Invisible colonic dysplasia - Revision history

Michael: /* Sign out */ +alternate

2021-10-05T14:38:46Z

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← Older revision		Revision as of 14:38, 5 October 2021
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	Comment:		Comment:
	If the tissue was NOT a polyp on endoscopy, close follow-up, a re-examination of the history/family history and re-biopsies are suggested.		If the tissue was NOT a polyp on endoscopy, close follow-up, a re-examination of the history/family history and re-biopsies are suggested.
			</pre>

			===Alternate===
			<pre>
			Rectum, Biopsy:
			- Polypoid fragment of rectal mucosa with LOW-GRADE DYSPLASIA, see comment.
			- NEGATIVE for high-grade dysplasia and NEGATIVE for malignancy.

			Comment:
			The histomorphology would be in keeping with a tubular adenoma; however, this specimen was not submitted as a polyp. Clinical correlation is recommended. Close follow-up with re-biopsy is suggested.
	</pre>		</pre>

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2021-03-09T19:34:52Z

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← Older revision		Revision as of 19:34, 9 March 2021
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	Comment:		Comment:
	If the tissue was NOT a polyp on endoscopy, close follow-up, a re-examination of the history/family history and re-biopsies ~~(with terminal ileum) is~~ suggested.		If the tissue was NOT a polyp on endoscopy, close follow-up, a re-examination of the history/family history and re-biopsies are suggested.
	</pre>		</pre>

Michael: /* General */

2021-03-09T19:33:01Z

General

← Older revision		Revision as of 19:33, 9 March 2021
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	==General==		==General==
	*The reason for random biopsies in inflammatory bowel disease.		*The reason for random biopsies in [[inflammatory bowel disease]].
	*Relatively uncommon - one series of [[ulcerative colitis]] patients estimated ~12% of lesions are "invisible".<ref>{{cite journal \|authors=Blonski W, Kundu R, Lewis J, Aberra F, Osterman M, Lichtenstein GR \|title=Is dysplasia visible during surveillance colonoscopy in patients with ulcerative colitis? \|journal=Scand J Gastroenterol \|volume=43 \|issue=6 \|pages=698–703 \|date=2008 \|pmid=18569987 \|doi=10.1080/00365520701866150 \|url=}}</ref>		*Relatively uncommon - one series of [[ulcerative colitis]] patients estimated ~12% of lesions are "invisible".<ref>{{cite journal \|authors=Blonski W, Kundu R, Lewis J, Aberra F, Osterman M, Lichtenstein GR \|title=Is dysplasia visible during surveillance colonoscopy in patients with ulcerative colitis? \|journal=Scand J Gastroenterol \|volume=43 \|issue=6 \|pages=698–703 \|date=2008 \|pmid=18569987 \|doi=10.1080/00365520701866150 \|url=}}</ref>

Michael: /* See also */

2021-03-09T19:32:43Z

Michael: /* See also */

2021-03-09T19:31:42Z

Michael at 19:28, 9 March 2021

2021-03-09T19:28:07Z

← Older revision		Revision as of 19:28, 9 March 2021
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|1}}

			[[Category:Diagnosis]]
			[[Category:Gastrointestinal pathology]]

Michael at 19:27, 9 March 2021

2021-03-09T19:27:10Z

← Older revision		Revision as of 19:27, 9 March 2021
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	==General==		==General==
	*The reason for random biopsies in inflammatory bowel disease.		*The reason for random biopsies in inflammatory bowel disease.
	*Relatively uncommon - one series of [[ulcerative colitis]] patients estimated ~12% of lesions are "invisible".<ref>{{cite journal \|~~vauthors~~=Blonski W, Kundu R, Lewis J, Aberra F, Osterman M, Lichtenstein GR \|title=Is dysplasia visible during surveillance colonoscopy in patients with ulcerative colitis? \|journal=Scand J Gastroenterol \|volume=43 \|issue=6 \|pages=698–703 \|date=2008 \|pmid=18569987 \|doi=10.1080/00365520701866150 \|url=}}</ref>		*Relatively uncommon - one series of [[ulcerative colitis]] patients estimated ~12% of lesions are "invisible".<ref>{{cite journal \|authors=Blonski W, Kundu R, Lewis J, Aberra F, Osterman M, Lichtenstein GR \|title=Is dysplasia visible during surveillance colonoscopy in patients with ulcerative colitis? \|journal=Scand J Gastroenterol \|volume=43 \|issue=6 \|pages=698–703 \|date=2008 \|pmid=18569987 \|doi=10.1080/00365520701866150 \|url=}}</ref>

