Mitchell: /* General */ added a sentence about oncocytic type

2017-02-10T17:39:28Z

General: added a sentence about oncocytic type

← Older revision		Revision as of 17:39, 10 February 2017
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	***Main duct (bad prognosis).		***Main duct (bad prognosis).
	***Branch (good prognosis).		***Branch (good prognosis).


	Clinical:		Clinical:
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	#*Less commonly associated with invasive carcinoma.		#*Less commonly associated with invasive carcinoma.

			The oncocytic subtype of IPMT is now known to be genetically separate from other types.<ref name=pmid27282351>{{cite journal \|author=Basturk O, Tan M, Bhanot U, Allen P, Adsay V, Scott SN, Shah R, Berger MF, Askan G, Dikoglu E, Jobanputra V, Wrzeszczynski KO, Sigel C, Iacobuzio-Donahue C, Klimstra DS. \|title=The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes \|journal=Mod Pathol \|volume=29 \|pages=1058-69 \|year=2016 \|pmid=27282351 }}</ref>
	=====Behaviour=====		=====Behaviour=====
	*Adenoma.		*Adenoma.

Michael: othe rname

2016-05-21T04:35:43Z

othe rname

← Older revision		Revision as of 04:35, 21 May 2016
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	'''Intraductal papillary mucinous tumour''', abbreviated '''IPMT''', is an uncommon tumour of the [[pancreas]].		'''Intraductal papillary mucinous tumour''', abbreviated '''IPMT''', is an uncommon tumour of the [[pancreas]].

			It is also known as '''intraductal papillary mucinous neoplasm''' (abbreviated '''IPMN''').

	==General==		==General==

Michael: split out

2016-05-21T04:33:31Z

split out

← Older revision		Revision as of 04:33, 21 May 2016
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	~~#redirect~~ [[~~Pancreas#Intraductal_papillary_mucinous_tumour~~]]		'''Intraductal papillary mucinous tumour''', abbreviated '''IPMT''', is an uncommon tumour of the [[pancreas]].

			==General==
			*Morphologically and biologically distinct from ductal adenocarcinoma, mucinous cystic tumour and ductal papillary hyperplasia.
			*Prognosis:
			**Favourable if caught early; not much different than ductal adenocarcinoma if caught late.<ref name=pmid12377813>{{cite journal \|author=Maire F, Hammel P, Terris B, ''et al.'' \|title=Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma \|journal=Gut \|volume=51 \|issue=5 \|pages=717–22 \|year=2002 \|month=November \|pmid=12377813 \|pmc=1773420 \|doi= \|url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12377813}}</ref>
			**Dependent what is involved:<ref name=pmid20374620>{{cite journal \|author=Baiocchi GL, Portolani N, Missale G, ''et al.'' \|title=Intraductal papillary mucinous neoplasm of the pancreas (IPMN): clinico-pathological correlations and surgical indications \|journal=World J Surg Oncol \|volume=8 \|issue= \|pages=25 \|year=2010 \|pmid=20374620 \|pmc=2858722 \|doi=10.1186/1477-7819-8-25 \|url=http://wjso.com/content/8/1/25}}</ref>
			***Main duct (bad prognosis).
			***Branch (good prognosis).

			Clinical:
			*Patient usually not jaundiced... as no obstruction.
			*Often diabetes... as pancreas is destroyed.
			*Patients may get a total pancreatectomy - as the disease is often multifocal.

			====Epidemiology====
			*~1% of all exocrine pancreatic tumours.
			*More common in males.
			*Mean age at presentation 62 years.
			*60-80% occur in the head of the pancreas.
			*Average size 4 cm.

			===Classification of IMPT===
			Commonly classified by the duct involvement:<ref name=pmid20397268>{{Cite journal \| last1 = Ikeuchi \| first1 = N. \| last2 = Itoi \| first2 = T. \| last3 = Sofuni \| first3 = A. \| last4 = Itokawa \| first4 = F. \| last5 = Tsuchiya \| first5 = T. \| last6 = Kurihara \| first6 = T. \| last7 = Ishii \| first7 = K. \| last8 = Tsuji \| first8 = S. \| last9 = Umeda \| first9 = J. \| title = Prognosis of cancer with branch duct type IPMN of the pancreas. \| journal = World J Gastroenterol \| volume = 16 \| issue = 15 \| pages = 1890-5 \| month = Apr \| year = 2010 \| doi = \| PMID = 20397268 PMC = 2856831 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856831/}}</ref>
			#Main duct type.
			#*Commonly associated with invasive carcinoma.
			#Branch duct type.
			#*Less commonly associated with invasive carcinoma.

			=====Behaviour=====
			*Adenoma.
			*Borderline mucinous tumour.
			*Carcinoma.

			Notes:
			*Borderline tumours are rare.
			*If intralobular dilated ducts... carcinoma.
			*Any margin with mucin cells in thought to be badness!

			==Gross==
			*May be patchy/multifocal.
			*Multiple cystic spaces.

			==Microscopic==
			Features:
			*Pancreatic duct lining cells jut into the duct lumen - papillomatous growth pattern.
			*Cytology:
			**Cell enlargement.
			***Increased mucin production.
			**Nuclear changes:
			***Increased [[NC ratio]].
			***Nuclear crowding and [[nuclear pleomorphism\|pleomorphism]].
			**Mitotic activity.

			Note:
			*No ovarian type stroma underneath (as seen in mucinous tumours).

			DDx:
			*[[PanIN]].
			*[[Invasive ductal carcinoma of the pancreas]].
			*Intra-ampullary papillary-tubular neoplasm -- see ''[[ampulla of Vater]]''.

			==See also==
			*[[Pancreas]].

			==References==
			{{Reflist\|1}}
			[[Category:Pancreas]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2011-10-18T03:47:24Z

redirect

New page

#redirect [[Pancreas#Intraductal_papillary_mucinous_tumour]]

[[Category:Diagnosis]]

Intraductal papillary mucinous tumour - Revision history

Mitchell: /* General */ added a sentence about oncocytic type

Michael: othe rname

Michael: split out

Michael: redirect