Intravascular large B-cell lymphoma - Revision history

Michael at 06:53, 9 November 2014

2014-11-09T06:53:50Z

← Older revision		Revision as of 06:53, 9 November 2014
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	\| Prognosis = poor		\| Prognosis = poor
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = dependent on presentation, may include [[stroke]]
	\| Tx =		\| Tx =
	}}		}}

Michael: /* Images */

2014-11-09T06:52:43Z

Images

← Older revision		Revision as of 06:52, 9 November 2014
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	===Images===		===Images===
	<gallery>		<gallery>
			Image:Intravascular_lymphoma_-_intermed_mag.jpg \| Intravascular lymphoma - intermed. mag. (WC/Nephron)
	Image:Intravascular_lymphoma_-_high_mag.jpg \| Intravascular lymphoma - high mag. (WC/Nephron)		Image:Intravascular_lymphoma_-_high_mag.jpg \| Intravascular lymphoma - high mag. (WC/Nephron)
	Image:Intravascular_lymphoma_-_very_high_mag.jpg \| Intravascular lymphoma - very high mag. (WC/Nephron)		Image:Intravascular_lymphoma_-_very_high_mag.jpg \| Intravascular lymphoma - very high mag. (WC/Nephron)

Michael at 06:52, 9 November 2014

2014-11-09T06:52:03Z

← Older revision		Revision as of 06:52, 9 November 2014
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	\| LMDDx = T-cell intravascular lymphoma		\| LMDDx = T-cell intravascular lymphoma
	\| Stains =		\| Stains =
	\| IHC = ~~CD45 +ve,~~ CD20 +ve, CD34 -ve, CD3 -ve		\| IHC = CD20 +ve, CD34 -ve, CD3 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 06:51, 9 November 2014

2014-11-09T06:51:50Z

← Older revision		Revision as of 06:51, 9 November 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Intravascular lymphoma - very high mag.jpg
			\| Width =
			\| Caption = Intravascular lymphoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = abundant atypical intravascular lymphoid cells (large ~2-3X size of a mature lymphocyte, nucleolus prominent)
			\| Subtypes =
			\| LMDDx = T-cell intravascular lymphoma
			\| Stains =
			\| IHC = CD45 +ve, CD20 +ve, CD34 -ve, CD3 -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[blood vessels]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = non-specific presentation - may include fever, skin lesions
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Intravascular large B-cell lymphoma''' refers to a rare form of [[lymphoma]] that is intravascular, B-cell derived, and does not manifest as a mass.		'''Intravascular large B-cell lymphoma''' refers to a rare form of [[lymphoma]] that is intravascular, B-cell derived, and does not manifest as a mass.

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	==General==		==General==
			*Rare - est. at one in million.<ref name=pmid22529262>{{Cite journal \| last1 = Raza \| first1 = M. \| last2 = Qayyum \| first2 = S. \| last3 = Raza \| first3 = S. \| last4 = Goorha \| first4 = S. \| title = Intravascular B-cell lymphoma: an elusive diagnosis. \| journal = J Clin Oncol \| volume = 30 \| issue = 15 \| pages = e144-5 \| month = May \| year = 2012 \| doi = 10.1200/JCO.2011.38.7720 \| PMID = 22529262 }}</ref>

	Clinical:		Clinical:
	*Often a non-specific presentation.<ref name=pmid11579120>{{cite journal \|author=Lapkuviene O, Forchetti D, Roepke JE \|title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms \|journal=J. Clin. Oncol. \|volume=19 \|issue=19 \|pages=3988–91 \|year=2001 \|month=October \|pmid=11579120 \|doi= \|url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref>		*Often a non-specific presentation.<ref name=pmid11579120>{{cite journal \|author=Lapkuviene O, Forchetti D, Roepke JE \|title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms \|journal=J. Clin. Oncol. \|volume=19 \|issue=19 \|pages=3988–91 \|year=2001 \|month=October \|pmid=11579120 \|doi= \|url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref>
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	Features:<ref name=pmid11579120/>		Features:<ref name=pmid11579120/>
	*CD20 +ve - '''key feature'''.		*CD20 +ve - '''key feature'''.
			*CD79a +ve.<ref name=pmid22529262/>
	*CD3 -ve.		*CD3 -ve.
	*CD34 -ve.		*CD34 -ve.

Michael: /* See also */

2014-04-05T21:04:30Z

Michael: split out

2014-03-09T04:05:46Z

split out

← Older revision		Revision as of 04:05, 9 March 2014
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	~~#redirect [[Lymphoma#~~Intravascular large B-cell lymphoma]]		'''Intravascular large B-cell lymphoma''' refers to a rare form of [[lymphoma]] that is intravascular, B-cell derived, and does not manifest as a mass.

			Several terms have been use to refer this entity, including '''angiotropic lymphoma''', '''intravascular malignant lymphomatosis''' and '''malignant angioendotheliomatosis'''.

			==General==
			Clinical:
			*Often a non-specific presentation.<ref name=pmid11579120>{{cite journal \|author=Lapkuviene O, Forchetti D, Roepke JE \|title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms \|journal=J. Clin. Oncol. \|volume=19 \|issue=19 \|pages=3988–91 \|year=2001 \|month=October \|pmid=11579120 \|doi= \|url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref>
			**+/-Fever.
			**+/-Multiple infarcts.
			**+/-Non-specific skin lesions.

			==Microscopic==
			Features:
			*Abundant atypical intravascular lymphoid cells that are:
			**Large (~2-3X size of a mature lymphocyte or RBC).
			**Nucleolus prominent.

			Notes:
			*It may be hard to find RBCs in the vessels.
			*Looks sorta like a [[DLBCL]] -- but is intravascular.

			===Images===
			<gallery>
			Image:Intravascular_lymphoma_-_high_mag.jpg \| Intravascular lymphoma - high mag. (WC/Nephron)
			Image:Intravascular_lymphoma_-_very_high_mag.jpg \| Intravascular lymphoma - very high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://jco.ascopubs.org/content/19/19/3988/F1.expansion.html ILBCL (ascopubs.org)].<ref name=pmid11579120/>
			*[http://theoncologist.alphamedpress.org/cgi/content/full/11/8/923/F1 ILBCL in bone marrow (alphamedpress.org)].
			*[http://annonc.oxfordjournals.org/content/13/9/1503/F1.expansion.html ILBCL - various images (oxfordjournals.org)].
			*[http://path.upmc.edu/cases/case473/images/fig01a.jpg ILBCL (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case473.html http://path.upmc.edu/cases/case473.html]. Accessed on: 21 January 2012.</ref>
			*[http://path.upmc.edu/cases/case697.html ILBCL - several images (upmc.edu)].

			==IHC==
			Features:<ref name=pmid11579120/>
			*CD20 +ve - '''key feature'''.
			*CD3 -ve.
			*CD34 -ve.

			==See also==
			*[[Intravascular lymphoma]].
			*[[Lymphoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Lymphoma]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect w/ cat.

2011-10-23T00:39:34Z

redirect w/ cat.

New page

#redirect [[Lymphoma#Intravascular large B-cell lymphoma]]

[[Category:Diagnosis]]

← Older revision		Revision as of 21:04, 5 April 2014
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	==See also==		==See also==
	*[[Intravascular lymphoma]].		*[[Intravascular lymphoma]].
			*[[Extramedullary leukemia]].
	*[[Lymphoma]].		*[[Lymphoma]].