	==Gross==		==Gross==
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	==Microscopic==		==Microscopic==
	Features:		Features:
	*~~Dysplasia~~.		#Nuclear changes at the surface of the mucosa - '''key feature'''.
			#*Size and shape ''or'' size change:
			#**Cigar-shaped (elongated) nucleus (usu. length:width > 3:1) with nuclear hyperchromasia (more blue).
			#**Large round nuclei +/- [[vesicular nuclei\|vesicular]] appearance (clearing) -- nuclei have white space.
			#*Nuclear crowding/pseudostratification - '''important'''.
			#*+/-Loss of nuclear polarity (nuclei no longer on basement membrane).
			#Loss/decrease of goblet cells (common).
			#Cytoplasmic hyperchromasia.

			Notes:
			*Nuclear changes deep to the surface are non-neoplastic if normal appearing mucosa (with small round nuclei) is superficial to it; mucosa that is more blue and atypical deep ''and'' less blue without nuclear atypia at the surface is said to be "maturing".
			**Classically, adenomatous polyps have "reverse maturation":
			***The surface is more hyperchromatic (more blue).
			***The base is more mature (more globlet cells, no nuclear changes -- less blue).
			*[[Ampullary adenoma]]s often have less prominent pseudostratification and fine chromatin.

			DDx:
			*Reactive changes due to inflammation.
			*Invasive adenocarcinoma.

	==See also==		==See also==

Michael: Created page with "'''Invisible colonic dysplasia''' is colonic dysplasia that is not seen on endoscopy. ==General== The reason for random biopsies in inflammatory bowel disease. Relatively..."

2021-03-09T19:10:29Z

Created page with "'''Invisible colonic dysplasia''' is colonic dysplasia that is not seen on endoscopy. ==General== *The reason for random biopsies in inflammatory bowel disease. *Relatively..."

New page

'''Invisible colonic dysplasia''' is colonic dysplasia that is not seen on endoscopy.

==General==
*The reason for random biopsies in inflammatory bowel disease.
*Relatively uncommon - one series of [[ulcerative colitis]] patients estimated ~12% of lesions are "invisible".<ref>{{cite journal |vauthors=Blonski W, Kundu R, Lewis J, Aberra F, Osterman M, Lichtenstein GR |title=Is dysplasia visible during surveillance colonoscopy in patients with ulcerative colitis? |journal=Scand J Gastroenterol |volume=43 |issue=6 |pages=698–703 |date=2008 |pmid=18569987 |doi=10.1080/00365520701866150 |url=}}</ref>

==Gross==
*Not visible - definitional.

==Microscopic==
Features:
*Dysplasia.

==See also==
*[[DALM]].

==References==
{{Reflist|1}}

← Older revision		Revision as of 19:32, 9 March 2021
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	==See also==		==See also==
	*[[~~DALM~~]].		*[[Dysplasia-associated lesion or mass]] (DALM).

	==References==		==References==

← Older revision		Revision as of 19:31, 9 March 2021
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	*Reactive changes due to inflammation.		*Reactive changes due to inflammation.
	*Invasive adenocarcinoma.		*Invasive adenocarcinoma.

			==Sign out==
			<pre>
			Submitted as "Colon Right, Biopsy":
			- Colonic mucosa with low-grade dysplasia, NEGATIVE for high-grade dysplasia,
			see comment.

			Comment:
			If the tissue was NOT a polyp on endoscopy, close follow-up, a re-examination of the history/family history and re-biopsies (with terminal ileum) is suggested.
			</pre>

	==See also==		==See also==

Invisible colonic dysplasia - Revision history

Michael: /* Sign out */ +alternate

Michael: /* Sign out */

Michael: /* General */

Michael: /* See also */

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Michael at 19:28, 9 March 2021

Michael at 19:27, 9 March 2021

Michael: Created page with "'''Invisible colonic dysplasia''' is colonic dysplasia that is not seen on endoscopy. ==General== *The reason for random biopsies in inflammatory bowel disease. *Relatively..."

Michael: Created page with "'''Invisible colonic dysplasia''' is colonic dysplasia that is not seen on endoscopy. ==General== The reason for random biopsies in inflammatory bowel disease. Relatively..."