as of 12:05, 25 March 2014
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	===Micro===		===Micro===
	The section shows unremarkable hair-bearing skin with a well-circumscribed subcutaneous lesion with a fascicular architecture. The lesion has no nuclear atypia and no mitotic activity is identified. At the periphery of the lesion is a medium-sized muscular artery from which the lesion appears to arise.		The section shows unremarkable hair-bearing skin with a well-circumscribed subcutaneous lesion with a fascicular architecture. The lesion has no nuclear atypia and no mitotic activity is identified. At the periphery of the lesion is a medium-sized muscular artery from which the lesion appears to arise.

			====Alternate====
			The sections show a spindle cell lesion with a fascicular architecture. Focal hyaline
			change is seen. No nuclear atypia is apparent. Mitotic activity is not readily identified. No necrosis is identified. The lesion extends to the edge of the tissue fragments.

	==See also==		==See also==