Juvenile polyposis syndrome - Revision history

Michael: /* See also */ more

2012-11-04T16:23:41Z

Michael: /* References */ fix

2011-09-27T02:41:46Z

References: fix

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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Syndromes]]		[[Category:Syndromes]]

Michael: tweak

2011-09-27T02:39:11Z

tweak

← Older revision		Revision as of 02:39, 27 September 2011
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	It is characterized by ([[hamartomatous]]) [[juvenile polyps]].		It is characterized by ([[hamartomatous]]) [[juvenile polyps]].

	Individuals with JPS have an increased risk of gastrointestinal cancer. Classically, individuals with JPS get [[colorectal carcinoma]].<ref name=pmid20301642>{{Cite journal \| last1 = Pagon \| first1 = RA. \| last2 = Bird \| first2 = TD. \| last3 = Dolan \| first3 = CR. \| last4 = Stephens \| first4 = K. \| last5 = Larsen Haidle \| first5 = J. \| last6 = Howe \| first6 = JR. \| title = Juvenile Polyposis Syndrome \| journal = \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301642 }}</ref>		Individuals with JPS have an increased risk of gastrointestinal cancer. Classically, individuals with JPS get [[colorectal carcinoma]].<ref name=pmid20301642>{{Cite journal \| last1 = Pagon \| first1 = RA. \| last2 = Bird \| first2 = TD. \| last3 = Dolan \| first3 = CR. \| last4 = Stephens \| first4 = K. \| last5 = Larsen Haidle \| first5 = J. \| last6 = Howe \| first6 = JR. \| title = Juvenile Polyposis Syndrome \| journal = '' \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301642 }}</ref>

	Note:		Note:
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	==Criteria for Dx of JPS==		==Criteria for Dx of JPS==
	One of the following:<ref name=pmid20301642>{{Cite journal \| last1 = Pagon \| first1 = RA. \| last2 = Bird \| first2 = TD. \| last3 = Dolan \| first3 = CR. \| last4 = Stephens \| first4 = K. \| last5 = Larsen Haidle \| first5 = J. \| last6 = Howe \| first6 = JR. \| title = Juvenile Polyposis Syndrome \| journal = \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301642 }}</ref>		One of the following:<ref name=pmid20301642>{{Cite journal \| last1 = Pagon \| first1 = RA. \| last2 = Bird \| first2 = TD. \| last3 = Dolan \| first3 = CR. \| last4 = Stephens \| first4 = K. \| last5 = Larsen Haidle \| first5 = J. \| last6 = Howe \| first6 = JR. \| title = Juvenile Polyposis Syndrome \| journal = '' \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301642 }}</ref>
	#Five juvenile polyps in the colorectum.		#Five juvenile polyps in the colorectum.
	#"Multiple" juvenile polyps through-out GI tract.		#"Multiple" juvenile polyps through-out GI tract.

Michael: more

2011-09-27T02:27:41Z

← Older revision		Revision as of 02:27, 27 September 2011
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	'''Juvenile polyposis syndrome''', abbreviated '''JPS''', is an autosomal dominant inherited condition ~~classically~~ due to a mutation in SMAD4.<ref>{{OMIM\|~~600993~~}}</ref>		'''Juvenile polyposis syndrome''', abbreviated '''JPS''', is an autosomal dominant inherited condition due to a mutation in SMAD4<ref name=omim600993>{{OMIM\|600993}}</ref> or BMPR1A.<ref name=omim601299>{{OMIM\|601299}}</ref>

			==General==
	It is characterized by ([[hamartomatous]]) [[juvenile polyps]].		It is characterized by ([[hamartomatous]]) [[juvenile polyps]].

	Individuals with JPS have an increased risk of cancer.		Individuals with JPS have an increased risk of gastrointestinal cancer. Classically, individuals with JPS get [[colorectal carcinoma]].<ref name=pmid20301642>{{Cite journal \| last1 = Pagon \| first1 = RA. \| last2 = Bird \| first2 = TD. \| last3 = Dolan \| first3 = CR. \| last4 = Stephens \| first4 = K. \| last5 = Larsen Haidle \| first5 = J. \| last6 = Howe \| first6 = JR. \| title = Juvenile Polyposis Syndrome \| journal = \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301642 }}</ref>

			Note:
			*SMAD4 is also associated with ''[[hereditary hemorrhagic telangiectasia syndrome]]''.<ref name=omim600993>{{OMIM\|600993}}</ref>

			==Criteria for Dx of JPS==
			One of the following:<ref name=pmid20301642>{{Cite journal \| last1 = Pagon \| first1 = RA. \| last2 = Bird \| first2 = TD. \| last3 = Dolan \| first3 = CR. \| last4 = Stephens \| first4 = K. \| last5 = Larsen Haidle \| first5 = J. \| last6 = Howe \| first6 = JR. \| title = Juvenile Polyposis Syndrome \| journal = \| volume = \| issue = \| pages = \| month = \| year = \| doi = \| PMID = 20301642 }}</ref>
			#Five juvenile polyps in the colorectum.
			#"Multiple" juvenile polyps through-out GI tract.
			#Juvenile polyp + family history of JPS.

			Note:
			*"Multiple" is not defined.

	==See also==		==See also==
	*[[Gastrointestinal polyps]].		*[[Gastrointestinal polyps]].
			*[[Peutz-Jeghers syndrome]].

	==References==		==References==

Michael: more

2011-09-27T02:15:18Z

← Older revision		Revision as of 02:15, 27 September 2011
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	'''Juvenile polyposis syndrome''', abbreviated '''JPS''', is an inherited condition due to a mutation in SMAD4.<ref>{{OMIM\|600993}}</ref>		'''Juvenile polyposis syndrome''', abbreviated '''JPS''', is an autosomal dominant inherited condition classically due to a mutation in SMAD4.<ref>{{OMIM\|600993}}</ref>

	It is characterized by [[juvenile polyps]].		It is characterized by ([[hamartomatous]]) [[juvenile polyps]].

			Individuals with JPS have an increased risk of cancer.

	==See also==		==See also==

Michael: create

2011-09-27T02:09:20Z

create

New page

'''Juvenile polyposis syndrome''', abbreviated '''JPS''', is an inherited condition due to a mutation in SMAD4.<ref>{{OMIM|600993}}</ref>

It is characterized by [[juvenile polyps]].

==See also==
*[[Gastrointestinal polyps]].

==References==
{{Reflist|1}}

[[Category:Syndromes]]

← Older revision		Revision as of 16:23, 4 November 2012
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	*[[Gastrointestinal polyps]].		*[[Gastrointestinal polyps]].
	*[[Peutz-Jeghers syndrome]].		*[[Peutz-Jeghers syndrome]].
			*[[Intestinal polyposis]].

	==References==		==References==